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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Icam1increases expressionISOIcam1 (Mus musculus)6480464CTDEstradiol results in increased expression of ICAM1 proteinPMID:17578864
Icam1increases expressionISOICAM1 (Homo sapiens)6480464CTDEstradiol results in increased expression of ICAM1 mRNAPMID:18692832 PMID:20106945 PMID:31614463
Icam1multiple interactionsISOIcam1 (Mus musculus)6480464CTDEstradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]PMID:21501669
Icam1multiple interactionsISOICAM1 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of ICAM1 protein; [Progesterone co-treated with Estradiol] results in increased expression of ICAM1 mRNA; MPO gene polymorphism affects the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of ICAM1 protein]PMID:20226447 PMID:21242819
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