Itga2b (integrin alpha 2b) - Rat Genome Database

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Gene: Itga2b (integrin alpha 2b) Mus musculus
Analyze
Symbol: Itga2b
Name: integrin alpha 2b
RGD ID: 1557725
MGI Page MGI
Description: Enables extracellular matrix binding activity. Acts upstream of or within cell-matrix adhesion. Located in external side of plasma membrane and focal adhesion. Is expressed in several structures, including early conceptus; hematopoietic system; liver; mesenchyme derived from splanchnopleure; and umbilical blood vessel. Used to study platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI172977; al; alpha IIb; alphaIIb; CD41; CD41B; Gp; GP IIb; GPalpha IIb; GpIIb; integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet membrane glycoprotein IIb
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,344,134 - 102,360,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,344,123 - 102,360,948 (-)EnsemblGRCm39 Ensembl
GRCm3811102,453,297 - 102,469,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,453,297 - 102,470,122 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,314,611 - 102,331,197 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,269,387 - 102,285,834 (-)NCBIMGSCv36mm8
Celera11114,163,479 - 114,180,083 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
anagrelide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cangrelor  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
etoposide  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
glucose  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methyllycaconitine  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (EXP)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
Nutlin-3  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
testosterone  (EXP)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. Ding G, etal., J Cereb Blood Flow Metab. 2005 Jan;25(1):87-97.
2. Different biochemical expression pattern of platelet surface glycoproteins suggests molecular diversity of Glanzmann's thrombasthenia in Iran. Farsinejad A, etal., Blood Coagul Fibrinolysis. 2013 Sep;24(6):613-8. doi: 10.1097/MBC.0b013e328360a558.
3. An exon 28 mutation resulting in alternative splicing of the glycoprotein IIb transcript and Glanzmann's thrombasthenia. Iwamoto S, etal., Blood. 1994 Feb 15;83(4):1017-23.
4. Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombasthenia. Kannan M, etal., J Thromb Haemost. 2009 Nov;7(11):1878-85. doi: 10.1111/j.1538-7836.2009.03579.x. Epub 2009 Aug 19.
5. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
6. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
7. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
8. Heterozygous ITGA2B R995W mutation inducing constitutive activation of the alphaIIbbeta3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Kunishima S, etal., Blood. 2011 May 19;117(20):5479-84. doi: 10.1182/blood-2010-12-323691. Epub 2011 Mar 31.
9. An alphaIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the beta-propeller (Asn2Asp) disrupts a calcium binding site in blade 6. Mansour W, etal., J Thromb Haemost. 2011 Jan;9(1):192-200. doi: 10.1111/j.1538-7836.2010.04087.x.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene. Peretz H, etal., Blood. 1995 Jan 15;85(2):414-20.
15. A novel amino acid substitution of integrin alphaIIb in Glanzmann thrombasthenia confirms that the N-terminal region of the receptor plays a role in maintaining beta-propeller structure. Pillois X, etal., Platelets. 2013;24(1):77-80. doi: 10.3109/09537104.2012.665278. Epub 2012 Mar 6.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation. Salter JW, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1432-9.
22. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
23. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Teeling JL, etal., Blood. 2001 Aug 15;98(4):1095-9.
24. Glycoprotein IIB/IIIA-inhibition and microcirculatory alterations during experimental endotoxemia--an intravital microscopic study in the rat. Walther A, etal., Microcirculation. 2004 Jan-Feb;11(1):79-88.
25. Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17. Zimdahl H, etal., Hypertension 2002 Jun;39(6):1050-2.
Additional References at PubMed
PMID:1431091   PMID:1512266   PMID:2018971   PMID:7774011   PMID:8216269   PMID:9291578   PMID:9427478   PMID:9679061   PMID:10337632   PMID:10349636   PMID:10572112   PMID:10713093  
PMID:10922068   PMID:10926935   PMID:10942384   PMID:10981960   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11353389   PMID:11686325   PMID:11698303   PMID:11884039   PMID:12183468  
PMID:12393463   PMID:12393529   PMID:12477932   PMID:12651156   PMID:12755332   PMID:12871637   PMID:12900455   PMID:14751927   PMID:15031111   PMID:15059849   PMID:15131115   PMID:15166241  
PMID:15226180   PMID:15345747   PMID:15533817   PMID:15543332   PMID:15725743   PMID:15781330   PMID:15882575   PMID:16051597   PMID:16103235   PMID:16141072   PMID:16141073   PMID:16210341  
PMID:16304048   PMID:16365395   PMID:16434494   PMID:16602821   PMID:16670270   PMID:16690964   PMID:16720835   PMID:16757682   PMID:17295603   PMID:17309829   PMID:17420226   PMID:18084279  
PMID:18086863   PMID:18317590   PMID:18334487   PMID:18371378   PMID:18430780   PMID:18487513   PMID:18544684   PMID:18684862   PMID:18971422   PMID:18987357   PMID:19005179   PMID:19360001  
PMID:19633199   PMID:19682090   PMID:19693543   PMID:19755424   PMID:19940148   PMID:19966813   PMID:20016849   PMID:20052668   PMID:20075254   PMID:20110424   PMID:20203303   PMID:20228271  
PMID:20562862   PMID:20660741   PMID:20670372   PMID:20699440   PMID:20876651   PMID:20887958   PMID:20947017   PMID:20971951   PMID:20980401   PMID:21041952   PMID:21246656   PMID:21267068  
PMID:21281624   PMID:21368290   PMID:21368762   PMID:21415271   PMID:21483770   PMID:21618089   PMID:21645497   PMID:21873635   PMID:22096246   PMID:22275070   PMID:22387002   PMID:22456341  
PMID:22554697   PMID:22647975   PMID:22687584   PMID:22730538   PMID:22812543   PMID:22863011   PMID:22865702   PMID:23028636   PMID:23082158   PMID:23091165   PMID:23148237   PMID:23152823  
PMID:23216754   PMID:23519467   PMID:23564910   PMID:23640884   PMID:23770641   PMID:23775711   PMID:23789102   PMID:23840065   PMID:23935982   PMID:24030382   PMID:24326267   PMID:24385425  
PMID:24523237   PMID:24585775   PMID:24969775   PMID:25079320   PMID:25139355   PMID:25139854   PMID:25298035   PMID:25772358   PMID:25774504   PMID:25908104   PMID:25995324   PMID:26204127  
PMID:26282541   PMID:26396195   PMID:26418893   PMID:26457609   PMID:26460546   PMID:26790499   PMID:27010197   PMID:27140400   PMID:27864380   PMID:27880904   PMID:28253287   PMID:28375155  
PMID:28542600   PMID:28815933   PMID:28954813   PMID:29195076   PMID:29361560   PMID:29386381   PMID:29791855   PMID:29853539   PMID:30033122   PMID:30333137   PMID:30355615   PMID:30573502  
PMID:30630213   PMID:30936549   PMID:31691484   PMID:31978220   PMID:32149421   PMID:33158859   PMID:33188196   PMID:33454424   PMID:33480126   PMID:33619517   PMID:33928629   PMID:34762852  
PMID:34816104   PMID:34910918   PMID:35395997   PMID:35452096   PMID:36441774   PMID:36479973   PMID:36674478   PMID:37669937   PMID:38237079   PMID:38482878   PMID:38580775   PMID:39040056  


Genomics

Comparative Map Data
Itga2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,344,134 - 102,360,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,344,123 - 102,360,948 (-)EnsemblGRCm39 Ensembl
GRCm3811102,453,297 - 102,469,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,453,297 - 102,470,122 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,314,611 - 102,331,197 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,269,387 - 102,285,834 (-)NCBIMGSCv36mm8
Celera11114,163,479 - 114,180,083 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
ITGA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,372,181 - 44,389,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,372,180 - 44,389,649 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,449,549 - 42,467,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,805,076 - 39,822,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,805,075 - 39,822,399NCBI
Celera1739,159,154 - 39,176,462 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,213,453 - 38,230,761 (-)NCBIHuRef
CHM1_11742,685,183 - 42,702,506 (-)NCBICHM1_1
T2T-CHM13v2.01745,226,172 - 45,243,631 (-)NCBIT2T-CHM13v2.0
Itga2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,908,697 - 87,926,225 (-)NCBIGRCr8
mRatBN7.21087,408,532 - 87,426,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,408,536 - 87,426,168 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01090,397,960 - 90,416,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,398,132 - 90,415,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,186,491 - 90,205,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,557,086 - 91,574,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1086,112,796 - 86,134,968 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Itga2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,382,779 - 17,391,859 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,381,323 - 17,392,122 (-)NCBIChiLan1.0ChiLan1.0
ITGA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,520,139 - 20,538,039 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,483,944 - 22,501,823 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,009,514 - 13,027,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,176,843 - 13,193,269 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,176,843 - 13,193,269 (+)Ensemblpanpan1.1panPan2
ITGA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,049,643 - 19,064,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,050,001 - 19,063,992 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,439,814 - 18,453,677 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,744,435 - 19,758,300 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,714,740 - 19,758,300 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,598,247 - 18,612,116 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,781,219 - 18,795,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,925,492 - 18,939,347 (+)NCBIUU_Cfam_GSD_1.0
Itga2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,365,697 - 18,380,441 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541814,171 - 828,291 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541813,815 - 828,826 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,001,082 - 62,019,470 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,001,352 - 62,019,289 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,766,163 - 32,785,616 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795683,968 - 703,710 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795683,899 - 695,262 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga2b
595 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1907
Count of miRNA genes:711
Interacting mature miRNAs:893
Transcripts:ENSMUST00000103086, ENSMUST00000124767, ENSMUST00000128752, ENSMUST00000130433, ENSMUST00000130757, ENSMUST00000131247, ENSMUST00000134735, ENSMUST00000145925, ENSMUST00000149519, ENSMUST00000151625
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
AI172977  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,453,354 - 102,453,491UniSTSGRCm38
MGSCv3711102,314,668 - 102,314,805UniSTSGRCm37
Celera11114,163,536 - 114,163,673UniSTS
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
Whitehead/MRC_RH111380.43UniSTS
PMC129049P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,469,493 - 102,469,860UniSTSGRCm38
MGSCv3711102,330,807 - 102,331,174UniSTSGRCm37
Celera11114,179,693 - 114,180,060UniSTS
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
Itga2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,456,303 - 102,457,511UniSTSGRCm38
MGSCv3711102,317,617 - 102,318,825UniSTSGRCm37
Celera11114,166,490 - 114,167,698UniSTS
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
PMC303331P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,469,720 - 102,469,981UniSTSGRCm38
MGSCv3711102,331,034 - 102,331,295UniSTSGRCm37
Celera11114,179,920 - 114,180,181UniSTS
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
Itga2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
Itga2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF045019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF166384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF169829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF170316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC120493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY204133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S43388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000103086   ⟹   ENSMUSP00000099375
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,344,123 - 102,360,709 (-)Ensembl
GRCm38.p6 Ensembl11102,453,297 - 102,469,883 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,352,038 - 102,352,763 (-)Ensembl
GRCm38.p6 Ensembl11102,461,212 - 102,461,937 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,346,665 - 102,348,146 (-)Ensembl
GRCm38.p6 Ensembl11102,455,839 - 102,457,320 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,348,336 - 102,351,661 (-)Ensembl
GRCm38.p6 Ensembl11102,457,510 - 102,460,835 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,358,626 - 102,360,948 (-)Ensembl
GRCm38.p6 Ensembl11102,467,800 - 102,470,122 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,348,026 - 102,349,185 (-)Ensembl
GRCm38.p6 Ensembl11102,457,200 - 102,458,359 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134735
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,344,130 - 102,347,016 (-)Ensembl
GRCm38.p6 Ensembl11102,453,304 - 102,456,190 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,357,113 - 102,357,781 (-)Ensembl
GRCm38.p6 Ensembl11102,466,287 - 102,466,955 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149519
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,347,298 - 102,358,025 (-)Ensembl
GRCm38.p6 Ensembl11102,456,472 - 102,467,199 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,346,723 - 102,349,391 (-)Ensembl
GRCm38.p6 Ensembl11102,455,897 - 102,458,565 (-)Ensembl
RefSeq Acc Id: NM_010575   ⟹   NP_034705
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911102,344,134 - 102,360,570 (-)NCBI
GRCm3811102,453,297 - 102,469,883 (-)NCBI
MGSCv3711102,314,611 - 102,331,197 (-)RGD
Celera11114,163,479 - 114,180,083 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034705   ⟸   NM_010575
- Peptide Label: precursor
- UniProtKB: Q64229 (UniProtKB/Swiss-Prot),   Q3U3R7 (UniProtKB/Swiss-Prot),   Q9Z2M0 (UniProtKB/Swiss-Prot),   Q9QUM0 (UniProtKB/Swiss-Prot),   B2RPR7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099375   ⟸   ENSMUST00000103086
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUM0-F1-model_v2 AlphaFold Q9QUM0 1-1033 view protein structure

Promoters
RGD ID:6821119
Promoter ID:MM_KWN:9995
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000005812,   OTTMUST00000005814
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,328,389 - 102,328,889 (-)MPROMDB
RGD ID:6821121
Promoter ID:MM_KWN:9996
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney
Transcripts:NM_010575,   OTTMUST00000005813
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,331,106 - 102,331,606 (-)MPROMDB
RGD ID:8676900
Promoter ID:EPDNEW_M16480
Type:single initiation site
Name:Itga2b_3
Description:Mus musculus integrin alpha 2b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16481  EPDNEW_M16482  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811102,467,206 - 102,467,266EPDNEW
RGD ID:8676902
Promoter ID:EPDNEW_M16481
Type:single initiation site
Name:Itga2b_1
Description:Mus musculus integrin alpha 2b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16480  EPDNEW_M16482  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811102,469,744 - 102,469,804EPDNEW
RGD ID:8676904
Promoter ID:EPDNEW_M16482
Type:initiation region
Name:Itga2b_2
Description:Mus musculus integrin alpha 2b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16480  EPDNEW_M16481  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811102,469,852 - 102,469,912EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96601 AgrOrtholog
Ensembl Genes ENSMUSG00000034664 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103086 ENTREZGENE
  ENSMUST00000103086.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16399 UniProtKB/Swiss-Prot
MGD MGI:96601 ENTREZGENE
NCBI Gene 16399 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN ALPHA-IIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ITGA2B RGD
PhenoGen Itga2b PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RPR7 ENTREZGENE, UniProtKB/TrEMBL
  ITA2B_MOUSE UniProtKB/Swiss-Prot
  Q3U3R7 ENTREZGENE
  Q64229 ENTREZGENE
  Q9QUM0 ENTREZGENE
  Q9Z2M0 ENTREZGENE
UniProt Secondary Q3U3R7 UniProtKB/Swiss-Prot
  Q64229 UniProtKB/Swiss-Prot
  Q9Z2M0 UniProtKB/Swiss-Prot