RGD Reference Report - Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells. - Rat Genome Database

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Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells.

Authors: Lan, F  Zeng, D  Higuchi, M  Huie, P  Higgins, JP  Strober, S 
Citation: Lan F, etal., J Immunol. 2001 Aug 15;167(4):2087-96.
RGD ID: 8693305
Pubmed: PMID:11489992   (View Abstract at PubMed)

We developed a nonmyeloablative host conditioning regimen in a mouse model of MHC-mismatched bone marrow transplantation that not only reduces radiation toxicity, but also protects against graft-vs-host disease. The regimen of fractionated irradiation directed to the lymphoid tissues and depletive anti-T cell Abs results in a marked change in the residual host T cells, such that NK1.1+ or DX5+asialo-GM1+ T cells become the predominant T cell subset in the lymphoid tissues of C57BL/6 and BALB/c mice, respectively. The latter "natural suppressor" T cells protect hosts from graft-vs-host disease after the infusion of allogeneic bone marrow and peripheral blood cells that ordinarily kill hosts conditioned with sublethal or lethal total body irradiation. Protected hosts become stable mixed chimeras, but fail to show the early expansion and infiltration of donor T cells in the gut, liver, and blood associated with host tissue injury. Cytokine secretion and adoptive transfer studies using wild-type and IL-4(-/-) mice showed that protection afforded by NK1.1+ and DX5+asialo-GM1+ T cells derived from either donors or hosts conditioned with lymphoid irradiation is dependent on their secretion of high levels of IL-4.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ITGA2Humangraft-versus-host disease treatmentISOItga2 (Mus musculus) RGD 
Itga2Ratgraft-versus-host disease treatmentISOItga2 (Mus musculus) RGD 
Itga2Mousegraft-versus-host disease treatmentIDA  RGD 


Genes (Rattus norvegicus)
Itga2  (integrin subunit alpha 2)

Genes (Mus musculus)
Itga2  (integrin alpha 2)

Genes (Homo sapiens)
ITGA2  (integrin subunit alpha 2)