RGD Reference Report - cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles. - Rat Genome Database

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cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles.

Authors: Yanaka, N  Kurosawa, Y  Minami, K  Kawai, E  Omori, K 
Citation: Yanaka N, etal., Biosci Biotechnol Biochem. 2003 May;67(5):973-9.
RGD ID: 2312523
Pubmed: PMID:12834273   (View Abstract at PubMed)
DOI: DOI:10.1271/bbb.67.973   (Journal Full-text)

Although expression of natriuretic peptides in cardiac tissues is up-regulated in response to pressure overload, no significant change in cGMP level in hypertrophied ventricles was observed. Activities of two cyclic nucleotide phosphodiesterase (PDE) isoforms, Ca2+/calmodulin-stimulated PDE (PDE1) and cGMP-stimulated PDE (PDE2), were significantly higher in rat left ventricles 14 days after aortic banding. The absence of significant changes in PDE1A and PDE2A mRNA levels indicated that the two PDE activities were post-transcriptionally up-regulated. These results suggested that the increased cGMP-PDE activity in response to pressure overload plays an important role in neutralizing cGMP action in cardiac tissue.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Pde1a  (phosphodiesterase 1A)
Pde2a  (phosphodiesterase 2A)
Pde3a  (phosphodiesterase 3A)

Genes (Mus musculus)
Pde1a  (phosphodiesterase 1A, calmodulin-dependent)
Pde2a  (phosphodiesterase 2A, cGMP-stimulated)
Pde3a  (phosphodiesterase 3A, cGMP inhibited)

Genes (Homo sapiens)
PDE1A  (phosphodiesterase 1A)
PDE2A  (phosphodiesterase 2A)
PDE3A  (phosphodiesterase 3A)


Additional Information