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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:696596480464CTDCannabidiol results in increased expression of ICAM1 mRNA, Cannabidiol results in increased expression of ICAM1 protein

PMID:22198381
multiple interactionsISORGD:696596480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA], AM 251 inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA], capsazepine inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA], ICAM1 mutant form inhibits the reaction [Cannabidiol results in increased expression of TIMP1 protein], iodopravadoline inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA]

PMID:22198381
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.