Grb14 (growth factor receptor bound protein 14) - Rat Genome Database

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Gene: Grb14 (growth factor receptor bound protein 14) Rattus norvegicus
Analyze
Symbol: Grb14
Name: growth factor receptor bound protein 14
RGD ID: 61869
Description: Enables phosphoprotein binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Located in endosome. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GRB14 (growth factor receptor bound protein 14); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GRB14 adapter protein; growth factor receptor-bound protein 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,976,331 - 70,091,921 (-)NCBIGRCr8
mRatBN7.2349,568,210 - 49,683,805 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl349,568,210 - 49,683,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx352,905,764 - 53,021,646 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0361,489,289 - 61,605,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0359,273,965 - 59,396,250 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0350,937,403 - 51,054,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl350,937,669 - 51,054,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0357,679,758 - 57,695,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0357,578,226 - 57,619,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4346,832,380 - 46,952,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1346,728,757 - 46,849,042 (-)NCBI
Celera349,175,830 - 49,290,450 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
hydroxyurea  (ISO)
imipramine  (EXP)
indometacin  (ISO)
inulin  (ISO)
ketoconazole  (EXP)
methapyrilene  (EXP)
Monobutylphthalate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Grb14 inhibits FGF receptor signaling through the regulation of PLCgamma recruitment and activation. Browaeys-Poly E, etal., FEBS Lett. 2010 Nov 5;584(21):4383-8. doi: 10.1016/j.febslet.2010.09.048. Epub 2010 Oct 8.
2. Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver. Desbuquois B, etal., FEBS J. 2008 Sep;275(17):4363-77. Epub 2008 Jul 24.
3. Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Eze IC, etal., Environ Int. 2016 Sep;94:263-271. doi: 10.1016/j.envint.2016.04.032. Epub 2016 Jun 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of the rat adapter Grb14 as an inhibitor of insulin actions. Kasus-Jacobi A, etal., J Biol Chem 1998 Oct 2;273(40):26026-35.
7. Endosomal proteolysis of internalised -human insulin at neutral pH generates the mature insulin peptide in rat liver in vivo. Kouach M, etal., Diabetologia. 2009 Dec;52(12):2621-32. Epub 2009 Oct 16.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. SAXS study of the PIR domain from the Grb14 molecular adaptor: a natively unfolded protein with a transient structure primer? Moncoq K, etal., Biophys J. 2004 Dec;87(6):4056-64. doi: 10.1529/biophysj.104.048645. Epub 2004 Oct 1.
10. The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling. Moncoq K, etal., FEBS Lett. 2003 Nov 20;554(3):240-6.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. Yang HC, etal., PLoS One. 2012;7(3):e32907. doi: 10.1371/journal.pone.0032907. Epub 2012 Mar 29.
18. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
Additional References at PubMed
PMID:10713090   PMID:11278563   PMID:16246733   PMID:20890309   PMID:24350791   PMID:25578860   PMID:25687571  


Genomics

Comparative Map Data
Grb14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,976,331 - 70,091,921 (-)NCBIGRCr8
mRatBN7.2349,568,210 - 49,683,805 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl349,568,210 - 49,683,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx352,905,764 - 53,021,646 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0361,489,289 - 61,605,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0359,273,965 - 59,396,250 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0350,937,403 - 51,054,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl350,937,669 - 51,054,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0357,679,758 - 57,695,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0357,578,226 - 57,619,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4346,832,380 - 46,952,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1346,728,757 - 46,849,042 (-)NCBI
Celera349,175,830 - 49,290,450 (-)NCBICelera
Cytogenetic Map3q21NCBI
GRB14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382164,492,417 - 164,621,482 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2164,492,417 - 164,621,482 (-)EnsemblGRCh38hg38GRCh38
GRCh372165,348,927 - 165,477,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362165,057,569 - 165,186,606 (-)NCBINCBI36Build 36hg18NCBI36
Build 342165,174,839 - 165,303,865NCBI
Celera2158,959,227 - 159,088,293 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2157,231,772 - 157,360,824 (-)NCBIHuRef
CHM1_12165,355,217 - 165,484,258 (-)NCBICHM1_1
T2T-CHM13v2.02164,949,755 - 165,079,884 (-)NCBIT2T-CHM13v2.0
Grb14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39264,742,820 - 64,853,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl264,742,820 - 64,855,331 (-)EnsemblGRCm39 Ensembl
GRCm38264,912,476 - 65,022,766 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl264,912,476 - 65,024,987 (-)EnsemblGRCm38mm10GRCm38
MGSCv37264,750,535 - 64,860,823 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36264,713,317 - 64,823,605 (-)NCBIMGSCv36mm8
Celera266,583,155 - 66,693,422 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map238.35NCBI
Grb14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554499,466,706 - 9,591,598 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554499,466,764 - 9,589,559 (+)NCBIChiLan1.0ChiLan1.0
GRB14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21367,158,657 - 67,287,266 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B67,173,633 - 67,302,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B51,773,844 - 51,902,420 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B169,135,019 - 169,262,834 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B169,135,231 - 169,263,874 (-)Ensemblpanpan1.1panPan2
GRB14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,711,885 - 9,843,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,712,142 - 9,721,769 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha369,856,214 - 9,987,580 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0369,844,049 - 9,975,461 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl369,844,059 - 9,975,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,855,062 - 9,986,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,897,060 - 10,011,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03610,011,150 - 10,142,536 (-)NCBIUU_Cfam_GSD_1.0
Grb14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303126,875,121 - 126,989,222 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646914,628,546 - 14,743,916 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646914,628,478 - 14,742,327 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1571,119,926 - 71,247,383 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11571,119,928 - 71,247,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21579,273,968 - 79,340,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11049,952,835 - 50,085,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1049,953,059 - 50,084,869 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040149,415,172 - 149,544,225 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grb14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624732811,484 - 950,343 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624732811,486 - 949,972 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grb14
906 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:91
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000052395
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8369,976,466 - 69,976,574 (+)Marker Load Pipeline
mRatBN7.2349,568,345 - 49,568,455 (+)MAPPERmRatBN7.2
Rnor_6.0350,937,537 - 50,937,644NCBIRnor6.0
Rnor_5.0357,578,360 - 57,578,467UniSTSRnor5.0
RGSC_v3.4346,832,514 - 46,832,621UniSTSRGSC3.4
Celera349,175,964 - 49,176,071UniSTS
Cytogenetic Map3q21UniSTS
AI505286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2349,568,477 - 49,568,589 (+)MAPPERmRatBN7.2
Rnor_6.0350,937,667 - 50,937,778NCBIRnor6.0
Rnor_5.0357,578,490 - 57,578,601UniSTSRnor5.0
RGSC_v3.4346,832,644 - 46,832,755UniSTSRGSC3.4
Celera349,176,094 - 49,176,205UniSTS
Cytogenetic Map3q21UniSTS
RH137906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2349,684,771 - 49,684,957 (+)MAPPERmRatBN7.2
Rnor_6.0351,066,278 - 51,066,463NCBIRnor6.0
Rnor_5.0357,706,527 - 57,706,712UniSTSRnor5.0
RGSC_v3.4346,953,780 - 46,953,965UniSTSRGSC3.4
Celera349,291,278 - 49,291,463UniSTS
RH 3.4 Map3625.3UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000089243   ⟹   ENSRNOP00000072564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl349,568,213 - 49,683,889 (-)Ensembl
Rnor_6.0 Ensembl350,937,669 - 51,054,378 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097641   ⟹   ENSRNOP00000082236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl349,588,872 - 49,638,518 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100574   ⟹   ENSRNOP00000083261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl349,568,210 - 49,683,878 (-)Ensembl
RefSeq Acc Id: NM_031623   ⟹   NP_113811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,976,333 - 70,091,921 (-)NCBI
mRatBN7.2349,568,212 - 49,683,805 (-)NCBI
Rnor_6.0350,937,403 - 51,054,447 (-)NCBI
Rnor_5.0357,578,226 - 57,619,404 (-)NCBI
Rnor_5.0357,679,758 - 57,695,025 (-)NCBI
RGSC_v3.4346,832,380 - 46,952,670 (-)RGD
Celera349,175,830 - 49,290,450 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105748   ⟹   XP_038961676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,976,331 - 70,046,595 (-)NCBI
mRatBN7.2349,568,210 - 49,638,478 (-)NCBI
RefSeq Acc Id: XM_039105749   ⟹   XP_038961677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,976,331 - 70,032,080 (-)NCBI
mRatBN7.2349,568,210 - 49,623,965 (-)NCBI
Protein Sequences
Protein RefSeqs NP_113811 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961676 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961677 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC61478 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072564.2
  ENSRNOP00000082236.1
  ENSRNOP00000083261.1
GenBank Protein O88900 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113811   ⟸   NM_031623
- UniProtKB: O88900 (UniProtKB/Swiss-Prot),   A0A0G2K3B0 (UniProtKB/TrEMBL),   A6HLW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072564   ⟸   ENSRNOT00000089243
RefSeq Acc Id: XP_038961676   ⟸   XM_039105748
- Peptide Label: isoform X1
- UniProtKB: O88900 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038961677   ⟸   XM_039105749
- Peptide Label: isoform X2
- UniProtKB: O88900 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000083261   ⟸   ENSRNOT00000100574
Ensembl Acc Id: ENSRNOP00000082236   ⟸   ENSRNOT00000097641
Protein Domains
PH   Ras-associating   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88900-F1-model_v2 AlphaFold O88900 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61869 AgrOrtholog
BioCyc Gene G2FUF-49568 BioCyc
Ensembl Genes ENSRNOG00000052498 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089243.2 UniProtKB/TrEMBL
  ENSRNOT00000097641.1 UniProtKB/TrEMBL
  ENSRNOT00000100574.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BPS-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRB/APBB1IP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Grb14_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_APBB1IP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58844 UniProtKB/Swiss-Prot
NCBI Gene 58844 ENTREZGENE
PANTHER PTHR11243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11243:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grb14 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052498 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209084
UniProt A0A0G2K3B0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVQ2_RAT UniProtKB/TrEMBL
  A0A8I5ZWE7_RAT UniProtKB/TrEMBL
  A6HLW6 ENTREZGENE, UniProtKB/TrEMBL
  GRB14_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Grb14  growth factor receptor bound protein 14       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression decreases insulin stimulation of both DNA and glycogen synthesis 61620
gene_physical_interaction binds to phosphorylated activation loop of insulin receptor 61620