Ptprj (protein tyrosine phosphatase, receptor type, J) - Rat Genome Database

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Gene: Ptprj (protein tyrosine phosphatase, receptor type, J) Rattus norvegicus
Analyze
Symbol: Ptprj
Name: protein tyrosine phosphatase, receptor type, J
RGD ID: 3454
Description: Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and gamma-catenin binding activity. Predicted to be involved in several processes, including hemopoiesis; regulation of cell migration; and regulation of signal transduction. Predicted to act upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Predicted to be located in several cellular components, including immunological synapse; nuclear lumen; and ruffle membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J); PARTICIPATES IN somatostatin signaling pathway; epidermal growth factor/neuregulin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: density enhanced phosphatase-1; DEP-1; protein tyrosine phosphatase receptor type J; receptor-type tyrosine-protein phosphatase eta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,861,785 - 97,017,702 (-)NCBIGRCr8
mRatBN7.2376,405,917 - 76,561,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,405,927 - 76,562,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx379,890,269 - 80,046,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,488,786 - 88,644,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,341,245 - 86,497,188 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,233,519 - 79,390,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,233,525 - 79,390,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0385,947,682 - 86,099,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4374,796,764 - 74,935,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1374,693,135 - 74,831,912 (-)NCBI
Celera375,621,921 - 75,777,388 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
diclofenac  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
hydralazine  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IBA)
B cell differentiation  (IEA,ISO)
blood coagulation  (IEA,ISO)
developmental process  (IEA)
glucose homeostasis  (IEA,ISO)
heart development  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of vascular permeability  (IEA,ISO)
oligodendrocyte differentiation  (IEA,ISO)
peptidyl-tyrosine dephosphorylation  (ISO)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity  (ISO)
platelet formation  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
positive chemotaxis  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of Fc receptor mediated stimulatory signaling pathway  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of platelet activation  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
regulation of cell adhesion  (IEA,ISO)
signal transduction  (IBA)
vasculogenesis  (IEA,ISO)

Cellular Component
cell junction  (IEA,ISO)
cell surface  (IEA,ISO)
cell-cell junction  (IEA,ISO)
immunological synapse  (IEA,ISO)
membrane  (IEA)
nuclear body  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)
ruffle membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
2. Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells. Borges LG, etal., Circ Res 1996 Sep;79(3):570-80.
3. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers. Mita Y, etal., J Cancer Res Clin Oncol. 2010 Feb;136(2):249-59. doi: 10.1007/s00432-009-0656-7. Epub 2009 Aug 12.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9531590   PMID:9780142   PMID:10821867   PMID:11259588   PMID:11526512   PMID:12062403   PMID:12370829   PMID:12475979   PMID:12588999   PMID:12771128   PMID:12833140   PMID:12913111  
PMID:14681019   PMID:14709717   PMID:15123617   PMID:15632090   PMID:15735685   PMID:15978577   PMID:16682945   PMID:18249142   PMID:18348712   PMID:18936167   PMID:19056867   PMID:19139271  
PMID:19246339   PMID:19268662   PMID:19332538   PMID:19494114   PMID:19836242   PMID:19922411   PMID:21091576   PMID:23376485   PMID:23533145   PMID:26063811   PMID:28926625  


Genomics

Comparative Map Data
Ptprj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,861,785 - 97,017,702 (-)NCBIGRCr8
mRatBN7.2376,405,917 - 76,561,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,405,927 - 76,562,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx379,890,269 - 80,046,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,488,786 - 88,644,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,341,245 - 86,497,188 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,233,519 - 79,390,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,233,525 - 79,390,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0385,947,682 - 86,099,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4374,796,764 - 74,935,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1374,693,135 - 74,831,912 (-)NCBI
Celera375,621,921 - 75,777,388 (-)NCBICelera
Cytogenetic Map3q24NCBI
PTPRJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,980,559 - 48,170,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,980,425 - 48,170,839 (+)EnsemblGRCh38hg38GRCh38
GRCh371148,002,111 - 48,192,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,958,686 - 48,148,970 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,958,688 - 48,146,246NCBI
Celera1148,154,504 - 48,344,533 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,683,384 - 47,903,543 (+)NCBIHuRef
CHM1_11148,001,881 - 48,191,974 (+)NCBICHM1_1
T2T-CHM13v2.01148,150,119 - 48,340,376 (+)NCBIT2T-CHM13v2.0
Ptprj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,260,100 - 90,411,102 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,260,098 - 90,410,991 (-)EnsemblGRCm39 Ensembl
GRCm38290,429,756 - 90,580,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl290,429,754 - 90,580,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,269,913 - 90,420,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,233,731 - 90,381,407 (-)NCBIMGSCv36mm8
Celera291,810,313 - 91,967,158 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.19NCBI
Ptprj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422399,357 - 443,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955422396,266 - 438,792 (-)NCBIChiLan1.0ChiLan1.0
PTPRJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2950,196,084 - 50,386,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,215,619 - 50,406,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,941,134 - 48,130,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,518,844 - 48,672,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,613,761 - 48,670,494 (+)Ensemblpanpan1.1panPan2
PTPRJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11841,586,262 - 41,635,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,426 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBIUU_Cfam_GSD_1.0
Ptprj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,050,113 - 19,123,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,165,304 - 1,211,817 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,161,764 - 1,234,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl214,548,428 - 14,724,474 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1214,548,489 - 14,724,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2215,632,255 - 16,007,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,137,896 - 17,328,836 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,135,907 - 17,328,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038114,433,977 - 114,653,560 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624767945,553 - 1,051,138 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624767942,786 - 1,051,112 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptprj
865 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:82
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000049832
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Rat226  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8396,993,191 - 96,993,340 (+)Marker Load Pipeline
mRatBN7.2376,537,328 - 76,537,477 (+)MAPPERmRatBN7.2
Rnor_6.0379,366,526 - 79,366,674NCBIRnor6.0
Rnor_5.0386,075,517 - 86,075,665UniSTSRnor5.0
RGSC_v3.4374,911,134 - 74,911,283RGDRGSC3.4
RGSC_v3.4374,911,135 - 74,911,283UniSTSRGSC3.4
RGSC_v3.1374,807,506 - 74,807,655RGD
Celera375,753,167 - 75,753,309UniSTS
SHRSP x BN Map342.7898UniSTS
SHRSP x BN Map342.7898RGD
FHH x ACI Map347.0699RGD
Cytogenetic Map3q32-q33UniSTS
D3Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8396,864,204 - 96,864,332 (+)Marker Load Pipeline
Rnor_6.0379,235,931 - 79,236,059NCBIRnor6.0
Celera375,624,332 - 75,624,449UniSTS
Cytogenetic Map3q32-q33UniSTS
BE101606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2376,485,291 - 76,485,508 (+)MAPPERmRatBN7.2
Rnor_6.0379,314,531 - 79,314,747NCBIRnor6.0
Rnor_5.0386,023,925 - 86,024,141UniSTSRnor5.0
RGSC_v3.4374,858,756 - 74,858,972UniSTSRGSC3.4
Celera375,701,228 - 75,701,444UniSTS
Cytogenetic Map3q32-q33UniSTS
AU046820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2376,534,159 - 76,534,319 (+)MAPPERmRatBN7.2
Rnor_6.0379,363,357 - 79,363,516NCBIRnor6.0
Rnor_5.0386,072,348 - 86,072,507UniSTSRnor5.0
RGSC_v3.4374,907,966 - 74,908,125UniSTSRGSC3.4
Celera375,749,996 - 75,750,157UniSTS
Cytogenetic Map3q32-q33UniSTS
RH135437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2376,553,449 - 76,553,664 (+)MAPPERmRatBN7.2
Rnor_6.0379,382,642 - 79,382,856NCBIRnor6.0
Rnor_5.0386,091,633 - 86,091,847UniSTSRnor5.0
RGSC_v3.4374,927,254 - 74,927,468UniSTSRGSC3.4
Celera375,769,257 - 75,769,471UniSTS
Cytogenetic Map3q32-q33UniSTS
AI407676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2376,531,519 - 76,531,738 (+)MAPPERmRatBN7.2
Rnor_6.0379,360,717 - 79,360,935NCBIRnor6.0
Rnor_5.0386,069,708 - 86,069,926UniSTSRnor5.0
RGSC_v3.4374,905,326 - 74,905,544UniSTSRGSC3.4
Celera375,747,363 - 75,747,581UniSTS
Cytogenetic Map3q32-q33UniSTS
PMC151692P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2376,413,280 - 76,413,384 (+)MAPPERmRatBN7.2
Rnor_6.0379,240,881 - 79,240,984NCBIRnor6.0
Rnor_5.0385,955,048 - 85,955,151UniSTSRnor5.0
Celera375,629,266 - 75,629,369UniSTS
Cytogenetic Map3q32-q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000049832   ⟹   ENSRNOP00000044688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,405,927 - 76,561,609 (-)Ensembl
Rnor_6.0 Ensembl379,237,106 - 79,282,493 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077943   ⟹   ENSRNOP00000070464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,405,927 - 76,561,669 (-)Ensembl
Rnor_6.0 Ensembl379,233,525 - 79,390,956 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105713   ⟹   ENSRNOP00000093369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl376,405,927 - 76,562,260 (-)Ensembl
RefSeq Acc Id: NM_001399120   ⟹   NP_001386049
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,861,785 - 97,017,656 (-)NCBI
mRatBN7.2376,405,917 - 76,561,797 (-)NCBI
RefSeq Acc Id: NM_017269   ⟹   NP_058965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,861,795 - 97,017,656 (-)NCBI
mRatBN7.2376,405,927 - 76,561,797 (-)NCBI
Rnor_6.0379,233,519 - 79,390,956 (-)NCBI
Rnor_5.0385,947,682 - 86,099,287 (-)NCBI
RGSC_v3.4374,796,764 - 74,935,540 (-)RGD
Celera375,621,921 - 75,777,388 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104656   ⟹   XP_038960584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,861,785 - 97,017,699 (-)NCBI
mRatBN7.2376,405,917 - 76,561,841 (-)NCBI
RefSeq Acc Id: XR_010064594
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,884,290 - 97,017,702 (-)NCBI
RefSeq Acc Id: XR_010064595
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,884,290 - 97,017,701 (-)NCBI
RefSeq Acc Id: XR_010064596
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,884,290 - 97,017,701 (-)NCBI
RefSeq Acc Id: XR_010064597
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8396,884,290 - 97,017,701 (-)NCBI
RefSeq Acc Id: NP_058965   ⟸   NM_017269
- Peptide Label: isoform 1 precursor
- UniProtKB: Q62884 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070464   ⟸   ENSRNOT00000077943
Ensembl Acc Id: ENSRNOP00000044688   ⟸   ENSRNOT00000049832
RefSeq Acc Id: XP_038960584   ⟸   XM_039104656
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GK94 (UniProtKB/TrEMBL),   A0A0G2JXZ9 (UniProtKB/TrEMBL),   A6HN64 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093369   ⟸   ENSRNOT00000105713
RefSeq Acc Id: NP_001386049   ⟸   NM_001399120
- Peptide Label: isoform 2 precursor
- UniProtKB: Q62884 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXZ9-F1-model_v2 AlphaFold A0A0G2JXZ9 1-1288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3454 AgrOrtholog
BioCyc Gene G2FUF-48775 BioCyc
Ensembl Genes ENSRNOG00000034025 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049832 ENTREZGENE
  ENSRNOT00000049832.6 UniProtKB/TrEMBL
  ENSRNOT00000077943 ENTREZGENE
  ENSRNOT00000077943.2 UniProtKB/TrEMBL
  ENSRNOT00000105713.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/TrEMBL
  RTP_Phos/Ushers UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
NCBI Gene 29645 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  CYTOKINE RECEPTOR UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  PTP_tm UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptprj PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034025 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2JXZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK94 ENTREZGENE, UniProtKB/TrEMBL
  A6HN64 ENTREZGENE, UniProtKB/TrEMBL
  E9PTB7_RAT UniProtKB/TrEMBL
  Q62884 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ptprj  Protein tyrosine phosphatase, receptor type, J      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a transmembrane domain, phosphatase catalytic domain, and eight fibronectin type III repeats 633836
gene_expression expression is decreased 3.5 fold in SHR compared with WKY rats 1357414