Neurod1 (neuronal differentiation 1) - Rat Genome Database

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Gene: Neurod1 (neuronal differentiation 1) Rattus norvegicus
Analyze
Symbol: Neurod1
Name: neuronal differentiation 1
RGD ID: 3165
Description: Enables double-stranded DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic helix-loop-helix factor 1; BHF-1; neurogenic differentiation 1; neurogenic differentiation factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,766,483 - 84,770,454 (-)NCBIGRCr8
mRatBN7.2364,359,554 - 64,363,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx367,711,247 - 67,715,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,294,848 - 76,298,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,041,670 - 74,045,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,414,314 - 66,417,617 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,974,876 - 72,978,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,224,633 - 62,227,936 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1362,121,017 - 62,124,302 (-)NCBI
Celera363,819,711 - 63,823,202 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. Boraska V, etal., Croat Med J. 2006 Aug;47(4):571-8.
2. Thyroid hormone regulates the expression of NeuroD/BHF1 during the development of rat cerebellum. Chantoux F and Francon J, Mol Cell Endocrinol. 2002 Aug 30;194(1-2):157-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1. Gonsorcikova L, etal., Pediatr Diabetes. 2008 Aug;9(4 Pt 2):367-72. Epub 2008 Mar 5.
6. Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. Jackson AE, etal., Diabetes. 2004 Aug;53(8):2122-5.
7. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. Kaneto H, etal., J Biol Chem 2002 Apr 12;277(15):12998-3006.
8. Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis. Kavvoura FK and Ioannidis JP, Hum Genet. 2005 Feb;116(3):192-9. Epub 2004 Dec 11.
9. Cloning and expression of a rat brain basic helix-loop-helix factor. Kawakami H, etal., Biochem Biophys Res Commun 1996 Apr 5;221(1):199-204.
10. MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1. Kristinsson SY, etal., Diabetologia. 2001 Nov;44(11):2098-103.
11. Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model. Krugel H, etal., J Neurochem. 2006 Apr;97 Suppl 1:74-81.
12. Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese. Liu L, etal., Mol Cell Biochem. 2006 Oct;290(1-2):199-204. Epub 2006 Jun 14.
13. A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family. Liu L, etal., Mol Cell Biochem. 2007 Sep;303(1-2):115-20. Epub 2007 Apr 18.
14. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Malecki MT, etal., Nat Genet. 1999 Nov;23(3):323-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Endocrine pancreatic tissue plasticity in obese humans is associated with cytoplasmic expression of PBX-1 in pancreatic ductal cells. Muharram G, etal., Biochem Biophys Res Commun. 2005 Aug 12;333(4):1153-9.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Overexpression of NeuroD in PC12 cells alters morphology and enhances expression of the adenylate kinase isozyme 1 gene. Noma T, etal., Brain Res Mol Brain Res 1999 Apr 6;67(1):53-63.
19. The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women. Oliveira CS, etal., Diabetes Metab. 2005 Dec;31(6):599-602.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization. Petersen HV, etal., FEBS Lett 2002 Sep 25;528(1-3):241-5.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus. Plengvidhya N, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):847-53. Epub 2008 Sep 22.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes. Vella A, etal., Diabetes. 2004 Apr;53(4):1158-61.
Additional References at PubMed
PMID:9308961   PMID:9512516   PMID:10398678   PMID:10639171   PMID:10804213   PMID:10868931   PMID:11152640   PMID:11861467   PMID:11891657   PMID:11981044   PMID:12368292   PMID:12477932  
PMID:14697366   PMID:14741104   PMID:14752053   PMID:15121856   PMID:15701640   PMID:15793245   PMID:16055439   PMID:16321656   PMID:16368089   PMID:17941991   PMID:17988662   PMID:18007592  
PMID:18388149   PMID:18462699   PMID:18848628   PMID:19272376   PMID:19619559   PMID:22513373   PMID:24338128   PMID:33340723  


Genomics

Comparative Map Data
Neurod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,766,483 - 84,770,454 (-)NCBIGRCr8
mRatBN7.2364,359,554 - 64,363,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx367,711,247 - 67,715,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,294,848 - 76,298,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,041,670 - 74,045,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,414,314 - 66,417,617 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,974,876 - 72,978,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,224,633 - 62,227,936 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1362,121,017 - 62,124,302 (-)NCBI
Celera363,819,711 - 63,823,202 (-)NCBICelera
Cytogenetic Map3q24NCBI
NEUROD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382181,668,295 - 181,680,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2181,668,295 - 181,680,827 (-)EnsemblGRCh38hg38GRCh38
GRCh372182,533,022 - 182,545,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,249,439 - 182,253,626 (-)NCBINCBI36Build 36hg18NCBI36
Build 342182,366,700 - 182,370,760NCBI
Celera2176,137,248 - 176,141,434 (-)NCBICelera
Cytogenetic Map2q31.3NCBI
HuRef2174,397,426 - 174,401,985 (-)NCBIHuRef
CHM1_12182,546,618 - 182,551,246 (-)NCBICHM1_1
T2T-CHM13v2.02182,158,398 - 182,170,625 (-)NCBIT2T-CHM13v2.0
Neurod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,282,981 - 79,286,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,282,865 - 79,287,095 (-)EnsemblGRCm39 Ensembl
GRCm38279,452,637 - 79,456,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,452,521 - 79,456,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,292,798 - 79,296,793 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36279,253,480 - 79,257,475 (-)NCBIMGSCv36mm8
Celera281,111,974 - 81,115,969 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.58NCBI
Neurod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540315,595,888 - 15,600,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540315,595,888 - 15,600,040 (+)NCBIChiLan1.0ChiLan1.0
NEUROD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,325,674 - 84,329,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,339,191 - 84,344,931 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B68,939,341 - 68,943,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B186,749,155 - 186,753,541 (-)NCBIpanpan1.1PanPan1.1panPan2
NEUROD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13624,853,591 - 24,857,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3624,876,367 - 24,880,645 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03625,015,921 - 25,020,202 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13625,105,431 - 25,109,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03625,071,760 - 25,074,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,205,991 - 25,210,288 (-)NCBIUU_Cfam_GSD_1.0
Neurod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303141,867,918 - 141,872,050 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,423,126 - 10,424,196 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,421,821 - 10,425,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEUROD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,175,765 - 87,179,959 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11587,175,629 - 87,179,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21596,661,749 - 96,664,352 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEUROD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,203,714 - 67,208,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,205,141 - 67,206,211 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040132,367,194 - 132,371,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Neurod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,494,677 - 3,497,759 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248443,493,819 - 3,497,814 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Neurod1
6 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir383rno-miR-383-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir30c1rno-miR-30c-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:63
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000007662
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
UniSTS:158749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,878 - 64,361,382 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,971 - 66,415,474NCBIRnor6.0
Rnor_5.0372,975,533 - 72,976,036UniSTSRnor5.0
RGSC_v3.4362,225,290 - 62,225,793UniSTSRGSC3.4
Celera363,820,368 - 63,820,871UniSTS
Cytogenetic Map3q24-q32UniSTS
RH80773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,692 - 64,360,878 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,785 - 66,414,970NCBIRnor6.0
Rnor_5.0372,975,347 - 72,975,532UniSTSRnor5.0
RGSC_v3.4362,225,104 - 62,225,289UniSTSRGSC3.4
Celera363,820,182 - 63,820,367UniSTS
Cytogenetic Map3q24-q32UniSTS
U28068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,590 - 64,360,743 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,683 - 66,414,835NCBIRnor6.0
Rnor_5.0372,975,245 - 72,975,397UniSTSRnor5.0
RGSC_v3.4362,225,002 - 62,225,154UniSTSRGSC3.4
Celera363,820,080 - 63,820,232UniSTS
Cytogenetic Map3q24-q32UniSTS
PMC85623P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,363,750 - 64,363,905 (+)MAPPERmRatBN7.2
Rnor_6.0366,417,842 - 66,417,996NCBIRnor6.0
Rnor_5.0372,978,404 - 72,978,558UniSTSRnor5.0
RGSC_v3.4362,228,161 - 62,228,315UniSTSRGSC3.4
Celera363,823,427 - 63,823,581UniSTS
Cytogenetic Map3q24-q32UniSTS
PMC140695P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,827 - 64,361,214 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,920 - 66,415,306NCBIRnor6.0
Rnor_5.0372,975,482 - 72,975,868UniSTSRnor5.0
RGSC_v3.4362,225,239 - 62,225,625UniSTSRGSC3.4
Celera363,820,317 - 63,820,703UniSTS
Cytogenetic Map3q24-q32UniSTS
PMC85623P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,835 - 64,361,122 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,928 - 66,415,214NCBIRnor6.0
Rnor_5.0372,975,490 - 72,975,776UniSTSRnor5.0
RGSC_v3.4362,225,247 - 62,225,533UniSTSRGSC3.4
Celera363,820,325 - 63,820,611UniSTS
Cytogenetic Map3q24-q32UniSTS
UniSTS:274183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,361,295 - 64,361,524 (+)MAPPERmRatBN7.2
Rnor_6.0366,415,388 - 66,415,616NCBIRnor6.0
Rnor_5.0372,975,950 - 72,976,178UniSTSRnor5.0
RGSC_v3.4362,225,707 - 62,225,935UniSTSRGSC3.4
Celera363,820,785 - 63,821,013UniSTS
Cytogenetic Map3q24-q32UniSTS
Neurod1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,360,893 - 64,361,106 (+)MAPPERmRatBN7.2
Rnor_6.0366,414,986 - 66,415,198NCBIRnor6.0
Rnor_5.0372,975,548 - 72,975,760UniSTSRnor5.0
RGSC_v3.4362,225,305 - 62,225,517UniSTSRGSC3.4
Celera363,820,383 - 63,820,595UniSTS
Cytogenetic Map3q24-q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 55
Low 3 19 6
Below cutoff 6 4 3 4 5 5 15 3 5

Sequence


RefSeq Acc Id: ENSRNOT00000007662   ⟹   ENSRNOP00000007662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)Ensembl
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl366,414,318 - 66,417,611 (-)Ensembl
RefSeq Acc Id: NM_019218   ⟹   NP_062091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8384,766,483 - 84,770,454 (-)NCBI
mRatBN7.2364,359,554 - 64,363,526 (-)NCBI
Rnor_6.0366,414,314 - 66,417,617 (-)NCBI
Rnor_5.0372,974,876 - 72,978,179 (-)NCBI
RGSC_v3.4362,224,633 - 62,227,936 (-)RGD
Celera363,819,711 - 63,823,202 (-)RGD
Sequence:
RefSeq Acc Id: NP_062091   ⟸   NM_019218
- UniProtKB: Q569P0 (UniProtKB/Swiss-Prot),   Q64289 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007662   ⟸   ENSRNOT00000007662
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64289-F1-model_v2 AlphaFold Q64289 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692176
Promoter ID:EPDNEW_R2692
Type:single initiation site
Name:Neurod1_1
Description:neuronal differentiation 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0366,417,629 - 66,417,689EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3165 AgrOrtholog
BioCyc Gene G2FUF-49239 BioCyc
Ensembl Genes ENSRNOG00000005609 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021577 UniProtKB/Swiss-Prot
  ENSRNOG00060014755 UniProtKB/Swiss-Prot
  ENSRNOG00065023756 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007662 ENTREZGENE
  ENSRNOT00000007662.8 UniProtKB/Swiss-Prot
  ENSRNOT00055036883 UniProtKB/Swiss-Prot
  ENSRNOT00060025223 UniProtKB/Swiss-Prot
  ENSRNOT00065040696 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312547 IMAGE-MGC_LOAD
  IMAGE:7318277 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NeuroD_DUF UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TF_bHLH_NeuroD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29458 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105447 IMAGE-MGC_LOAD
  MGC:105448 IMAGE-MGC_LOAD
NCBI Gene 29458 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROGENIC DIFFERENTIATION FACTOR 1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_bHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Neurod1 PhenoGen
PIRSF bHLH_NeuroD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005609 RatGTEx
  ENSRNOG00055021577 RatGTEx
  ENSRNOG00060014755 RatGTEx
  ENSRNOG00065023756 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HML3_RAT UniProtKB/TrEMBL
  NDF1_RAT UniProtKB/Swiss-Prot
  Q569P0 ENTREZGENE
  Q64289 ENTREZGENE
UniProt Secondary Q569P0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Neurod1  neuronal differentiation 1  Neurod1  neurogenic differentiation 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Neurod1  neurogenic differentiation 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates Adenylate kinase isozyme 1 (AK1) expression in PC12 cells 727267