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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621862
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf2
Name: activating transcription factor 2
Acc ID: CHEBI:50095
Term: bucladesine
Definition: A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.
Chemical ID: MESH:D003994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf2increases expressionISOATF2 (Homo sapiens)6480464CTDBucladesine results in increased expression of ATF2 protein modified formPMID:26049102
Atf2increases phosphorylationISOATF2 (Homo sapiens)6480464CTDBucladesine results in increased phosphorylation of ATF2 proteinPMID:26049102
Atf2multiple interactionsISOATF2 (Homo sapiens)6480464CTDBucladesine promotes the reaction [ATF2 protein binds to ABCC2 promoter]; Bucladesine promotes the reaction [JUN protein binds to ATF2 protein]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ATF2 protein modified form]PMID:26049102
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