Itgal (integrin subunit alpha L) - Rat Genome Database

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Gene: Itgal (integrin subunit alpha L) Chinchilla lanigera
Analyze
Symbol: Itgal
Name: integrin subunit alpha L
RGD ID: 8916185
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); ICAM-3 receptor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); calcium-mediated signaling (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Behcet's disease (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha-L; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,397,991 - 7,439,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,397,813 - 7,435,420 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Itgal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,397,991 - 7,439,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,397,813 - 7,435,420 (+)NCBIChiLan1.0ChiLan1.0
ITGAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,472,742 - 30,523,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,472,658 - 30,523,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,484,063 - 30,534,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,391,572 - 30,442,007 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,391,571 - 30,442,006NCBI
Celera1629,763,904 - 29,814,478 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,046,747 - 28,097,233 (+)NCBIHuRef
CHM1_11631,801,165 - 31,851,694 (+)NCBICHM1_1
T2T-CHM13v2.01630,859,706 - 30,910,154 (+)NCBIT2T-CHM13v2.0
Itgal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,895,404 - 126,934,309 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,895,432 - 126,934,310 (+)EnsemblGRCm39 Ensembl
GRCm387127,296,139 - 127,335,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,296,260 - 127,335,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv377134,439,862 - 134,477,412 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,087,558 - 127,124,876 (+)NCBIMGSCv36mm8
Celera7127,147,867 - 127,186,306 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.44NCBI
Itgal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,348,424 - 191,386,228 (+)NCBIGRCr8
mRatBN7.21181,918,183 - 181,955,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,918,183 - 181,955,732 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,268,740 - 190,306,294 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,454,828 - 197,492,382 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,123,273 - 190,161,047 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,744,053 - 198,781,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,744,050 - 198,781,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,742,280 - 205,780,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,561,795 - 186,598,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,716,379 - 186,726,577 (+)NCBI
Celera1179,569,739 - 179,607,287 (+)NCBICelera
Cytogenetic Map1q37NCBI
ITGAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21833,678,868 - 33,730,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,480,286 - 38,531,140 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01624,445,966 - 24,496,037 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11630,843,567 - 30,894,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,843,747 - 30,892,597 (+)Ensemblpanpan1.1panPan2
ITGAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,605,611 - 17,645,134 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,605,760 - 17,644,986 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,178,232 - 19,219,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,735,141 - 17,775,970 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,733,504 - 17,775,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,535,332 - 17,576,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,450,788 - 17,491,710 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,765,852 - 17,806,699 (-)NCBIUU_Cfam_GSD_1.0
Itgal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,823,517 - 124,869,013 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,922,642 - 12,966,663 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,921,509 - 12,966,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,817,011 - 17,858,012 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,817,785 - 17,858,057 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,259,483 - 18,299,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,157,866 - 27,206,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,157,878 - 27,206,714 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,301,391 - 2,352,795 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,640,996 - 13,669,541 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,635,217 - 13,671,401 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000021013   ⟹   ENSCLAP00000020813
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554937,397,991 - 7,439,070 (+)Ensembl
RefSeq Acc Id: XM_013504854   ⟹   XP_013360308
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554937,397,813 - 7,435,420 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013360308 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000020813
  ENSCLAP00000020813.1
RefSeq Acc Id: XP_013360308   ⟸   XM_013504854
- UniProtKB: A0A8C2YSV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000020813   ⟸   ENSCLAT00000021013
Protein Domains
VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014257 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021013 ENTREZGENE
  ENSCLAT00000021013.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.2120 UniProtKB/TrEMBL
  2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene Itgal ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-L UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8C2YSV6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Itgal  integrin subunit alpha L    integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)  Symbol and/or name change 5135510 APPROVED