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Gene: Itga2 (integrin subunit alpha 2) Rattus norvegicus
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Symbol: Itga2
Name: integrin subunit alpha 2
Description: Exhibits collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including gland development; positive regulation of cell migration; and positive regulation of cellular component organization. Localizes to several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); diabetes mellitus (multiple); inherited blood coagulation disease (multiple); and iron deficiency anemia. Orthologous to human ITGA2 (integrin subunit alpha 2); PARTICIPATES IN integrin mediated signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: MODEL
Also known as: CD49B; GPIa; HPA-5; integrin alpha 2; integrin alpha-2; integrin, alpha 2; platelet glycoprotein Ia
Orthologs:
Homo sapiens (human) : ITGA2 (integrin subunit alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Itga2 (integrin alpha 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga2 (integrin subunit alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA2 (integrin subunit alpha 2)
Canis lupus familiaris (dog) : ITGA2 (integrin subunit alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga2 (integrin subunit alpha 2)
Sus scrofa (pig) : ITGA2 (integrin subunit alpha 2)
Chlorocebus sabaeus (African green monkey) : ITGA2 (integrin subunit alpha 2)
Heterocephalus glaber (naked mole-rat) : Itga2 (integrin subunit alpha 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC3.4rn4RGSC3.4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Itga2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621632
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.