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Gene: ITGA4 (integrin subunit alpha 4) Homo sapiens
Symbol: ITGA4
Name: integrin subunit alpha 4
Description: Exhibits cell adhesion molecule binding activity. Contributes to C-X3-C chemokine binding activity. Involved in several processes, including cell-cell adhesion in response to extracellular stimulus; cell-cell adhesion mediated by integrin; and cellular response to amyloid-beta. Localizes to the cell surface and integrin alpha4-beta7 complex. Implicated in autism spectrum disorder and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha 4; integrin alpha-4; integrin alpha-4 subunit; integrin alpha-IV; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); MGC90518; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Mus musculus (house mouse) : Itga4 (integrin alpha 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itga4 (integrin subunit alpha 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga4 (integrin subunit alpha 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA4 (integrin subunit alpha 4)
Canis lupus familiaris (dog) : ITGA4 (integrin subunit alpha 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga4 (integrin subunit alpha 4)
Sus scrofa (pig) : ITGA4 (integrin subunit alpha 4)
Chlorocebus sabaeus (African green monkey) : ITGA4 (integrin subunit alpha 4)
Heterocephalus glaber (naked mole-rat) : Itga4 (integrin subunit alpha 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2181,457,202 - 181,538,940 (+)Ensembl
GRCh382181,456,892 - 181,538,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372182,321,619 - 182,402,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,029,864 - 182,110,719 (+)NCBINCBI36hg18NCBI36
Build 342182,146,716 - 182,226,420NCBI
Celera2175,917,712 - 175,998,559 (+)NCBI
Cytogenetic Map2q31.3NCBI
HuRef2174,178,675 - 174,259,339 (+)NCBIHuRef
CHM1_12182,327,169 - 182,408,848 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITGA4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348031
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.