Atf2 (activating transcription factor 2) - Rat Genome Database

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Gene: Atf2 (activating transcription factor 2) Rattus norvegicus
Analyze
Symbol: Atf2
Name: activating transcription factor 2
RGD ID: 621862
Description: Enables cAMP response element binding activity. Involved in several processes, including amelogenesis; positive regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Part of CCAAT-binding activity factor complex. Used to study hypertension and transient cerebral ischemia. Biomarker of glaucoma and transient cerebral ischemia. Orthologous to human ATF2 (activating transcription factor 2); PARTICIPATES IN adenosine signaling pathway; interleukin-12 signaling pathway; influenza A pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2; cyclic AMP-dependent transcription factor ATF-2; RATF2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8379,125,814 - 79,202,896 (-)NCBIGRCr8
mRatBN7.2358,718,323 - 58,795,280 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl358,718,332 - 58,795,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx362,114,861 - 62,189,669 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0370,698,518 - 70,773,330 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0368,463,548 - 68,538,382 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0360,721,137 - 60,795,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl360,721,135 - 60,795,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0367,199,880 - 67,274,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4356,403,676 - 56,496,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1356,323,607 - 56,392,845 (-)NCBI
Celera358,247,269 - 58,321,865 (-)NCBICelera
RH 3.4 Map5689.89RGD
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (ISO)
(-)-anisomycin  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-aminobiphenyl  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
baicalin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium trioxide  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibromoacetic acid  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
enalapril  (EXP)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gingerol  (ISO)
Goe 6976  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
KT 5720  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mevinphos  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylarsine oxide  (ISO)
piperine  (ISO)
piperonyl butoxide  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
abducens nucleus development  (ISO)
adipose tissue development  (ISO)
amelogenesis  (IDA)
apoptotic process  (ISO)
apoptotic process involved in development  (ISO)
BMP signaling pathway  (ISO)
brainstem development  (ISO)
brown fat cell proliferation  (ISO)
cellular response to anisomycin  (ISO)
cellular response to leucine starvation  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to virus  (ISO)
detection of cell density  (ISO)
DNA damage response  (IEA,ISO,ISS)
energy homeostasis  (ISO)
facial nucleus development  (ISO)
gene expression  (ISO)
growth plate cartilage chondrocyte differentiation  (ISO)
growth plate cartilage chondrocyte proliferation  (ISO)
heart development  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hepatocyte apoptotic process  (ISO)
hypoglossal nucleus development  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to hypoxia  (ISO)
JNK cascade  (ISO)
lipid metabolic process  (ISO)
liver development  (ISO)
MAPK cascade  (ISO)
mitotic intra-S DNA damage checkpoint signaling  (ISO,ISS)
motor neuron apoptotic process  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
neurofilament cytoskeleton organization  (ISO)
NK T cell differentiation  (ISO)
outflow tract morphogenesis  (ISO)
p38MAPK cascade  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of cardiac muscle myoblast proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO,ISS)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transforming growth factor beta2 production  (ISO)
protein import into nucleus  (ISO)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to osmotic stress  (ISO,ISS)
temperature homeostasis  (ISO)
transcription initiation-coupled chromatin remodeling  (ISO)
vacuole organization  (ISO)
white fat cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene. Alonso CR, etal., J Biol Chem. 1996 Sep 6;271(36):22271-9. doi: 10.1074/jbc.271.36.22271.
2. Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia. Feng A, etal., PLoS One. 2013 Dec 2;8(12):e80997. doi: 10.1371/journal.pone.0080997. eCollection 2013.
3. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Feng AW, etal., Fitoterapia. 2011 May 27.
4. Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. Fischer TA, etal., Hypertension. 2001 May;37(5):1222-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain. Hu BR, etal., Neuroscience. 1999 Mar;89(2):437-52.
8. Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor. Kageyama R, etal., J Biol Chem 1991 Aug 15;266(23):15525-31.
9. Co-expression of c-Jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury. Kreutz MR, etal., Brain Res Mol Brain Res. 1999 Jun 8;69(2):232-41.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Increased levels of transcription factors Elk-1, cyclic adenosine monophosphate response element-binding protein, and activating transcription factor 2 in the cerebellar vermis of schizophrenic patients. Kyosseva SV, etal., Arch Gen Psychiatry. 2000 Jul;57(7):685-91.
12. Activating transcription factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic acid. Lee MY, etal., Diabetes. 2002 Dec;51(12):3400-7.
13. Regulation of cell death and survival pathways in experimental glaucoma. Levkovitch-Verbin H, etal., Exp Eye Res. 2007 Aug;85(2):250-8. Epub 2007 May 13.
14. dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons. Ma C, etal., J Biol Chem. 2007 Oct 19;282(42):30901-9. Epub 2007 Apr 11.
15. Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury. Martin-Villalba A, etal., Brain Res Mol Brain Res. 1998 Nov 20;62(2):158-66.
16. Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivation. Meeker RB and Fernandes A, Neuroendocrinology. 2002 Aug;76(2):111-20.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease. Nieto-Bodelon M, etal., Acta Neuropathol. 2006 Apr;111(4):341-50. Epub 2006 Feb 23.
21. Transient increase in anti-p-ATF2 immunoreactivity in the late secretion ameloblasts apical to the transition zone of rat incisors. Nishikawa S Anat Sci Int. 2004 Jun;79(2):87-94.
22. Activating transcription factor 2 expression in the adult human brain: association with both neurodegeneration and neurogenesis. Pearson AG, etal., Neuroscience. 2005;133(2):437-51.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. Suzuki T, etal., J Biol Chem 2002 Oct 25;277(43):40768-74.
30. Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion. Xiao L, etal., Am J Physiol Cell Physiol. 2010 May;298(5):C1226-34. doi: 10.1152/ajpcell.00021.2010. Epub 2010 Feb 24.
31. Expression of activating transcription factor-2 (ATF-2), one of the cyclic AMP response element (CRE) binding proteins, in Alzheimer disease and non-neurological brain tissues. Yamada T, etal., Brain Res. 1997 Feb 28;749(2):329-34.
32. Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Yuan Z, etal., Mol Cell Biol. 2009 May;29(9):2431-42. doi: 10.1128/MCB.01344-08. Epub 2009 Mar 2.
Additional References at PubMed
PMID:2196176   PMID:2516827   PMID:8798441   PMID:9139739   PMID:10821277   PMID:12220541   PMID:15030387   PMID:15916964   PMID:16125722   PMID:16300731   PMID:16407200   PMID:16452470  
PMID:17767158   PMID:17804813   PMID:18305237   PMID:18320311   PMID:18386196   PMID:18387947   PMID:18397884   PMID:18671972   PMID:19861239   PMID:19923798   PMID:19948881   PMID:21098032  
PMID:21300140   PMID:21996423   PMID:22304920   PMID:22982025   PMID:23729669   PMID:24368669   PMID:26601778   PMID:26781764   PMID:28977001   PMID:29921170  


Genomics

Comparative Map Data
Atf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8379,125,814 - 79,202,896 (-)NCBIGRCr8
mRatBN7.2358,718,323 - 58,795,280 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl358,718,332 - 58,795,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx362,114,861 - 62,189,669 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0370,698,518 - 70,773,330 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0368,463,548 - 68,538,382 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0360,721,137 - 60,795,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl360,721,135 - 60,795,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0367,199,880 - 67,274,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4356,403,676 - 56,496,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1356,323,607 - 56,392,845 (-)NCBI
Celera358,247,269 - 58,321,865 (-)NCBICelera
RH 3.4 Map5689.89RGD
Cytogenetic Map3q23NCBI
ATF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382175,072,259 - 175,168,203 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2175,072,250 - 175,168,382 (-)EnsemblGRCh38hg38GRCh38
GRCh372175,936,987 - 176,032,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362175,647,252 - 175,741,143 (-)NCBINCBI36Build 36hg18NCBI36
Build 342175,764,514 - 175,858,404NCBI
Celera2169,552,560 - 169,646,448 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2167,817,672 - 167,913,976 (-)NCBIHuRef
CHM1_12175,942,954 - 176,038,909 (-)NCBICHM1_1
T2T-CHM13v2.02175,561,049 - 175,656,993 (-)NCBIT2T-CHM13v2.0
Atf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39273,646,853 - 73,723,094 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl273,646,853 - 73,722,983 (-)EnsemblGRCm39 Ensembl
GRCm38273,816,509 - 73,892,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl273,816,509 - 73,892,639 (-)EnsemblGRCm38mm10GRCm38
MGSCv37273,654,578 - 73,730,685 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36273,617,360 - 73,693,467 (-)NCBIMGSCv36mm8
Celera275,503,543 - 75,579,494 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map243.86NCBI
Atf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955449338,193 - 411,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955449332,563 - 411,218 (+)NCBIChiLan1.0ChiLan1.0
ATF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21377,735,869 - 77,832,175 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B77,750,835 - 77,847,150 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B62,348,245 - 62,444,428 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B179,799,362 - 179,895,007 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B179,799,365 - 179,895,007 (-)Ensemblpanpan1.1panPan2
ATF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13619,032,376 - 19,103,382 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3619,010,717 - 19,103,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3619,041,505 - 19,126,647 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03619,170,174 - 19,255,411 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3619,149,065 - 19,255,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13619,246,271 - 19,331,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03619,244,588 - 19,329,566 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03619,355,712 - 19,440,684 (-)NCBIUU_Cfam_GSD_1.0
Atf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303136,176,081 - 136,272,458 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365094,732,930 - 4,826,443 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365094,729,984 - 4,826,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1580,985,126 - 81,081,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11580,984,969 - 81,076,573 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21590,260,285 - 90,303,424 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11060,644,623 - 60,734,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1060,644,635 - 60,734,475 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040138,879,027 - 138,969,502 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478712,241,838 - 12,338,089 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atf2
284 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:55
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000002174, ENSRNOT00000050513
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Got255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2358,760,594 - 58,760,754 (+)MAPPERmRatBN7.2
Rnor_6.0360,761,289 - 60,761,448NCBIRnor6.0
Rnor_5.0367,240,032 - 67,240,191UniSTSRnor5.0
RGSC_v3.4356,461,809 - 56,461,968UniSTSRGSC3.4
Celera358,287,192 - 58,287,365UniSTS
Cytogenetic Map3q23UniSTS
RH142313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2358,731,515 - 58,732,666 (+)MAPPERmRatBN7.2
Rnor_6.0360,732,211 - 60,733,361NCBIRnor6.0
Rnor_5.0367,210,954 - 67,212,104UniSTSRnor5.0
RGSC_v3.4356,432,731 - 56,433,881UniSTSRGSC3.4
Celera358,258,115 - 58,259,265UniSTS
RH 3.4 Map5689.89UniSTS
Cytogenetic Map3q23UniSTS
BE107846  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2358,713,791 - 58,713,943 (+)MAPPERmRatBN7.2
Rnor_6.0360,714,319 - 60,714,470NCBIRnor6.0
Rnor_5.0367,193,062 - 67,193,213UniSTSRnor5.0
RGSC_v3.4356,412,450 - 56,412,601UniSTSRGSC3.4
Celera358,240,451 - 58,240,602UniSTS
Cytogenetic Map3q23UniSTS
Atf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8379,126,872 - 79,126,935 (+)Marker Load Pipeline
mRatBN7.2358,719,387 - 58,719,451 (+)MAPPERmRatBN7.2
Rnor_6.0360,719,915 - 60,719,978NCBIRnor6.0
Rnor_5.0367,198,658 - 67,198,721UniSTSRnor5.0
RGSC_v3.4356,406,942 - 56,407,005UniSTSRGSC3.4
Celera358,246,047 - 58,246,110UniSTS
Cytogenetic Map3q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY724488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002174   ⟹   ENSRNOP00000002174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl358,718,335 - 58,795,166 (-)Ensembl
Rnor_6.0 Ensembl360,721,135 - 60,795,951 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050513   ⟹   ENSRNOP00000046001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl358,718,332 - 58,795,236 (-)Ensembl
Rnor_6.0 Ensembl360,721,171 - 60,765,645 (-)Ensembl
RefSeq Acc Id: NM_031018   ⟹   NP_112280
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,128,095 - 79,202,745 (-)NCBI
mRatBN7.2358,720,610 - 58,795,266 (-)NCBI
Rnor_6.0360,721,137 - 60,795,951 (-)NCBI
Rnor_5.0367,199,880 - 67,274,694 (-)NCBI
RGSC_v3.4356,403,676 - 56,496,473 (-)RGD
Celera358,247,269 - 58,321,865 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105916   ⟹   XP_038961844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,885 (-)NCBI
mRatBN7.2358,718,323 - 58,795,280 (-)NCBI
RefSeq Acc Id: XM_063284624   ⟹   XP_063140694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,470 (-)NCBI
RefSeq Acc Id: XM_063284625   ⟹   XP_063140695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,885 (-)NCBI
RefSeq Acc Id: XM_063284626   ⟹   XP_063140696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,896 (-)NCBI
RefSeq Acc Id: XM_063284627   ⟹   XP_063140697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,470 (-)NCBI
RefSeq Acc Id: XM_063284628   ⟹   XP_063140698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,473 (-)NCBI
RefSeq Acc Id: XM_063284629   ⟹   XP_063140699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,885 (-)NCBI
RefSeq Acc Id: XM_063284630   ⟹   XP_063140700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8379,125,814 - 79,202,473 (-)NCBI
RefSeq Acc Id: NP_112280   ⟸   NM_031018
- UniProtKB: Q62870 (UniProtKB/Swiss-Prot),   Q00969 (UniProtKB/Swiss-Prot),   A6HMA9 (UniProtKB/TrEMBL),   A6HMB2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002174   ⟸   ENSRNOT00000002174
Ensembl Acc Id: ENSRNOP00000046001   ⟸   ENSRNOT00000050513
RefSeq Acc Id: XP_038961844   ⟸   XM_039105916
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140696   ⟸   XM_063284626
- Peptide Label: isoform X2
- UniProtKB: A6HMB2 (UniProtKB/TrEMBL),   A0A8L2Q100 (UniProtKB/TrEMBL),   A6HMB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140699   ⟸   XM_063284629
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140695   ⟸   XM_063284625
- Peptide Label: isoform X1
- UniProtKB: Q62870 (UniProtKB/Swiss-Prot),   Q00969 (UniProtKB/Swiss-Prot),   A6HMB2 (UniProtKB/TrEMBL),   A6HMA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140700   ⟸   XM_063284630
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140698   ⟸   XM_063284628
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140697   ⟸   XM_063284627
- Peptide Label: isoform X2
- UniProtKB: A6HMB2 (UniProtKB/TrEMBL),   A0A8L2Q100 (UniProtKB/TrEMBL),   A6HMB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140694   ⟸   XM_063284624
- Peptide Label: isoform X1
- UniProtKB: Q62870 (UniProtKB/Swiss-Prot),   Q00969 (UniProtKB/Swiss-Prot),   A6HMB2 (UniProtKB/TrEMBL),   A6HMA9 (UniProtKB/TrEMBL)
Protein Domains
bZIP   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00969-F1-model_v2 AlphaFold Q00969 1-487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692146
Promoter ID:EPDNEW_R2671
Type:initiation region
Name:Atf2_1
Description:activating transcription factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0360,795,965 - 60,796,025EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621862 AgrOrtholog
BioCyc Gene G2FUF-49357 BioCyc
Ensembl Genes ENSRNOG00000001597 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002174 ENTREZGENE
  ENSRNOT00000050513 ENTREZGENE
  ENSRNOT00000050513.5 UniProtKB/Swiss-Prot
  ENSRNOT00000157814 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  bZIP_transcription_factors UniProtKB/Swiss-Prot
  TF_CRE-BP1-typ UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:81647 UniProtKB/Swiss-Prot
NCBI Gene 81647 ENTREZGENE
PANTHER CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Atf2 PhenoGen
PIRSF ATF2_CRE-BP1 UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001597 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt A0A8L2Q100 ENTREZGENE, UniProtKB/TrEMBL
  A6HMA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HMB1 ENTREZGENE, UniProtKB/TrEMBL
  A6HMB2 ENTREZGENE, UniProtKB/TrEMBL
  ATF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62870 ENTREZGENE
UniProt Secondary Q62870 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Atf2  activating transcription factor 2    RATF2  Name updated 1299863 APPROVED
2002-08-07 Atf2  RATF2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds the cAMP responsive element of the tyrosine hydroxylase gene 727574