Hipk3 (homeodomain interacting protein kinase 3) - Rat Genome Database

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Gene: Hipk3 (homeodomain interacting protein kinase 3) Rattus norvegicus
Analyze
Symbol: Hipk3
Name: homeodomain interacting protein kinase 3
RGD ID: 619884
Description: Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including mRNA transcription; negative regulation of JUN kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and plasma membrane. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: androgen receptor-interacting nuclear protein kinase; ANPK; homeodomain-interacting protein kinase 3; nuclear serine/threonine protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2390,796,980 - 90,866,701 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl390,800,296 - 90,867,759 (-)Ensembl
Rnor_6.0394,349,778 - 94,419,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl394,352,969 - 94,419,048 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,985,832 - 101,054,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4389,749,949 - 89,816,787 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1389,646,381 - 89,713,215 (-)NCBI
Celera389,860,648 - 89,926,769 (-)NCBICelera
Cytogenetic Map3q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleus  (IBA)
plasma membrane  (IEA,ISO)
PML body  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Activation of androgen receptor function by a novel nuclear protein kinase. Moilanen AM, etal., Mol Biol Cell 1998 Sep;9(9):2527-43.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10919273   PMID:11034606   PMID:12477932   PMID:14766760   PMID:17210646   PMID:32356246   PMID:33660818  


Genomics

Comparative Map Data
Hipk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2390,796,980 - 90,866,701 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl390,800,296 - 90,867,759 (-)Ensembl
Rnor_6.0394,349,778 - 94,419,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl394,352,969 - 94,419,048 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,985,832 - 101,054,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4389,749,949 - 89,816,787 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1389,646,381 - 89,713,215 (-)NCBI
Celera389,860,648 - 89,926,769 (-)NCBICelera
Cytogenetic Map3q32NCBI
HIPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381133,256,672 - 33,357,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1133,256,672 - 33,357,023 (+)EnsemblGRCh38hg38GRCh38
GRCh371133,278,218 - 33,378,569 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361133,235,744 - 33,332,515 (+)NCBINCBI36hg18NCBI36
Build 341133,264,532 - 33,331,690NCBI
Celera1133,425,771 - 33,522,554 (+)NCBI
Cytogenetic Map11p13NCBI
HuRef1132,972,945 - 33,073,572 (+)NCBIHuRef
CHM1_11133,277,522 - 33,377,905 (+)NCBICHM1_1
T2T-CHM13v2.01133,392,109 - 33,492,540 (+)NCBI
Hipk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392104,256,826 - 104,324,834 (-)NCBIGRCm39mm39
GRCm39 Ensembl2104,256,826 - 104,324,791 (-)Ensembl
GRCm382104,426,481 - 104,494,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2104,426,481 - 104,494,446 (-)EnsemblGRCm38mm10GRCm38
MGSCv372104,266,638 - 104,334,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv362104,230,603 - 104,295,083 (-)NCBImm8
Celera2105,663,732 - 105,714,737 (-)NCBICelera
Cytogenetic Map2E2NCBI
Hipk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542212,845,258 - 12,904,144 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542212,841,781 - 12,928,194 (-)NCBIChiLan1.0ChiLan1.0
HIPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11133,114,534 - 33,212,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,114,534 - 33,212,783 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01133,230,731 - 33,330,617 (+)NCBIMhudiblu_PPA_v0panPan3
HIPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11834,305,208 - 34,397,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1834,308,584 - 34,397,511 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1833,917,398 - 34,009,903 (-)NCBI
ROS_Cfam_1.01834,915,823 - 35,008,659 (-)NCBI
ROS_Cfam_1.0 Ensembl1834,915,831 - 35,008,567 (-)Ensembl
UMICH_Zoey_3.11834,485,400 - 34,577,749 (-)NCBI
UNSW_CanFamBas_1.01834,068,380 - 34,161,131 (-)NCBI
UU_Cfam_GSD_1.01834,704,139 - 34,796,361 (-)NCBI
Hipk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494731,445,805 - 31,538,172 (-)NCBI
SpeTri2.0NW_0049365334,570,600 - 4,662,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl227,580,129 - 27,685,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1227,580,125 - 27,685,926 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2230,028,373 - 30,057,948 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HIPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1131,944,760 - 32,009,328 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl131,944,749 - 32,009,297 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038129,033,340 - 129,127,349 (-)NCBIVero_WHO_p1.0
Hipk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476713,853,515 - 13,972,569 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476713,854,461 - 13,972,012 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Rat263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,825,641 - 90,825,874 (+)MAPPERmRatBN7.2
Rnor_6.0394,378,437 - 94,378,669NCBIRnor6.0
Rnor_5.03101,014,491 - 101,014,723UniSTSRnor5.0
RGSC_v3.4389,775,293 - 89,775,525RGDRGSC3.4
RGSC_v3.4389,775,294 - 89,775,526UniSTSRGSC3.4
RGSC_v3.1389,671,721 - 89,671,953RGD
Celera389,885,993 - 89,886,225UniSTS
SHRSP x BN Map347.2698UniSTS
SHRSP x BN Map347.2698RGD
Cytogenetic Map3q32UniSTS
D3Got302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,827,227 - 90,827,392 (+)MAPPERmRatBN7.2
Rnor_6.0394,380,023 - 94,380,187NCBIRnor6.0
Rnor_5.03101,016,077 - 101,016,241UniSTSRnor5.0
RGSC_v3.4389,776,880 - 89,777,044UniSTSRGSC3.4
Celera389,887,579 - 89,887,743UniSTS
Cytogenetic Map3q32UniSTS
HIPK3__6530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,800,246 - 90,800,791 (+)MAPPERmRatBN7.2
Rnor_6.0394,353,045 - 94,353,589NCBIRnor6.0
Rnor_5.03100,989,099 - 100,989,643UniSTSRnor5.0
RGSC_v3.4389,749,900 - 89,750,444UniSTSRGSC3.4
Celera389,860,599 - 89,861,143UniSTS
Cytogenetic Map3q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:7
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000015775
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 42 54 38 19 38 8 11 74 35 41 11 8
Low 1 1 3 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015775   ⟹   ENSRNOP00000015775
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,800,296 - 90,866,312 (-)Ensembl
Rnor_6.0 Ensembl394,353,094 - 94,419,048 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089554   ⟹   ENSRNOP00000073200
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,800,299 - 90,865,962 (-)Ensembl
Rnor_6.0 Ensembl394,352,969 - 94,418,711 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105868   ⟹   ENSRNOP00000085704
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,800,299 - 90,867,759 (-)Ensembl
RefSeq Acc Id: NM_031787   ⟹   NP_113975
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,800,296 - 90,866,312 (-)NCBI
Rnor_6.0394,353,094 - 94,419,048 (-)NCBI
Rnor_5.03100,985,832 - 101,054,939 (-)NCBI
RGSC_v3.4389,749,949 - 89,816,787 (-)RGD
Celera389,860,648 - 89,926,769 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234658   ⟹   XP_006234720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,865,977 (-)NCBI
Rnor_6.0394,349,778 - 94,419,183 (-)NCBI
Rnor_5.03100,985,832 - 101,054,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762072   ⟹   XP_008760294
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,845,242 (-)NCBI
Rnor_6.0394,349,778 - 94,419,185 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105934   ⟹   XP_038961862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,866,701 (-)NCBI
RefSeq Acc Id: XM_039105935   ⟹   XP_038961863
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,865,977 (-)NCBI
RefSeq Acc Id: XM_039105936   ⟹   XP_038961864
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,807,413 (-)NCBI
RefSeq Acc Id: XM_039105937   ⟹   XP_038961865
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,807,413 (-)NCBI
RefSeq Acc Id: XM_039105938   ⟹   XP_038961866
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,807,235 (-)NCBI
RefSeq Acc Id: XM_039105939   ⟹   XP_038961867
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2390,796,980 - 90,807,236 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113975   ⟸   NM_031787
- Sequence:
RefSeq Acc Id: XP_006234720   ⟸   XM_006234658
- Peptide Label: isoform X3
- UniProtKB: Q498U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760294   ⟸   XM_008762072
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073200   ⟸   ENSRNOT00000089554
RefSeq Acc Id: ENSRNOP00000015775   ⟸   ENSRNOT00000015775
RefSeq Acc Id: XP_038961862   ⟸   XM_039105934
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961863   ⟸   XM_039105935
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961865   ⟸   XM_039105937
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038961864   ⟸   XM_039105936
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038961867   ⟸   XM_039105939
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038961866   ⟸   XM_039105938
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000085704   ⟸   ENSRNOT00000105868
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88850-F1-model_v2 AlphaFold O88850 1-1191 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692265
Promoter ID:EPDNEW_R2785
Type:single initiation site
Name:Hipk3_1
Description:homeodomain interacting protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0394,418,706 - 94,418,766EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 94397370 94397371 C A snv SR/JrHsd (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 101033424 101033425 C A snv ACI/EurMcwi (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619884 AgrOrtholog
BioCyc Gene G2FUF-48536 BioCyc
Ensembl Genes ENSRNOG00000011358 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015775 ENTREZGENE
  ENSRNOP00000015775.2 UniProtKB/TrEMBL
  ENSRNOP00000073200 ENTREZGENE
  ENSRNOP00000073200.1 UniProtKB/TrEMBL
  ENSRNOP00000085704.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015775 ENTREZGENE
  ENSRNOT00000015775.4 UniProtKB/TrEMBL
  ENSRNOT00000089554 ENTREZGENE
  ENSRNOT00000089554.2 UniProtKB/TrEMBL
  ENSRNOT00000105868.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111326 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83617 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112610 IMAGE-MGC_LOAD
NCBI Gene 83617 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hipk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4W6_RAT UniProtKB/TrEMBL
  A0A8I6GE65_RAT UniProtKB/TrEMBL
  F7EY07_RAT UniProtKB/TrEMBL
  HIPK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q498U5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hipk3  homeodomain interacting protein kinase 3    homeodomain-interacting protein kinase 3  Name updated 1299863 APPROVED
2002-08-07 Hipk3  homeodomain-interacting protein kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity over the protein kinase region to minibrain, a protein kinase associated with Down syndrome 632993