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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itgal
Name: integrin subunit alpha L
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgalincreases expressionEXP 6480464CTDStreptozocin results in increased expression of ITGAL proteinPMID:16129698
Itgalmultiple interactionsEXP 6480464CTD[resveratrol co-treated with Streptozocin] results in increased expression of ITGAL mRNA; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAL protein]PMID:16129698 PMID:25905778
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