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Gene: Itgb6 (integrin beta 6) Mus musculus
Symbol: Itgb6
Name: integrin beta 6
Description: Exhibits integrin binding activity. Involved in cell adhesion mediated by integrin; inflammatory response; and transforming growth factor-beta secretion. Localizes to the external side of plasma membrane and integrin alphav-beta6 complex. Used to study asthma and pulmonary emphysema. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Is expressed in several structures, including diaphragm; gut; limb; metanephros; and vertebral axis musculature. Orthologous to human ITGB6 (integrin subunit beta 6); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210409C20Rik; 4831415H04Rik; integrin beta-6
Homo sapiens (human) : ITGB6 (integrin subunit beta 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgb6 (integrin subunit beta 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb6 (integrin subunit beta 6)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB6 (integrin subunit beta 6)
Canis lupus familiaris (dog) : ITGB6 (integrin subunit beta 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb6 (integrin subunit beta 6)
Sus scrofa (pig) : ITGB6 (integrin subunit beta 6)
Chlorocebus sabaeus (green monkey) : ITGB6 (integrin subunit beta 6)
Heterocephalus glaber (naked mole-rat) : Itgb6 (integrin subunit beta 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl260,598,292 - 60,722,643 (-)Ensembl
GRCm38260,598,292 - 60,722,603 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37260,436,349 - 60,560,660 (-)NCBIGRCm37mm9NCBIm37
MGSCv36260,399,131 - 60,474,500 (-)NCBImm8
Celera262,295,485 - 62,419,857 (-)NCBICelera
Cytogenetic Map2 C1.2NCBI
cM Map234.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itgb6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552765
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.