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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hipk3 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Hipk3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of HIPK3 mRNA | CTD | PMID:22206623 | Hipk3 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Hipk3 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of HIPK3 mRNA] | CTD | PMID:22206623 | Hipk3 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of HIPK3 mRNA | CTD | PMID:29097150 | Hipk3 | Rat | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of HIPK3 mRNA | CTD | PMID:32145629 | Hipk3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hipk3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HIPK3 mRNA | CTD | PMID:21570461 | Hipk3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HIPK3 mRNA | CTD | PMID:33387578 | Hipk3 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of HIPK3 mRNA | CTD | PMID:20188158 | Hipk3 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of HIPK3 mRNA | CTD | PMID:31881176 | Hipk3 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of HIPK3 mRNA | CTD | PMID:28959563 | Hipk3 | Rat | aflatoxin B1 | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of HIPK3 mRNA | CTD | PMID:19770486 | Hipk3 | Rat | aflatoxin B1 | decreases methylation | ISO | HIPK3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HIPK3 gene | CTD | PMID:27153756 | Hipk3 | Rat | all-trans-retinoic acid | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of HIPK3 mRNA | CTD | PMID:23724009 | Hipk3 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HIPK3 mRNA | CTD | PMID:16483693 | Hipk3 | Rat | aristolochic acid A | decreases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HIPK3 mRNA | CTD | PMID:33212167 | Hipk3 | Rat | arsenite(3-) | multiple interactions | ISO | HIPK3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to HIPK3 mRNA] | CTD | PMID:32406909 | Hipk3 | Rat | atrazine | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Atrazine results in increased expression of HIPK3 mRNA | CTD | PMID:22378314 | Hipk3 | Rat | benzo[a]pyrene | decreases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HIPK3 mRNA | CTD | PMID:20106945 and PMID:21632981 | Hipk3 | Rat | benzo[a]pyrene | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of HIPK3 mRNA | CTD | PMID:22228805 | Hipk3 | Rat | benzo[a]pyrene | multiple interactions | ISO | Hipk3 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of HIPK3 mRNA] | CTD | PMID:22228805 | Hipk3 | Rat | benzo[a]pyrene | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of HIPK3 mRNA | CTD | PMID:22316170 | Hipk3 | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | Hipk3 | Rat | beta-lapachone | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of HIPK3 mRNA | CTD | PMID:38218311 | Hipk3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HIPK3 mRNA | CTD | PMID:25181051 more ... | Hipk3 | Rat | bisphenol A | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of HIPK3 mRNA | CTD | PMID:33221593 | Hipk3 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of HIPK3 mRNA | CTD | PMID:32145629 | Hipk3 | Rat | bisphenol A | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of HIPK3 mRNA | CTD | PMID:29275510 | Hipk3 | Rat | carbon nanotube | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Hipk3 | Rat | CGP 52608 | multiple interactions | ISO | HIPK3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HIPK3 gene] | CTD | PMID:28238834 | Hipk3 | Rat | chloroprene | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Chloroprene results in increased expression of HIPK3 mRNA | CTD | PMID:23125180 | Hipk3 | Rat | cisplatin | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of HIPK3 mRNA | CTD | PMID:27392435 | Hipk3 | Rat | clofibrate | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Clofibrate results in increased expression of HIPK3 mRNA | CTD | PMID:17585979 | Hipk3 | Rat | crocidolite asbestos | affects expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of HIPK3 mRNA | CTD | PMID:17331233 | Hipk3 | Rat | cyclosporin A | affects expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Cyclosporine affects the expression of HIPK3 mRNA | CTD | PMID:25562108 | Hipk3 | Rat | DDE | decreases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of HIPK3 mRNA | CTD | PMID:38568856 | Hipk3 | Rat | DDT | increases methylation | EXP | | 6480464 | DDT results in increased methylation of HIPK3 gene | CTD | PMID:30207508 | Hipk3 | Rat | Dibutyl phosphate | affects expression | ISO | HIPK3 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of HIPK3 mRNA | CTD | PMID:37042841 | Hipk3 | Rat | dibutyl phthalate | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of HIPK3 mRNA | CTD | PMID:21266533 | Hipk3 | Rat | doxorubicin | decreases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HIPK3 mRNA | CTD | PMID:29803840 | Hipk3 | Rat | ethanol | affects splicing | ISO | Hipk3 (Mus musculus) | 6480464 | Ethanol affects the splicing of HIPK3 mRNA | CTD | PMID:30319688 | Hipk3 | Rat | ethyl methanesulfonate | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of HIPK3 mRNA | CTD | PMID:23649840 | Hipk3 | Rat | folic acid | multiple interactions | ISO | Hipk3 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of HIPK3 mRNA] | CTD | PMID:22206623 | Hipk3 | Rat | formaldehyde | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of HIPK3 mRNA | CTD | PMID:23649840 | Hipk3 | Rat | FR900359 | increases phosphorylation | ISO | HIPK3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of HIPK3 protein | CTD | PMID:37730182 | Hipk3 | Rat | fulvestrant | increases methylation | ISO | HIPK3 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of HIPK3 gene | CTD | PMID:31601247 | Hipk3 | Rat | hypochlorous acid | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Hypochlorous Acid results in increased expression of HIPK3 mRNA | CTD | PMID:19376150 | Hipk3 | Rat | isoprenaline | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of HIPK3 mRNA | CTD | PMID:20003209 | Hipk3 | Rat | lead(0) | affects expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Lead affects the expression of HIPK3 mRNA | CTD | PMID:28903495 | Hipk3 | Rat | lipopolysaccharide | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of HIPK3 mRNA alternative form | CTD | PMID:36052886 | Hipk3 | Rat | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of HIPK3 mRNA | CTD | PMID:28801915 | Hipk3 | Rat | MeIQx | decreases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | 2-amino-3 more ... | CTD | PMID:20816883 | Hipk3 | Rat | methidathion | decreases expression | ISO | Hipk3 (Mus musculus) | 6480464 | methidathion results in decreased expression of HIPK3 mRNA | CTD | PMID:34813904 | Hipk3 | Rat | methoxyacetic acid | affects expression | EXP | | 6480464 | methoxyacetic acid affects the expression of HIPK3 mRNA | CTD | PMID:20864626 | Hipk3 | Rat | methyl methanesulfonate | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of HIPK3 mRNA | CTD | PMID:23649840 | Hipk3 | Rat | methylmercury chloride | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of HIPK3 mRNA | CTD | PMID:28001369 | Hipk3 | Rat | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of HIPK3 mRNA | CTD | PMID:28801915 | Hipk3 | Rat | ozone | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Ozone results in increased expression of HIPK3 mRNA | CTD | PMID:12763052 | Hipk3 | Rat | paracetamol | affects expression | ISO | Hipk3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of HIPK3 mRNA | CTD | PMID:17562736 | Hipk3 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HIPK3 mRNA | CTD | PMID:22112502 | Hipk3 | Rat | rimonabant | multiple interactions | ISO | Hipk3 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of HIPK3 mRNA] | CTD | PMID:19030233 | Hipk3 | Rat | silicon dioxide | decreases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of HIPK3 mRNA | CTD | PMID:19073995 | Hipk3 | Rat | silicon dioxide | decreases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of HIPK3 mRNA | CTD | PMID:23806026 | Hipk3 | Rat | sodium arsenate | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of HIPK3 mRNA | CTD | PMID:21795629 | Hipk3 | Rat | sodium arsenite | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of HIPK3 mRNA | CTD | PMID:38568856 | Hipk3 | Rat | sodium fluoride | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of HIPK3 mRNA | CTD | PMID:27862939 | Hipk3 | Rat | T-2 toxin | decreases expression | EXP | | 6480464 | T-2 Toxin results in decreased expression of HIPK3 mRNA | CTD | PMID:26141394 | Hipk3 | Rat | testosterone | decreases expression | ISO | Hipk3 (Mus musculus) | 6480464 | Testosterone results in decreased expression of HIPK3 mRNA | CTD | PMID:20403060 | Hipk3 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of HIPK3 mRNA | CTD | PMID:22112502 | Hipk3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of HIPK3 mRNA | CTD | PMID:34492290 | Hipk3 | Rat | thiram | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Thiram results in increased expression of HIPK3 mRNA | CTD | PMID:38568856 | Hipk3 | Rat | titanium dioxide | increases methylation | ISO | Hipk3 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of HIPK3 gene | CTD | PMID:35295148 | Hipk3 | Rat | titanium dioxide | decreases methylation | ISO | Hipk3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of HIPK3 gene | CTD | PMID:35295148 | Hipk3 | Rat | trichostatin A | affects expression | ISO | HIPK3 (Homo sapiens) | 6480464 | trichostatin A affects the expression of HIPK3 mRNA | CTD | PMID:28542535 | Hipk3 | Rat | triptonide | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | triptonide results in increased expression of HIPK3 mRNA | CTD | PMID:33045310 | Hipk3 | Rat | troglitazone | increases expression | ISO | Hipk3 (Mus musculus) | 6480464 | troglitazone results in increased expression of HIPK3 mRNA | CTD | PMID:12732648 | Hipk3 | Rat | urethane | increases expression | ISO | HIPK3 (Homo sapiens) | 6480464 | Urethane results in increased expression of HIPK3 mRNA | CTD | PMID:28818685 | Hipk3 | Rat | valproic acid | increases methylation | ISO | HIPK3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HIPK3 gene | CTD | PMID:29154799 | Hipk3 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of HIPK3 mRNA | CTD | PMID:29427782 | |