Pde1a (phosphodiesterase 1A) - Rat Genome Database

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Gene: Pde1a (phosphodiesterase 1A) Rattus norvegicus
Analyze
Symbol: Pde1a
Name: phosphodiesterase 1A
RGD ID: 68329
Description: Enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process; regulation of smooth muscle cell apoptotic process; and regulation of smooth muscle cell proliferation. Located in neuronal cell body. Orthologous to human PDE1A (phosphodiesterase 1A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; calcium/calcium-mediated signaling pathway; purine metabolic pathway; INTERACTS WITH 3',5'-cyclic GMP; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3'-RACE clone 8 phosphodiesterase 1A; 3'-RACEclone8phosphodiesterase1A; 3-RACE clone 8 phosphodiesterase 1A; 3-RACEclone8phosphodiesterase1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; LOC102554725; phosphodiesterase 1A calmodulin-dependent; phosphodiesterase 1A, calmodulin-dependent; uncharacterized LOC102554725
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,152,053 - 85,432,289 (-)NCBIGRCr8
mRatBN7.2364,745,140 - 65,025,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,747,269 - 65,024,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,099,398 - 68,377,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,682,980 - 76,960,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,430,024 - 74,703,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,803,247 - 67,263,658 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,803,247 - 66,885,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0373,362,390 - 73,443,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,650,092 - 62,928,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1362,546,463 - 62,824,859 (-)NCBI
Celera364,201,583 - 64,477,508 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3',5'-cyclic GMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fosinopril  (EXP)
furan  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
olanzapine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock. Cho CH, etal., Exp Mol Med 2000 Sep 30;32(3):110-4.
2. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Nagel DJ, etal., Circ Res. 2006 Mar 31;98(6):777-84. Epub 2006 Mar 2.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. Santone R, etal., J Neurosci Res. 2006 Oct;84(5):1020-6.
13. cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles. Yanaka N, etal., Biosci Biotechnol Biochem. 2003 May;67(5):973-9.
Additional References at PubMed
PMID:15901640   PMID:19292454   PMID:19672103   PMID:19797176   PMID:20139324   PMID:21078118   PMID:21282562   PMID:22012077   PMID:28910498  


Genomics

Comparative Map Data
Pde1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,152,053 - 85,432,289 (-)NCBIGRCr8
mRatBN7.2364,745,140 - 65,025,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,747,269 - 65,024,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,099,398 - 68,377,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,682,980 - 76,960,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,430,024 - 74,703,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,803,247 - 67,263,658 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,803,247 - 66,885,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0373,362,390 - 73,443,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,650,092 - 62,928,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1362,546,463 - 62,824,859 (-)NCBI
Celera364,201,583 - 64,477,508 (-)NCBICelera
Cytogenetic Map3q24NCBI
PDE1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382182,140,041 - 182,716,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2182,139,968 - 182,523,359 (-)EnsemblGRCh38hg38GRCh38
GRCh372183,004,768 - 183,388,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,715,428 - 183,095,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 342182,832,688 - 183,212,759NCBI
Celera2176,602,916 - 176,983,707 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2174,860,781 - 175,243,522 (-)NCBIHuRef
CHM1_12183,010,710 - 183,393,630 (-)NCBICHM1_1
T2T-CHM13v2.02182,629,098 - 183,205,733 (-)NCBIT2T-CHM13v2.0
Pde1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,664,797 - 80,026,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,664,797 - 79,959,802 (-)EnsemblGRCm39 Ensembl
GRCm38279,834,453 - 80,196,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,834,453 - 80,129,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,674,610 - 79,969,569 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36279,635,295 - 79,929,810 (-)NCBIMGSCv36mm8
Celera281,494,586 - 81,789,784 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.64NCBI
Pde1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540314,906,479 - 15,203,313 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540314,906,069 - 15,202,710 (+)NCBIChiLan1.0ChiLan1.0
PDE1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,789,542 - 85,184,965 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,804,515 - 85,199,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B69,407,511 - 69,798,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B187,215,372 - 187,605,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B187,215,046 - 187,604,948 (-)Ensemblpanpan1.1panPan2
PDE1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13625,250,398 - 25,591,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3625,256,314 - 25,578,768 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3625,212,919 - 25,448,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03625,410,014 - 25,745,454 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3625,410,016 - 25,732,666 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13625,542,676 - 25,772,033 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03625,472,278 - 25,701,927 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,608,455 - 25,838,496 (-)NCBIUU_Cfam_GSD_1.0
Pde1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303142,265,162 - 142,589,515 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,818,912 - 11,142,501 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,819,067 - 11,142,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,619,067 - 87,966,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11587,619,049 - 87,965,068 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21597,009,302 - 97,084,300 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,674,428 - 68,105,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,715,963 - 67,770,675 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040131,491,332 - 131,895,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,898,913 - 4,206,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248443,898,993 - 4,207,596 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde1a
1491 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2
Count of miRNA genes:2
Interacting mature miRNAs:2
Transcripts:ENSRNOT00000008872
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Got290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,981,215 - 64,981,438 (+)MAPPERmRatBN7.2
Rnor_6.0367,284,321 - 67,284,543NCBIRnor6.0
Rnor_6.0367,220,004 - 67,220,226NCBIRnor6.0
Rnor_5.0373,777,626 - 73,777,848UniSTSRnor5.0
Rnor_5.0373,841,903 - 73,842,125UniSTSRnor5.0
RGSC_v3.4362,884,190 - 62,884,412UniSTSRGSC3.4
Celera364,435,109 - 64,435,331UniSTS
Cytogenetic Map3q24UniSTS
RH140302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2364,918,505 - 64,918,719 (+)MAPPERmRatBN7.2
Rnor_6.0366,979,304 - 66,979,517NCBIRnor6.0
Rnor_6.0367,133,137 - 67,133,350NCBIRnor6.0
Rnor_5.0373,538,453 - 73,538,666UniSTSRnor5.0
Rnor_5.0373,693,104 - 73,693,317UniSTSRnor5.0
RGSC_v3.4362,820,791 - 62,821,004UniSTSRGSC3.4
Celera364,372,632 - 64,372,845UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 2 36 35 30
Low 3 36 55 41 19 41 8 10 38 8 11 8
Below cutoff 2 1 3

Sequence


Ensembl Acc Id: ENSRNOT00000084299   ⟹   ENSRNOP00000071226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,764,298 - 64,812,336 (-)Ensembl
Rnor_6.0 Ensembl366,805,395 - 66,885,085 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090547   ⟹   ENSRNOP00000072275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,747,269 - 64,866,718 (-)Ensembl
Rnor_6.0 Ensembl366,803,247 - 66,885,094 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097071   ⟹   ENSRNOP00000086595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,747,269 - 64,936,422 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099888   ⟹   ENSRNOP00000087351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,747,269 - 65,024,874 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102686   ⟹   ENSRNOP00000077769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,764,249 - 64,936,201 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112170   ⟹   ENSRNOP00000076926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,747,269 - 65,024,874 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112686   ⟹   ENSRNOP00000091537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl364,747,269 - 64,812,403 (-)Ensembl
RefSeq Acc Id: NM_030871   ⟹   NP_110498
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,154,184 - 85,431,778 (-)NCBI
mRatBN7.2364,747,269 - 65,024,874 (-)NCBI
Rnor_6.0366,803,247 - 67,263,658 (-)NCBI
Rnor_5.0373,362,390 - 73,443,903 (-)NCBI
RGSC_v3.4362,650,092 - 62,928,487 (-)RGD
Celera364,201,583 - 64,477,508 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105907   ⟹   XP_038961835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,171,017 - 85,431,630 (-)NCBI
mRatBN7.2364,764,095 - 65,024,570 (-)NCBI
RefSeq Acc Id: XM_039105908   ⟹   XP_038961836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,152,053 - 85,432,072 (-)NCBI
mRatBN7.2364,745,140 - 65,025,178 (-)NCBI
RefSeq Acc Id: XM_039105909   ⟹   XP_038961837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,152,053 - 85,343,212 (-)NCBI
mRatBN7.2364,745,140 - 64,936,276 (-)NCBI
RefSeq Acc Id: XM_039105910   ⟹   XP_038961838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,152,053 - 85,219,333 (-)NCBI
mRatBN7.2364,745,140 - 64,812,395 (-)NCBI
RefSeq Acc Id: XM_063284612   ⟹   XP_063140682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,152,053 - 85,432,289 (-)NCBI
RefSeq Acc Id: XM_063284613   ⟹   XP_063140683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,171,017 - 85,432,289 (-)NCBI
RefSeq Acc Id: XM_063284614   ⟹   XP_063140684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,171,017 - 85,343,217 (-)NCBI
RefSeq Acc Id: XM_063284616   ⟹   XP_063140686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,171,017 - 85,219,336 (-)NCBI
RefSeq Acc Id: XM_063284617   ⟹   XP_063140687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,171,017 - 85,431,750 (-)NCBI
RefSeq Acc Id: NP_110498   ⟸   NM_030871
- UniProtKB: Q9EPR9 (UniProtKB/TrEMBL),   A0A8I5Y792 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072275   ⟸   ENSRNOT00000090547
Ensembl Acc Id: ENSRNOP00000071226   ⟸   ENSRNOT00000084299
RefSeq Acc Id: XP_038961836   ⟸   XM_039105908
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A416 (UniProtKB/TrEMBL),   A6HMM1 (UniProtKB/TrEMBL),   A0A8I5Y792 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961837   ⟸   XM_039105909
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A5M3 (UniProtKB/TrEMBL),   A0A0G2K2K1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961838   ⟸   XM_039105910
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GJQ6 (UniProtKB/TrEMBL),   A0A0G2JZX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961835   ⟸   XM_039105907
- Peptide Label: isoform X5
- UniProtKB: A6HMM2 (UniProtKB/TrEMBL),   A0A8I5Y792 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077769   ⟸   ENSRNOT00000102686
Ensembl Acc Id: ENSRNOP00000086595   ⟸   ENSRNOT00000097071
Ensembl Acc Id: ENSRNOP00000087351   ⟸   ENSRNOT00000099888
Ensembl Acc Id: ENSRNOP00000076926   ⟸   ENSRNOT00000112170
Ensembl Acc Id: ENSRNOP00000091537   ⟸   ENSRNOT00000112686
RefSeq Acc Id: XP_063140682   ⟸   XM_063284612
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y792 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140683   ⟸   XM_063284613
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y792 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140687   ⟸   XM_063284617
- Peptide Label: isoform X5
- UniProtKB: A0A8I5Y792 (UniProtKB/TrEMBL),   A6HMM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140684   ⟸   XM_063284614
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K2K1 (UniProtKB/TrEMBL),   A0A8I5Y879 (UniProtKB/TrEMBL),   A6HMM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140686   ⟸   XM_063284616
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JZX9 (UniProtKB/TrEMBL)
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2K1-F1-model_v2 AlphaFold A0A0G2K2K1 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68329 AgrOrtholog
BioCyc Gene G2FUF-49229 BioCyc
Ensembl Genes ENSRNOG00000054212 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084299.2 UniProtKB/TrEMBL
  ENSRNOT00000090547.2 UniProtKB/TrEMBL
  ENSRNOT00000097071.1 UniProtKB/TrEMBL
  ENSRNOT00000099888.1 UniProtKB/TrEMBL
  ENSRNOT00000102686.1 UniProtKB/TrEMBL
  ENSRNOT00000112170.1 UniProtKB/TrEMBL
  ENSRNOT00000112686.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
  PDEase_N UniProtKB/TrEMBL
KEGG Report rno:81529 UniProtKB/TrEMBL
NCBI Gene 81529 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam PDEase_I UniProtKB/TrEMBL
  PDEase_I_N UniProtKB/TrEMBL
PhenoGen Pde1a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054212 RatGTEx
SMART HDc UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A0G2JZX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2K1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y792 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y879 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A416 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5M3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6HMM1 ENTREZGENE, UniProtKB/TrEMBL
  A6HMM2 ENTREZGENE, UniProtKB/TrEMBL
  A6HMM4 ENTREZGENE, UniProtKB/TrEMBL
  A6HMM5_RAT UniProtKB/TrEMBL
  Q9EPR9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pde1a  phosphodiesterase 1A  LOC102554725  uncharacterized LOC102554725  Data merged from RGD:7502853 737654 PROVISIONAL
2015-11-30 Pde1a  phosphodiesterase 1A  Pde1a  phosphodiesterase 1A, calmodulin-dependent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102554725  uncharacterized LOC102554725      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Pde1a  phosphodiesterase 1A, calmodulin-dependent    phosphodiesterase 1A  Name updated 1299863 APPROVED
2002-06-10 Pde1a  phosphodiesterase 1A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference