Neurod1 (neurogenic differentiation 1) - Rat Genome Database

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Gene: Neurod1 (neurogenic differentiation 1) Mus musculus
Analyze
Symbol: Neurod1
Name: neurogenic differentiation 1
RGD ID: 735545
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including enteroendocrine cell differentiation; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study type 1 diabetes mellitus 7. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-cell E-box transcriptional activator 2; BETA2; BHF-1; bHLH; bHLHa3; Nd; Nd1; Neu; Neurod; neurogenic differentiation factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,282,981 - 79,286,980 (-)NCBIGRCm39mm39
GRCm39 Ensembl279,282,865 - 79,287,095 (-)Ensembl
GRCm38279,452,637 - 79,456,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,452,521 - 79,456,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,292,798 - 79,296,793 (-)NCBIGRCm37mm9NCBIm37
MGSCv36279,253,480 - 79,257,475 (-)NCBImm8
Celera281,111,974 - 81,115,969 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amacrine cell differentiation  (IDA)
anterior/posterior pattern specification  (IMP)
camera-type eye development  (IGI)
cell differentiation  (IEA)
cell fate commitment  (IGI)
cellular response to glucose stimulus  (ISO)
cerebellum development  (IMP,ISO)
dentate gyrus development  (IGI,IMP)
embryonic organ morphogenesis  (IMP)
endocrine pancreas development  (IMP)
enteroendocrine cell differentiation  (IMP)
glucose homeostasis  (IMP)
hindbrain development  (IMP)
inner ear development  (IMP)
insulin secretion  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (IDA)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
nervous system development  (IEA)
neuron development  (IEA)
neuron differentiation  (IBA)
nitric oxide mediated signal transduction  (ISO)
nucleocytoplasmic transport  (ISO)
pancreatic A cell fate commitment  (IGI)
pancreatic PP cell fate commitment  (IGI)
positive regulation of apoptotic process  (IDA)
positive regulation of cell differentiation  (IDA)
positive regulation of DNA-binding transcription factor activity  (IDA,ISO)
positive regulation of neuron differentiation  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of transcription, DNA-templated  (IDA)
regulation of intestinal epithelial structure maintenance  (IDA)
regulation of neuron differentiation  (IGI)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
response to glucose  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction involved in regulation of gene expression  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amacrine cell morphology  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal head movements  (IAGP)
abnormal hippocampus CA4 region morphology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal hippocampus granule cell layer  (IAGP)
abnormal hippocampus granule cell morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal intestinal enteroendocrine cell morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal retinal apoptosis  (IAGP)
abnormal retinal bipolar cell morphology  (IAGP)
abnormal retinal cone cell morphology  (IAGP)
abnormal retinal ganglion cell morphology  (IAGP)
abnormal retinal ganglion layer morphology  (IAGP)
abnormal retinal horizontal cell morphology  (IAGP)
abnormal retinal inner nuclear layer morphology  (IAGP)
abnormal retinal layer morphology  (IAGP)
abnormal retinal neuronal layer morphology  (IAGP)
abnormal retinal outer nuclear layer morphology  (IAGP)
abnormal retinal photoreceptor layer morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal vestibular ganglion morphology  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
absent amacrine cells  (IAGP)
absent cochlear ganglion  (IAGP)
absent dentate gyrus  (IAGP)
absent endocochlear potential  (IAGP)
absent pancreatic islets  (IAGP)
ataxia  (IAGP)
circling  (IAGP)
deafness  (IAGP)
decreased amacrine cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased pancreatic alpha cell number  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic delta cell number  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased retinal cone cell number  (IAGP)
decreased retinal ganglion cell number  (IAGP)
decreased retinal photoreceptor cell number  (IAGP)
decreased sensory neuron number  (IAGP)
decreased solitary pulmonary neuroendocrine cell number  (IAGP)
dehydration  (IAGP)
disorganized retinal outer nuclear layer  (IAGP)
head tilt  (IAGP)
head tossing  (IEA)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
impaired ability to fire action potentials  (IAGP)
impaired balance  (IAGP)
impaired lung alveolus development  (IAGP)
increased number of pulmonary neuroendocrine bodies  (IAGP)
increased pancreas apoptosis  (IAGP)
increased retinal apoptosis  (IAGP)
increased retinal ganglion cell number  (IAGP)
ketoaciduria  (IAGP)
overexpanded pulmonary alveoli  (IAGP)
pancreatic acinar cell zymogen granule accumulation  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
reduced cochlear modiolus  (IAGP)
seizures  (IAGP)
small cerebellum  (IAGP)
sporadic seizures  (IAGP)
thin external granule cell layer  (IAGP)
thin retinal inner nuclear layer  (IAGP)
tonic-clonic seizures  (IAGP)
References

References - curated
1. Boraska V, etal., Croat Med J. 2006 Aug;47(4):571-8.
2. Gonsorcikova L, etal., Pediatr Diabetes. 2008 Aug;9(4 Pt 2):367-72. Epub 2008 Mar 5.
3. Jackson AE, etal., Diabetes. 2004 Aug;53(8):2122-5.
4. Kavvoura FK and Ioannidis JP, Hum Genet. 2005 Feb;116(3):192-9. Epub 2004 Dec 11.
5. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Kawakami H, etal., Biochem Biophys Res Commun 1996 Apr 5;221(1):199-204.
7. Kristinsson SY, etal., Diabetologia. 2001 Nov;44(11):2098-103.
8. Liu L, etal., Mol Cell Biochem. 2006 Oct;290(1-2):199-204. Epub 2006 Jun 14.
9. Liu L, etal., Mol Cell Biochem. 2007 Sep;303(1-2):115-20. Epub 2007 Apr 18.
10. Ma Q, etal., Cell 1996 Oct 4;87(1):43-52.
11. Malecki MT, etal., Nat Genet. 1999 Nov;23(3):323-8.
12. MGD and Homologene mouse data transfer
13. MGD data from the GO Consortium
14. MGD IEA
15. Muharram G, etal., Biochem Biophys Res Commun. 2005 Aug 12;333(4):1153-9.
16. Oliveira CS, etal., Diabetes Metab. 2005 Dec;31(6):599-602.
17. OMIM Disease Annotation Pipeline
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Plengvidhya N, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):847-53. Epub 2008 Sep 22.
20. RGD automated import pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Vella A, etal., Diabetes. 2004 Apr;53(4):1158-61.
Additional References at PubMed
PMID:2137249   PMID:7754368   PMID:8786144   PMID:8816493   PMID:8889548   PMID:8915591   PMID:9000438   PMID:9102301   PMID:9108377   PMID:9308961   PMID:9512516   PMID:9520323  
PMID:9539122   PMID:9539123   PMID:9647776   PMID:9806930   PMID:9834183   PMID:10349636   PMID:10398678   PMID:10398684   PMID:10476967   PMID:10575234   PMID:10603349   PMID:10615124  
PMID:10639171   PMID:10640277   PMID:10655590   PMID:10677506   PMID:10725233   PMID:10757813   PMID:10767080   PMID:10781944   PMID:10804213   PMID:10842072   PMID:10868931   PMID:10903178  
PMID:10952889   PMID:10976052   PMID:11032813   PMID:11042159   PMID:11060228   PMID:11076861   PMID:11086988   PMID:11090132   PMID:11152640   PMID:11222142   PMID:11239431   PMID:11313460  
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PMID:20058311   PMID:20059953   PMID:20071536   PMID:20080708   PMID:20107170   PMID:20110327   PMID:20144606   PMID:20211142   PMID:20233719   PMID:20374962   PMID:20412781   PMID:20413507  
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PMID:28507510   PMID:28576773   PMID:28766169   PMID:28837861   PMID:28838968   PMID:28925510   PMID:28958789   PMID:28965759   PMID:29021239   PMID:29137925   PMID:29259128   PMID:29272356  
PMID:29352015   PMID:29352183   PMID:29395133   PMID:29578405   PMID:29588831   PMID:29650591   PMID:29684311   PMID:29770538   PMID:29867343   PMID:29910119   PMID:30008200   PMID:30048641  
PMID:30135482   PMID:30307165   PMID:30392794   PMID:30485816   PMID:30504125   PMID:30541910   PMID:30635555   PMID:30638745   PMID:30692224   PMID:30723302   PMID:30917305   PMID:30917309  
PMID:31065682   PMID:31171666   PMID:31519700   PMID:31526806   PMID:31634536   PMID:31668390   PMID:31776253   PMID:31801063   PMID:31862906   PMID:31918020   PMID:31991126   PMID:32027432  
PMID:32541002   PMID:32579914   PMID:32708917   PMID:32857951   PMID:32880858   PMID:32994168   PMID:33192541   PMID:33492553   PMID:33527355   PMID:33591268   PMID:33795231  


Genomics

Comparative Map Data
Neurod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,282,981 - 79,286,980 (-)NCBIGRCm39mm39
GRCm39 Ensembl279,282,865 - 79,287,095 (-)Ensembl
GRCm38279,452,637 - 79,456,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,452,521 - 79,456,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,292,798 - 79,296,793 (-)NCBIGRCm37mm9NCBIm37
MGSCv36279,253,480 - 79,257,475 (-)NCBImm8
Celera281,111,974 - 81,115,969 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.58NCBI
NEUROD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2181,668,295 - 181,680,827 (-)EnsemblGRCh38hg38GRCh38
GRCh382181,668,295 - 181,680,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372182,533,022 - 182,545,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,249,439 - 182,253,626 (-)NCBINCBI36hg18NCBI36
Build 342182,366,700 - 182,370,760NCBI
Celera2176,137,248 - 176,141,434 (-)NCBI
Cytogenetic Map2q31.3NCBI
HuRef2174,397,426 - 174,401,985 (-)NCBIHuRef
CHM1_12182,546,618 - 182,551,246 (-)NCBICHM1_1
Neurod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2364,360,222 - 64,363,526 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl366,414,308 - 66,417,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0366,414,314 - 66,417,617 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0372,974,876 - 72,978,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,224,633 - 62,227,936 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1362,121,017 - 62,124,302 (-)NCBI
Celera363,819,711 - 63,823,202 (-)NCBICelera
Cytogenetic Map3q24NCBI
Neurod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540315,595,888 - 15,600,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540315,595,888 - 15,600,040 (+)NCBIChiLan1.0ChiLan1.0
NEUROD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B186,749,155 - 186,753,541 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02B68,939,341 - 68,943,516 (-)NCBIMhudiblu_PPA_v0panPan3
NEUROD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13624,853,591 - 24,857,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3624,876,367 - 24,880,645 (-)NCBI
ROS_Cfam_1.03625,015,921 - 25,020,202 (-)NCBI
UMICH_Zoey_3.13625,105,431 - 25,109,707 (-)NCBI
UNSW_CanFamBas_1.03625,071,760 - 25,074,709 (-)NCBI
UU_Cfam_GSD_1.03625,205,991 - 25,210,288 (-)NCBI
Neurod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303141,867,918 - 141,872,050 (-)NCBI
SpeTri2.0NW_00493650910,421,821 - 10,425,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEUROD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,175,764 - 87,179,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11587,175,629 - 87,179,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21596,661,749 - 96,664,352 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEUROD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,203,714 - 67,208,644 (-)NCBI
ChlSab1.1 Ensembl1067,205,141 - 67,206,211 (-)Ensembl
Vero_WHO_p1.0NW_023666040132,367,194 - 132,371,760 (+)NCBI
Neurod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248443,493,819 - 3,497,814 (-)NCBI

Position Markers
U28068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,453,675 - 79,453,825UniSTSGRCm38
MGSCv37279,293,832 - 79,293,982UniSTSGRCm37
Celera281,113,008 - 81,113,158UniSTS
Cytogenetic Map2C3UniSTS
cM Map246.0UniSTS
Whitehead_YAC2 UniSTS
Neurod1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,453,964 - 79,454,977UniSTSGRCm38
MGSCv37279,294,121 - 79,295,134UniSTSGRCm37
Celera281,113,297 - 81,114,310UniSTS
Cytogenetic Map2C3UniSTS
cM Map246.0UniSTS
cM Map246.0UniSTS
PMC140695P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,453,910 - 79,454,296UniSTSGRCm38
MGSCv37279,294,067 - 79,294,453UniSTSGRCm37
Celera281,113,243 - 81,113,629UniSTS
Cytogenetic Map2C3UniSTS
cM Map246.0UniSTS
NEUROD1_221  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,452,651 - 79,453,490UniSTSGRCm38
MGSCv37279,292,808 - 79,293,647UniSTSGRCm37
Celera281,111,984 - 81,112,823UniSTS
Cytogenetic Map2C3UniSTS
cM Map246.0UniSTS
PMC85623P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,456,849 - 79,457,003UniSTSGRCm38
MGSCv37279,297,006 - 79,297,160UniSTSGRCm37
Celera281,116,182 - 81,116,336UniSTS
Cytogenetic Map2C3UniSTS
cM Map246.0UniSTS
Neurod1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,454,378 - 79,454,606UniSTSGRCm38
MGSCv37279,294,535 - 79,294,763UniSTSGRCm37
Celera281,113,711 - 81,113,939UniSTS
Cytogenetic Map2C3UniSTS
Neurod1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C3UniSTS
Neurod1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,453,976 - 79,454,188UniSTSGRCm38
MGSCv37279,294,133 - 79,294,345UniSTSGRCm37
Celera281,113,309 - 81,113,521UniSTS
Cytogenetic Map2C3UniSTS
Neurod1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38279,453,961 - 79,454,464UniSTSGRCm38
MGSCv37279,294,118 - 79,294,621UniSTSGRCm37
Celera281,113,294 - 81,113,797UniSTS
Cytogenetic Map2C3UniSTS
cM Map246.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141809Pbwg1.1_mpostnatal body weight growth 1.1 (mouse)Not determined4830206882302151Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24830206882302151Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24843940282439590Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24843940282439590Mouse
1302085Mobe1_mmodifier of obesity 1 (mouse)Not determined24843940282439590Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24843940282439590Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174843940282439590Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25098897084988970Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25109283185092934Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25187293285873081Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25261767586617792Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25261767586617792Mouse
4142299Pbwg1.4_mpostnatal body weight growth 1.4 (mouse)Not determined5562407289624172Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267817543101817798Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267817543101817798Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268893925102894063Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268893925102894063Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74693773114293051Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276591138110591306Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276848414103265478Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir19b-1mmu-miR-19b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21781967

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:272
Interacting mature miRNAs:315
Transcripts:ENSMUST00000041099
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041099   ⟹   ENSMUSP00000040364
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl279,452,521 - 79,456,751 (-)Ensembl
RefSeq Acc Id: NM_010894   ⟹   NP_035024
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39279,282,981 - 79,286,980 (-)NCBI
GRCm38279,452,637 - 79,456,636 (-)NCBI
MGSCv37279,292,798 - 79,296,793 (-)RGD
Celera281,111,974 - 81,115,969 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035024   ⟸   NM_010894
- UniProtKB: Q60867 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040364   ⟸   ENSMUST00000041099
Protein Domains
bHLH

Promoters
RGD ID:6831919
Promoter ID:MM_KWN:29884
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000088056
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36279,295,299 - 79,295,799 (-)MPROMDB
RGD ID:6831945
Promoter ID:MM_KWN:29885
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:OTTMUST00000032176,   OTTMUST00000032189
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36279,296,579 - 79,297,079 (-)MPROMDB
RGD ID:6877738
Promoter ID:EPDNEW_M2319
Type:multiple initiation site
Name:Neurod1_1
Description:Mus musculus neurogenic differentiation 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38279,456,636 - 79,456,696EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339708 AgrOrtholog
Ensembl Genes ENSMUSG00000034701 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000040364 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041099 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurod1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurogenic_DUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_bHLH_NeuroD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18012 UniProtKB/Swiss-Prot
MGD MGI:1339708 ENTREZGENE
NCBI Gene 18012 ENTREZGENE
PANTHER PTHR19290:SF88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_bHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Neurod1 PhenoGen
PIRSF bHLH_NeuroD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NDF1_MOUSE UniProtKB/Swiss-Prot
  Q505D0_MOUSE UniProtKB/TrEMBL
  Q60867 ENTREZGENE
  Q8CEI7_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q545N9 UniProtKB/Swiss-Prot
  Q60897 UniProtKB/Swiss-Prot