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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107566480464CTDEstradiol results in increased expression of ICAM1 protein

PMID:17578864
increases expressionISORGD:696596480464CTDEstradiol results in increased expression of ICAM1 mRNA

PMID:18692832, PMID:20106945
multiple interactionsISORGD:107566480464CTDEstradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA], Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]

PMID:21501669
multiple interactionsISORGD:696596480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of ICAM1 protein, [Progesterone co-treated with Estradiol] results in increased expression of ICAM1 mRNA, MPO gene polymorphism affects the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of ICAM1 protein]

PMID:20226447, PMID:21242819
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.