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Gene: Lrp4 (LDL receptor related protein 4) Rattus norvegicus
Symbol: Lrp4
Name: LDL receptor related protein 4
RGD ID: 619731
Description: Exhibits apolipoprotein binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in dendrite morphogenesis and synapse organization. Localizes to several cellular components, including neuronal cell body; plasma membrane raft; and postsynaptic density. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4; LRP-4; Megf7; multiple epidermal growth factor-like domains 7
Homo sapiens (human) : LRP4 (LDL receptor related protein 4)  HGNC  Alliance
Mus musculus (house mouse) : Lrp4 (low density lipoprotein receptor-related protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp4 (LDL receptor related protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP4 (LDL receptor related protein 4)
Canis lupus familiaris (dog) : LRP4 (LDL receptor related protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp4 (LDL receptor related protein 4)
Sus scrofa (pig) : LRP4 (LDL receptor related protein 4)
Chlorocebus sabaeus (African green monkey) : LRP4 (LDL receptor related protein 4)
Heterocephalus glaber (naked mole-rat) : Lrp4 (LDL receptor related protein 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Celera376,634,746 - 76,688,537 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Lrp4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619731
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.