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Gene: Itgb3 (integrin beta 3) Mus musculus
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Symbol: Itgb3
Name: integrin beta 3
Description: Exhibits integrin binding activity and protein kinase C binding activity. Predicted to contribute to C-X3-C chemokine binding activity; fibrinogen binding activity; and growth factor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of cell-substrate adhesion. Localizes to several cellular components, including the alpha9-beta1 integrin-ADAM8 complex; alphav-beta3 integrin-PKCalpha complex; and focal adhesion. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal failure; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 16. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Orthologous to human ITGB3 (integrin subunit beta 3); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD61; GP3A; GPIIIa; INGRB3; integrin beta-3; MGC159221; MGC159223; platelet gpIIIa; platelet membrane glycoprotein IIIa
Orthologs:
Homo sapiens (human) : ITGB3 (integrin subunit beta 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgb3 (integrin subunit beta 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb3 (integrin subunit beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB3 (integrin subunit beta 3)
Canis lupus familiaris (dog) : ITGB3 (integrin subunit beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb3 (integrin subunit beta 3)
Sus scrofa (pig) : ITGB3 (integrin subunit beta 3)
Chlorocebus sabaeus (African green monkey) : ITGB3 (integrin subunit beta 3)
Heterocephalus glaber (naked mole-rat) : Itgb3 (integrin subunit beta 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBImm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Itgb3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737483
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.