Itga2 (integrin subunit alpha 2) - Rat Genome Database

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Gene: Itga2 (integrin subunit alpha 2) Rattus norvegicus
Symbol: Itga2
Name: integrin subunit alpha 2
RGD ID: 621632
Description: Enables collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and positive regulation of cellular component organization. Located in several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Is active in presynapse. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2); PARTICIPATES IN integrin mediated signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD49B; GPIa; HPA-5; integrin alpha 2; integrin alpha-2; integrin, alpha 2; platelet glycoprotein Ia
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8248,253,412 - 48,354,509 (-)NCBIGRCr8
mRatBN7.2246,520,345 - 46,621,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-adrenaline  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
fenfluramine  (ISO)
Fulvic acid  (ISO)
genistein  (ISO)
geranylgeraniol  (EXP,ISO)
glyphosate  (ISO)
histamine  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
methylisothiazolinone  (ISO)
mevalonic acid  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morusin  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paricalcitol  (ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
prostaglandin E2  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion mediated by integrin  (IBA,ISO)
cell-cell adhesion  (IBA)
cell-matrix adhesion  (IBA,ISO)
cell-substrate adhesion  (ISO)
cellular response to estradiol stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to organic cyclic compound  (IEP)
collagen-activated signaling pathway  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
female pregnancy  (IEP)
focal adhesion assembly  (IMP)
hepatocyte differentiation  (IEP)
hypotonic response  (IMP)
integrin-mediated signaling pathway  (IBA,ISO)
mammary gland development  (IEP)
mesodermal cell differentiation  (ISO)
positive regulation of alkaline phosphatase activity  (IMP)
positive regulation of cell adhesion  (IMP)
positive regulation of cell projection organization  (IMP)
positive regulation of collagen binding  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA binding  (IMP)
positive regulation of epithelial cell migration  (IMP)
positive regulation of leukocyte migration  (IMP)
positive regulation of phagocytosis, engulfment  (IMP)
positive regulation of positive chemotaxis  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of smooth muscle contraction  (IMP)
positive regulation of translation  (IMP)
positive regulation of transmission of nerve impulse  (IMP)
response to amine  (IEP)
response to hypoxia  (IEP)
response to L-ascorbic acid  (IEP)
response to muscle activity  (IEP)
response to organic cyclic compound  (IEP)
response to parathyroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
skin morphogenesis  (IMP)
substrate-dependent cell migration  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. Alessandri-Haber N, etal., J Neurosci. 2008 Jan 30;28(5):1046-57.
2. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction. Antoniades C, etal., J Am Coll Cardiol. 2006 May 16;47(10):1959-66. Epub 2006 Apr 27.
3. Platelet glycoprotein Ia gene dimorphism alpha2-807 in malignant arrhythmia in coronary artery disease. Anvari A, etal., Thromb Res. 2000 May 15;98(4):281-6.
4. No association between the ITGA2 807T allele and retinopathy in french patients with type 2 diabetes. Arsene S, etal., Thromb Res. 2011 Sep;128(3):293-5. doi: 10.1016/j.thromres.2011.05.009. Epub 2011 Jun 1.
5. Association analysis of genetic variations of eNOS and alpha2beta1 integrin genes with type 2 diabetic retinopathy. Azmy R, etal., Appl Clin Genet. 2012 Jul 24;5:55-65. doi: 10.2147/TACG.S31979. Print 2012.
6. Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors. Ballesteros F, etal., Audiol Neurootol. 2012;17(6):400-8. doi: 10.1159/000341989. Epub 2012 Aug 30.
7. Differential integrin expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts. Burgess ML, etal., Cardiovasc Pathol. 2002 Mar-Apr;11(2):78-87.
8. Iron deficiency anaemia in young women. Carlsson LE, etal., Eur J Haematol. 2002 Jun;68(6):341-4.
9. Infiltrating cells and IFNgamma production in the injected eye after uniocular anterior chamber inoculation of HSV-1. Cathcart HM, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2269-75. doi: 10.1167/iovs.08-2874.
10. Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2. Choi S, etal., Biochem Biophys Res Commun. 2009 Jun 26;384(2):231-5. Epub 2009 Apr 24.
11. The integrin alpha2beta1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production. Chung CH, etal., Br J Pharmacol. 2009 Mar;156(5):846-56. Epub 2009 Feb 23.
12. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. Cole VJ, etal., J Thromb Haemost. 2003 May;1(5):963-70.
13. Glanzmann's thrombasthenia: modulation of clinical phenotype by alpha2C807T gene polymorphism. D'Andrea G and Margaglione M, Haematologica. 2003 Dec;88(12):1378-82.
14. The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion. Dodson PM, etal., Eye (Lond). 2003 Aug;17(6):772-7.
15. Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes. Eibl N, etal., Eur J Clin Invest. 2004 Mar;34(3):205-9.
16. Distribution of alpha and beta integrin subunits in the adult rat hippocampus after pilocarpine-induced neuronal cell loss, axonal reorganization and reactive astrogliosis. Fasen K, etal., Acta Neuropathol. 2003 Oct;106(4):319-22. Epub 2003 Jul 8.
17. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. Fujimura T, etal., J Dermatol Sci. 2007 Jan;45(1):45-53. Epub 2006 Nov 21.
18. Ascorbic acid alters collagen integrins in bone culture. Ganta DR, etal., Endocrinology. 1997 Sep;138(9):3606-12.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Placental gene expression in a rat 'model' of placental insufficiency. Goyal R, etal., Placenta. 2010 Jul;31(7):568-75. Epub 2010 Jun 8.
22. Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Huang Y, etal., Diabetes. 2008 Sep;57(9):2360-70. Epub 2008 Jun 20.
23. Collagen phagocytosis and apoptosis are induced by high level alkaline phosphatase expression in rat fibroblasts. Hui MZ, etal., J Cell Physiol. 1997 Sep;172(3):323-33.
24. Modulation of alpha2beta1 integrin changes during mammary gland development by beta-oestradiol. Iype T, etal., Biochim Biophys Acta. 2001 Jan 15;1499(3):232-41.
25. Progesterone modulates integrin {alpha}2 (ITGA2) and {alpha}11 (ITGA11) in the pregnant cervix. Ji H, etal., Reprod Sci. 2011 Feb;18(2):156-63. doi: 10.1177/1933719110382305. Epub 2010 Oct 19.
26. Distribution of integrin subunits in human diabetic kidneys. Jin DK, etal., J Am Soc Nephrol. 1996 Dec;7(12):2636-45.
27. Parathyroid hormone (1-34) regulates integrin expression in vivo in rat osteoblasts. Kaiser E, etal., J Cell Biochem 2001;83(4):617-30.
28. Decreased expression of alpha2 integrin in fibroblasts isolated from cyclosporin A- induced gingival overgrowth in rats. Kataoka M, etal., J Periodontal Res 2003 Oct;38(5):533-7.
29. Integrin alpha2beta1 affects mechano-transduction in slowly and rapidly adapting cutaneous mechanoreceptors in rat hairy skin. Khalsa PS, etal., Neuroscience. 2004;129(2):447-59.
30. The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro. Koenig S, etal., J Hepatol. 2006 Jun;44(6):1115-24. Epub 2005 Nov 7.
31. Enhanced laminin carbonylation by monocytes in diabetes mellitus. Kostidou E, etal., Clin Biochem. 2007 Jun;40(9-10):671-9. Epub 2007 Mar 28.
32. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
33. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
34. Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection. Laine O, etal., Thromb Res. 2012 May;129(5):611-5. doi: 10.1016/j.thromres.2011.11.007. Epub 2011 Nov 30.
35. Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells. Lan F, etal., J Immunol. 2001 Aug 15;167(4):2087-96.
36. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Li H, etal., Mol Vis. 2008 Sep 15;14:1698-704.
37. [The effect of mechanical stimulation on the expression of alpha 2, beta 1, beta 3 integrins and the proliferation, synthetic function in rat osteoblasts] Li L, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Jun;20(2):187-92.
38. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. Lin Y, etal., Reproduction. 2009 Jun;137(6):943-55. Epub 2009 Mar 25.
39. Polymorphism in Integrin ITGA2 is Associated with Ischemic Stroke and Altered Serum Cholesterol in Chinese Individuals. Lu JX, etal., Balkan Med J. 2014 Mar;31(1):55-9. doi: 10.5152/balkanmedj.2013.7993. Epub 2014 Mar 1.
40. Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice. Lundberg S, etal., Inflamm Bowel Dis. 2006 Mar;12(3):172-7.
41. The 807T allele in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes. Maeno T, etal., Diabetes. 2002 May;51(5):1523-8.
42. Role of MT1-MMP in the osteogenic differentiation. Manduca P, etal., Bone. 2009 Feb;44(2):251-65. Epub 2008 Nov 5.
43. A mandibular propulsive appliance modulates collagen-binding integrins distribution in the young rat condylar cartilage. Marques MR, etal., Biorheology. 2006;43(3-4):293-302.
44. Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2. Mendrick DL, etal., Lab Invest. 1995 Mar;72(3):367-75.
45. Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes. Merzouk H, etal., Clin Sci (Lond). 2000 Jan;98(1):21-30.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction. Mizuno M, etal., J Cell Physiol. 2000 Aug;184(2):207-13.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. Phenotypic heterogeneity influences the behavior of rat aortic smooth muscle cells in collagen lattice. Orlandi A, etal., Exp Cell Res. 2005 Dec 10;311(2):317-27. Epub 2005 Nov 2.
51. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. Park S, etal., Yonsei Med J. 2004 Jun 30;45(3):428-34.
52. Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1. Pereira J, etal., Thromb Haemost. 2003 Dec;90(6):1135-40.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
55. Polymorphism of the glycoprotein Ia and IIIa in the group of women in childbirth does not correlate with an increased risk of developing thrombosis. Podciechowski L, etal., Neuro Endocrinol Lett. 2005 Dec;26(6):789-94.
56. Association of the platelet glycoprotein Ia C807T/G873A gene polymorphism and thrombosis in Behcet patients. Polat G, etal., Haematologia (Budap). 2002;32(2):121-8.
57. The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. Racine-Samson L, etal., J Biol Chem. 1997 Dec 5;272(49):30911-7.
58. Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. Reiner AP, etal., Thromb Haemost. 2003 Jan;89(1):142-8.
59. GOA pipeline RGD automated data pipeline
60. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
61. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
62. Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation. Ridger VC, etal., J Immunol. 2001 Mar 1;166(5):3484-90.
63. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Risbud MV, etal., Spine. 2004 Dec 1;29(23):2627-32.
64. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Risbud MV, etal., Spine. 2005 Nov 15;30(22):2503-9.
65. Vascular risk factors in sudden hearing loss. Rudack C, etal., Thromb Haemost. 2006 Mar;95(3):454-61.
66. Polyamines are important for attachment of IEC-6 cells to extracellular matrix. Santos MF, etal., Am J Physiol. 1997 Jul;273(1 Pt 1):G175-83.
67. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients. Santoso S, etal., Blood. 1999 Apr 15;93(8):2449-53.
68. Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture. Sato M, etal., Cell Biol Int. 1998;22(2):115-25.
69. Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells. Schocklmann HO, etal., Kidney Int. 2000 Sep;58(3):1108-20.
70. Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans. Sperr WR, etal., Thromb Res. 1998 May 1;90(3):117-23.
71. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
72. Differential susceptibility of osteosarcoma cells and primary osteoblasts to cell detachment caused by snake venom metalloproteinase protein. Tang CH, etal., Toxicon. 2004 Jan;43(1):11-20.
73. Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line. Valles AM, etal., Cell Adhes Commun. 1996 Sep;4(3):187-99.
74. Smooth muscle actin determines mechanical force-induced p38 activation. Wang J, etal., J Biol Chem. 2005 Feb 25;280(8):7273-84. Epub 2004 Dec 9.
75. Improvement of fertility with adoptive CD25+ natural killer cell transfer in subfertile non-obese diabetic mice. Wang W, etal., Reprod Biomed Online. 2009 Jan;18(1):95-103.
76. The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Wang XQ and Frazier WA, Mol Biol Cell. 1998 Apr;9(4):865-74.
77. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion. Weger M, etal., Ophthalmology. 2005 Nov;112(11):1910-5. Epub 2005 Sep 12.
78. Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. Werr J, etal., Blood. 2000 Mar 1;95(5):1804-9.
79. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Wu JE and Santoro SA, Dev Dyn 1994 Apr;199(4):292-314.
80. Identification of a heparin binding site and the biological activities of the laminin alpha1 chain carboxy-terminal globular domain. Yoshida I, etal., J Cell Physiol. 1999 Apr;179(1):18-28.
81. Correlation between the polymorphism of glycoprotein Ia gene and acute coronary syndrome. Zhao Y, etal., Chin Med Sci J. 2004 Mar;19(1):13-8.
Additional References at PubMed
PMID:11518510   PMID:11767049   PMID:14707119   PMID:15811857   PMID:16973387   PMID:18098323   PMID:19581412   PMID:19648922   PMID:19933311   PMID:20563599   PMID:20818394   PMID:21126803  
PMID:21310825   PMID:21423176   PMID:23023225   PMID:23154389   PMID:23382103   PMID:23658023   PMID:24823363   PMID:25336636   PMID:27169768   PMID:27827993   PMID:29023021   PMID:31964805  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8248,253,412 - 48,354,509 (-)NCBIGRCr8
mRatBN7.2246,520,345 - 46,621,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38552,989,352 - 53,094,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,989,340 - 53,094,779 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,285,182 - 52,390,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,320,913 - 52,426,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,321,013 - 52,423,947NCBI
Celera549,238,739 - 49,344,187 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,257,212 - 49,362,658 (+)NCBIHuRef
CHM1_1552,287,738 - 52,393,158 (+)NCBICHM1_1
T2T-CHM13v2.0553,817,115 - 53,922,565 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3913114,969,617 - 115,068,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,969,617 - 115,068,636 (-)EnsemblGRCm39 Ensembl
GRCm3813114,833,081 - 114,932,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,833,081 - 114,932,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,626,120 - 115,722,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,956,790 - 116,052,919 (-)NCBIMGSCv36mm8
Celera13119,179,611 - 119,279,864 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544614,309,349 - 14,422,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,309,516 - 14,421,991 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2460,843,032 - 60,952,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,996,794 - 59,105,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,935,452 - 61,040,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,554,387 - 62,659,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,555,370 - 62,659,720 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1462,170,137 - 62,268,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,170,452 - 62,268,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,941,741 - 62,043,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,664,801 - 62,766,959 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,668,472 - 62,766,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,440,055 - 62,542,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,564,620 - 62,666,770 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,091,317 - 63,193,515 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213205,383,765 - 205,481,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,320,692 - 14,417,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,320,292 - 14,417,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,336,240 - 32,440,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,164,830 - 34,262,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1449,280,289 - 49,382,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,317,648 - 49,380,051 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,745,561 - 1,848,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247596,281,561 - 6,376,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247596,281,698 - 6,376,702 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Itga2
705 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:112
Interacting mature miRNAs:119
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,370,500 - 81,371,432 (+)MAPPERmRatBN7.2
mRatBN7.25151,753,551 - 151,753,981 (+)MAPPERmRatBN7.2
Rnor_6.05157,965,849 - 157,966,278NCBIRnor6.0
Rnor_6.0887,860,151 - 87,861,082NCBIRnor6.0
Rnor_5.05161,705,374 - 161,705,803UniSTSRnor5.0
Rnor_5.0887,397,241 - 87,398,172UniSTSRnor5.0
RGSC_v3.45158,300,223 - 158,300,652UniSTSRGSC3.4
RGSC_v3.4885,503,428 - 85,504,359UniSTSRGSC3.4
Celera5150,133,234 - 150,133,663UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map2q14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 2 1 3 5
Low 1 38 38 24 18 24 6 7 49 34 33 6 6
Below cutoff 5 15 15 15 2 4 20 1 4 2


RefSeq Acc Id: ENSRNOT00000077401   ⟹   ENSRNOP00000072929
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)Ensembl
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)Ensembl
RefSeq Acc Id: NM_001427291   ⟹   NP_001414220
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8248,253,412 - 48,354,509 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414220 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB62267 (Get FASTA)   NCBI Sequence Viewer  
  EDM10390 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072929.1
RefSeq Acc Id: ENSRNOP00000072929   ⟸   ENSRNOT00000077401
RefSeq Acc Id: NP_001414220   ⟸   NM_001427291
- Peptide Label: precursor
- UniProtKB: A0A0G2K470 (UniProtKB/TrEMBL),   A6I5T2 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K470-F1-model_v2 AlphaFold A0A0G2K470 1-1178 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691158
Promoter ID:EPDNEW_R1673
Type:multiple initiation site
Description:integrin subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,096,969 - 47,097,029EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621632 AgrOrtholog
BioCyc Gene G2FUF-54326 BioCyc
Ensembl Genes ENSRNOG00000058111 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077401.2 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:170921 UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
PhenoGen Itga2 PhenoGen
RatGTEx ENSRNOG00000058111 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-07 Itga2  integrin subunit alpha 2  Itga2  integrin alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-02 Itga2  integrin alpha 2  Itga2  integrin, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Itga2  integrin, alpha 2    integrin alpha 2  Name updated 1299863 APPROVED
2002-08-07 Itga2  integrin alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL