RGD Reference Report - Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. - Rat Genome Database

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Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load.

Authors: Fischer, TA  Ludwig, S  Flory, E  Gambaryan, S  Singh, K  Finn, P  Pfeffer, MA  Kelly, RA  Pfeffer, JM 
Citation: Fischer TA, etal., Hypertension. 2001 May;37(5):1222-8.
RGD ID: 10047414
Pubmed: PMID:11358932   (View Abstract at PubMed)

The role of mitogen-activated protein kinase (MAPK) pathways as signal transduction intermediates of hemodynamic stress leading to cardiac hypertrophy in the adult heart is not fully established. In a rat model of pressure-overload hypertrophy, we examined whether activation of MAPK pathways, namely, the extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), and the p38-MAPK pathways, occurs during rapid changes in hemodynamic load in vivo. A slight activation of ERK2 and marked increases in JNK1 and p38-MAPK activities were observed 30 minutes after aortic banding. The increase in p38-MAPK activity was accompanied by an increase in the phosphorylation of the p38 substrate MAPK-activated protein kinases 2 and 3. Activation of these kinases was coincident with an increase in phosphorylation of c-Jun and activating transcription factor-2 (ATF-2) and enhanced DNA binding of activator protein-1 factors. Thus, hemodynamic stress of the adult rat heart in vivo results in rapid activation of several parallel MAPK kinase cascades, particularly stress-activated MAPK and p38-MAPK and their target transcription factors c-Jun and ATF-2.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATF2Humanhypertension  ISOAtf2 (Rattus norvegicus) RGD 
Atf2Rathypertension  IDA  RGD 
Atf2Mousehypertension  ISOAtf2 (Rattus norvegicus) RGD 
JUNHumanhypertension  ISOJun (Rattus norvegicus) RGD 
JunRathypertension  IDA  RGD 
JunMousehypertension  ISOJun (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atf2  (activating transcription factor 2)
Jun  (Jun proto-oncogene, AP-1 transcription factor subunit)

Genes (Mus musculus)
Atf2  (activating transcription factor 2)
Jun  (jun proto-oncogene)

Genes (Homo sapiens)
ATF2  (activating transcription factor 2)
JUN  (Jun proto-oncogene, AP-1 transcription factor subunit)


Additional Information