Itgb3 (integrin beta 3) - Rat Genome Database

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Gene: Itgb3 (integrin beta 3) Mus musculus
Analyze
Symbol: Itgb3
Name: integrin beta 3
RGD ID: 737483
MGI Page MGI
Description: Enables integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell-substrate adhesion; and positive regulation of fibroblast migration. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and focal adhesion. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is active in glutamatergic synapse. Is integral component of synaptic membrane. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD61; GP3A; GPIIIa; INGRB3; integrin beta-3; MGC159221; MGC159223; platelet glycoprotein IIIa (GP3A); platelet gpIIIa; platelet membrane glycoprotein IIIa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBImm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myeloid leukemia  (IMP,ISO)
Arterial Occlusive Diseases  (ISO)
arteriosclerosis  (IMP)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (IMP,ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Bronchial Hyperreactivity  (ISO)
Carotid Artery Injuries  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (IMP)
Cerebral Hemorrhage  (ISO)
colorectal carcinoma  (ISO)
Coronary Disease  (ISO)
coronary thrombosis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (IGI)
Glanzmann's thrombasthenia  (IEA,ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hantavirus Infections  (IMP)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hip Fractures  (ISO)
lung disease  (IMP)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Neonatal Alloimmune Thrombocytopenia  (ISO)
Neoplasm Metastasis  (IEP,ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
Pathologic Constriction  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 16  (IEA,ISO)
Platelet-Type Bleeding Disorder 23  (ISO)
Platelet-Type Bleeding Disorder 24  (ISO)
pneumonia  (IMP)
Posttransfusion Purpura  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Stroke  (ISO)
Sudden Cardiac Death  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (IMP,ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
ADP  (ISO)
aldehydo-D-glucose  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
Arg-Gly-Asp  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (ISO)
cangrelor  (ISO)
cannabidiol  (ISO)
carbon disulfide  (EXP)
carbon nanotube  (EXP)
carmustine  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clomiphene  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
desferrioxamine B  (EXP)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
glucose  (ISO)
hydroquinone  (EXP)
hydroxysafflor yellow A  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leuprolide  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP,ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
orphenadrine  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulindac  (ISO)
tamoxifen  (EXP)
Tellimagrandin I  (ISO)
tert-butyl hydroperoxide  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (IGI,ISO)
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IBA,ISO)
cell migration  (IBA)
cell projection morphogenesis  (IC)
cell-matrix adhesion  (IBA,IGI,ISO)
cell-substrate adhesion  (ISO)
cell-substrate junction assembly  (IDA)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to xenobiotic stimulus  (ISO)
embryo implantation  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (IBA)
mesodermal cell differentiation  (ISO)
negative chemotaxis  (ISO)
negative regulation of cell death  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
platelet activation  (ISO)
platelet aggregation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IMP)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of bone resorption  (IC,ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast migration  (IMP,ISO)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of glomerular mesangial cell proliferation  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of osteoclast differentiation  (IC)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
positive regulation of T cell migration  (IDA)
regulation of actin cytoskeleton organization  (IMP)
regulation of cell migration  (IMP)
regulation of extracellular matrix organization  (IMP)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein localization  (IMP)
regulation of protein tyrosine kinase activity  (IMP)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of serotonin uptake  (IMP)
response to activity  (ISO)
response to platelet-derived growth factor  (ISO)
response to radiation  (ISO)
smooth muscle cell migration  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
viral entry into host cell  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood coagulation  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell migration  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal hemostasis  (IAGP)
abnormal induced retinal neovascularization  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal miscarriage rate  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal platelet activation  (IAGP)
abnormal platelet dense granule physiology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal tumor vascularization  (IAGP)
abnormal uterine environment  (IAGP)
anemia  (IAGP)
atherosclerotic lesions  (IAGP)
cardiac hypertrophy  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased collagen level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased heart rate  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased left ventricle systolic pressure  (IAGP)
decreased macrophage cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to induced thrombosis  (IAGP)
dermatitis  (IAGP)
enhanced wound healing  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
gastrointestinal hemorrhage  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased angiogenesis  (IAGP)
increased bleeding time  (IAGP)
increased bone mineral density  (IAGP)
increased circulating glucose level  (IAGP)
increased compact bone thickness  (IAGP)
increased heart weight  (IAGP)
increased IgG level  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased left ventricle weight  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular volume  (IAGP)
increased monocyte cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased response of heart to induced stress  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased transforming growth factor beta level  (IAGP)
increased tumor growth/size  (IAGP)
intracranial hemorrhage  (IAGP)
lung inflammation  (IAGP)
maternal effect  (IAGP)
myositis  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
osteosclerosis  (IAGP)
pale placenta  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
petechiae  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
pregnancy-related premature death  (IAGP)
premature death  (IAGP)
purpura  (IAGP)
reduced female fertility  (IAGP)
renal necrosis  (IAGP)
reticulocytosis  (IAGP)
skin hemorrhage  (IAGP)
thick dermal layer  (IAGP)
uterine hemorrhage  (IAGP)
References

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Additional References at PubMed
PMID:1431091   PMID:1512266   PMID:2018971   PMID:8198553   PMID:8306881   PMID:8512576   PMID:8601592   PMID:8821033   PMID:8918453   PMID:8940024   PMID:8986815   PMID:9022036  
PMID:9339637   PMID:9420328   PMID:9553049   PMID:9832163   PMID:9849968   PMID:9916011   PMID:9916135   PMID:10048576   PMID:10091056   PMID:10337632   PMID:10349636   PMID:10548108  
PMID:10549293   PMID:10683372   PMID:11042159   PMID:11071623   PMID:11076861   PMID:11217851   PMID:11241672   PMID:11342577   PMID:11353389   PMID:11438667   PMID:11493451   PMID:11786903  
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PMID:15059849   PMID:15131115   PMID:15166241   PMID:15284116   PMID:15329828   PMID:15336554   PMID:15545316   PMID:15574772   PMID:15591537   PMID:15654327   PMID:15690355   PMID:15760908  
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PMID:16304048   PMID:16317099   PMID:16337627   PMID:16365395   PMID:16391195   PMID:16391197   PMID:16400188   PMID:16407244   PMID:16467530   PMID:16533881   PMID:16571912   PMID:16600665  
PMID:16602821   PMID:16608535   PMID:16622802   PMID:16670270   PMID:16679515   PMID:16705383   PMID:16720835   PMID:16790614   PMID:16824188   PMID:16887829   PMID:16995821   PMID:17003372  
PMID:17028191   PMID:17030947   PMID:17062734   PMID:17075060   PMID:17099249   PMID:17170121   PMID:17184791   PMID:17261592   PMID:17359504   PMID:17426256   PMID:17446174   PMID:17492052  
PMID:17530709   PMID:17597067   PMID:17606926   PMID:17627302   PMID:17641225   PMID:17674000   PMID:17898081   PMID:17925492   PMID:17951320   PMID:17983596   PMID:17996853   PMID:18082680  
PMID:18084301   PMID:18086863   PMID:18156175   PMID:18165225   PMID:18174291   PMID:18184798   PMID:18255021   PMID:18256319   PMID:18278053   PMID:18288635   PMID:18317590   PMID:18326492  
PMID:18334487   PMID:18346467   PMID:18366072   PMID:18369617   PMID:18378693   PMID:18381073   PMID:18430780   PMID:18456735   PMID:18487513   PMID:18544684   PMID:18552165   PMID:18579532  
PMID:18611961   PMID:18640270   PMID:18829523   PMID:18840708   PMID:18985734   PMID:18997092   PMID:19005179   PMID:19017937   PMID:19023115   PMID:19036705   PMID:19074851   PMID:19075116  
PMID:19118216   PMID:19122172   PMID:19218546   PMID:19255147   PMID:19332769   PMID:19364763   PMID:19454719   PMID:19487690   PMID:19576795   PMID:19643138   PMID:19645751   PMID:19695571  
PMID:19729481   PMID:19755424   PMID:19758485   PMID:19805288   PMID:19808614   PMID:19808644   PMID:19837659   PMID:19933310   PMID:19940148   PMID:19967726   PMID:20007808   PMID:20016849  
PMID:20075254   PMID:20087368   PMID:20110424   PMID:20151413   PMID:20155273   PMID:20164359   PMID:20184965   PMID:20203303   PMID:20339539   PMID:20393597   PMID:20404115   PMID:20440000  
PMID:20525921   PMID:20564195   PMID:20647570   PMID:20670372   PMID:20675382   PMID:20826760   PMID:20887958   PMID:20926684   PMID:20971951   PMID:21035850   PMID:21051860   PMID:21224474  
PMID:21228213   PMID:21254450   PMID:21267068   PMID:21350117   PMID:21357746   PMID:21368290   PMID:21406181   PMID:21421844   PMID:21464228   PMID:21622854   PMID:21636859   PMID:21645497  
PMID:21670307   PMID:21677750   PMID:21700775   PMID:21708300   PMID:21764795   PMID:21873635   PMID:21937717   PMID:21945075   PMID:21953216   PMID:21996747   PMID:22019589   PMID:22027834  
PMID:22037761   PMID:22046433   PMID:22074485   PMID:22096246   PMID:22096247   PMID:22134168   PMID:22210777   PMID:22232691   PMID:22275070   PMID:22318609   PMID:22349694   PMID:22350844  
PMID:22363548   PMID:22424110   PMID:22456341   PMID:22479530   PMID:22479590   PMID:22492581   PMID:22494046   PMID:22511753   PMID:22527796   PMID:22615494   PMID:22647975   PMID:22653978  
PMID:22730538   PMID:22748100   PMID:22760780   PMID:22808199   PMID:22812543   PMID:22895695   PMID:22962684   PMID:22975325   PMID:22984613   PMID:22996695   PMID:23023225   PMID:23064962  
PMID:23086489   PMID:23118343   PMID:23145320   PMID:23152823   PMID:23176290   PMID:23213478   PMID:23216754   PMID:23226954   PMID:23230271   PMID:23325830   PMID:23382219   PMID:23395612  
PMID:23454767   PMID:23465490   PMID:23515331   PMID:23519467   PMID:23551977   PMID:23553959   PMID:23640884   PMID:23788140   PMID:23789102   PMID:23833236   PMID:23870190   PMID:23955631  
PMID:24006485   PMID:24023288   PMID:24029230   PMID:24030382   PMID:24083985   PMID:24103390   PMID:24107997   PMID:24151012   PMID:24162846   PMID:24216753   PMID:24292710   PMID:24294595  
PMID:24303107   PMID:24385425   PMID:24441829   PMID:24496617   PMID:24500921   PMID:24523237   PMID:24558484   PMID:24585775   PMID:24611720   PMID:24778313   PMID:24840544   PMID:24859337  
PMID:24884715   PMID:24951426   PMID:24952961   PMID:24969775   PMID:25024172   PMID:25117682   PMID:25194508   PMID:25352128   PMID:25363539   PMID:25430721   PMID:25520155   PMID:25547154  
PMID:25587038   PMID:25614287   PMID:25684064   PMID:25774504   PMID:25820496   PMID:25911094   PMID:25977332   PMID:26036802   PMID:26159543   PMID:26185093   PMID:26212910   PMID:26278818  
PMID:26291522   PMID:26352002   PMID:26438512   PMID:26507506   PMID:26529254   PMID:26556550   PMID:26744458   PMID:26790499   PMID:26858344   PMID:26953352   PMID:26965188   PMID:27216180  
PMID:27233450   PMID:27264390   PMID:27281793   PMID:27349568   PMID:27452457   PMID:27576787   PMID:27596966   PMID:27746115   PMID:27812539   PMID:27851790   PMID:27990663   PMID:28028021  
PMID:28220032   PMID:28410990   PMID:28445073   PMID:28576878   PMID:28650456   PMID:28673932   PMID:28744026   PMID:28794456   PMID:28815933   PMID:28846069   PMID:28864764   PMID:28924218  
PMID:28962574   PMID:29038237   PMID:29087614   PMID:29459744   PMID:29530978   PMID:29632205   PMID:29739775   PMID:29794068   PMID:29794156   PMID:29802249   PMID:29853537   PMID:30022046  
PMID:30076648   PMID:30190457   PMID:30235285   PMID:30333137   PMID:30333317   PMID:30425049   PMID:30455459   PMID:30458180   PMID:30462575   PMID:30653955   PMID:30931941   PMID:31022732  
PMID:31064775   PMID:31618629   PMID:32237906   PMID:32268102   PMID:32440878   PMID:32473126   PMID:32817592   PMID:32998468   PMID:33131250   PMID:33153107   PMID:33493267   PMID:33577037  


Genomics

Comparative Map Data
Itgb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBImm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
ITGB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1747,253,827 - 47,313,743 (+)EnsemblGRCh38hg38GRCh38
GRCh381747,253,827 - 47,313,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371745,331,193 - 45,391,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,686,207 - 42,745,076 (+)NCBINCBI36hg18NCBI36
Build 341742,686,206 - 42,745,076NCBI
Celera1741,781,276 - 41,840,192 (+)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1740,709,287 - 40,768,167 (+)NCBIHuRef
CHM1_11745,396,156 - 45,455,032 (+)NCBICHM1_1
Itgb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21089,509,917 - 89,564,679 (+)NCBI
Rnor_6.0 Ensembl1092,667,869 - 92,783,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01092,667,869 - 92,783,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01092,424,545 - 92,538,859 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1088,202,821 - 88,257,185 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Itgb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554789,788,192 - 9,830,254 (-)NCBIChiLan1.0ChiLan1.0
ITGB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11710,353,111 - 10,388,924 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBIMhudiblu_PPA_v0panPan3
ITGB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,179,667 - 9,231,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBI
ROS_Cfam_1.0910,772,116 - 10,823,763 (-)NCBI
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBI
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBI
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBI
Itgb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBI
SpeTri2.0NW_0049365412,822,789 - 2,871,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,693,505 - 16,752,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,694,466 - 16,752,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,718,915 - 16,775,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11659,372,171 - 59,431,434 (-)NCBI
Vero_WHO_p1.0NW_02366607730,082,743 - 30,143,493 (-)NCBI
Itgb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248491,895,378 - 1,952,755 (-)NCBI

Position Markers
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
cM Map1168.0UniSTS
D11Mit10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811104,611,774 - 104,611,872UniSTSGRCm38
MGSCv3711104,473,088 - 104,473,186UniSTSGRCm37
Celera11116,340,088 - 116,340,186UniSTS
Cytogenetic Map11E1UniSTS
cM Map1163.0UniSTS
Whitehead Genetic1164.5UniSTS
Whitehead_YAC11 UniSTS
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179922933104611872Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101613994114581537Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101613994114581537Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101613994114581537Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101613994114581537Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102453297112493297Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103383166115130618Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA18679415
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA18679415

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:648
Interacting mature miRNAs:790
Transcripts:ENSMUST00000021028, ENSMUST00000127140
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021028   ⟹   ENSMUSP00000021028
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127140
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11104,637,389 - 104,669,813 (+)Ensembl
RefSeq Acc Id: NM_016780   ⟹   NP_058060
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911104,498,826 - 104,561,299 (+)NCBI
GRCm3811104,608,000 - 104,670,473 (+)NCBI
MGSCv3711104,469,314 - 104,531,787 (+)RGD
Celera11116,336,310 - 116,392,711 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532312   ⟹   XP_006532375
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911104,499,030 - 104,561,302 (+)NCBI
GRCm3811104,608,198 - 104,670,476 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058060   ⟸   NM_016780
- Peptide Label: precursor
- UniProtKB: O54890 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532375   ⟸   XM_006532312
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000021028   ⟸   ENSMUST00000021028
Protein Domains
INB   PSI   VWFA

Promoters
RGD ID:6821124
Promoter ID:MM_KWN:10150
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000006576,   UC007LWX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611104,498,296 - 104,498,796 (+)MPROMDB
RGD ID:8677024
Promoter ID:EPDNEW_M16539
Type:initiation region
Name:Itgb3_1
Description:Mus musculus integrin beta 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811104,608,054 - 104,608,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96612 AgrOrtholog
Ensembl Genes ENSMUSG00000020689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000021028 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021028 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_beta-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/Swiss-Prot
  Integrin_bsu_tail UniProtKB/Swiss-Prot
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot
  Integrin_bsu_VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16416 UniProtKB/Swiss-Prot
MGD MGI:96612 ENTREZGENE
NCBI Gene 16416 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10082:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  Integrin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI_integrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ITGB3 RGD
PhenoGen Itgb3 PhenoGen
PIRSF Integrin_B UniProtKB/Swiss-Prot
PRINTS INTEGRINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  INTEGRIN_BETA UniProtKB/Swiss-Prot
SMART INB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69179 UniProtKB/Swiss-Prot
  SSF69687 UniProtKB/Swiss-Prot
UniProt ITB3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P97483_MOUSE UniProtKB/TrEMBL
  Q6QHD5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TZC6 UniProtKB/Swiss-Prot