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Gene: Itgb6 (integrin beta 6) Mus musculus
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Symbol: Itgb6
Name: integrin beta 6
Description: Exhibits integrin binding activity. Involved in cell adhesion mediated by integrin; inflammatory response; and transforming growth factor-beta secretion. Localizes to the external side of plasma membrane and integrin alphav-beta6 complex. Used to study asthma and pulmonary emphysema. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Is expressed in several structures, including diaphragm; gut; limb; metanephros; and vertebral axis musculature. Orthologous to human ITGB6 (integrin subunit beta 6); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210409C20Rik; 4831415H04Rik; integrin beta-6
Orthologs:
Homo sapiens (human) : ITGB6 (integrin subunit beta 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgb6 (integrin subunit beta 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb6 (integrin subunit beta 6)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB6 (integrin subunit beta 6)
Canis lupus familiaris (dog) : ITGB6 (integrin subunit beta 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb6 (integrin subunit beta 6)
Sus scrofa (pig) : ITGB6 (integrin subunit beta 6)
Chlorocebus sabaeus (green monkey) : ITGB6 (integrin subunit beta 6)
Heterocephalus glaber (naked mole-rat) : Itgb6 (integrin subunit beta 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl260,598,292 - 60,722,643 (-)Ensembl
GRCm38260,598,292 - 60,722,603 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37260,436,349 - 60,560,660 (-)NCBIGRCm37mm9NCBIm37
MGSCv36260,399,131 - 60,474,500 (-)NCBImm8
Celera262,295,485 - 62,419,857 (-)NCBICelera
Cytogenetic Map2 C1.2NCBI
cM Map234.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Itgb6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552765
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.