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Gene: ITGA1 (integrin subunit alpha 1) Homo sapiens
Symbol: ITGA1
Name: integrin subunit alpha 1
Description: Exhibits collagen binding activity involved in cell-matrix adhesion and protein phosphatase binding activity. Involved in cell-matrix adhesion; negative regulation of cell population proliferation; and positive regulation of phosphoprotein phosphatase activity. Localizes to cell surface; focal adhesion; and integrin alpha1-beta1 complex. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD49 antigen-like family member A; CD49a; integrin alpha 1; integrin alpha-1; integrin, alpha 1; laminin and collagen receptor; very late activation protein 1; VLA-1; VLA1
Mus musculus (house mouse) : Itga1 (integrin alpha 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itga1 (integrin subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga1 (integrin subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA1 (integrin subunit alpha 1)
Canis lupus familiaris (dog) : ITGA1 (integrin subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga1 (integrin subunit alpha 1)
Sus scrofa (pig) : ITGA1 (integrin subunit alpha 1)
Chlorocebus sabaeus (African green monkey) : ITGA1 (integrin subunit alpha 1)
Heterocephalus glaber (naked mole-rat) : Itga1 (integrin subunit alpha 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl552,787,916 - 52,959,209 (+)EnsemblGRCh38hg38GRCh38
GRCh38552,787,916 - 52,959,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37552,084,136 - 52,249,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,119,893 - 52,285,242 (+)NCBINCBI36hg18NCBI36
Build 34552,119,892 - 52,285,241NCBI
Celera549,037,686 - 49,203,085 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef549,055,982 - 49,221,542 (+)NCBIHuRef
CHM1_1552,086,786 - 52,252,111 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITGA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69006
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.