Stk39 (serine threonine kinase 39) - Rat Genome Database

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Gene: Stk39 (serine threonine kinase 39) Rattus norvegicus
Analyze
Symbol: Stk39
Name: serine threonine kinase 39
RGD ID: 621643
Description: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in positive regulation of ion transport; positive regulation of p38MAPK cascade; and protein autophosphorylation. Located in cytoskeleton and cytosol. Is extrinsic component of membrane. Orthologous to human STK39 (serine/threonine kinase 39); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pancreatic serine/threonine-protein kinase; PS/TK; PSTK1; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine kinase 39, STE20/SPS1 homolog; serine/threonine kinase 39, STE20/SPS1 homolog (yeast); serine/threonine-protein kinase 39; Spak; Ste-20 related kinase; ste-20-related kinase; STE20/SPS1-related proline-alanine-rich protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Stk39em2Mcwi   Stk39em5Mcwi   Stk39em6Mcwi  
Genetic Models: SS-Stk39em6Mcwi SS-Stk39em5Mcwi SS-Stk39em2Mcwi-/+ SS-Stk39em2Mcwi-/- SS-Stk39em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx356,307,442 - 56,572,955 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0364,891,008 - 65,156,536 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0362,649,675 - 62,915,802 (-)NCBIRnor_WKY
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Celera352,482,845 - 52,746,814 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dactolisib  (ISO)
daidzein  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
eplerenone  (ISO)
equol  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methoxyacetic acid  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosomorpholine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Rebamipide  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). Dowd BF and Forbush B, J Biol Chem. 2003 Jul 25;278(30):27347-53. Epub 2003 May 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. Geng Y, etal., J Biol Chem. 2009 May 22;284(21):14020-8. Epub 2009 Mar 23.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Johnston AM, etal., Oncogene 2000 Aug 31;19(37):4290-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia. Ushiro H, etal., Arch Biochem Biophys 1998 Jul 15;355(2):233-40.
12. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, etal., Biochem J. 2005 Oct 1;391(Pt 1):17-24.
13. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Vorontsova I, etal., Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.
Additional References at PubMed
PMID:10990492   PMID:12386165   PMID:16530727   PMID:16669787   PMID:21317537   PMID:21705622   PMID:21907141   PMID:22238094   PMID:24133122   PMID:24393035   PMID:24811174   PMID:25531585  
PMID:27400149   PMID:27782176   PMID:28755400   PMID:30053369   PMID:34396440   PMID:35163352  


Genomics

Comparative Map Data
Stk39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx356,307,442 - 56,572,955 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0364,891,008 - 65,156,536 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0362,649,675 - 62,915,802 (-)NCBIRnor_WKY
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Celera352,482,845 - 52,746,814 (-)NCBICelera
Cytogenetic Map3q21NCBI
STK39
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382167,954,022 - 168,247,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2167,954,020 - 168,247,595 (-)EnsemblGRCh38hg38GRCh38
GRCh372168,810,532 - 169,104,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362168,518,776 - 168,812,351 (-)NCBINCBI36Build 36hg18NCBI36
Build 342168,636,037 - 168,929,612NCBI
Celera2162,419,314 - 162,712,878 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2160,690,590 - 160,918,691 (-)NCBIHuRef
CHM1_12168,816,415 - 169,109,972 (-)NCBICHM1_1
T2T-CHM13v2.02168,411,922 - 168,705,066 (-)NCBIT2T-CHM13v2.0
Stk39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,040,789 - 68,302,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,040,789 - 68,302,612 (-)EnsemblGRCm39 Ensembl
GRCm38268,210,445 - 68,472,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37268,048,504 - 68,310,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,011,286 - 68,272,820 (-)NCBIMGSCv36mm8
Celera269,878,607 - 70,140,879 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
Stk39
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554496,167,752 - 6,390,736 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554496,112,726 - 6,387,925 (+)NCBIChiLan1.0ChiLan1.0
STK39
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B172,674,514 - 172,904,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B172,674,514 - 172,970,063 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B55,204,203 - 55,501,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
STK39
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13612,866,867 - 13,118,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3612,867,188 - 13,183,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3612,875,995 - 13,167,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03612,983,192 - 13,273,757 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3612,913,021 - 13,297,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,068,051 - 13,358,464 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,054,289 - 13,344,871 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,165,580 - 13,457,184 (-)NCBIUU_Cfam_GSD_1.0
Stk39
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,101,476 - 130,374,107 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646911,274,398 - 11,516,244 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK39
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,447,787 - 74,758,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11574,441,019 - 74,757,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21583,412,068 - 83,666,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK39
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,451,035 - 53,747,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,450,891 - 53,682,993 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040145,776,885 - 146,078,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk39
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247875,681,928 - 5,966,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247875,682,023 - 5,966,770 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
AW227544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,913,777 - 52,913,926 (+)MAPPERmRatBN7.2
Rnor_6.0354,359,644 - 54,359,792NCBIRnor6.0
Rnor_5.0360,973,636 - 60,973,784UniSTSRnor5.0
RGSC_v3.4350,249,819 - 50,249,967UniSTSRGSC3.4
Celera352,483,038 - 52,483,186UniSTS
Cytogenetic Map3q21UniSTS
AI577947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,913,613 - 52,913,790 (+)MAPPERmRatBN7.2
Rnor_6.0354,359,480 - 54,359,656NCBIRnor6.0
Rnor_5.0360,973,472 - 60,973,648UniSTSRnor5.0
RGSC_v3.4350,249,655 - 50,249,831UniSTSRGSC3.4
Celera352,482,874 - 52,483,050UniSTS
Cytogenetic Map3q21UniSTS
RH130764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,914,052 - 52,914,233 (+)MAPPERmRatBN7.2
Rnor_6.0354,359,919 - 54,360,099NCBIRnor6.0
Rnor_5.0360,973,911 - 60,974,091UniSTSRnor5.0
RGSC_v3.4350,250,094 - 50,250,274UniSTSRGSC3.4
Celera352,483,313 - 52,483,493UniSTS
Cytogenetic Map3q21UniSTS
BE107798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,160,193 - 53,160,413 (+)MAPPERmRatBN7.2
Rnor_6.0354,606,508 - 54,606,727NCBIRnor6.0
Rnor_5.0361,222,231 - 61,222,450UniSTSRnor5.0
RGSC_v3.4350,497,811 - 50,498,030UniSTSRGSC3.4
Celera352,728,532 - 52,728,751UniSTS
Cytogenetic Map3q21UniSTS
RH138572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,916,585 - 52,916,765 (+)MAPPERmRatBN7.2
Rnor_6.0354,362,452 - 54,362,631NCBIRnor6.0
Rnor_5.0360,976,444 - 60,976,623UniSTSRnor5.0
RGSC_v3.4350,252,627 - 50,252,806UniSTSRGSC3.4
Celera352,485,845 - 52,486,024UniSTS
RH 3.4 Map3607.5UniSTS
Cytogenetic Map3q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat


Genetic Models
This gene Stk39 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:421
Count of miRNA genes:214
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000037133
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 19 4 11 4 74 35 41 2
Low 5 30 29 8 29 8 10 9 8
Below cutoff 8 8 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037133   ⟹   ENSRNOP00000034162
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl352,913,585 - 53,120,996 (-)Ensembl
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087122   ⟹   ENSRNOP00000071256
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl352,913,585 - 53,147,323 (-)Ensembl
Rnor_6.0 Ensembl354,360,420 - 54,593,306 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098784   ⟹   ENSRNOP00000089326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)Ensembl
RefSeq Acc Id: NM_019362   ⟹   NP_062235
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2352,913,585 - 53,179,060 (-)NCBI
Rnor_6.0354,359,451 - 54,625,414 (-)NCBI
Rnor_5.0360,973,443 - 61,244,306 (-)NCBI
RGSC_v3.4350,249,626 - 50,517,085 (-)RGD
Celera352,482,845 - 52,746,814 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761922   ⟹   XP_008760144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2352,913,583 - 53,147,292 (-)NCBI
Rnor_6.0354,359,449 - 54,593,415 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062235   ⟸   NM_019362
- UniProtKB: O70541 (UniProtKB/Swiss-Prot),   O88506 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008760144   ⟸   XM_008761922
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K007 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071256   ⟸   ENSRNOT00000087122
RefSeq Acc Id: ENSRNOP00000034162   ⟸   ENSRNOT00000037133
RefSeq Acc Id: ENSRNOP00000089326   ⟸   ENSRNOT00000098784
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88506-F1-model_v2 AlphaFold O88506 1-553 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 54519274 54519275 T G snv SR/JrHsd (MCW)
3 54547270 54547271 C T snv MR/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 50439068 50439069 C T snv MR/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621643 AgrOrtholog
BioCyc Gene G2FUF-49524 BioCyc
Ensembl Genes ENSRNOG00000024808 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034162.4 UniProtKB/TrEMBL
  ENSRNOP00000071256 ENTREZGENE
  ENSRNOP00000071256.1 UniProtKB/TrEMBL
  ENSRNOP00000089326 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037133.6 UniProtKB/TrEMBL
  ENSRNOT00000087122 ENTREZGENE
  ENSRNOT00000087122.2 UniProtKB/TrEMBL
  ENSRNOT00000098784 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
KEGG Report rno:54348 UniProtKB/Swiss-Prot
NCBI Gene 54348 ENTREZGENE
Pfam OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stk39 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K007 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QHT8_RAT UniProtKB/TrEMBL
  O70541 ENTREZGENE
  O88506 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O70541 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Stk39  serine threonine kinase 39  Stk39  serine/threonine kinase 39, STE20/SPS1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Stk39  serine/threonine kinase 39, STE20/SPS1 homolog (yeast)    serine threonine kinase 39 (STE20/SPS1 homolog, yeast)  Name updated 1299863 APPROVED
2002-08-07 Stk39  serine threonine kinase 39 (STE20/SPS1 homolog, yeast)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization found in the cytoplasm and cytoskeleton 730130
gene_domains contains a putative caspase cleavage site near the C-terminal region 727300
gene_expression mRNA expressed ubiquitously, but in higher amounts in brain and pancreas 727300
gene_pathway specifically activates the p38 pathway 727300
gene_product belongs to the SPS1 subfamily of STE20 kinases 727300