P2rx3 (purinergic receptor P2X 3) - Rat Genome Database

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Gene: P2rx3 (purinergic receptor P2X 3) Rattus norvegicus
Analyze
Symbol: P2rx3
Name: purinergic receptor P2X 3
RGD ID: 620253
Description: Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; neuronal action potential; and positive regulation of sensory perception of pain. Located in several cellular components, including dendritic spine; membrane raft; and rough endoplasmic reticulum. Is active in presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; P2X purinoceptor 3; P2X3; purinergic receptor P2X ligand-gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2370,080,850 - 70,124,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,080,851 - 70,125,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,462,764 - 73,506,383 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0382,061,439 - 82,105,058 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0379,819,891 - 79,863,521 (-)NCBIRnor_WKY
Rnor_6.0372,403,992 - 72,447,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,403,993 - 72,447,801 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,914,029 - 78,958,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,228,045 - 68,270,751 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1368,124,416 - 68,167,123 (-)NCBI
Celera369,431,850 - 69,475,670 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. Aschrafi A, etal., J Mol Biol. 2004 Sep 3;342(1):333-43.
2. A P2X purinoceptor expressed by a subset of sensory neurons. Chen CC, etal., Nature 1995 Oct 5;377(6548):428-31.
3. Presence of different ATP receptors on rat midbrain single synaptic terminals. Involvement of the P2X(3) subunits. Diaz-Hernandez M, etal., Neurosci Lett. 2001 Apr 6;301(3):159-62.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Presence of diverse functional P2X receptors in rat cerebellar synaptic terminals. Hervas C, etal., Biochem Pharmacol. 2005 Sep 1;70(5):770-85.
7. P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors. Krimon S, etal., Pharmacol Biochem Behav. 2013 Nov;112:49-55. doi: 10.1016/j.pbb.2013.09.017. Epub 2013 Oct 9.
8. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Lewis C, etal., Nature 1995 Oct 5;377(6548):432-5.
9. Ultrastructural localization of P2X3 receptors in rat sensory neurons. Llewellyn-Smith IJ and Burnstock G, Neuroreport. 1998 Aug 3;9(11):2545-50.
10. Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons. Luo J, etal., Brain Res. 2006 Oct 18;1115(1):9-15. Epub 2006 Aug 24.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus. Rodrigues RJ, etal., Neuropharmacology. 2016 Jun;105:241-257. doi: 10.1016/j.neuropharm.2016.01.022. Epub 2016 Jan 19.
17. The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA(B) receptor activation. Sokolova E, etal., Neurosci Lett. 2003 Mar 6;338(3):181-4.
18. P2X3 receptor localizes into lipid rafts in neuronal cells. Vacca F, etal., J Neurosci Res. 2004 Jun 1;76(5):653-61.
Additional References at PubMed
PMID:11069181   PMID:11069182   PMID:11466438   PMID:12477932   PMID:12813150   PMID:14672995   PMID:15081800   PMID:15258768   PMID:15292517   PMID:15736235   PMID:15927378   PMID:15947072  
PMID:15961431   PMID:15973739   PMID:16000618   PMID:16322458   PMID:16566843   PMID:16616417   PMID:16753051   PMID:17074061   PMID:17287582   PMID:17462717   PMID:17481957   PMID:17512257  
PMID:17521813   PMID:17917716   PMID:18026985   PMID:18067147   PMID:18276198   PMID:18309781   PMID:18551569   PMID:18565509   PMID:18715715   PMID:18722504   PMID:19064335   PMID:19223122  
PMID:19266560   PMID:19283865   PMID:19383439   PMID:19625689   PMID:19628002   PMID:20118742   PMID:20121714   PMID:20406659   PMID:20705122   PMID:20860800   PMID:20868656   PMID:21051571  
PMID:21195750   PMID:21303687   PMID:21642505   PMID:21669492   PMID:21678417   PMID:21810163   PMID:21851615   PMID:21883226   PMID:21907716   PMID:21958474   PMID:22044944   PMID:22157653  
PMID:22286789   PMID:22314033   PMID:22422599   PMID:22528605   PMID:22616675   PMID:22790888   PMID:23186588   PMID:23201260   PMID:23249537   PMID:23382219   PMID:23520364   PMID:23771671  
PMID:24154957   PMID:24378336   PMID:24387161   PMID:24755854   PMID:24798490   PMID:25367719   PMID:25592684   PMID:25634810   PMID:25680470   PMID:26130762   PMID:26475709   PMID:26686228  
PMID:26836462   PMID:27385722   PMID:27595323   PMID:27626375   PMID:27802438   PMID:28979194   PMID:29219199   PMID:29550358   PMID:29560791   PMID:29608947   PMID:29636447   PMID:29932348  
PMID:30196147   PMID:31074048   PMID:31115830   PMID:31269659   PMID:31950033   PMID:32145326   PMID:33902429   PMID:34622458   PMID:36397224  


Genomics

Comparative Map Data
P2rx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2370,080,850 - 70,124,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,080,851 - 70,125,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,462,764 - 73,506,383 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0382,061,439 - 82,105,058 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0379,819,891 - 79,863,521 (-)NCBIRnor_WKY
Rnor_6.0372,403,992 - 72,447,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,403,993 - 72,447,801 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,914,029 - 78,958,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,228,045 - 68,270,751 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1368,124,416 - 68,167,123 (-)NCBI
Celera369,431,850 - 69,475,670 (-)NCBICelera
Cytogenetic Map3q24NCBI
P2RX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,335,950 - 57,372,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1157,338,352 - 57,372,396 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,105,826 - 57,139,869 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,862,525 - 56,894,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 341156,862,524 - 56,894,125NCBI
Celera1154,464,979 - 54,477,411 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,454,728 - 53,486,434 (+)NCBIHuRef
CHM1_11156,971,953 - 57,003,678 (+)NCBICHM1_1
T2T-CHM13v2.01157,287,846 - 57,321,889 (+)NCBIT2T-CHM13v2.0
P2rx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,826,893 - 84,867,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,828,927 - 84,867,806 (-)EnsemblGRCm39 Ensembl
GRCm38284,996,549 - 85,037,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,998,583 - 85,037,462 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,836,709 - 84,875,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,797,391 - 84,836,673 (-)NCBIMGSCv36mm8
Celera286,595,241 - 86,634,592 (-)NCBICelera
Cytogenetic Map2DNCBI
P2rx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,389,717 - 2,411,008 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555112,389,717 - 2,410,968 (+)NCBIChiLan1.0ChiLan1.0
P2RX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13160,070,860 - 160,104,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,070,875 - 160,106,120 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01152,579,190 - 52,614,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
P2RX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,773,930 - 38,801,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,772,529 - 38,802,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,319,548 - 38,346,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,455,279 - 39,482,558 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,453,201 - 39,482,831 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11839,035,826 - 39,065,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,609,330 - 38,638,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,242,142 - 39,269,413 (-)NCBIUU_Cfam_GSD_1.0
P2rx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494715,002,140 - 15,032,591 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365815,115,492 - 5,146,634 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365815,116,276 - 5,146,378 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,584,925 - 13,617,785 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,584,913 - 13,619,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2213,347,685 - 13,381,122 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,872,124 - 15,906,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038113,214,882 - 113,249,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,229,979 - 3,253,094 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248643,233,019 - 3,253,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2rx3
233 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:148
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000033427
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat

Markers in Region
RH139270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2370,080,953 - 70,081,198 (+)MAPPERmRatBN7.2
Rnor_6.0372,404,096 - 72,404,340NCBIRnor6.0
Rnor_5.0378,914,133 - 78,914,377UniSTSRnor5.0
RGSC_v3.4368,228,149 - 68,228,393UniSTSRGSC3.4
Celera369,431,954 - 69,432,198UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 4 45 29 18 29 1 1 46 35 40 11 1
Below cutoff 35 12 12 1 12 7 10 28 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033427   ⟹   ENSRNOP00000031629
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl370,080,851 - 70,125,178 (-)Ensembl
Rnor_6.0 Ensembl372,403,993 - 72,445,775 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077573   ⟹   ENSRNOP00000071698
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl370,080,851 - 70,125,178 (-)Ensembl
Rnor_6.0 Ensembl372,403,993 - 72,445,775 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088815   ⟹   ENSRNOP00000072187
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl372,405,837 - 72,447,801 (-)Ensembl
RefSeq Acc Id: NM_001270621   ⟹   NP_001257550
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2370,080,850 - 70,122,638 (-)NCBI
Rnor_6.0372,403,992 - 72,445,775 (-)NCBI
Rnor_5.0378,914,029 - 78,958,459 (-)NCBI
Celera369,431,850 - 69,473,642 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031075   ⟹   NP_112337
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2370,080,850 - 70,122,638 (-)NCBI
Rnor_6.0372,403,992 - 72,445,775 (-)NCBI
Rnor_5.0378,914,029 - 78,958,459 (-)NCBI
RGSC_v3.4368,228,045 - 68,270,751 (-)RGD
Celera369,431,850 - 69,473,642 (-)NCBI
Sequence:
RefSeq Acc Id: NR_073054
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2370,080,850 - 70,124,664 (-)NCBI
Rnor_6.0372,403,992 - 72,447,801 (-)NCBI
Rnor_5.0378,914,029 - 78,958,459 (-)NCBI
Celera369,431,850 - 69,475,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105918   ⟹   XP_038961846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2370,080,850 - 70,124,339 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_112337   ⟸   NM_031075
- Peptide Label: isoform 1
- UniProtKB: P49654 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257550   ⟸   NM_001270621
- Peptide Label: isoform 2
- UniProtKB: P49654 (UniProtKB/Swiss-Prot),   Q9R1K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031629   ⟸   ENSRNOT00000033427
RefSeq Acc Id: ENSRNOP00000071698   ⟸   ENSRNOT00000077573
RefSeq Acc Id: ENSRNOP00000072187   ⟸   ENSRNOT00000088815
RefSeq Acc Id: XP_038961846   ⟸   XM_039105918
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QGY3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49654-F1-model_v2 AlphaFold P49654 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620253 AgrOrtholog
BioCyc Gene G2FUF-49140 BioCyc
Ensembl Genes ENSRNOG00000008552 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000031629 ENTREZGENE
  ENSRNOP00000031629.6 UniProtKB/TrEMBL
  ENSRNOP00000071698.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033427 ENTREZGENE
  ENSRNOT00000033427.7 UniProtKB/TrEMBL
  ENSRNOT00000077573.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134300 IMAGE-MGC_LOAD
InterPro P2X3_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81739 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93384 IMAGE-MGC_LOAD
NCBI Gene 81739 ENTREZGENE
PANTHER PTHR10125:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx3 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS P2X3RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs P2X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K147_RAT UniProtKB/TrEMBL
  A0A8L2QGY3 ENTREZGENE, UniProtKB/TrEMBL
  P2RX3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HM4_RAT UniProtKB/TrEMBL
  Q9R1K3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2rx3  purinergic receptor P2X 3  P2rx3  purinergic receptor P2X, ligand-gated ion channel, 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 P2rx3  purinergic receptor P2X, ligand-gated ion channel, 3    purinergic receptor P2X ligand-gated ion channel, 3  Name updated 1299863 APPROVED
2002-08-07 P2rx3  purinergic receptor P2X ligand-gated ion channel, 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms heteromer with P2X2 to create the ATP-activated currents seen in sensory neurons 728995