G6pc2 (glucose-6-phosphatase catalytic subunit 2) - Rat Genome Database

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Gene: G6pc2 (glucose-6-phosphatase catalytic subunit 2) Rattus norvegicus
Analyze
Symbol: G6pc2
Name: glucose-6-phosphatase catalytic subunit 2
RGD ID: 69398
Description: Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in glucose homeostasis and regulation of insulin secretion. Predicted to be located in endoplasmic reticulum. Orthologous to human G6PC2 (glucose-6-phosphatase catalytic subunit 2); INTERACTS WITH 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G6pc-rs; glucose-6-phosphatase 2; glucose-6-phosphatase catalytic related sequence; glucose-6-phosphatase, catalytic, 2; glucose-6-phosphatase, catalytic, related sequence; Igrp; islet-specific glucose-6-phosphatase catalytic subunit-related protein; LOC681817; similar to glucose-6-phosphatase, catalytic, related
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,404,976 - 74,413,391 (+)NCBIGRCr8
mRatBN7.2353,999,821 - 54,005,539 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0355,464,528 - 55,467,170 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,071,522 - 62,078,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,563,645 - 53,566,287 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. Martin CC, etal., J Biol Chem 2001 Jul 6;276(27):25197-207.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10787428   PMID:14722102   PMID:16223860   PMID:20668700   PMID:21873635  


Genomics

Comparative Map Data
G6pc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,404,976 - 74,413,391 (+)NCBIGRCr8
mRatBN7.2353,999,821 - 54,005,539 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0355,464,528 - 55,467,170 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,071,522 - 62,078,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,563,645 - 53,566,287 (+)NCBICelera
Cytogenetic Map3q21NCBI
G6PC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,901,291 - 168,910,000 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,901,291 - 168,910,000 (+)EnsemblGRCh38hg38GRCh38
GRCh372169,757,801 - 169,766,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,465,996 - 169,474,756 (+)NCBINCBI36Build 36hg18NCBI36
Build 342169,583,348 - 169,590,096NCBI
Celera2163,383,072 - 163,391,831 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,653,943 - 161,663,046 (+)NCBIHuRef
CHM1_12169,763,602 - 169,772,361 (+)NCBICHM1_1
T2T-CHM13v2.02169,375,781 - 169,384,490 (+)NCBIT2T-CHM13v2.0
G6pc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,041,417 - 69,058,337 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,041,417 - 69,058,185 (+)EnsemblGRCm39 Ensembl
GRCm38269,211,073 - 69,227,993 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,211,073 - 69,227,841 (+)EnsemblGRCm38mm10GRCm38
MGSCv37269,058,055 - 69,066,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,020,810 - 69,028,689 (+)NCBIMGSCv36mm8
Celera270,886,206 - 70,894,208 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.66NCBI
G6pc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,519,054 - 5,525,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,519,541 - 5,525,310 (-)NCBIChiLan1.0ChiLan1.0
G6PC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,562,022 - 71,570,742 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,576,995 - 71,585,315 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,178,623 - 56,187,394 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,643,660 - 173,652,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,643,660 - 173,652,424 (+)Ensemblpanpan1.1panPan2
G6PC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,723,410 - 13,731,086 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,723,358 - 13,731,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,734,418 - 13,742,067 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,839,763 - 13,847,410 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,839,759 - 13,847,446 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,924,505 - 13,932,153 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,912,317 - 13,919,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,025,318 - 14,032,964 (+)NCBIUU_Cfam_GSD_1.0
G6pc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,999,178 - 131,005,326 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,612,394 - 10,618,542 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,612,394 - 10,618,542 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,382,313 - 75,390,150 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,382,442 - 75,388,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,486,126 - 84,492,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
G6PC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,433,329 - 54,442,623 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040145,091,870 - 145,098,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
G6pc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,635,385 - 6,641,937 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,635,361 - 6,643,107 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in G6pc2
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000073549
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat


Expression


Sequence


RefSeq Acc Id: XM_017592318   ⟹   XP_017447807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,404,976 - 74,413,391 (+)NCBI
mRatBN7.2353,999,821 - 54,005,539 (+)NCBI
Rnor_6.0355,464,528 - 55,467,170 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017447807 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_017447807   ⟸   XM_017592318
- Sequence:


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69398 AgrOrtholog
BioCyc Gene G2FUF-49513 BioCyc
NCBI Gene G6pc2 ENTREZGENE
PhenoGen G6pc2 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 G6pc2  glucose-6-phosphatase catalytic subunit 2  G6pc2  glucose-6-phosphatase, catalytic, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-03 G6pc2  glucose-6-phosphatase, catalytic, 2  LOC681817  similar to glucose-6-phosphatase, catalytic, related  Data merged from RGD:1590543 737654 APPROVED
2006-11-20 LOC681817  similar to glucose-6-phosphatase, catalytic, related      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 G6pc2  glucose-6-phosphatase, catalytic, 2    glucose-6-phosphatase, catalytic, related sequence  Name updated 1299863 APPROVED
2004-09-10 G6pc2  glucose-6-phosphatase, catalytic, related sequence  G6pc-rs    Symbol and Name updated 1299863 APPROVED
2003-04-09 G6pc-rs  glucose-6-phosphatase, catalytic, related sequence    glucose-6-phosphatase, catalytic, related sequence   Symbol and Name updated 629477 APPROVED
2003-03-19 G6pc-rs  glucose-6-phosphatase, catalytic, related sequence   Igrp  islet-specific glucose-6-phosphatase catalytic subunit-related protein  Data merged from RGD:69652 628472 PROVISIONAL
2002-06-10 G6pc-rs  glucose-6-phosphatase, catalytic, related sequence       Name updated 70584 APPROVED
2002-06-10 Igrp  islet-specific glucose-6-phosphatase catalytic subunit-related protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is restricted to islets 68671
gene_function homolog of G6Pase catalytic subunit, which catalyzes the terminal step of the gluconeogenic pathway 68671
gene_process may be involved in the regulation of islet metabolism 68671