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Gene: ATF2 (activating transcription factor 2) Homo sapiens
Symbol: ATF2
Name: activating transcription factor 2
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cardiac muscle myoblast proliferation; positive regulation of mitochondrial membrane permeability involved in apoptotic process; and regulation of transcription, DNA-templated. Localizes to the mitochondrial outer membrane; nucleoplasm; and site of double-strand break. Biomarker of Alzheimer's disease; Huntington's disease; Pick's disease; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activating transcription factor 2 splice variant ATF2-var2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE-BP1; CREB-2; CREB2; cyclic AMP-dependent transcription factor ATF-2; cyclic AMP-responsive element-binding protein 2; HB16; histone acetyltransferase ATF2; MGC111558; ratf2; TREB7
Mus musculus (house mouse) : Atf2 (activating transcription factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atf2 (activating transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf2 (activating transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF2 (activating transcription factor 2)
Canis lupus familiaris (dog) : ATF2 (activating transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf2 (activating transcription factor 2)
Sus scrofa (pig) : ATF2 (activating transcription factor 2)
Chlorocebus sabaeus (green monkey) : ATF2 (activating transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Atf2 (activating transcription factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2175,072,250 - 175,168,382 (-)Ensembl
GRCh382175,072,250 - 175,168,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372175,936,978 - 176,032,934 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362175,647,252 - 175,741,143 (-)NCBINCBI36hg18NCBI36
Build 342175,764,514 - 175,858,404NCBI
Celera2169,552,560 - 169,646,448 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2167,817,672 - 167,913,976 (-)NCBIHuRef
CHM1_12175,942,954 - 176,038,909 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ATF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732287
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.