RGD Reference Report - Polymorphism in Integrin ITGA2 is Associated with Ischemic Stroke and Altered Serum Cholesterol in Chinese Individuals. - Rat Genome Database

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Polymorphism in Integrin ITGA2 is Associated with Ischemic Stroke and Altered Serum Cholesterol in Chinese Individuals.

Authors: Lu, Jian-Xia  Lu, Zhong-Qian  Zhang, Shao-Lan  Zhi, Juan  Chen, Zheng-Ping  Wang, Wan-Xiang 
Citation: Lu JX, etal., Balkan Med J. 2014 Mar;31(1):55-9. doi: 10.5152/balkanmedj.2013.7993. Epub 2014 Mar 1.
RGD ID: 13592606
Pubmed: PMID:25207168   (View Abstract at PubMed)
PMCID: PMC4115989   (View Article at PubMed Central)
DOI: DOI:10.5152/balkanmedj.2013.7993   (Journal Full-text)


BACKGROUND: Recent studies have reported contrasting results regarding the association of polymorphisms in two integrin genes, ITGA2 and ITGB3, with ischemic stroke.
AIMS: The present study aimed to investigate the correlation between the ITGA2 C807T and ITGB3 T176C polymorphic loci with ischemic stroke, as well as plasma lipid and lipoprotein levels.
STUDY DESIGN: Case control study.
METHODS: Human venous blood samples were collected from patients admitted for ischemic stroke (n=350, 'patients') and healthy individuals (n=300, 'controls'). Blood was genotyped at these loci by polymerase chain reaction-restriction fragment length polymorphism. Plasma lipid and lipoprotein levels were measured by routine enzymatic, masking, and turbidimetry methods.
RESULTS: As expected, total cholesterol, triglycerides, and low-density lipoprotein were all significantly higher in patients than in controls (p<0.05). Genotype and allele frequencies of ITGA2 C807T were significantly different between patients and controls (p<0.05), but no difference was detected in genotype or allele frequencies for ITGA3 T176C. For ITGA-2, the T allele conferred a 1.226 times higher relative risk of ischemic stroke than the C allele (odds ratio=1.226, 95% confidence interval=1.053-1.428). Similarly, total cholesterol was higher in T allele carriers than in non-carriers (p<0.05).
CONCLUSION: ITGA2 C807T polymorphism is associated with ischemic stroke, with the T allele acting as a susceptibility allele that appears to confer increased cholesterol levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGA2HumanStroke susceptibilityIAGP DNA:SNP::807C>T(human)RGD 
Itga2RatStroke susceptibilityISOITGA2 (Homo sapiens)DNA:SNP::807C>T(human)RGD 
Itga2MouseStroke susceptibilityISOITGA2 (Homo sapiens)DNA:SNP::807C>T(human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGA2HumanHypercholesterolemia  IAGP DNA:SNP::associated with stroke and 807C>T(human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Itga2  (integrin subunit alpha 2)

Genes (Mus musculus)
Itga2  (integrin alpha 2)

Genes (Homo sapiens)
ITGA2  (integrin subunit alpha 2)


Additional Information