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Gene: Itga2 (integrin subunit alpha 2) Rattus norvegicus
Symbol: Itga2
Name: integrin subunit alpha 2
Description: Exhibits collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including gland development; positive regulation of cell migration; and positive regulation of cellular component organization. Localizes to several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); diabetes mellitus (multiple); inherited blood coagulation disease (multiple); and iron deficiency anemia. Orthologous to human ITGA2 (integrin subunit alpha 2); PARTICIPATES IN integrin mediated signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: MODEL
Also known as: CD49B; GPIa; HPA-5; integrin alpha 2; integrin alpha-2; integrin, alpha 2; platelet glycoprotein Ia
Homo sapiens (human) : ITGA2 (integrin subunit alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Itga2 (integrin alpha 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga2 (integrin subunit alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA2 (integrin subunit alpha 2)
Canis lupus familiaris (dog) : ITGA2 (integrin subunit alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga2 (integrin subunit alpha 2)
Sus scrofa (pig) : ITGA2 (integrin subunit alpha 2)
Chlorocebus sabaeus (African green monkey) : ITGA2 (integrin subunit alpha 2)
Heterocephalus glaber (naked mole-rat) : Itga2 (integrin subunit alpha 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC3.4rn4RGSC3.4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Itga2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621632
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.