Kcnh7 (potassium voltage-gated channel subfamily H member 7) - Rat Genome Database

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Gene: Kcnh7 (potassium voltage-gated channel subfamily H member 7) Rattus norvegicus
Analyze
Symbol: Kcnh7
Name: potassium voltage-gated channel subfamily H member 7
RGD ID: 621112
Description: Enables inward rectifier potassium channel activity. Involved in circadian rhythm and potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH7 (potassium voltage-gated channel subfamily H member 7); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eag-related protein 3; ERG-3; erg3; ether-a-go-go-related gene potassium channel 3; ether-a-go-go-related protein 3; potassium channel erg3; potassium channel, voltage gated eag related subfamily H, member 7; potassium voltage-gated channel, subfamily H (eag-related), member 7; voltage-gated potassium channel subunit Kv11.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnh7Tn(sb-T2/Bart3)2.295Mcwi  
Genetic Models: F344-Kcnh7Tn(sb-T2/Bart3)2.295Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,737,900 - 68,230,950 (-)NCBIGRCr8
mRatBN7.2347,329,338 - 47,822,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,338,501 - 47,822,195 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,693,240 - 51,172,491 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,276,771 - 59,756,022 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0357,049,903 - 57,529,711 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,662,450 - 49,168,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,671,079 - 48,831,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,325,680 - 55,822,973 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,657,361 - 45,153,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,553,732 - 45,049,881 (-)NCBI
Celera346,979,379 - 47,455,872 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, etal., J Physiol. 2005 Apr 1;564(Pt 1):33-49. Epub 2005 Jan 27.
3. Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family. Long RM, etal., Biochem Biophys Res Commun 1988 Oct 31;156(2):866-73.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Muhlbauer E, etal., Cell Mol Life Sci. 2007 Mar;64(6):768-80.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, etal., J Neurosci 1997 Dec 15;17(24):9423-32.
12. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, etal., Pflugers Arch. 2001 Jan;441(4):450-5.
Additional References at PubMed
PMID:10718922   PMID:18162604   PMID:22871113  


Genomics

Comparative Map Data
Kcnh7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,737,900 - 68,230,950 (-)NCBIGRCr8
mRatBN7.2347,329,338 - 47,822,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,338,501 - 47,822,195 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,693,240 - 51,172,491 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,276,771 - 59,756,022 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0357,049,903 - 57,529,711 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,662,450 - 49,168,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,671,079 - 48,831,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,325,680 - 55,822,973 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,657,361 - 45,153,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,553,732 - 45,049,881 (-)NCBI
Celera346,979,379 - 47,455,872 (-)NCBICelera
Cytogenetic Map3q21NCBI
KCNH7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,371,407 - 162,838,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2162,371,407 - 162,838,767 (-)EnsemblGRCh38hg38GRCh38
GRCh372163,227,917 - 163,695,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,936,163 - 163,403,486 (-)NCBINCBI36Build 36hg18NCBI36
Build 342163,105,265 - 163,520,747NCBI
Celera2156,838,249 - 157,305,494 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2155,110,219 - 155,577,951 (-)NCBIHuRef
CHM1_12163,233,802 - 163,700,825 (-)NCBICHM1_1
T2T-CHM13v2.02162,828,067 - 163,295,631 (-)NCBIT2T-CHM13v2.0
Kcnh7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,524,428 - 63,014,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,523,758 - 63,014,631 (-)EnsemblGRCm39 Ensembl
GRCm38262,693,410 - 63,184,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,693,414 - 63,184,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,541,003 - 63,022,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,503,787 - 62,990,422 (-)NCBIMGSCv36mm8
Celera264,395,436 - 64,884,597 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map236.5NCBI
Kcnh7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,052,777 - 11,491,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,052,767 - 11,495,193 (+)NCBIChiLan1.0ChiLan1.0
KCNH7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21365,057,056 - 65,538,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B65,072,031 - 65,553,616 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,657,021 - 50,140,216 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B167,033,119 - 167,507,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B167,033,119 - 167,506,691 (-)Ensemblpanpan1.1panPan2
KCNH7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,781,323 - 8,260,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,649,727 - 8,261,048 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,924,497 - 8,405,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,912,971 - 8,393,200 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,921,442 - 8,393,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,931,129 - 8,410,170 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,972,137 - 8,444,518 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0368,079,838 - 8,559,344 (-)NCBIUU_Cfam_GSD_1.0
Kcnh7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,933,273 - 125,395,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,222,005 - 16,691,596 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,221,750 - 16,674,526 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1569,059,870 - 69,555,049 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11569,053,456 - 69,555,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,700,311 - 77,198,048 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,786,795 - 48,248,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,785,318 - 47,950,144 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040151,280,149 - 151,747,051 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247322,684,948 - 3,148,951 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247322,684,719 - 3,150,749 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnh7
4046 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:115
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000009920
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Got33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,769,862 - 47,770,067 (+)MAPPERmRatBN7.2
Rnor_6.0349,115,270 - 49,115,474NCBIRnor6.0
Rnor_5.0355,769,295 - 55,769,499UniSTSRnor5.0
RGSC_v3.4345,100,293 - 45,100,498RGDRGSC3.4
RGSC_v3.4345,100,294 - 45,100,498UniSTSRGSC3.4
RGSC_v3.1344,996,666 - 44,996,870RGD
Celera347,403,621 - 47,403,821UniSTS
RH 3.4 Map3603.83UniSTS
RH 3.4 Map3603.83RGD
RH 2.0 Map3380.1RGD
Cytogenetic Map3q21UniSTS
D3Got307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,364,366 - 47,364,545 (+)MAPPERmRatBN7.2
Rnor_6.0348,697,897 - 48,698,075NCBIRnor6.0
Rnor_5.0355,361,074 - 55,361,252UniSTSRnor5.0
Celera347,005,192 - 47,005,368UniSTS
Cytogenetic Map3q21UniSTS
AU047731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,657,829 - 47,658,067 (+)MAPPERmRatBN7.2
Rnor_6.0349,003,513 - 49,003,750NCBIRnor6.0
Rnor_5.0355,657,751 - 55,657,988UniSTSRnor5.0
RGSC_v3.4344,978,788 - 44,979,025UniSTSRGSC3.4
Celera347,297,713 - 47,297,934UniSTS
Cytogenetic Map3q21UniSTS


Genetic Models
This gene Kcnh7 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20
Low 10 48 2 1
Below cutoff 8 12 6 6 6 3 3 6 14 24 6 3

Sequence


RefSeq Acc Id: ENSRNOT00000009920   ⟹   ENSRNOP00000009920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,338,501 - 47,497,311 (-)Ensembl
Rnor_6.0 Ensembl348,671,241 - 48,831,417 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085246   ⟹   ENSRNOP00000072574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,338,501 - 47,497,311 (-)Ensembl
Rnor_6.0 Ensembl348,671,079 - 48,831,467 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095298   ⟹   ENSRNOP00000078806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,338,501 - 47,497,866 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112058   ⟹   ENSRNOP00000078922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,338,501 - 47,822,195 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119314   ⟹   ENSRNOP00000078968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,425,115 - 47,822,195 (-)Ensembl
RefSeq Acc Id: NM_131912   ⟹   NP_571987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8367,747,063 - 68,230,671 (-)NCBI
mRatBN7.2347,338,501 - 47,822,122 (-)NCBI
Rnor_6.0348,671,241 - 49,168,639 (-)NCBI
Rnor_5.0355,325,680 - 55,822,973 (-)NCBI
RGSC_v3.4344,657,361 - 45,153,509 (-)RGD
Celera346,979,379 - 47,455,872 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234269   ⟹   XP_006234331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8367,737,900 - 68,230,950 (-)NCBI
mRatBN7.2347,329,338 - 47,821,992 (-)NCBI
Rnor_6.0348,662,450 - 49,168,716 (-)NCBI
Rnor_5.0355,325,680 - 55,822,973 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591438   ⟹   XP_017446927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8367,737,900 - 68,230,950 (-)NCBI
mRatBN7.2347,329,338 - 47,821,992 (-)NCBI
Rnor_6.0348,662,450 - 49,168,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283031   ⟹   XP_063139101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8367,737,900 - 68,230,950 (-)NCBI
RefSeq Acc Id: XM_063283033   ⟹   XP_063139103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8367,737,900 - 68,230,950 (-)NCBI
RefSeq Acc Id: NP_571987   ⟸   NM_131912
- UniProtKB: O54852 (UniProtKB/Swiss-Prot),   A6HLW2 (UniProtKB/TrEMBL),   A0A8I5ZLI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234331   ⟸   XM_006234269
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446927   ⟸   XM_017591438
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072574   ⟸   ENSRNOT00000085246
RefSeq Acc Id: ENSRNOP00000009920   ⟸   ENSRNOT00000009920
RefSeq Acc Id: ENSRNOP00000078922   ⟸   ENSRNOT00000112058
RefSeq Acc Id: ENSRNOP00000078806   ⟸   ENSRNOT00000095298
RefSeq Acc Id: ENSRNOP00000078968   ⟸   ENSRNOT00000119314
RefSeq Acc Id: XP_063139103   ⟸   XM_063283033
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139101   ⟸   XM_063283031
- Peptide Label: isoform X3
Protein Domains
Cyclic nucleotide-binding   Ion transport   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54852-F1-model_v2 AlphaFold O54852 1-1195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621112 AgrOrtholog
BioCyc Gene G2FUF-49582 BioCyc
Ensembl Genes ENSRNOG00000007528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000680 UniProtKB/Swiss-Prot
  ENSRNOG00060009915 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009920.5 UniProtKB/TrEMBL
  ENSRNOT00000085246.2 UniProtKB/TrEMBL
  ENSRNOT00000095298.1 UniProtKB/TrEMBL
  ENSRNOT00000112058 ENTREZGENE
  ENSRNOT00000112058.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119314.1 UniProtKB/TrEMBL
  ENSRNOT00055001187 UniProtKB/Swiss-Prot
  ENSRNOT00060016841 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170739 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 170739 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnh7 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERGCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007528 RatGTEx
  ENSRNOG00055000680 RatGTEx
  ENSRNOG00060009915 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3B8_RAT UniProtKB/TrEMBL
  A0A0H2UHF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLU2_RAT UniProtKB/TrEMBL
  A6HLW2 ENTREZGENE, UniProtKB/TrEMBL
  A6HLW3_RAT UniProtKB/TrEMBL
  KCNH7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Kcnh7  potassium voltage-gated channel, subfamily H (eag-related), member 7  erg3  potassium channel erg3  Symbol and Name updated 1299863 APPROVED
2002-08-07 erg3  potassium channel erg3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the fundus and antrum of the stomach 625508
gene_expression enriched in the nervous system 632748
gene_product 374 bp 625508
gene_product member of the erg potassium channel gene family 632748