ITGA2 (integrin subunit alpha 2) - Rat Genome Database

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Pathways
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Gene: ITGA2 (integrin subunit alpha 2) Sus scrofa
Analyze
Symbol: ITGA2
Name: integrin subunit alpha 2
RGD ID: 14280626
Description: ENCODES a protein that exhibits collagen binding (ortholog); integrin binding (ortholog); laminin binding (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to mechanical stimulus (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN integrin mediated signaling pathway; syndecan signaling pathway; ASSOCIATED WITH acute retinal necrosis syndrome (ortholog); arteriosclerosis (ortholog); Behcet's disease (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell projection (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: integrin alpha 2 subunit; integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); VLA-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,336,240 - 32,440,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,164,830 - 34,262,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IBA,IEA)
cell-cell adhesion  (IBA,IEA)
cell-matrix adhesion  (IBA,IEA)
cell-substrate adhesion  (IEA)
cellular response to estradiol stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
collagen-activated signaling pathway  (IEA)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
female pregnancy  (ISO)
focal adhesion assembly  (ISO)
hepatocyte differentiation  (ISO)
hypotonic response  (ISO)
integrin-mediated signaling pathway  (IBA,IEA)
mammary gland development  (ISO)
mesodermal cell differentiation  (IEA)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell projection organization  (ISO)
positive regulation of collagen binding  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of translation  (ISO)
positive regulation of transmission of nerve impulse  (ISO)
response to amine  (ISO)
response to hypoxia  (ISO)
response to L-ascorbic acid  (ISO)
response to muscle activity  (ISO)
response to organic cyclic compound  (ISO)
response to parathyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
skin morphogenesis  (ISO)
substrate-dependent cell migration  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7949129   PMID:14681463   PMID:15625692   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ITGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,336,240 - 32,440,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,164,830 - 34,262,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,989,352 - 53,094,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,989,340 - 53,094,779 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,285,182 - 52,390,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,320,913 - 52,426,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,321,013 - 52,423,947NCBI
Celera549,238,739 - 49,344,187 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,257,212 - 49,362,658 (+)NCBIHuRef
CHM1_1552,287,738 - 52,393,158 (+)NCBICHM1_1
T2T-CHM13v2.0553,817,115 - 53,922,565 (+)NCBIT2T-CHM13v2.0
Itga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,969,617 - 115,068,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,969,617 - 115,068,636 (-)EnsemblGRCm39 Ensembl
GRCm3813114,833,081 - 114,932,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,833,081 - 114,932,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,626,120 - 115,722,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,956,790 - 116,052,919 (-)NCBIMGSCv36mm8
Celera13119,179,611 - 119,279,864 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
Itga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,253,412 - 48,354,509 (-)NCBIGRCr8
mRatBN7.2246,520,345 - 46,621,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
Itga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,309,349 - 14,422,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,309,516 - 14,421,991 (-)NCBIChiLan1.0ChiLan1.0
ITGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,843,032 - 60,952,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,996,794 - 59,105,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,935,452 - 61,040,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,554,387 - 62,659,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,555,370 - 62,659,720 (-)Ensemblpanpan1.1panPan2
ITGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,170,137 - 62,268,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,170,452 - 62,268,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,941,741 - 62,043,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,664,801 - 62,766,959 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,668,472 - 62,766,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,440,055 - 62,542,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,564,620 - 62,666,770 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,091,317 - 63,193,515 (-)NCBIUU_Cfam_GSD_1.0
Itga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,383,765 - 205,481,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,320,692 - 14,417,786 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,320,292 - 14,417,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,280,289 - 49,382,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,317,648 - 49,380,051 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,745,561 - 1,848,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,281,561 - 6,376,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247596,281,698 - 6,376,702 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ITGA2
3536 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 3
Low 5 4 3 5 2 23 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018391   ⟹   ENSSSCP00000017895
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081667   ⟹   ENSSSCP00000061132
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)Ensembl
RefSeq Acc Id: NM_001244272   ⟹   NP_001231201
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11632,336,290 - 32,433,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076566   ⟹   XP_020932225
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11632,336,240 - 32,440,311 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020932225   ⟸   XM_021076566
- Peptide Label: isoform X1
- UniProtKB: A0A480Y3P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231201   ⟸   NM_001244272
- Peptide Label: precursor
- UniProtKB: A0A480HGI9 (UniProtKB/TrEMBL),   A0A4X1SNX1 (UniProtKB/TrEMBL),   A0A480Y3P5 (UniProtKB/TrEMBL),   F1SMF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000061132   ⟸   ENSSSCT00000081667
RefSeq Acc Id: ENSSSCP00000017895   ⟸   ENSSSCT00000018391
Protein Domains
VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016887 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00050034179 UniProtKB/TrEMBL
  ENSSSCG00070002807 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018391 ENTREZGENE
  ENSSSCT00000018391.4 UniProtKB/TrEMBL
  ENSSSCT00000081667.1 UniProtKB/TrEMBL
  ENSSSCT00050045827.1 UniProtKB/TrEMBL
  ENSSSCT00070005331.1 UniProtKB/TrEMBL
  ENSSSCT00070005344.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene ITGA2 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-2 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A480HGI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A480Y3P5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SNX1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SQF8_PIG UniProtKB/TrEMBL
  A0A5G2QAT5_PIG UniProtKB/TrEMBL
  F1SMF4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89234 ENTREZGENE