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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:81520
Term: 2,3',4,4',5-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C070055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA, 2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 protein

PMID:26519956
multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA], MAPK8 affects the reaction [2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA], MAPK9 affects the reaction [2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA]

PMID:26519956
affects response to substanceISORGD:107566480464CTDICAM1 protein affects the susceptibility to 2, 3', 4, 4', 5-pentachlorobiphenyl

PMID:22240979
increases expressionISORGD:107566480464CTD2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA, 2, 3', 4, 4', 5-pentachlorobiphenyl results in increased expression of ICAM1 protein

PMID:22240979
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.