NEUROD1 (neuronal differentiation 1) - Rat Genome Database

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Gene: NEUROD1 (neuronal differentiation 1) Chlorocebus sabaeus
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Symbol: NEUROD1
Name: neuronal differentiation 1
RGD ID: 18532426
Description: ENCODES a protein that exhibits double-stranded DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); camera-type eye development (ortholog); cell fate commitment (ortholog); ASSOCIATED WITH diabetes mellitus (ortholog); Experimental Diabetes Mellitus (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); RNA polymerase II transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neurogenic differentiation factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,203,714 - 67,208,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,205,141 - 67,206,211 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040132,367,194 - 132,371,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amacrine cell differentiation  (IEA)
anterior/posterior pattern specification  (IEA,ISO)
axon development  (IEA)
camera-type eye development  (IEA,ISO)
cell differentiation  (IEA)
cell fate commitment  (IEA,ISO)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cerebellum development  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
embryonic organ morphogenesis  (IEA)
endocrine pancreas development  (IEA)
enteroendocrine cell differentiation  (IEA)
glucose homeostasis  (IEA)
hindbrain development  (IEA,ISO)
inner ear development  (IEA)
insulin secretion  (IEA,ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
negative regulation of type B pancreatic cell apoptotic process  (IEA)
nervous system development  (IEA)
nucleocytoplasmic transport  (ISO)
pancreatic A cell fate commitment  (IEA,ISO)
pancreatic PP cell fate commitment  (IEA,ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of cell differentiation  (IEA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of intestinal epithelial structure maintenance  (IEA)
regulation of neuron differentiation  (IEA,ISO)
response to glucose  (IEA)
sensory organ development  (IEA)
signal transduction involved in regulation of gene expression  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
NEUROD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,203,714 - 67,208,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,205,141 - 67,206,211 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040132,367,194 - 132,371,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NEUROD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382181,668,295 - 181,680,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2181,668,295 - 181,680,827 (-)EnsemblGRCh38hg38GRCh38
GRCh372182,533,022 - 182,545,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,249,439 - 182,253,626 (-)NCBINCBI36Build 36hg18NCBI36
Build 342182,366,700 - 182,370,760NCBI
Celera2176,137,248 - 176,141,434 (-)NCBICelera
Cytogenetic Map2q31.3NCBI
HuRef2174,397,426 - 174,401,985 (-)NCBIHuRef
CHM1_12182,546,618 - 182,551,246 (-)NCBICHM1_1
T2T-CHM13v2.02182,158,398 - 182,170,625 (-)NCBIT2T-CHM13v2.0
Neurod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,282,981 - 79,286,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,282,865 - 79,287,095 (-)EnsemblGRCm39 Ensembl
GRCm38279,452,637 - 79,456,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,452,521 - 79,456,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,292,798 - 79,296,793 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36279,253,480 - 79,257,475 (-)NCBIMGSCv36mm8
Celera281,111,974 - 81,115,969 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.58NCBI
Neurod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,766,483 - 84,770,454 (-)NCBIGRCr8
mRatBN7.2364,359,554 - 64,363,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,359,395 - 64,363,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx367,711,247 - 67,715,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,294,848 - 76,298,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,041,670 - 74,045,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,414,314 - 66,417,617 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,974,876 - 72,978,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,224,633 - 62,227,936 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1362,121,017 - 62,124,302 (-)NCBI
Celera363,819,711 - 63,823,202 (-)NCBICelera
Cytogenetic Map3q24NCBI
Neurod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540315,595,888 - 15,600,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540315,595,888 - 15,600,040 (+)NCBIChiLan1.0ChiLan1.0
NEUROD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,325,674 - 84,329,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,339,191 - 84,344,931 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B68,939,341 - 68,943,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B186,749,155 - 186,753,541 (-)NCBIpanpan1.1PanPan1.1panPan2
NEUROD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13624,853,591 - 24,857,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3624,876,367 - 24,880,645 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03625,015,921 - 25,020,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3625,017,362 - 25,018,352 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13625,105,431 - 25,109,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03625,071,760 - 25,074,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,205,991 - 25,210,288 (-)NCBIUU_Cfam_GSD_1.0
Neurod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303141,867,918 - 141,872,050 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,423,126 - 10,424,196 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,421,821 - 10,425,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEUROD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,175,765 - 87,179,959 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11587,175,629 - 87,179,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21596,661,749 - 96,664,352 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Neurod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,494,677 - 3,497,759 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248443,493,819 - 3,497,814 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
40 20 17 17 17 40 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007965536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000018742   ⟹   ENSCSAP00000018178
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1067,205,141 - 67,206,211 (-)Ensembl
RefSeq Acc Id: XM_007965536   ⟹   XP_007963727
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11067,203,714 - 67,208,644 (-)NCBI
Vero_WHO_p1.0NW_023666040132,367,194 - 132,371,760 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007963727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000018178
  ENSCSAP00000018178.1
RefSeq Acc Id: XP_007963727   ⟸   XM_007965536
- UniProtKB: A0A0D9SBD9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000018178   ⟸   ENSCSAT00000018742


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018742.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  bHLH_transcription_factors UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Neurogenic_DUF UniProtKB/TrEMBL
  TF_bHLH_NeuroD UniProtKB/TrEMBL
KEGG Report csab:103217452 UniProtKB/TrEMBL
NCBI Gene NEUROD1 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/TrEMBL
  PTHR19290:SF88 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  Neuro_bHLH UniProtKB/TrEMBL
PIRSF bHLH_NeuroD UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A0D9SBD9 ENTREZGENE, UniProtKB/TrEMBL