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Gene: ITGAV (integrin subunit alpha V) Homo sapiens
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Symbol: ITGAV
Name: integrin subunit alpha V
Description: Exhibits several functions, including extracellular matrix protein binding activity; fibronectin binding activity; and integrin binding activity. Contributes to C-X3-C chemokine binding activity and growth factor binding activity. Involved in several processes, including negative regulation of entry of bacterium into host cell; negative regulation of lipid localization; and negative regulation of protein metabolic process. Localizes to several cellular components, including the alphav-beta3 integrin-HMGB1 complex; cell projection membrane; and integrin complex. Implicated in abdominal aortic aneurysm and acute myeloid leukemia. Biomarker of hyperglycemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen identified by monoclonal antibody L230; CD51; DKFZp686A08142; integrin alpha V; integrin alpha-V; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; vitronectin receptor; vitronectin receptor subunit alpha; VNRA; VTNR
Orthologs:
Mus musculus (house mouse) : Itgav (integrin alpha V)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgav (integrin subunit alpha V)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgav (integrin subunit alpha V)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGAV (integrin subunit alpha V)
Canis lupus familiaris (dog) : ITGAV (integrin subunit alpha V)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgav (integrin subunit alpha V)
Sus scrofa (pig) : ITGAV (integrin subunit alpha V)
Chlorocebus sabaeus (green monkey) : ITGAV (integrin subunit alpha V)
Heterocephalus glaber (naked mole-rat) : Itgav (integrin subunit alpha V)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2186,590,056 - 186,680,901 (+)Ensembl
GRCh382186,590,056 - 186,680,902 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372187,454,058 - 187,545,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ITGAV
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321618
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.