Itga3 (integrin alpha 3) - Rat Genome Database

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Gene: Itga3 (integrin alpha 3) Mus musculus
Analyze
Symbol: Itga3
Name: integrin alpha 3
RGD ID: 1321178
MGI Page MGI
Description: Predicted to enable several functions, including fibronectin binding activity; integrin binding activity; and protein heterodimerization activity. Involved in postsynapse organization and synaptic membrane adhesion. Acts upstream of or within several processes, including dendritic spine maintenance; exploration behavior; and negative regulation of Rho protein signal transduction. Located in several cellular components, including basolateral plasma membrane; external side of plasma membrane; and synaptic membrane. Is active in glutamatergic synapse; neuromuscular junction; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa. Orthologous to human ITGA3 (integrin subunit alpha 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA407068; alpha3-integrin; CD49 antigen-like family member C; CD49C; galactoprotein B3; GAPB3; integrin alpha-3; VLA-3 alpha 3; VLA-3 receptor, alpha 3 subunit; VLA-3 subunit alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,935,301 - 94,967,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,935,300 - 94,967,627 (-)EnsemblGRCm39 Ensembl
GRCm381195,044,475 - 95,076,844 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,044,474 - 95,076,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,905,796 - 94,938,028 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,860,572 - 94,892,804 (-)NCBIMGSCv36mm8
Celera11104,654,874 - 104,687,668 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-pinene  (ISO)
aluminium oxide  (ISO)
amphetamine  (ISO)
arsenite(3-)  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethyl malate  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
ethyl trans-caffeate  (ISO)
ethylparaben  (ISO)
fenamidone  (EXP)
flutamide  (ISO)
folic acid  (ISO)
genistein  (EXP)
glucose  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (ISO)
notoginsenoside R1  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bronchiole epithelium morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal distal convoluted tubule morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal left lung morphology  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal Mullerian duct morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal primitive urogenital sinus morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal retina nerve fiber layer morphology  (IAGP)
abnormal right lung morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal vitreous body morphology  (IAGP)
abnormal Wolffian duct morphology  (IAGP)
absent podocyte foot process  (IAGP)
absent ureter  (IAGP)
absent urinary bladder  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
blistering  (IAGP)
decreased glomerular capillary number  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased kidney collecting duct number  (IAGP)
decreased lung compliance  (IAGP)
decreased tumor growth/size  (IAGP)
dehydration  (IAGP)
dilated glomerular capillary  (IAGP)
dilated proximal convoluted tubule  (IAGP)
disorganized retina ganglion layer  (IAGP)
edema  (IAGP)
enhanced wound healing  (IAGP)
fetal growth retardation  (IAGP)
glomerulosclerosis  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in terminal bronchiole morphogenesis  (IAGP)
impaired lung lobe morphogenesis  (IAGP)
impaired spatial working memory  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased type II pneumocyte number  (IAGP)
increased urine protein level  (IAGP)
kidney cyst  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oligodactyly  (IAGP)
pale kidney  (IAGP)
pancreas hypoplasia  (IAGP)
podocyte foot process effacement  (IAGP)
preweaning lethality, complete penetrance  (IEA)
pulmonary fibrosis  (IAGP)
pulmonary hyperplasia  (IAGP)
pulmonary hypoplasia  (IAGP)
reduced long-term potentiation  (IAGP)
renal cast  (IAGP)
skin inflammation  (IAGP)
small kidney  (IAGP)
syndactyly  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick skin  (IAGP)
urethra atresia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling. Bryant JE, etal., J Mol Cell Cardiol. 2009 Feb;46(2):186-92. Epub 2008 Nov 7.
2. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
3. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
4. Reelin glycoprotein: structure, biology and roles in health and disease. Fatemi SH Mol Psychiatry. 2005 Mar;10(3):251-7.
5. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
6. Spironolactone ameliorates podocytic adhesive capacity via restoring integrin {alpha}3 expression in streptozotocin-induced diabetic rats. Lin S, etal., J Renin Angiotensin Aldosterone Syst. 2010 Jun 4.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria. Nosaka H, etal., J Nephrol. 2009 Jul-Aug;22(4):484-90.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
18. Expression of collagen binding integrins during cardiac development and hypertrophy. Terracio L, etal., Circ Res. 1991 Mar;68(3):734-44.
Additional References at PubMed
PMID:1431091   PMID:1946438   PMID:7534781   PMID:7560884   PMID:7691492   PMID:7759572   PMID:8306881   PMID:8626034   PMID:8722691   PMID:8725284   PMID:8889548   PMID:8951069  
PMID:8986815   PMID:9019241   PMID:9151677   PMID:9427478   PMID:9553049   PMID:9732295   PMID:9763436   PMID:9858678   PMID:10069334   PMID:10079228   PMID:10090148   PMID:10091056  
PMID:10206722   PMID:10349636   PMID:10433923   PMID:10444387   PMID:10547352   PMID:10706142   PMID:10742111   PMID:10910775   PMID:10922068   PMID:10934043   PMID:10939329   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11307167   PMID:11336507   PMID:11381080   PMID:11431366   PMID:11461117   PMID:11784011   PMID:11891657   PMID:12130536   PMID:12217315   PMID:12230564  
PMID:12477932   PMID:12591243   PMID:12843252   PMID:12904471   PMID:12904583   PMID:12921739   PMID:14566019   PMID:14610273   PMID:14681479   PMID:14691142   PMID:15091337   PMID:15181153  
PMID:15197181   PMID:15265981   PMID:15280429   PMID:15361520   PMID:15368439   PMID:15370361   PMID:15489334   PMID:15537685   PMID:15703255   PMID:15728252   PMID:15913604   PMID:16141072  
PMID:16141073   PMID:16319112   PMID:16319116   PMID:16365040   PMID:16498405   PMID:16602821   PMID:16785564   PMID:16917494   PMID:17015618   PMID:17021047   PMID:17043354   PMID:17079689  
PMID:17363568   PMID:17601529   PMID:17602244   PMID:17616930   PMID:17716972   PMID:17762853   PMID:17848500   PMID:18045589   PMID:18077697   PMID:18082680   PMID:18159948   PMID:18246199  
PMID:18554416   PMID:18590826   PMID:18786638   PMID:18787044   PMID:18794124   PMID:18799693   PMID:18973680   PMID:19060336   PMID:19104148   PMID:19118220   PMID:19176588   PMID:19229884  
PMID:19383784   PMID:19435806   PMID:19755493   PMID:20052668   PMID:20382852   PMID:20493807   PMID:20639457   PMID:20852388   PMID:21209007   PMID:21267068   PMID:21487391   PMID:21873635  
PMID:21905163   PMID:21931791   PMID:22687584   PMID:22711877   PMID:22728432   PMID:22911573   PMID:23114595   PMID:23152823   PMID:23236172   PMID:23236390   PMID:23382219   PMID:23529140  
PMID:23587851   PMID:23595732   PMID:23671573   PMID:23792458   PMID:23874761   PMID:24002891   PMID:24036115   PMID:24077284   PMID:24227711   PMID:24390135   PMID:24694902   PMID:24706882  
PMID:24952961   PMID:25202019   PMID:25278585   PMID:25358791   PMID:25503068   PMID:25751421   PMID:25808491   PMID:26733533   PMID:27562932   PMID:28386022   PMID:28416479   PMID:28457749  
PMID:28472154   PMID:28777373   PMID:28831020   PMID:29038237   PMID:29091766   PMID:29981310   PMID:30193894   PMID:30389854   PMID:30783098   PMID:30878678   PMID:31101121   PMID:31358811  
PMID:31988184   PMID:32423907   PMID:32454065   PMID:34321999   PMID:34323105   PMID:36623578   PMID:37831759   PMID:38133204   PMID:38367510  


Genomics

Comparative Map Data
Itga3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,935,301 - 94,967,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,935,300 - 94,967,627 (-)EnsemblGRCm39 Ensembl
GRCm381195,044,475 - 95,076,844 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,044,474 - 95,076,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,905,796 - 94,938,028 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,860,572 - 94,892,804 (-)NCBIMGSCv36mm8
Celera11104,654,874 - 104,687,668 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
ITGA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,056,110 - 50,090,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,055,968 - 50,090,481 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,133,474 - 48,167,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,488,730 - 45,522,843 (+)NCBINCBI36Build 36hg18NCBI36
Build 341745,488,729 - 45,522,843NCBI
Celera1744,591,582 - 44,627,962 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,500,496 - 43,535,731 (+)NCBIHuRef
CHM1_11748,197,214 - 48,232,155 (+)NCBICHM1_1
T2T-CHM13v2.01750,921,575 - 50,957,585 (+)NCBIT2T-CHM13v2.0
Itga3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,486,998 - 80,522,548 (-)NCBIGRCr8
mRatBN7.21079,990,160 - 80,022,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,990,161 - 80,022,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,939,254 - 84,971,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,437,323 - 84,469,271 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,830,424 - 79,862,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,855,841 - 82,887,755 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,855,613 - 82,887,497 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,666,856 - 82,698,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,728,710 - 83,759,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,744,399 - 83,774,825 (-)NCBI
Celera1078,763,866 - 78,796,174 (-)NCBICelera
Cytogenetic Map10q26NCBI
Itga3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,561,704 - 11,589,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,563,120 - 11,590,119 (-)NCBIChiLan1.0ChiLan1.0
ITGA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,243,873 - 66,279,253 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,050,327 - 71,085,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,145,974 - 44,181,343 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,019,889 - 49,055,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,019,892 - 49,055,245 (+)Ensemblpanpan1.1panPan2
ITGA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,065,792 - 26,095,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,062,393 - 26,094,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,458,998 - 25,488,798 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,860,362 - 26,890,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,856,943 - 26,890,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,628,148 - 25,657,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,886,765 - 25,916,569 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,016,729 - 26,046,536 (+)NCBIUU_Cfam_GSD_1.0
Itga3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,491,793 - 25,521,235 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,553,861 - 11,583,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,553,904 - 11,583,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,235,258 - 26,269,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,234,769 - 26,269,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,288,983 - 26,308,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,248,341 - 43,282,045 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,250,435 - 43,281,670 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,964,390 - 13,998,162 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,062,290 - 6,092,557 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,062,438 - 6,092,556 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga3
771 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2456
Count of miRNA genes:617
Interacting mature miRNAs:799
Transcripts:ENSMUST00000001548, ENSMUST00000107739, ENSMUST00000120375, ENSMUST00000140342, ENSMUST00000141693, ENSMUST00000145671
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
13524529Bodwtq10_mbody wweight QTL 10 (mouse)119067951297699512Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
1300847Par1_mpulmonary adenoma resistance 1 (mouse)Not determined119406377996167421Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse

Markers in Region
RH124558  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,044,630 - 95,044,718UniSTSGRCm38
MGSCv371194,905,944 - 94,906,032UniSTSGRCm37
Celera11104,655,022 - 104,655,110UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.5UniSTS
cM Map1156.0UniSTS
RH125645  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,044,539 - 95,044,788UniSTSGRCm38
MGSCv371194,905,853 - 94,906,102UniSTSGRCm37
Celera11104,654,931 - 104,655,180UniSTS
Cytogenetic Map11DUniSTS
cM Map1156.0UniSTS
cM Map1155.5UniSTS
Whitehead/MRC_RH111255.22UniSTS
D11Lis2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,052,290 - 95,052,442UniSTSGRCm38
MGSCv371194,913,604 - 94,913,756UniSTSGRCm37
Celera11104,662,703 - 104,662,855UniSTS
Cytogenetic Map11DUniSTS
cM Map11 UniSTS
Itga3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371194,907,836 - 94,908,262UniSTSGRCm37
MGSCv371194,907,031 - 94,908,348UniSTSGRCm37
Celera11104,656,109 - 104,657,426UniSTS
Celera11104,656,914 - 104,657,340UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.5UniSTS
cM Map1156.0UniSTS
cM Map1156.0UniSTS
cM Map1156.0UniSTS
cM Map1156.0UniSTS
Itga3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1156.0UniSTS
Itga3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,045,717 - 95,047,034UniSTSGRCm38
MGSCv371194,907,031 - 94,908,348UniSTSGRCm37
Celera11104,656,109 - 104,657,426UniSTS
Cytogenetic Map11DUniSTS
cM Map1156.0UniSTS
Itga3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,046,522 - 95,046,948UniSTSGRCm38
MGSCv371194,907,836 - 94,908,262UniSTSGRCm37
Celera11104,656,914 - 104,657,340UniSTS
Cytogenetic Map11DUniSTS
cM Map1156.0UniSTS
Itga3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001306071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001306162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB080229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ032311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ089026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S66292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S66294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001548   ⟹   ENSMUSP00000001548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,935,300 - 94,967,540 (-)Ensembl
GRCm38.p6 Ensembl1195,044,474 - 95,076,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000107739   ⟹   ENSMUSP00000103368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,935,300 - 94,960,024 (-)Ensembl
GRCm38.p6 Ensembl1195,044,474 - 95,069,198 (-)Ensembl
RefSeq Acc Id: ENSMUST00000120375   ⟹   ENSMUSP00000113556
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,935,300 - 94,967,627 (-)Ensembl
GRCm38.p6 Ensembl1195,044,474 - 95,076,801 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,949,091 - 94,953,097 (-)Ensembl
GRCm38.p6 Ensembl1195,058,265 - 95,062,271 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,944,051 - 94,947,021 (-)Ensembl
GRCm38.p6 Ensembl1195,053,225 - 95,056,195 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145671   ⟹   ENSMUSP00000115970
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1194,953,987 - 94,967,623 (-)Ensembl
GRCm38.p6 Ensembl1195,063,161 - 95,076,797 (-)Ensembl
RefSeq Acc Id: NM_001306071   ⟹   NP_001293000
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,935,301 - 94,960,024 (-)NCBI
GRCm381195,044,475 - 95,069,198 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001306162   ⟹   NP_001293091
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,935,301 - 94,967,637 (-)NCBI
GRCm381195,044,475 - 95,076,811 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013565   ⟹   NP_038593
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,935,301 - 94,967,540 (-)NCBI
GRCm381195,044,475 - 95,076,714 (-)NCBI
MGSCv371194,905,796 - 94,938,028 (-)RGD
Celera11104,654,874 - 104,687,668 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532310   ⟹   XP_006532373
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,935,301 - 94,967,637 (-)NCBI
GRCm381195,044,475 - 95,076,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006532311   ⟹   XP_006532374
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,935,301 - 94,967,637 (-)NCBI
GRCm381195,044,475 - 95,076,844 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_038593   ⟸   NM_013565
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q5SWB9 (UniProtKB/Swiss-Prot),   Q5SWA8 (UniProtKB/Swiss-Prot),   Q08442 (UniProtKB/Swiss-Prot),   Q08441 (UniProtKB/Swiss-Prot),   Q6P6I1 (UniProtKB/Swiss-Prot),   Q62470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532374   ⟸   XM_006532311
- Peptide Label: isoform X2
- UniProtKB: Q5SWB9 (UniProtKB/Swiss-Prot),   Q5SWA8 (UniProtKB/Swiss-Prot),   Q08442 (UniProtKB/Swiss-Prot),   Q08441 (UniProtKB/Swiss-Prot),   Q6P6I1 (UniProtKB/Swiss-Prot),   Q62470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532373   ⟸   XM_006532310
- Peptide Label: isoform X1
- UniProtKB: Q62470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001293091   ⟸   NM_001306162
- Peptide Label: isoform 3 precursor
- UniProtKB: Q62470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001293000   ⟸   NM_001306071
- Peptide Label: isoform 2
- UniProtKB: Q62470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000001548   ⟸   ENSMUST00000001548
RefSeq Acc Id: ENSMUSP00000103368   ⟸   ENSMUST00000107739
RefSeq Acc Id: ENSMUSP00000115970   ⟸   ENSMUST00000145671
RefSeq Acc Id: ENSMUSP00000113556   ⟸   ENSMUST00000120375
Protein Domains
Integrin alpha third immunoglobulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62470-F1-model_v2 AlphaFold Q62470 1-1053 view protein structure

Promoters
RGD ID:6846848
Promoter ID:MM_ACW:8652
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ITGA3.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,908,091 - 94,908,591 (-)MPROMDB
RGD ID:6821125
Promoter ID:MM_KWN:9316
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000003163
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,917,056 - 94,917,556 (-)MPROMDB
RGD ID:6821123
Promoter ID:MM_KWN:9317
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000003162
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,923,106 - 94,923,606 (-)MPROMDB
RGD ID:6821120
Promoter ID:MM_KWN:9319
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Transcripts:ENSMUST00000073698,   ENSMUST00000120375,   OTTMUST00000003158,   OTTMUST00000003160
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,937,656 - 94,938,457 (-)MPROMDB
RGD ID:8676256
Promoter ID:EPDNEW_M16159
Type:initiation region
Name:Itga3_1
Description:Mus musculus integrin alpha 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16160  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381195,076,668 - 95,076,728EPDNEW
RGD ID:8676258
Promoter ID:EPDNEW_M16160
Type:single initiation site
Name:Itga3_2
Description:Mus musculus integrin alpha 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16159  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381195,076,811 - 95,076,871EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96602 AgrOrtholog
Ensembl Genes ENSMUSG00000001507 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001548 ENTREZGENE
  ENSMUST00000001548.14 UniProtKB/Swiss-Prot
  ENSMUST00000107739 ENTREZGENE
  ENSMUST00000107739.8 UniProtKB/Swiss-Prot
  ENSMUST00000120375 ENTREZGENE
  ENSMUST00000120375.8 UniProtKB/Swiss-Prot
  ENSMUST00000145671.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/Swiss-Prot
  Int_alpha_beta-p UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha-2 UniProtKB/Swiss-Prot
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16400 UniProtKB/Swiss-Prot
MGD MGI:96602 ENTREZGENE
NCBI Gene 16400 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN ALPHA-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/Swiss-Prot
PhenoGen Itga3 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot
PROSITE FG_GAP UniProtKB/Swiss-Prot
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot
SMART Int_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6UD16_MOUSE UniProtKB/TrEMBL
  ITA3_MOUSE UniProtKB/Swiss-Prot
  Q08441 ENTREZGENE
  Q08442 ENTREZGENE
  Q5SWA8 ENTREZGENE
  Q5SWB9 ENTREZGENE
  Q62470 ENTREZGENE
  Q6P6I1 ENTREZGENE
  Q8C8X8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q08441 UniProtKB/Swiss-Prot
  Q08442 UniProtKB/Swiss-Prot
  Q5SWA8 UniProtKB/Swiss-Prot
  Q5SWB9 UniProtKB/Swiss-Prot
  Q6P6I1 UniProtKB/Swiss-Prot