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Gene: Itgb3 (integrin beta 3) Mus musculus
Symbol: Itgb3
Name: integrin beta 3
Description: Exhibits integrin binding activity and protein kinase C binding activity. Predicted to contribute to C-X3-C chemokine binding activity; fibrinogen binding activity; and growth factor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of cell-substrate adhesion. Localizes to several cellular components, including the alpha9-beta1 integrin-ADAM8 complex; alphav-beta3 integrin-PKCalpha complex; and focal adhesion. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal failure; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 16. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Orthologous to human ITGB3 (integrin subunit beta 3); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD61; GP3A; GPIIIa; INGRB3; integrin beta-3; MGC159221; MGC159223; platelet gpIIIa; platelet membrane glycoprotein IIIa
Homo sapiens (human) : ITGB3 (integrin subunit beta 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgb3 (integrin subunit beta 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb3 (integrin subunit beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB3 (integrin subunit beta 3)
Canis lupus familiaris (dog) : ITGB3 (integrin subunit beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb3 (integrin subunit beta 3)
Sus scrofa (pig) : ITGB3 (integrin subunit beta 3)
Chlorocebus sabaeus (African green monkey) : ITGB3 (integrin subunit beta 3)
Heterocephalus glaber (naked mole-rat) : Itgb3 (integrin subunit beta 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBImm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itgb3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737483
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.