Itgb3 (integrin beta 3) - Rat Genome Database

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Gene: Itgb3 (integrin beta 3) Mus musculus
Analyze
Symbol: Itgb3
Name: integrin beta 3
RGD ID: 737483
MGI Page MGI
Description: Enables integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including blood coagulation; positive regulation of cell-substrate adhesion; and regulation of cell migration. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and focal adhesion. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is active in glutamatergic synapse and synaptic membrane. Is expressed in several structures, including brain; dorsal aorta; gut; liver; and urinary system. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD61; GP3A; GPIIIa; INGRB3; integrin beta-3; MGC159221; MGC159223; platelet glycoprotein IIIa (GP3A); platelet gpIIIa; platelet membrane glycoprotein IIIa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)EnsemblGRCm39 Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBIMGSCv36mm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myeloid leukemia  (IMP,ISO)
Arterial Occlusive Diseases  (ISO)
arteriosclerosis  (IMP)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (IMP,ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Bronchial Hyperreactivity  (ISO)
Carotid Artery Injuries  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (IMP)
Cerebral Hemorrhage  (ISO)
colorectal carcinoma  (ISO)
Coronary Disease  (ISO)
coronary thrombosis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
focal segmental glomerulosclerosis  (IGI)
genetic disease  (ISO)
Glanzmann Thrombasthenia 1  (ISO)
Glanzmann Thrombasthenia 2  (ISO)
Glanzmann's thrombasthenia  (IAGP,ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hantavirus Infections  (IMP)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hip Fractures  (ISO)
lung disease  (IMP)
lung non-small cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Neonatal Alloimmune Thrombocytopenia  (ISO)
Neoplasm Metastasis  (IEP,ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
Pathologic Constriction  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 16  (IAGP,ISO)
Platelet-Type Bleeding Disorder 24  (ISO)
pneumonia  (IMP)
Posttransfusion Purpura  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Stroke  (ISO)
Sudden Cardiac Death  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (IMP,ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
ADP  (ISO)
aldehydo-D-glucose  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
Arg-Gly-Asp  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butyric acid  (ISO)
C60 fullerene  (ISO)
cangrelor  (ISO)
cannabidiol  (ISO)
carbon disulfide  (EXP)
carbon nanotube  (EXP)
carmustine  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clomiphene  (EXP,ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
desferrioxamine B  (EXP)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hydroquinone  (EXP)
hydroxysafflor yellow A  (ISO)
lead(0)  (ISO)
leuprolide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
manganese(II) chloride  (EXP,ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quinoline  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
serotonin  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Sophoricoside  (EXP)
sotorasib  (ISO)
sulindac  (ISO)
tamoxifen  (EXP)
Tellimagrandin I  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
tranilast  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (IGI,ISO)
blood coagulation, fibrin clot formation  (IMP)
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IBA,ISO)
cell migration  (IBA)
cell projection morphogenesis  (IC)
cell-matrix adhesion  (IBA,IGI,ISO)
cell-substrate adhesion  (ISO)
cell-substrate junction assembly  (IDA)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to xenobiotic stimulus  (ISO)
embryo implantation  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (IBA)
maintenance of postsynaptic specialization structure  (ISO)
mesodermal cell differentiation  (ISO)
negative chemotaxis  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
platelet activation  (ISO)
platelet aggregation  (IBA,IMP,ISO)
platelet-derived growth factor receptor signaling pathway  (IMP)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of bone resorption  (IC,ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell-matrix adhesion  (IMP)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast migration  (IMP,ISO)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of glomerular mesangial cell proliferation  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of osteoclast differentiation  (IC)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
positive regulation of T cell migration  (IDA)
regulation of actin cytoskeleton organization  (IMP)
regulation of extracellular matrix organization  (IMP)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein localization  (IMP)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of serotonin uptake  (IMP)
regulation of trophoblast cell migration  (IMP)
response to activity  (ISO)
response to platelet-derived growth factor  (ISO)
smooth muscle cell migration  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
symbiont entry into host cell  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood coagulation  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell migration  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal hemostasis  (IAGP)
abnormal induced retina neovascularization  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal platelet activation  (IAGP)
abnormal platelet dense granule physiology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal tumor vascularization  (IAGP)
abnormal uterine environment  (IAGP)
anemia  (IAGP)
atherosclerotic lesions  (IAGP)
cardiac hypertrophy  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased collagen level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased heart rate  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased left ventricle systolic pressure  (IAGP)
decreased macrophage cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to induced thrombosis  (IAGP)
dermatitis  (IAGP)
enhanced wound healing  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
gastrointestinal hemorrhage  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased angiogenesis  (IAGP)
increased bleeding time  (IAGP)
increased bone mineral density  (IAGP)
increased circulating glucose level  (IAGP)
increased compact bone thickness  (IAGP)
increased heart left ventricle weight  (IAGP)
increased heart weight  (IAGP)
increased IgG level  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular volume  (IAGP)
increased miscarriage rate  (IAGP)
increased monocyte cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased response of heart to induced stress  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased transforming growth factor beta level  (IAGP)
increased tumor growth/size  (IAGP)
intracranial hemorrhage  (IAGP)
lung inflammation  (IAGP)
maternal effect  (IAGP)
myositis  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
osteosclerosis  (IAGP)
pale placenta  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
petechiae  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
pregnancy-related premature death  (IAGP)
premature death  (IAGP)
purpura  (IAGP)
reduced female fertility  (IAGP)
renal necrosis  (IAGP)
reticulocytosis  (IAGP)
skin hemorrhage  (IAGP)
thick dermal layer  (IAGP)
uterine hemorrhage  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Surgical injury enhances the expression of genes that mediate breast cancer metastasis to the lung. Al-Sahaf O, etal., Ann Surg. 2010 Dec;252(6):1037-43.
2. PLA1/A2 polymorphism of the platelet glycoprotein receptors IIIA in Behcet's disease. Atzeni F, etal., Clin Exp Rheumatol. 2011 Jul-Aug;29(4 Suppl 67):S38-43. Epub 2011 Sep 27.
3. Analysis of inherited thrombophilic mutations and natural anticoagulant deficiency in patients with idiopathic portal hypertension. Bayan K, etal., J Thromb Thrombolysis. 2009 Jul;28(1):57-62. doi: 10.1007/s11239-008-0244-8. Epub 2008 Aug 7.
4. Structure and function of the platelet integrin alphaIIbbeta3. Bennett JS J Clin Invest. 2005 Dec;115(12):3363-9.
5. Cross-reactive antibodies between HIV-gp120 and platelet gpIIIa (CD61) in HIV-related immune thrombocytopenic purpura. Bettaieb A, etal., Clin Exp Immunol. 1996 Jan;103(1):19-23.
6. Increased prevalence of microthromboses in retinal capillaries of diabetic individuals. Boeri D, etal., Diabetes. 2001 Jun;50(6):1432-9.
7. Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia. Bray PF and Shuman MA, Blood. 1990 Feb 15;75(4):881-8.
8. Inhibition of the intimal hyperplasia in an arterial autograft model by blockade of the N-terminal of the integrin beta3 subunit by monoclonal antibody P37. Bujan J, etal., Platelets. 1997;8(5):337-47.
9. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
10. Association of the platelet Pl(A) polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bbeta 448 polymorphism with myocardial infarction and extent of coronary artery disease. Carter AM, etal., Circulation. 1997 Sep 2;96(5):1424-31.
11. Platelet GP IIIA polymorphism HPA-1 (PLA1/2) is associated with hypertension as the primary cause for end-stage renal disease in hemodialysis patients from Greece. Chiras T, etal., In Vivo. 2009 Jan-Feb;23(1):177-81.
12. Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice. Choi ET, etal., Circulation. 2004 Mar 30;109(12):1564-9. Epub 2004 Mar 8.
13. Comparative study of myelodysplastic syndromes and normal bone marrow biopsies with conventional staining and immunocytochemistry. Das R, etal., Anal Quant Cytol Histol. 2005 Jun;27(3):152-6.
14. Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. Ding G, etal., J Cereb Blood Flow Metab. 2005 Jan;25(1):87-97.
15. Coronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism. Durante-Mangoni E, etal., Thromb Haemost. 1998 Aug;80(2):218-9.
16. Different biochemical expression pattern of platelet surface glycoproteins suggests molecular diversity of Glanzmann's thrombasthenia in Iran. Farsinejad A, etal., Blood Coagul Fibrinolysis. 2013 Sep;24(6):613-8. doi: 10.1097/MBC.0b013e328360a558.
17. Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients. Felekis T, etal., Graefes Arch Clin Exp Ophthalmol. 2010 Jun;248(6):877-84. doi: 10.1007/s00417-010-1308-y. Epub 2010 Feb 17.
18. Natural history of platelet antibody formation against alphaIIbbeta3 in a French cohort of Glanzmann thrombasthenia patients. Fiore M, etal., Haemophilia. 2012 May;18(3):e201-9. doi: 10.1111/j.1365-2516.2011.02744.x. Epub 2012 Jan 18.
19. The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events. Galasso G, etal., BMC Cardiovasc Disord. 2010 Sep 16;10:41.
20. Identification of mimotopes of platelet autoantigens associated with autoimmune thrombocytopenic purpura. Gevorkian G, etal., J Autoimmun. 2000 Aug;15(1):33-40.
21. Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease. Goldschmidt-Clermont PJ, etal., Arch Pathol Lab Med. 1999 Dec;123(12):1223-9.
22. Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families. Gresele P, etal., Haematologica. 2009 May;94(5):663-9. doi: 10.3324/haematol.2008.002246. Epub 2009 Mar 31.
23. Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia. Guo L, etal., Blood. 2014 Jan 16;123(3):422-7. doi: 10.1182/blood-2013-08-523308. Epub 2013 Nov 20.
24. Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis. Haas CS, etal., Arthritis Rheum. 2006 Aug;54(8):2402-14.
25. Distribution of alphavbeta3, alphavbeta5 integrins and the integrin associated protein--IAP (CD47) in human glomerular diseases. Hafdi Z, etal., Cell Adhes Commun. 2000;7(6):441-51.
26. Blockade of integrin beta3-FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury. Han M, etal., Cardiovasc Pathol. 2007 Sep-Oct;16(5):283-90. Epub 2007 Jun 20.
27. The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. Hooper WC, etal., Chest. 1999 Oct;116(4):880-6.
28. Expression of integrin subunits alphav and beta3 in acute lung inflammation. Janardhan KS, etal., Histochem Cell Biol. 2004 May;121(5):383-90. Epub 2004 Apr 28.
29. Genetic variation in platelet integrin alphabeta (GPIIb/IIIa) and the metastatic potential of renal cell carcinoma. Kallio JP, etal., BJU Int. 2006 Jul;98(1):201-4.
30. Differential regulation of osteopontin receptors, CD44 and the alpha(v) and beta(3) integrin subunits, in the rat hippocampus following transient forebrain ischemia. Kang WS, etal., Brain Res. 2008 Sep 4;1228:208-16. Epub 2008 Jul 3.
31. Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombasthenia. Kannan M, etal., J Thromb Haemost. 2009 Nov;7(11):1878-85. doi: 10.1111/j.1538-7836.2009.03579.x. Epub 2009 Aug 19.
32. Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3. Kanzaki T and Otabe M, Diabetes. 2003 Mar;52(3):824-8.
33. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Kornak U, etal., Cell 2001 Jan 26;104(2):205-15.
34. Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaque morphology: the Atherosclerosis Risk in Communities (ARIC) Study. Kucharska-Newton AM, etal., Atherosclerosis. 2011 May;216(1):151-6. doi: 10.1016/j.atherosclerosis.2011.01.038. Epub 2011 Feb 2.
35. Intensity of platelet beta(3) integrin in patients with hemorrhagic fever with renal syndrome and its correlation with disease severity. Liu Z, etal., Viral Immunol. 2008 Jun;21(2):255-62.
36. Basic fibroblast growth factor-2/beta3 integrin expression profile: signature of local progression after chemoradiotherapy for patients with locally advanced non-small-cell lung cancer. Massabeau C, etal., Int J Radiat Oncol Biol Phys. 2009 Nov 1;75(3):696-702. Epub 2009 Apr 20.
37. Genes that characterize T3-predominant Graves' thyroid tissues. Matsumoto C, etal., Eur J Endocrinol. 2013 Jan 17;168(2):137-44. doi: 10.1530/EJE-12-0507. Print 2013 Feb.
38. Platelet CD61 expression in vascular calcineurin inhibitor toxicity of renal allografts. Meehan SM, etal., Hum Pathol. 2008 Apr;39(4):550-6. doi: 10.1016/j.humpath.2007.08.012. Epub 2008 Jan 30.
39. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
40. MGDs mouse GO annotations MGD data from the GO Consortium
41. MGD IEA MGD IEA
42. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Miller PG, etal., Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13.
43. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Moon C, etal., Respir Res. 2009 Mar 9;10:18.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene. Peretz H, etal., Blood. 1995 Jan 15;85(2):414-20.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
49. Mouse MP Annotation Import Pipeline RGD automated import pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation. Salter JW, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1432-9.
53. Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma. Sato T, etal., Anticancer Res. 2001 Jan-Feb;21(1B):643-7.
54. Quantification of epithelial cell differentiation in mammary glands and carcinomas from DMBA- and MNU-exposed rats. Sharma D, etal., PLoS One. 2011;6(10):e26145. doi: 10.1371/journal.pone.0026145. Epub 2011 Oct 12.
55. In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry. Song JW, etal., Exp Mol Med. 2005 Apr 30;37(2):121-7.
56. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
57. Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia. Tanaka S, etal., J Thromb Haemost. 2005 Jan;3(1):68-73.
58. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Teeling JL, etal., Blood. 2001 Aug 15;98(4):1095-9.
59. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. Thompson EE, etal., J Allergy Clin Immunol. 2007 Jun;119(6):1423-9.
60. Glycoprotein IIB/IIIA-inhibition and microcirculatory alterations during experimental endotoxemia--an intravital microscopic study in the rat. Walther A, etal., Microcirculation. 2004 Jan-Feb;11(1):79-88.
61. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
62. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Wei C, etal., Nat Med. 2011 Jul 31;17(8):952-60. doi: 10.1038/nm.2411.
63. Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. Weiss LA, etal., Am J Respir Crit Care Med. 2005 Jul 1;172(1):67-73. Epub 2005 Apr 7.
64. Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Weng S, etal., Proc Natl Acad Sci U S A. 2003 May 27;100(11):6730-5. Epub 2003 May 13.
65. Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats. Wu X, etal., J Clin Invest. 1994 Sep;94(3):928-36.
66. Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17. Zimdahl H, etal., Hypertension 2002 Jun;39(6):1050-2.
Additional References at PubMed
PMID:1431091   PMID:1512266   PMID:2018971   PMID:8198553   PMID:8306881   PMID:8512576   PMID:8601592   PMID:8821033   PMID:8918453   PMID:8940024   PMID:8986815   PMID:9022036  
PMID:9339637   PMID:9420328   PMID:9553049   PMID:9832163   PMID:9849968   PMID:9916011   PMID:9916135   PMID:10048576   PMID:10091056   PMID:10337632   PMID:10349636   PMID:10548108  
PMID:10549293   PMID:10683372   PMID:11042159   PMID:11071623   PMID:11076861   PMID:11217851   PMID:11241672   PMID:11342577   PMID:11353389   PMID:11438667   PMID:11493451   PMID:11786903  
PMID:11875495   PMID:12055214   PMID:12377945   PMID:12393886   PMID:12466851   PMID:12477932   PMID:12486108   PMID:12603314   PMID:12618529   PMID:12629153   PMID:12690105   PMID:12761858  
PMID:12842087   PMID:12855554   PMID:12867986   PMID:12900455   PMID:12904471   PMID:12927791   PMID:14516789   PMID:14524530   PMID:14593208   PMID:14612570   PMID:14718670   PMID:15031111  
PMID:15059849   PMID:15131115   PMID:15166241   PMID:15284116   PMID:15329828   PMID:15336554   PMID:15545316   PMID:15574772   PMID:15591537   PMID:15654327   PMID:15690355   PMID:15760908  
PMID:15782199   PMID:15972454   PMID:16014375   PMID:16037392   PMID:16051597   PMID:16141072   PMID:16141073   PMID:16150802   PMID:16216233   PMID:16247034   PMID:16288021   PMID:16294265  
PMID:16304048   PMID:16317099   PMID:16337627   PMID:16365395   PMID:16391195   PMID:16391197   PMID:16400188   PMID:16407244   PMID:16467530   PMID:16533881   PMID:16571912   PMID:16600665  
PMID:16602821   PMID:16608535   PMID:16622802   PMID:16670270   PMID:16679515   PMID:16705383   PMID:16720835   PMID:16790614   PMID:16824188   PMID:16887829   PMID:16995821   PMID:17003372  
PMID:17028191   PMID:17030947   PMID:17062734   PMID:17075060   PMID:17099249   PMID:17170121   PMID:17184791   PMID:17261592   PMID:17359504   PMID:17426256   PMID:17446174   PMID:17492052  
PMID:17530709   PMID:17597067   PMID:17606926   PMID:17627302   PMID:17641225   PMID:17674000   PMID:17898081   PMID:17925492   PMID:17951320   PMID:17983596   PMID:17996853   PMID:18082680  
PMID:18084301   PMID:18086863   PMID:18156175   PMID:18165225   PMID:18174291   PMID:18184798   PMID:18255021   PMID:18256319   PMID:18278053   PMID:18288635   PMID:18317590   PMID:18326492  
PMID:18334487   PMID:18346467   PMID:18366072   PMID:18369617   PMID:18378693   PMID:18381073   PMID:18430780   PMID:18456735   PMID:18487513   PMID:18544684   PMID:18552165   PMID:18579532  
PMID:18611961   PMID:18640270   PMID:18829523   PMID:18840708   PMID:18985734   PMID:18997092   PMID:19005179   PMID:19017937   PMID:19023115   PMID:19036705   PMID:19074851   PMID:19075116  
PMID:19118216   PMID:19122172   PMID:19218546   PMID:19255147   PMID:19332769   PMID:19364763   PMID:19454719   PMID:19487690   PMID:19576795   PMID:19643138   PMID:19645751   PMID:19695571  
PMID:19729481   PMID:19755424   PMID:19758485   PMID:19805288   PMID:19808614   PMID:19808644   PMID:19837659   PMID:19933310   PMID:19940148   PMID:19967726   PMID:20007808   PMID:20016849  
PMID:20075254   PMID:20087368   PMID:20110424   PMID:20151413   PMID:20155273   PMID:20164359   PMID:20184965   PMID:20203303   PMID:20339539   PMID:20393597   PMID:20404115   PMID:20440000  
PMID:20525921   PMID:20564195   PMID:20647570   PMID:20670372   PMID:20675382   PMID:20826760   PMID:20887958   PMID:20926684   PMID:20971951   PMID:21035850   PMID:21051860   PMID:21224474  
PMID:21228213   PMID:21254450   PMID:21267068   PMID:21350117   PMID:21357746   PMID:21368290   PMID:21406181   PMID:21421844   PMID:21464228   PMID:21622854   PMID:21636859   PMID:21645497  
PMID:21670307   PMID:21677750   PMID:21700775   PMID:21708300   PMID:21764795   PMID:21873635   PMID:21937717   PMID:21945075   PMID:21953216   PMID:21996747   PMID:22019589   PMID:22027834  
PMID:22037761   PMID:22046433   PMID:22074485   PMID:22096246   PMID:22096247   PMID:22134168   PMID:22210777   PMID:22232691   PMID:22275070   PMID:22318609   PMID:22349694   PMID:22350844  
PMID:22363548   PMID:22424110   PMID:22456341   PMID:22479530   PMID:22479590   PMID:22492581   PMID:22494046   PMID:22511753   PMID:22527796   PMID:22615494   PMID:22647975   PMID:22653978  
PMID:22730538   PMID:22748100   PMID:22760780   PMID:22808199   PMID:22812543   PMID:22895695   PMID:22962684   PMID:22975325   PMID:22984613   PMID:22996695   PMID:23023225   PMID:23064962  
PMID:23086489   PMID:23118343   PMID:23145320   PMID:23152823   PMID:23176290   PMID:23213478   PMID:23216754   PMID:23226954   PMID:23230271   PMID:23325830   PMID:23382219   PMID:23395612  
PMID:23454767   PMID:23465490   PMID:23515331   PMID:23519467   PMID:23551977   PMID:23553959   PMID:23640884   PMID:23788140   PMID:23789102   PMID:23833236   PMID:23870190   PMID:23955631  
PMID:24006485   PMID:24023288   PMID:24029230   PMID:24030382   PMID:24083985   PMID:24103390   PMID:24107997   PMID:24151012   PMID:24162846   PMID:24216753   PMID:24292710   PMID:24294595  
PMID:24303107   PMID:24385425   PMID:24441829   PMID:24496617   PMID:24500921   PMID:24523237   PMID:24558484   PMID:24585775   PMID:24611720   PMID:24778313   PMID:24840544   PMID:24859337  
PMID:24884715   PMID:24951426   PMID:24952961   PMID:24969775   PMID:25024172   PMID:25117682   PMID:25352128   PMID:25363539   PMID:25430721   PMID:25520155   PMID:25547154   PMID:25587038  
PMID:25614287   PMID:25684064   PMID:25774504   PMID:25820496   PMID:25911094   PMID:25977332   PMID:26036802   PMID:26159543   PMID:26185093   PMID:26212910   PMID:26278818   PMID:26291522  
PMID:26352002   PMID:26438512   PMID:26507506   PMID:26529254   PMID:26556550   PMID:26744458   PMID:26790499   PMID:26858344   PMID:26953352   PMID:26965188   PMID:27216180   PMID:27233450  
PMID:27264390   PMID:27281793   PMID:27349568   PMID:27452457   PMID:27505886   PMID:27576787   PMID:27596966   PMID:27746115   PMID:27812539   PMID:27851790   PMID:27990663   PMID:28028021  
PMID:28220032   PMID:28410990   PMID:28445073   PMID:28576878   PMID:28650456   PMID:28673932   PMID:28744026   PMID:28794456   PMID:28815933   PMID:28846069   PMID:28864764   PMID:28924218  
PMID:28962574   PMID:29038237   PMID:29087614   PMID:29386381   PMID:29459744   PMID:29530978   PMID:29632205   PMID:29739775   PMID:29794068   PMID:29794156   PMID:29802249   PMID:29853537  
PMID:30022046   PMID:30076648   PMID:30190457   PMID:30235285   PMID:30333137   PMID:30333317   PMID:30425049   PMID:30455459   PMID:30458180   PMID:30462575   PMID:30653955   PMID:30730305  
PMID:30787865   PMID:30931941   PMID:31022732   PMID:31064775   PMID:31534047   PMID:31618629   PMID:32102567   PMID:32193334   PMID:32237906   PMID:32268102   PMID:32440878   PMID:32473126  
PMID:32817592   PMID:32882513   PMID:32998468   PMID:33131250   PMID:33153107   PMID:33176450   PMID:33317577   PMID:33493267   PMID:33577037   PMID:33818281   PMID:33880575   PMID:33927296  
PMID:34321999   PMID:34735454   PMID:34752599   PMID:34990407   PMID:35062222   PMID:35247972   PMID:35734962   PMID:36674478   PMID:36748196   PMID:36982771   PMID:37171626   PMID:37219531  
PMID:37296444   PMID:37939263   PMID:38220131   PMID:38247863  


Genomics

Comparative Map Data
Itgb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)EnsemblGRCm39 Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBIMGSCv36mm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
ITGB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,253,827 - 47,313,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,253,827 - 47,313,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371745,331,193 - 45,391,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,686,207 - 42,745,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 341742,686,206 - 42,745,076NCBI
Celera1741,781,276 - 41,840,192 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1740,709,287 - 40,768,167 (+)NCBIHuRef
CHM1_11745,396,156 - 45,455,032 (+)NCBICHM1_1
T2T-CHM13v2.01748,116,181 - 48,176,126 (+)NCBIT2T-CHM13v2.0
Itgb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81090,009,927 - 90,067,787 (+)NCBIGRCr8
mRatBN7.21089,509,917 - 89,564,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1089,509,989 - 89,564,679 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1094,545,884 - 94,600,315 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01094,009,074 - 94,063,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01089,414,016 - 89,475,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01092,667,869 - 92,783,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,667,869 - 92,783,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01092,424,545 - 92,538,859 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1088,202,821 - 88,257,185 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Itgb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554789,788,149 - 9,823,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554789,788,192 - 9,830,254 (-)NCBIChiLan1.0ChiLan1.0
ITGB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,697,521 - 17,760,403 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,665,154 - 19,725,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11710,353,111 - 10,388,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,353,111 - 10,392,382 (-)Ensemblpanpan1.1panPan2
ITGB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,179,667 - 9,231,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0910,772,116 - 10,823,763 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl910,772,333 - 10,825,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBIUU_Cfam_GSD_1.0
Itgb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365412,815,738 - 2,871,035 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365412,822,789 - 2,871,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,693,514 - 16,752,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,694,466 - 16,752,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,718,915 - 16,775,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11659,372,171 - 59,431,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1659,374,889 - 59,410,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607730,082,743 - 30,143,493 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,895,914 - 1,952,665 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,895,378 - 1,952,755 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgb3
2170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:648
Interacting mature miRNAs:790
Transcripts:ENSMUST00000021028, ENSMUST00000127140
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse

Markers in Region
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
cM Map1168.0UniSTS
D11Mit10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811104,611,774 - 104,611,872UniSTSGRCm38
MGSCv3711104,473,088 - 104,473,186UniSTSGRCm37
Celera11116,340,088 - 116,340,186UniSTS
Cytogenetic Map11E1UniSTS
cM Map1163.0UniSTS
Whitehead Genetic1164.5UniSTS
Whitehead_YAC11 UniSTS
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
Itgb3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021028   ⟹   ENSMUSP00000021028
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)Ensembl
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11104,528,215 - 104,560,639 (+)Ensembl
GRCm38.p6 Ensembl11104,637,389 - 104,669,813 (+)Ensembl
RefSeq Acc Id: NM_016780   ⟹   NP_058060
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911104,498,826 - 104,561,299 (+)NCBI
GRCm3811104,608,000 - 104,670,473 (+)NCBI
MGSCv3711104,469,314 - 104,531,787 (+)RGD
Celera11116,336,310 - 116,392,711 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532312   ⟹   XP_006532375
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911104,499,030 - 104,561,302 (+)NCBI
GRCm3811104,608,198 - 104,670,476 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058060   ⟸   NM_016780
- Peptide Label: precursor
- UniProtKB: Q3TZC6 (UniProtKB/Swiss-Prot),   O54890 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532375   ⟸   XM_006532312
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000021028   ⟸   ENSMUST00000021028
Protein Domains
EGF-like   Integrin beta subunit VWA   PSI   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54890-F1-model_v2 AlphaFold O54890 1-787 view protein structure

Promoters
RGD ID:6821124
Promoter ID:MM_KWN:10150
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000006576,   UC007LWX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611104,498,296 - 104,498,796 (+)MPROMDB
RGD ID:8677024
Promoter ID:EPDNEW_M16539
Type:initiation region
Name:Itgb3_1
Description:Mus musculus integrin beta 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811104,608,054 - 104,608,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96612 AgrOrtholog
Ensembl Genes ENSMUSG00000020689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021028 ENTREZGENE
  ENSMUST00000021028.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/Swiss-Prot
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  ligand-binding face of the semaphorins, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
InterPro EGF_extracell UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/Swiss-Prot
  Integrin_bsu_tail UniProtKB/Swiss-Prot
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot
  Integrin_bsu_VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16416 UniProtKB/Swiss-Prot
MGD MGI:96612 ENTREZGENE
NCBI Gene 16416 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10082:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  Integrin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI_integrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ITGB3 RGD
PhenoGen Itgb3 PhenoGen
PIRSF Integrin_B UniProtKB/Swiss-Prot
PRINTS INTEGRINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  INTEGRIN_BETA UniProtKB/Swiss-Prot
SMART INB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  Plexin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69179 UniProtKB/Swiss-Prot
  SSF69687 UniProtKB/Swiss-Prot
UniProt ITB3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P97483_MOUSE UniProtKB/TrEMBL
  Q3TZC6 ENTREZGENE
  Q6QHD5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TZC6 UniProtKB/Swiss-Prot