Chrna1 (cholinergic receptor nicotinic alpha 1 subunit) - Rat Genome Database

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Gene: Chrna1 (cholinergic receptor nicotinic alpha 1 subunit) Rattus norvegicus
Analyze
Symbol: Chrna1
Name: cholinergic receptor nicotinic alpha 1 subunit
RGD ID: 69277
Description: Enables acetylcholine-gated cation-selective channel activity. Involved in cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH acetylcholine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acetylcholine receptor subunit alpha; cholinergic receptor nicotinic alpha polypeptide 1; cholinergic receptor nicotinic alpha polypeptide 1 (muscle); cholinergic receptor, nicotinic, alpha 1; cholinergic receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1; cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2358,454,763 - 58,469,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl358,454,744 - 58,469,840 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx361,848,304 - 61,863,363 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0370,431,954 - 70,447,013 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0368,196,984 - 68,212,044 (-)NCBIRnor_WKY
Rnor_6.0360,445,657 - 60,460,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl360,445,666 - 60,460,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0366,925,891 - 66,940,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4356,087,754 - 56,102,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1355,984,129 - 55,999,193 (-)NCBI
Celera357,981,902 - 57,996,970 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes. Alberola-Die A, etal., J Neurochem. 2011 Jun;117(6):1009-19. doi: 10.1111/j.1471-4159.2011.07271.x. Epub 2011 May 10.
2. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Suppression of ongoing experimental myasthenia by oral treatment with an acetylcholine receptor recombinant fragment. Im SH, etal., J Clin Invest 1999 Dec;104(12):1723-30.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats. Rasoulpour RJ, etal., Toxicol Sci. 2012 Jun;127(2):522-34. doi: 10.1093/toxsci/kfs118. Epub 2012 Mar 29.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Unwin N, J Mol Biol. 2005 Mar 4;346(4):967-89. doi: 10.1016/j.jmb.2004.12.031. Epub 2005 Jan 25.
14. Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle. Witzemann V, etal., Eur J Biochem 1990 Dec 12;194(2):437-48.
15. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
Additional References at PubMed
PMID:2383398   PMID:4781450   PMID:8872460   PMID:8910344   PMID:9221765   PMID:9546329   PMID:12388596   PMID:12928480   PMID:16203963   PMID:18252226   PMID:20053883   PMID:21187406  


Genomics

Comparative Map Data
Chrna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2358,454,763 - 58,469,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl358,454,744 - 58,469,840 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx361,848,304 - 61,863,363 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0370,431,954 - 70,447,013 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0368,196,984 - 68,212,044 (-)NCBIRnor_WKY
Rnor_6.0360,445,657 - 60,460,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl360,445,666 - 60,460,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0366,925,891 - 66,940,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4356,087,754 - 56,102,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1355,984,129 - 55,999,193 (-)NCBI
Celera357,981,902 - 57,996,970 (-)NCBICelera
Cytogenetic Map3q23NCBI
CHRNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382174,747,592 - 174,764,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2174,747,592 - 174,787,935 (-)EnsemblGRCh38hg38GRCh38
GRCh372175,612,320 - 175,629,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362175,320,566 - 175,337,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 342175,438,113 - 175,454,677NCBI
Celera2169,225,856 - 169,242,726 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2167,492,831 - 167,509,717 (-)NCBIHuRef
CHM1_12175,618,423 - 175,635,290 (-)NCBICHM1_1
T2T-CHM13v2.02175,236,308 - 175,253,177 (-)NCBIT2T-CHM13v2.0
Chrna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39273,393,625 - 73,410,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl273,393,559 - 73,410,682 (-)EnsemblGRCm39 Ensembl
GRCm38273,563,281 - 73,580,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl273,563,215 - 73,580,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37273,401,338 - 73,418,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36273,364,120 - 73,381,145 (-)NCBIMGSCv36mm8
Celera275,249,906 - 75,266,913 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map243.76NCBI
Chrna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955449661,304 - 683,873 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955449661,310 - 683,873 (+)NCBIChiLan1.0ChiLan1.0
CHRNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B179,476,147 - 179,509,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B179,476,677 - 179,504,763 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B62,022,498 - 62,039,370 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CHRNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13618,726,243 - 18,742,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3618,726,243 - 18,742,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3618,734,972 - 18,751,239 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03618,862,735 - 18,878,999 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3618,860,880 - 18,878,999 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13618,939,222 - 18,955,468 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03618,937,561 - 18,953,818 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03619,048,764 - 19,065,033 (-)NCBIUU_Cfam_GSD_1.0
Chrna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303135,898,803 - 135,941,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365094,452,616 - 4,470,658 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365094,452,382 - 4,470,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1580,673,067 - 80,692,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11580,673,072 - 80,692,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21589,888,938 - 89,906,230 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11060,279,837 - 60,298,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040139,305,978 - 139,322,913 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478711,934,433 - 11,950,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478711,933,927 - 11,950,017 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrna1
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:43
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000024706
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat

Markers in Region
CHRNA1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2358,459,838 - 58,460,577 (+)MAPPERmRatBN7.2
Rnor_6.0360,450,733 - 60,451,471NCBIRnor6.0
Rnor_5.0366,930,967 - 66,931,705UniSTSRnor5.0
RGSC_v3.4356,092,830 - 56,093,568UniSTSRGSC3.4
Celera357,986,977 - 57,987,715UniSTS
Cytogenetic Map3q23UniSTS
Chrna1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2358,459,835 - 58,460,565 (+)MAPPERmRatBN7.2
Rnor_6.0360,450,730 - 60,451,459NCBIRnor6.0
Rnor_5.0366,930,964 - 66,931,693UniSTSRnor5.0
Celera357,986,974 - 57,987,703UniSTS
Cytogenetic Map3q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 1
Low 3 19 42 26 19 26 7 10 66 21 40 11 7
Below cutoff 24 15 15 15 8 14 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024706   ⟹   ENSRNOP00000024706
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl358,454,744 - 58,469,840 (-)Ensembl
Rnor_6.0 Ensembl360,445,666 - 60,460,724 (-)Ensembl
RefSeq Acc Id: NM_024485   ⟹   NP_077811
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2358,454,763 - 58,469,832 (-)NCBI
Rnor_6.0360,445,657 - 60,460,724 (-)NCBI
Rnor_5.0366,925,891 - 66,940,958 (-)NCBI
RGSC_v3.4356,087,754 - 56,102,821 (-)RGD
Celera357,981,902 - 57,996,970 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077811 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA52826 (Get FASTA)   NCBI Sequence Viewer  
  EDL79151 (Get FASTA)   NCBI Sequence Viewer  
  EDL79152 (Get FASTA)   NCBI Sequence Viewer  
  P25108 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_077811   ⟸   NM_024485
- Peptide Label: precursor
- UniProtKB: P25108 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024706   ⟸   ENSRNOT00000024706

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25108-F1-model_v2 AlphaFold P25108 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69277 AgrOrtholog
BioCyc Gene G2FUF-49365 BioCyc
Ensembl Genes ENSRNOG00000018286 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000024706 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024706 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:79557 UniProtKB/Swiss-Prot
NCBI Gene 79557 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Chrna1 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
TIGRFAMs LIC UniProtKB/Swiss-Prot
UniProt ACHA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Chrna1  cholinergic receptor nicotinic alpha 1 subunit  Chrna1  cholinergic receptor, nicotinic, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Chrna1  cholinergic receptor, nicotinic, alpha 1  Chrna1  cholinergic receptor, nicotinic, alpha 1 (muscle)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Chrna1  cholinergic receptor, nicotinic, alpha 1 (muscle)  Chrna1  cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Chrna1  cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)    cholinergic receptor, nicotinic, alpha polypeptide 1  Name updated 1299863 APPROVED
2002-06-10 Chrna1  cholinergic receptor, nicotinic, alpha polypeptide 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference