Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621862
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf2
Name: activating transcription factor 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf2increases expressionEXP 6480464CTDsodium arsenite results in increased expression of ATF2 protein modified formPMID:16797887
Atf2multiple interactionsEXP 6480464CTDsodium arsenite promotes the reaction [[[ATF2 protein binds to ATF2 protein] which binds to PCK1 promoter] which results in increased expression of PCK1 mRNA]PMID:9712902
Atf2decreases expressionISOATF2 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of ATF2 mRNAPMID:28595984 PMID:34032870
Atf2increases activityISOATF2 (Homo sapiens)6480464CTDsodium arsenite results in increased activity of ATF2 proteinPMID:12220541 PMID:15292961
Atf2increases expressionISOATF2 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of ATF2 mRNA; sodium arsenite results in increased expression of ATF2 protein; sodium arsenite results in increased expression of ATF2 protein modified formPMID:12016162 PMID:17879257 PMID:23591579 PMID:30090515
Atf2increases phosphorylationISOATF2 (Homo sapiens)6480464CTDsodium arsenite results in increased phosphorylation of ATF2 proteinPMID:9728050
Atf2increases phosphorylationISOAtf2 (Mus musculus)6480464CTDsodium arsenite results in increased phosphorylation of ATF2 proteinPMID:11807808
Atf2multiple interactionsISOATF2 (Homo sapiens)6480464CTDATF2 protein inhibits the reaction [sodium arsenite results in increased expression of CXCL8 mRNA]; ATF2 protein inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of BCL2 protein]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of CCND1 mRNA]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of CCND1 protein]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of MMP1 mRNA]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of PCNA mRNA]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of PCNA protein]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]PMID:23591579 PMID:30090515
Go Back to source page   Continue to Ontology report