Itga1 (integrin subunit alpha 1) - Rat Genome Database

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Gene: Itga1 (integrin subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Itga1
Name: integrin subunit alpha 1
RGD ID: 2923
Description: Enables collagen binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; and vasodilation. Located in acrosomal vesicle; external side of plasma membrane; and perikaryon. Orthologous to human ITGA1 (integrin subunit alpha 1); PARTICIPATES IN altered integrin mediated signaling pathway; myocardial infarction pathway; integrin mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD49 antigen-like family member A; integrin alpha 1; integrin alpha-1; integrin, alpha 1; laminin and collagen receptor; VLA-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,379,181 - 48,545,336 (-)NCBIGRCr8
mRatBN7.2246,646,125 - 46,812,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,760,440 - 53,912,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,818,812 - 51,971,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,688,983 - 46,841,874 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0247,127,403 - 47,281,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,666,601 - 71,823,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4247,107,849 - 47,206,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,036,084 - 47,134,488 (-)NCBI
Celera242,407,780 - 42,559,904 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
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Original Reference(s)
Itga1Ratarteriosclerosis  ISOItga1 (Mus musculus)2302133atherosclerosis and DNA:knockout::genetic knockout or treatment with a blocking antibody reduced atherosclerotic inflammation and plaque formation in ApoE-/- mice (mouse)RGD 
Itga1Ratbreast cancer  ISOITGA1 (Homo sapiens)2302120protein:decreased expression:tumor:down-regulated in tumors lacking a basement membrane (human)RGD 
Itga1RatCOVID-19  ISOITGA1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Itga1RatHyperalgesia  IMP 2302389PGE2-inducedRGD 
Itga1RatHyperalgesia  IMP 2302139knock-down using a specific monoclonal antibody or RNAiRGD 
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Itga1RatNeurodevelopmental Disorders  ISOITGA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Itga1RatGliosis  ISOITGA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12851778
Itga1Rattype 2 diabetes mellitus  ISOITGA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30718926

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Original Reference(s)
Itga1Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of ITGA1 proteinCTDPMID:12851778
Itga1Rat1,2-dimethylhydrazine increases expressionISOItga1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ITGA1 mRNACTDPMID:22206623
Itga1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ITGA1 mRNACTDPMID:15576828 and PMID:29097150
Itga1Rat17beta-estradiol decreases expressionISOItga1 (Mus musculus)6480464Estradiol results in decreased expression of ITGA1 mRNACTDPMID:25210133
Itga1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of ITGA1 mRNACTDPMID:32145629
Itga1Rat17beta-estradiol multiple interactionsISOITGA1 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in increased expression of ITGA1 protein more ...CTDPMID:11507064
Itga1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOITGA1 (Homo sapiens)64804642 more ...CTDPMID:37385330
Itga1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ITGA1 mRNACTDPMID:16054898 and PMID:32109520
Itga1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ITGA1 mRNACTDPMID:34747641
Itga1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOITGA1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of ITGA1 mRNACTDPMID:26238291 and PMID:27913140
Itga1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ITGA1 mRNACTDPMID:19490992
Itga1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Itga1Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:23196670
Itga1Rat3,4-dichloroaniline increases expressionEXP 64804643 and 4-dichloroaniline results in increased expression of ITGA1 mRNACTDPMID:24172598
Itga1Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ITGA1 mRNACTDPMID:30071829
Itga1Rat3-Nitrobenzanthrone decreases expressionISOITGA1 (Homo sapiens)64804643-nitrobenzanthrone results in decreased expression of ITGA1 mRNACTDPMID:34036453
Itga1Rat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of ITGA1 mRNACTDPMID:30723492
Itga1Rat4,4'-sulfonyldiphenol increases expressionISOItga1 (Mus musculus)6480464bisphenol S results in increased expression of ITGA1 mRNACTDPMID:30951980
Itga1Rat4,4'-sulfonyldiphenol decreases expressionISOItga1 (Mus musculus)6480464bisphenol S results in decreased expression of ITGA1 mRNACTDPMID:39298647
Itga1Rat5-aza-2'-deoxycytidine affects methylationISOITGA1 (Homo sapiens)6480464Decitabine affects the methylation of ITGA1 geneCTDPMID:17669516

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Biological Process
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Original Reference(s)
Itga1Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Itga1Ratcell adhesion acts_upstream_of_or_withinIEAUniProtKB:Q3V3R4 and ensembl:ENSMUSP000000771321600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratcell adhesion acts_upstream_of_or_withinISOItga1 (Mus musculus)1624291MGI:2661083 PMID:10528208RGDPMID:10528208
Itga1Ratcell adhesion involved_inIEAInterPro:IPR0004131600115GO_REF:0000002InterProGO_REF:0000002
Itga1Ratcell adhesion mediated by integrin involved_inIBAFB:FBgn0001250 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga1Ratcell chemotaxis  IMP 2302138toward collagen types I and IVRGD 
Itga1Ratcell-cell adhesion involved_inIBAMGI:96602 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga1Ratcell-matrix adhesion involved_inISOITGA1 (Homo sapiens)1624291 PMID:24823363RGDPMID:24823363
Itga1Ratcell-matrix adhesion involved_inIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratcellular extravasation acts_upstream_of_or_withinIEAUniProtKB:Q3V3R4 and ensembl:ENSMUSP000000771321600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratcellular extravasation acts_upstream_of_or_withinISOItga1 (Mus musculus)1624291MGI:2661083 PMID:10528208RGDPMID:10528208
Itga1Ratintegrin-mediated signaling pathway involved_inIEAUniProtKB-KW:KW-04011600115GO_REF:0000043UniProtGO_REF:0000043
Itga1Ratintegrin-mediated signaling pathway involved_inIBAPANTHER:PTN001144284 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga1Ratnegative regulation of cell population proliferation involved_inISSUniProtKB:P561991600115GO_REF:0000024UniProtGO_REF:0000024
Itga1Ratnegative regulation of cell population proliferation involved_inIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratnegative regulation of cell population proliferation involved_inISOITGA1 (Homo sapiens)1624291 PMID:15592458RGDPMID:15592458
Itga1Ratnegative regulation of epidermal growth factor receptor signaling pathway involved_inISSUniProtKB:Q3V3R41600115GO_REF:0000024UniProtGO_REF:0000024
Itga1Ratnegative regulation of epidermal growth factor receptor signaling pathway involved_inIEAUniProtKB:Q3V3R4 and ensembl:ENSMUSP000000771321600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratnegative regulation of epidermal growth factor receptor signaling pathway involved_inISOItga1 (Mus musculus)1624291 PMID:15592458RGDPMID:15592458
Itga1Ratneuron projection morphogenesis  IMP 1579850positive regulation of thrombospondin type 1 repeat-mediated neurite outgrowthRGD 
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Cellular Component
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Original Reference(s)
Itga1Ratacrosomal vesicle  IDA 1581320 RGD 
Itga1Ratbasal part of cell located_inISOItga1 (Mus musculus)1624291 PMID:11767049RGDPMID:11767049
Itga1Ratbasal part of cell located_inIEAUniProtKB:Q3V3R4 and ensembl:ENSMUSP000000771321600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratcell surface located_inIEAARBA:ARBA000273491600115GO_REF:0000117UniProtGO_REF:0000117
Itga1Ratcell surface located_inIEAUniProtKB:Q3V3R4 and ensembl:ENSMUSP000000771321600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratcell surface located_inIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratcell surface located_inISOITGA1 (Homo sapiens)1624291 PMID:19933311 and PMID:20563599RGDPMID:19933311 and PMID:20563599
Itga1Ratcell surface located_inISOItga1 (Mus musculus)1624291 PMID:23023225RGDPMID:23023225
Itga1Ratcell surface  ISOItga1 (Chinchilla lanigera)1624291 RGD (All species) and (All species)
Itga1Ratexternal side of plasma membrane  IDA 2302135 RGD 
Itga1Ratexternal side of plasma membrane located_inIEAUniProtKB:Q3V3R4 and ensembl:ENSMUSP000000771321600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratexternal side of plasma membrane located_inISOItga1 (Mus musculus)1624291 PMID:16973387 and PMID:9553049RGDPMID:16973387 and PMID:9553049
Itga1Ratexternal side of plasma membrane is_active_inIBAMGI:1298377 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga1Ratexternal side of plasma membrane  IDA 2302385punctate staining of non-permeabilized hippocampal neuronsRGD 
Itga1Ratfocal adhesion located_inISOITGA1 (Homo sapiens)1624291 PMID:11518510RGDPMID:11518510
Itga1Ratfocal adhesion located_inIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratintegrin alpha1-beta1 complex part_ofISOITGA1 (Homo sapiens)1624291 PMID:24823363RGDPMID:24823363
Itga1Ratintegrin alpha1-beta1 complex part_ofIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratintegrin complex part_ofIBAFB:FBgn0001250 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga1Ratintegrin complex part_ofIEAInterPro:IPR0004131600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
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Original Reference(s)
Itga1Ratcollagen binding  IMP 2302138rat type I and type IV collagensRGD 
Itga1Ratcollagen binding involved in cell-matrix adhesion enablesISOITGA1 (Homo sapiens)1624291 PMID:24823363RGDPMID:24823363
Itga1Ratcollagen binding involved in cell-matrix adhesion enablesIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratintegrin binding enablesIBAMGI:104756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Itga1Ratphosphatase activator activity enablesISSUniProtKB:P561991600115GO_REF:0000024UniProtGO_REF:0000024
Itga1Ratphosphatase activator activity enablesIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratphosphatase activator activity enablesISOITGA1 (Homo sapiens)1624291 PMID:15592458RGDPMID:15592458
Itga1Ratprotein binding enablesISOItga1 (Mus musculus)1624291PR:Q91V88 more ...RGDPMID:11470831 more ...
Itga1Ratprotein binding enablesISOITGA1 (Homo sapiens)1624291UniProtKB:P04512 more ...RGDPMID:16754661 and PMID:18587047
Itga1Ratprotein phosphatase binding enablesISOITGA1 (Homo sapiens)1624291UniProtKB:P17706 and PMID:15592458RGDPMID:15592458
Itga1Ratprotein phosphatase binding enablesIEAUniProtKB:P56199 and ensembl:ENSP000002825881600115GO_REF:0000107EnsemblGO_REF:0000107
Itga1Ratsignaling receptor binding  IPICasr (Rattus norvegicus)7205691 RGD 
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Itga1Ratarrhythmogenic right ventricular cardiomyopathy pathway  IEA 6907045 KEGGrno:05412
Itga1Ratcell-extracellular matrix signaling pathway  IEA 6907045 KEGGrno:04512
Itga1Ratdilated cardiomyopathy pathway  IEA 6907045 KEGGrno:05414
Itga1Rathypertrophic cardiomyopathy pathway  IEA 6907045 KEGGrno:05410

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#
Reference Title
Reference Citation
1. alpha1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons. Anderson KL and Ferreira A, J Neurosci Res. 2004 Mar 1;75(5):688-97.
2. Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin. Bamdad M, etal., Cell Tissue Res. 2004 Jan;315(1):15-25. Epub 2003 Oct 16.
3. Integrin expression on normal and neoplastic human breast epithelium. Damjanovich L, etal., Acta Chir Hung. 1997;36(1-4):69-71.
4. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
5. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
6. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. Fujimura T, etal., J Dermatol Sci. 2007 Jan;45(1):45-53. Epub 2006 Nov 21.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Localization of integrin beta 1, alpha 1, alpha 5 and alpha 9 subunits in the rat testis. Giebel J, etal., Int J Androl. 1997 Feb;20(1):3-9.
9. Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Gindraux F, etal., Cell Tissue Res. 2007 Mar;327(3):471-83. Epub 2006 Nov 16.
10. Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen. Ignatius MJ, etal., J Cell Biol 1990 Aug;111(2):709-20.
11. Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells. Kitamura A, etal., Biochem Biophys Res Commun 2002 Dec 13;299(4):555-61.
12. Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries. Loufrani L, etal., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1906-13. Epub 2008 Feb 1.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Nawata J, etal., Cardiovasc Res 1999 Aug 1;43(2):371-81.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Olfa KZ, etal., Lab Invest. 2005 Dec;85(12):1507-16.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:9553049   PMID:10386626   PMID:10528208   PMID:11518510   PMID:11767049   PMID:15592458   PMID:16271045   PMID:16973387   PMID:17161391   PMID:19056867   PMID:19581412   PMID:19933311  
PMID:19946888   PMID:20563599   PMID:21423176   PMID:22847004   PMID:23023225   PMID:23658023   PMID:24823363   PMID:26520903   PMID:27108411   PMID:27484337  



Itga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,379,181 - 48,545,336 (-)NCBIGRCr8
mRatBN7.2246,646,125 - 46,812,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,760,440 - 53,912,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,818,812 - 51,971,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,688,983 - 46,841,874 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0247,127,403 - 47,281,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,666,601 - 71,823,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4247,107,849 - 47,206,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,036,084 - 47,134,488 (-)NCBI
Celera242,407,780 - 42,559,904 (-)NCBICelera
Cytogenetic Map2q14NCBI
ITGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,787,916 - 52,959,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,787,916 - 52,959,209 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,083,750 - 52,255,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,119,893 - 52,285,242 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,119,892 - 52,285,241NCBI
Celera549,037,686 - 49,203,085 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,055,982 - 49,221,542 (+)NCBIHuRef
CHM1_1552,086,786 - 52,252,111 (+)NCBICHM1_1
T2T-CHM13v2.0553,615,621 - 53,786,944 (+)NCBIT2T-CHM13v2.0
Itga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913115,094,615 - 115,238,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13115,089,632 - 115,238,500 (-)EnsemblGRCm39 Ensembl
GRCm3813114,958,079 - 115,101,964 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,953,096 - 115,101,964 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,748,287 - 115,892,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613116,080,957 - 116,222,842 (-)NCBIMGSCv36mm8
Celera13119,308,615 - 119,462,806 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
Itga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,446,300 - 14,577,605 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,439,571 - 14,582,236 (-)NCBIChiLan1.0ChiLan1.0
ITGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,984,567 - 61,160,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1559,135,090 - 59,312,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0561,073,507 - 61,247,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,692,673 - 62,865,771 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,692,673 - 62,865,769 (-)Ensemblpanpan1.1panPan2
ITGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,287,823 - 62,455,940 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,293,082 - 62,455,650 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha462,062,740 - 62,230,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,785,836 - 62,953,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,791,553 - 62,953,332 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,561,013 - 62,729,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,685,631 - 62,847,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,212,383 - 63,380,850 (-)NCBIUU_Cfam_GSD_1.0
Itga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,502,947 - 205,654,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,443,685 - 14,591,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,442,481 - 14,591,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,129,612 - 32,304,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,130,265 - 32,309,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21633,940,969 - 34,132,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,081,687 - 49,248,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,082,787 - 49,246,186 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,876,808 - 2,052,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,404,758 - 6,543,211 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247596,397,743 - 6,543,652 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Itga1
1003 total Variants

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000016353
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat

1 to 10 of 49 rows
RH130277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,797,854 - 46,798,034 (+)MAPPERmRatBN7.2
Rnor_6.0247,266,760 - 47,266,939NCBIRnor6.0
Rnor_5.0271,808,493 - 71,808,672UniSTSRnor5.0
RGSC_v3.4245,900,725 - 45,900,904UniSTSRGSC3.4
Celera242,545,598 - 42,545,777UniSTS
RH 3.4 Map2307.3UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map2q16-q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000086114   ⟹   ENSRNOP00000074337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,657,201 - 46,812,238 (-)Ensembl
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106157   ⟹   ENSRNOP00000086956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)Ensembl
RefSeq Acc Id: NM_030994   ⟹   NP_112256
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,386,244 - 48,545,283 (-)NCBI
mRatBN7.2246,653,188 - 46,812,237 (-)NCBI
Rnor_6.0247,127,403 - 47,281,387 (-)NCBI
Rnor_5.0271,666,601 - 71,823,120 (-)NCBI
RGSC_v3.4247,107,849 - 47,206,261 (-)RGD
Celera242,407,780 - 42,559,904 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101763   ⟹   XP_038957691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,379,181 - 48,545,336 (-)NCBI
mRatBN7.2246,646,125 - 46,811,914 (-)NCBI
RefSeq Acc Id: XR_010063584
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,413,961 - 48,545,324 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_112256 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957691 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA36384 (Get FASTA)   NCBI Sequence Viewer  
  EDM10391 (Get FASTA)   NCBI Sequence Viewer  
  EDM10392 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086956
  ENSRNOP00000086956.1
  ENSRNOP00000101823
GenBank Protein P18614 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_112256   ⟸   NM_030994
- Peptide Label: precursor
- UniProtKB: P18614 (UniProtKB/Swiss-Prot),   A6I5T3 (UniProtKB/TrEMBL),   A0A8L2R8Q8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074337   ⟸   ENSRNOT00000086114
RefSeq Acc Id: XP_038957691   ⟸   XM_039101763
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R8Q8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086956   ⟸   ENSRNOT00000106157
VWFA

Name Modeler Protein Id AA Range Protein Structure
AF-P18614-F1-model_v2 AlphaFold P18614 1-1180 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691151
Promoter ID:EPDNEW_R1675
Type:multiple initiation site
Name:Itga1_2
Description:integrin subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1676  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,281,160 - 47,281,220EPDNEW
RGD ID:13691152
Promoter ID:EPDNEW_R1676
Type:multiple initiation site
Name:Itga1_1
Description:integrin subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1675  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,281,392 - 47,281,452EPDNEW


1 to 40 of 47 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-54324 BioCyc
Ensembl Genes ENSRNOG00000053550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106157 ENTREZGENE
  ENSRNOT00000106157.1 UniProtKB/Swiss-Prot
  ENSRNOT00000150403 ENTREZGENE
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot
  3.40.50.410 UniProtKB/Swiss-Prot
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro FG-GAP UniProtKB/Swiss-Prot
  Int_alpha_beta-p UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha-2 UniProtKB/Swiss-Prot
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot
  Integrin_alpha_N UniProtKB/Swiss-Prot
  Integrin_dom_sf UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25118 UniProtKB/Swiss-Prot
NCBI Gene 25118 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot
  INTEGRIN ALPHA-1 UniProtKB/Swiss-Prot
Pfam FG-GAP UniProtKB/Swiss-Prot
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot
  Integrin_alpha2 UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
PhenoGen Itga1 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot
  VWFADOMAIN UniProtKB/Swiss-Prot
PROSITE FG_GAP UniProtKB/Swiss-Prot
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot
  VWFA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053550 RatGTEx
SMART Int_alpha UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
1 to 40 of 47 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga1  integrin subunit alpha 1  Itga1  integrin, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itga1  integrin, alpha 1  Itga1  integrin alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Itga1  integrin alpha 1    integrin, alpha 1  Name updated 629478 APPROVED
2002-06-10 Itga1  integrin, alpha 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function associates with the beta-1 chain to form a dual laminin/collagen receptor 729264
gene_process has a role in cell attachment and neurite outgrowth on laminin and collagen as well as in peripheral nerve regeneration  
gene_process involved in mesangial cell (MC) migration 727474
gene_regulation activity stimulated by Endothelin-1 (ET) in mesangial cells 727474