Itga1 (integrin subunit alpha 1) - Rat Genome Database

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Gene: Itga1 (integrin subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Itga1
Name: integrin subunit alpha 1
RGD ID: 2923
Description: Enables collagen binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; and vasodilation. Located in acrosomal vesicle; external side of plasma membrane; and perikaryon. Orthologous to human ITGA1 (integrin subunit alpha 1); PARTICIPATES IN altered integrin mediated signaling pathway; myocardial infarction pathway; integrin mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD49 antigen-like family member A; integrin alpha 1; integrin alpha-1; integrin, alpha 1; laminin and collagen receptor; VLA-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,379,181 - 48,545,336 (-)NCBIGRCr8
mRatBN7.2246,646,125 - 46,812,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,760,440 - 53,912,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,818,812 - 51,971,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,688,983 - 46,841,874 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0247,127,403 - 47,281,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,666,601 - 71,823,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4247,107,849 - 47,206,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,036,084 - 47,134,488 (-)NCBI
Celera242,407,780 - 42,559,904 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
aluminium oxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
Methylazoxymethanol acetate  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. alpha1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons. Anderson KL and Ferreira A, J Neurosci Res. 2004 Mar 1;75(5):688-97.
2. Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin. Bamdad M, etal., Cell Tissue Res. 2004 Jan;315(1):15-25. Epub 2003 Oct 16.
3. Integrin expression on normal and neoplastic human breast epithelium. Damjanovich L, etal., Acta Chir Hung. 1997;36(1-4):69-71.
4. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
5. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
6. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. Fujimura T, etal., J Dermatol Sci. 2007 Jan;45(1):45-53. Epub 2006 Nov 21.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Localization of integrin beta 1, alpha 1, alpha 5 and alpha 9 subunits in the rat testis. Giebel J, etal., Int J Androl. 1997 Feb;20(1):3-9.
9. Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Gindraux F, etal., Cell Tissue Res. 2007 Mar;327(3):471-83. Epub 2006 Nov 16.
10. Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen. Ignatius MJ, etal., J Cell Biol 1990 Aug;111(2):709-20.
11. Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells. Kitamura A, etal., Biochem Biophys Res Commun 2002 Dec 13;299(4):555-61.
12. Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries. Loufrani L, etal., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1906-13. Epub 2008 Feb 1.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Nawata J, etal., Cardiovasc Res 1999 Aug 1;43(2):371-81.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Olfa KZ, etal., Lab Invest. 2005 Dec;85(12):1507-16.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice. Schapira K, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1917-24. Epub 2005 Jun 23.
22. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
23. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
24. Calcium-sensing receptor modulates cell adhesion and migration via integrins. Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
Additional References at PubMed
PMID:9553049   PMID:10386626   PMID:10528208   PMID:11518510   PMID:11767049   PMID:15592458   PMID:16271045   PMID:16973387   PMID:17161391   PMID:19056867   PMID:19581412   PMID:19933311  
PMID:19946888   PMID:20563599   PMID:21423176   PMID:22847004   PMID:23023225   PMID:23658023   PMID:24823363   PMID:26520903   PMID:27108411   PMID:27484337  


Genomics

Comparative Map Data
Itga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,379,181 - 48,545,336 (-)NCBIGRCr8
mRatBN7.2246,646,125 - 46,812,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,760,440 - 53,912,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,818,812 - 51,971,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,688,983 - 46,841,874 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0247,127,403 - 47,281,387 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,666,601 - 71,823,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4247,107,849 - 47,206,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1247,036,084 - 47,134,488 (-)NCBI
Celera242,407,780 - 42,559,904 (-)NCBICelera
Cytogenetic Map2q14NCBI
ITGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,787,916 - 52,959,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,787,916 - 52,959,209 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,083,750 - 52,255,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,119,893 - 52,285,242 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,119,892 - 52,285,241NCBI
Celera549,037,686 - 49,203,085 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,055,982 - 49,221,542 (+)NCBIHuRef
CHM1_1552,086,786 - 52,252,111 (+)NCBICHM1_1
T2T-CHM13v2.0553,615,621 - 53,786,944 (+)NCBIT2T-CHM13v2.0
Itga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913115,094,615 - 115,238,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13115,089,632 - 115,238,500 (-)EnsemblGRCm39 Ensembl
GRCm3813114,958,079 - 115,101,964 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,953,096 - 115,101,964 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,748,287 - 115,892,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613116,080,957 - 116,222,842 (-)NCBIMGSCv36mm8
Celera13119,308,615 - 119,462,806 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
Itga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,446,300 - 14,577,605 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,439,571 - 14,582,236 (-)NCBIChiLan1.0ChiLan1.0
ITGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,984,567 - 61,160,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1559,135,090 - 59,312,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0561,073,507 - 61,247,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,692,673 - 62,865,771 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,692,673 - 62,865,769 (-)Ensemblpanpan1.1panPan2
ITGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,287,823 - 62,455,940 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,293,082 - 62,455,650 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha462,062,740 - 62,230,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,785,836 - 62,953,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,791,553 - 62,953,332 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,561,013 - 62,729,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,685,631 - 62,847,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,212,383 - 63,380,850 (-)NCBIUU_Cfam_GSD_1.0
Itga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,502,947 - 205,654,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,443,685 - 14,591,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,442,481 - 14,591,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,129,612 - 32,304,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,130,265 - 32,309,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21633,940,969 - 34,132,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,081,687 - 49,248,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,082,787 - 49,246,186 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,876,808 - 2,052,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,404,758 - 6,543,211 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247596,397,743 - 6,543,652 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga1
977 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000016353
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH130277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,797,854 - 46,798,034 (+)MAPPERmRatBN7.2
Rnor_6.0247,266,760 - 47,266,939NCBIRnor6.0
Rnor_5.0271,808,493 - 71,808,672UniSTSRnor5.0
RGSC_v3.4245,900,725 - 45,900,904UniSTSRGSC3.4
Celera242,545,598 - 42,545,777UniSTS
RH 3.4 Map2307.3UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map2q16-q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40 20 10 13 10 3 3 35 10 11 3
Low 3 3 37 31 6 31 5 8 74 31 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000086114   ⟹   ENSRNOP00000074337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,657,201 - 46,812,238 (-)Ensembl
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106157   ⟹   ENSRNOP00000086956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)Ensembl
RefSeq Acc Id: NM_030994   ⟹   NP_112256
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,386,244 - 48,545,283 (-)NCBI
mRatBN7.2246,653,188 - 46,812,237 (-)NCBI
Rnor_6.0247,127,403 - 47,281,387 (-)NCBI
Rnor_5.0271,666,601 - 71,823,120 (-)NCBI
RGSC_v3.4247,107,849 - 47,206,261 (-)RGD
Celera242,407,780 - 42,559,904 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101763   ⟹   XP_038957691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,379,181 - 48,545,336 (-)NCBI
mRatBN7.2246,646,125 - 46,811,914 (-)NCBI
RefSeq Acc Id: XR_010063584
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,413,961 - 48,545,324 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112256 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957691 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA36384 (Get FASTA)   NCBI Sequence Viewer  
  EDM10391 (Get FASTA)   NCBI Sequence Viewer  
  EDM10392 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074337.2
  ENSRNOP00000086956.1
  ENSRNOP00055008053
  ENSRNOP00065027567
GenBank Protein P18614 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112256   ⟸   NM_030994
- Peptide Label: precursor
- UniProtKB: P18614 (UniProtKB/Swiss-Prot),   A6I5T3 (UniProtKB/TrEMBL),   A0A8L2R8Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074337   ⟸   ENSRNOT00000086114
RefSeq Acc Id: XP_038957691   ⟸   XM_039101763
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R8Q8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086956   ⟸   ENSRNOT00000106157
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18614-F1-model_v2 AlphaFold P18614 1-1180 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691151
Promoter ID:EPDNEW_R1675
Type:multiple initiation site
Name:Itga1_2
Description:integrin subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1676  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,281,160 - 47,281,220EPDNEW
RGD ID:13691152
Promoter ID:EPDNEW_R1676
Type:multiple initiation site
Name:Itga1_1
Description:integrin subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1675  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,281,392 - 47,281,452EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2923 AgrOrtholog
BioCyc Gene G2FUF-54324 BioCyc
Ensembl Genes ENSRNOG00000053550 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006382 UniProtKB/Swiss-Prot
  ENSRNOG00065020378 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086114.2 UniProtKB/TrEMBL
  ENSRNOT00000106157.1 UniProtKB/Swiss-Prot
  ENSRNOT00055010377 UniProtKB/Swiss-Prot
  ENSRNOT00065034418 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25118 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25118 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itga1 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053550 RatGTEx
  ENSRNOG00055006382 RatGTEx
  ENSRNOG00065020378 RatGTEx
SMART Int_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R8Q8 ENTREZGENE, UniProtKB/TrEMBL
  A6I5T3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5T4_RAT UniProtKB/TrEMBL
  ITA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga1  integrin subunit alpha 1  Itga1  integrin, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itga1  integrin, alpha 1  Itga1  integrin alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Itga1  integrin alpha 1    integrin, alpha 1  Name updated 629478 APPROVED
2002-06-10 Itga1  integrin, alpha 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function associates with the beta-1 chain to form a dual laminin/collagen receptor 729264
gene_process has a role in cell attachment and neurite outgrowth on laminin and collagen as well as in peripheral nerve regeneration  
gene_process involved in mesangial cell (MC) migration 727474
gene_regulation activity stimulated by Endothelin-1 (ET) in mesangial cells 727474