RGD Reference Report - Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection. - Rat Genome Database

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Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection.

Authors: Laine, O  Joutsi-Korhonen, L  Makela, S  Mikkelsson, J  Pessi, T  Tuomisto, S  Huhtala, H  Libraty, D  Vaheri, A  Karhunen, P  Mustonen, J 
Citation: Laine O, etal., Thromb Res. 2012 May;129(5):611-5. doi: 10.1016/j.thromres.2011.11.007. Epub 2011 Nov 30.
RGD ID: 11530072
Pubmed: PMID:22133274   (View Abstract at PubMed)
PMCID: PMC3879723   (View Article at PubMed Central)
DOI: DOI:10.1016/j.thromres.2011.11.007   (Journal Full-text)

INTRODUCTION: Puumala virus (PUUV) infection is a viral hemorrhagic fever with renal syndrome (HFRS) characterized by thrombocytopenia and acute impairment of renal function. We aimed to assess whether genetic polymorphisms of platelet antigens together with those of von Willebrand factor (VWF) and plasminogen activator inhibitor (PAI-1) correlate with disease severity. Patients and methods 172 consecutive hospital-treated patients with serologically confirmed acute PUUV infection were included. Platelet glycoprotein (GP) IIIa T>C (rs5918), GP Ia T>C (rs1126643), GP Ib C>T (rs6065), GP VI T>C (rs1613662), VWF A>G (rs1063856) and PAI-1 A>G (rs2227631) were genotyped. The associations of the rarer alleles with variables reflecting the severity of the disease were analyzed. RESULTS: PAI-1G-carriers had higher maximum creatinine level compared with the non-carriers (median 213 mumol/l, range 60-1499 mumol/l vs. median 122 mumol/l, range 51-1156 mumol/l, p = 0.01). The GG-genotypes had higher creatinine levels than GA- and AA-genotypes (medians 249 mumol/l, 204 mumol/l and 122 mumol/l, respectively, p = 0.03). Polymorphisms of GP VI and VWF associated with lower creatinine levels during PUUV infection. The minor C-allele of GP Ia associated with lower platelet counts (median 44 x 10(9)/l, range 20-90 x 10(9)/l vs median 64 x 10(9)/l, range 3-238 x 10(9)/l; p = 0.02). CONCLUSIONS: Polymorphism of PAI-1, a major regulator of fibrinolysis, has an adverse impact on the outcome of kidney function in PUUV-HFRS. Platelet collagen receptor GP Ia polymorphism associates with lower platelet count.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGA2Humanthrombocytopenia  IAGP associated with Hantavirus Infections and DNA:SNP: :807C>T (rs1126643) (human)RGD 
Itga2Ratthrombocytopenia  ISOITGA2 (Homo sapiens)associated with Hantavirus Infections and DNA:SNP: :807C>T (rs1126643) (human)RGD 
Itga2Mousethrombocytopenia  ISOITGA2 (Homo sapiens)associated with Hantavirus Infections and DNA:SNP: :807C>T (rs1126643) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Itga2  (integrin subunit alpha 2)

Genes (Mus musculus)
Itga2  (integrin alpha 2)

Genes (Homo sapiens)
ITGA2  (integrin subunit alpha 2)


Additional Information