Itgav (integrin subunit alpha V) - Rat Genome Database

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Gene: Itgav (integrin subunit alpha V) Ictidomys tridecemlineatus
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Symbol: Itgav
Name: integrin subunit alpha V
RGD ID: 12600844
Description: ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); extracellular matrix binding (ortholog); extracellular matrix protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Cerebral Hemorrhage (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: integrin alpha-V
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBI
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (ISO)
blood vessel development  (ISO)
calcium ion transmembrane transport  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell migration  (ISO)
cell-matrix adhesion  (ISO)
cell-substrate adhesion  (ISO)
endodermal cell differentiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (ISO)
negative chemotaxis  (ISO)
negative regulation of entry of bacterium into host cell  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO)
regulation of phagocytosis  (ISO)
regulation of transforming growth factor beta activation  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
transforming growth factor beta production  (ISO)
vasculogenesis  (ISO)
viral entry into host cell  (ISO)

References

Genomics

Comparative Map Data
Itgav
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBI
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2186,590,056 - 186,680,901 (+)EnsemblGRCh38hg38GRCh38
GRCh382186,590,056 - 186,680,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372187,454,783 - 187,545,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
Itgav
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,551,625 - 83,637,261 (+)NCBIGRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBImm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
Itgav
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2368,838,524 - 68,926,653 (+)NCBI
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
Itgav
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,592,339 - 11,659,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,588,536 - 11,669,809 (-)NCBIChiLan1.0ChiLan1.0
ITGAV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B191,680,655 - 191,773,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B191,680,655 - 191,773,028 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B73,880,962 - 73,972,486 (+)NCBIMhudiblu_PPA_v0panPan3
ITGAV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBI
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBI
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBI
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBI
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBI
ITGAV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,604,676 - 91,711,840 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,604,666 - 91,711,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,654,958 - 101,717,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAV
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,125,710 - 72,216,757 (+)NCBI
ChlSab1.1 Ensembl1072,125,962 - 72,216,809 (+)Ensembl
Vero_WHO_p1.0NW_023666040127,289,910 - 127,381,992 (-)NCBI
Itgav
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248993,235,434 - 3,292,584 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005324396   ⟹   XP_005324453
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBI
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725779   ⟹   XP_021581454
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303145,999,374 - 146,084,389 (+)NCBI
SpeTri2.0NW_00493650610,750,116 - 10,838,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040294564   ⟹   XP_040150498
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303146,028,366 - 146,087,955 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005324453 (Get FASTA)   NCBI Sequence Viewer  
  XP_021581454 (Get FASTA)   NCBI Sequence Viewer  
  XP_040150498 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005324453   ⟸   XM_005324396
- Peptide Label: isoform X1
- UniProtKB: I3M227 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581454   ⟸   XM_021725779
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040150498   ⟸   XM_040294564
- Peptide Label: isoform X3
Protein Domains
Integrin_alpha2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003299 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000002972 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000021604 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003323 UniProtKB/TrEMBL
  ENSSTOT00000025198 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
NCBI Gene Itgav ENTREZGENE
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
UniProt I3M227 ENTREZGENE, UniProtKB/TrEMBL
  I3NB57_ICTTR UniProtKB/TrEMBL