Calcrl (calcitonin receptor like receptor) - Rat Genome Database

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Gene: Calcrl (calcitonin receptor like receptor) Rattus norvegicus
Analyze
Symbol: Calcrl
Name: calcitonin receptor like receptor
RGD ID: 2255
Description: Predicted to enable adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in negative regulation of inflammatory response and negative regulation of smooth muscle contraction. Predicted to be located in endoplasmic reticulum; endosome; and lysosome. Predicted to be part of CGRP receptor complex and adrenomedullin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcitonin gene-related peptide type 1 receptor; calcitonin receptor-like; calcitonin receptor-like receptor; CGRP type 1 receptor; CLR; Crlr; RATCRLR; RNCLR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2369,428,348 - 69,525,910 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl369,430,120 - 69,525,910 (-)Ensembl
Rnor_6.0371,747,938 - 71,845,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,747,956 - 71,845,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,269,326 - 78,366,557 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,553,022 - 67,646,877 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1367,449,393 - 67,543,249 (-)NCBI
Celera368,788,591 - 68,882,607 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Chang CP, etal., Neuron 1993 Dec;11(6):1187-95.
2. THE ROLE OF CALCITONIN RECEPTOR-LIKE RECEPTOR IN COLONIC MOTILITY AND INFLAMMATION. Clifton MS, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar 15;.
3. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. A new calcitonin-receptor-like sequence in rat pulmonary blood vessels. Njuki F, etal., Clin Sci (Lond) 1993 Oct;85(4):385-8.
9. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex. Sueur S, etal., J Mol Cell Cardiol. 2005 Dec;39(6):955-63. Epub 2005 Oct 19.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Yoshihara F, etal., Hypertension 2001 Feb;37(2):216-22.
Additional References at PubMed
PMID:8582325   PMID:9620797   PMID:10882736   PMID:11556887   PMID:11847213   PMID:12538603   PMID:12801991   PMID:12837925   PMID:14642779   PMID:15193773   PMID:15315911   PMID:15643132  
PMID:15680493   PMID:16537897   PMID:16713642   PMID:17301036   PMID:17310067   PMID:17614212   PMID:17660394   PMID:18039931   PMID:18434369   PMID:18655130   PMID:19041918   PMID:20074556  
PMID:20596610   PMID:21034462   PMID:21040789   PMID:21111722   PMID:22102369   PMID:22208649   PMID:22233274   PMID:23570731   PMID:24177018   PMID:25061099   PMID:26927337   PMID:27338549  
PMID:29087309  


Genomics

Comparative Map Data
Calcrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2369,428,348 - 69,525,910 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl369,430,120 - 69,525,910 (-)Ensembl
Rnor_6.0371,747,938 - 71,845,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,747,956 - 71,845,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,269,326 - 78,366,557 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,553,022 - 67,646,877 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1367,449,393 - 67,543,249 (-)NCBI
Celera368,788,591 - 68,882,607 (-)NCBICelera
Cytogenetic Map3q24NCBI
CALCRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382187,341,964 - 187,448,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2187,341,964 - 187,448,460 (-)EnsemblGRCh38hg38GRCh38
GRCh372188,206,691 - 188,312,979 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,916,091 - 188,021,266 (-)NCBINCBI36hg18NCBI36
Build 342188,035,337 - 188,138,484NCBI
Celera2181,804,216 - 181,909,138 (-)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2180,066,508 - 180,172,591 (-)NCBIHuRef
CHM1_12188,212,632 - 188,318,691 (-)NCBICHM1_1
T2T-CHM13v2.02187,831,183 - 187,937,204 (-)NCBI
Calcrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,160,970 - 84,255,786 (-)NCBIGRCm39mm39
GRCm39 Ensembl284,160,970 - 84,255,755 (-)Ensembl
GRCm38284,330,626 - 84,425,405 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,330,626 - 84,425,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,170,783 - 84,265,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv36284,131,465 - 84,177,826 (-)NCBImm8
Celera285,934,298 - 86,033,453 (-)NCBICelera
Cytogenetic Map2DNCBI
Calcrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,080,874 - 11,118,494 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,016,753 - 11,118,494 (+)NCBIChiLan1.0ChiLan1.0
CALCRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B192,422,283 - 192,525,916 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B192,422,283 - 192,463,064 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B74,622,892 - 74,728,067 (-)NCBIMhudiblu_PPA_v0panPan3
CALCRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13629,342,869 - 29,442,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3629,345,236 - 29,442,732 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3629,242,232 - 29,342,195 (-)NCBI
ROS_Cfam_1.03629,565,888 - 29,666,202 (-)NCBI
ROS_Cfam_1.0 Ensembl3629,565,658 - 29,666,020 (-)Ensembl
UMICH_Zoey_3.13629,628,014 - 29,728,166 (-)NCBI
UNSW_CanFamBas_1.03629,561,790 - 29,663,178 (-)NCBI
UU_Cfam_GSD_1.03629,731,680 - 29,831,875 (-)NCBI
Calcrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303146,545,711 - 146,646,302 (-)NCBI
SpeTri2.0NW_00493650610,191,789 - 10,292,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALCRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1592,233,269 - 92,332,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11592,233,264 - 92,332,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215102,426,205 - 102,522,564 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALCRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,884,271 - 72,986,916 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,887,139 - 72,925,198 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040126,514,636 - 126,617,444 (+)NCBIVero_WHO_p1.0
Calcrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248992,487,225 - 2,594,780 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248992,487,261 - 2,593,304 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,430,219 - 69,430,414 (+)MAPPERmRatBN7.2
Rnor_6.0371,749,798 - 71,749,992NCBIRnor6.0
Rnor_5.0378,271,111 - 78,271,305UniSTSRnor5.0
RGSC_v3.4367,552,320 - 67,552,514UniSTSRGSC3.4
Celera368,787,875 - 68,788,083UniSTS
Cytogenetic Map3q24UniSTS
UniSTS:488324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,517,643 - 69,518,316 (+)MAPPERmRatBN7.2
Rnor_6.0371,837,227 - 71,837,899NCBIRnor6.0
Rnor_5.0378,358,296 - 78,358,968UniSTSRnor5.0
RGSC_v3.4367,638,872 - 67,639,544UniSTSRGSC3.4
Celera368,874,596 - 68,875,268UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map6q16UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:105
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000006462
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 32 30 22 16 22 6 6 18 29 32 11 6
Low 1 11 27 19 3 19 2 5 56 6 7 2
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078645   ⟹   ENSRNOP00000074452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,430,120 - 69,525,910 (-)Ensembl
Rnor_6.0 Ensembl371,750,500 - 71,845,232 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088170   ⟹   ENSRNOP00000070720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,430,120 - 69,473,780 (-)Ensembl
Rnor_6.0 Ensembl371,747,956 - 71,798,531 (-)Ensembl
RefSeq Acc Id: NM_012717   ⟹   NP_036849
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2369,428,350 - 69,525,910 (-)NCBI
Rnor_6.0371,750,500 - 71,845,232 (-)NCBI
Rnor_5.0378,269,326 - 78,366,557 (-)NCBI
RGSC_v3.4367,553,022 - 67,646,877 (-)RGD
Celera368,788,591 - 68,882,607 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234439   ⟹   XP_006234501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2369,428,348 - 69,525,798 (-)NCBI
Rnor_6.0371,747,938 - 71,845,402 (-)NCBI
Rnor_5.0378,269,326 - 78,366,557 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036849 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234501 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA49997 (Get FASTA)   NCBI Sequence Viewer  
  EDL79299 (Get FASTA)   NCBI Sequence Viewer  
  EDL79300 (Get FASTA)   NCBI Sequence Viewer  
  Q63118 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036849   ⟸   NM_012717
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006234501   ⟸   XM_006234439
- Peptide Label: isoform X1
- UniProtKB: Q63118 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074452   ⟸   ENSRNOT00000078645
RefSeq Acc Id: ENSRNOP00000070720   ⟸   ENSRNOT00000088170

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63118-F1-model_v2 AlphaFold Q63118 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2255 AgrOrtholog
BioCyc Gene G2FUF-49183 BioCyc
Ensembl Genes ENSRNOG00000054695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000070720 ENTREZGENE
  ENSRNOP00000074452 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078645 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000088170 ENTREZGENE
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot
InterPro GCPR_2_calcitonin_rcpt_fam UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_CGRP1_rcpt UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot
KEGG Report rno:25029 UniProtKB/Swiss-Prot
NCBI Gene 25029 ENTREZGENE
Pfam 7tm_2 UniProtKB/Swiss-Prot
  HRM UniProtKB/Swiss-Prot
PhenoGen Calcrl PhenoGen
PRINTS CGRPRECEPTOR UniProtKB/Swiss-Prot
  CTRFAMILY UniProtKB/Swiss-Prot
  GPCRSECRETIN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
SMART HormR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111418 UniProtKB/Swiss-Prot
TIGR TC230639
UniProt CALRL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-13 Calcrl  calcitonin receptor like receptor  Calcrl  calcitonin receptor-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Calcrl  calcitonin receptor-like  Calcrl  calcitonin receptor-like receptor  Name updated 629478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in chronic heart failure 625420
gene_expression expressed in lung 68902
gene_expression expressed in atria and ventricles of the heart 625420
gene_function acts as either a calcitonin gene-related peptide receptor or an adrenomedullin receptor 68718
gene_function acts as either a calcitonin gene-related peptide receptor or an adrenomedullin receptor 68902
gene_process may play a role in vascular tone maintenance 68686
gene_regulation induced by several growth factors including colony stimulating factor-1, epidermal growth factor, and Ang II 68718