PDE2A (phosphodiesterase 2A) - Rat Genome Database

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Gene: PDE2A (phosphodiesterase 2A) Homo sapiens
Analyze
Symbol: PDE2A
Name: phosphodiesterase 2A
RGD ID: 730957
HGNC Page HGNC
Description: Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; cyclic nucleotide binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane; PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 8-Br-cAMP.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; cGSPDE; cyclic GMP-stimulated phosphodiesterase; IDDPADS; PDE2A1; PED2A4; phosphodiesterase 2A, cGMP-stimulated
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,576,141 - 72,674,591 (-)EnsemblGRCh38hg38GRCh38
GRCh381172,576,141 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,287,185 - 72,385,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (EXP)
calcitriol  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
clofibric acid  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (ISO)
formaldehyde  (EXP)
leflunomide  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nitrofen  (ISO)
nitroglycerin  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
propiconazole  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sulindac sulfone  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IDA)
aorta development  (ISS)
cAMP-mediated signaling  (IBA,IMP)
cardiac septum development  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (IDA)
cellular response to cAMP  (IDA)
cellular response to cGMP  (IDA)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IDA)
cellular response to lipopolysaccharide  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (IDA)
cellular response to mechanical stimulus  (ISS)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cGMP catabolic process  (IBA,IDA)
cGMP-mediated signaling  (IBA,IMP)
coronary vasculature development  (ISO)
establishment of endothelial barrier  (ISS)
heart development  (ISO)
heart valve development  (ISS)
monocyte differentiation  (IEP)
negative regulation of cAMP-mediated signaling  (IBA,IMP,ISO)
negative regulation of cell death  (ISO)
negative regulation of cGMP-mediated signaling  (IBA)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of vascular permeability  (IMP)
positive regulation of gene expression  (IBA)
positive regulation of inflammatory response  (ISS)
positive regulation of vascular permeability  (IMP)
regulation of cAMP-mediated signaling  (IMP)
regulation of cGMP-mediated signaling  (IMP)
regulation of mitochondrion organization  (IBA)
regulation of nitric oxide mediated signal transduction  (ISO)
response to hydrogen sulfide  (ISO)
signal transduction  (IBA,IEA)
ventricular septum development  (ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8557689   PMID:9210593   PMID:10375378   PMID:11156964   PMID:12038792   PMID:12271124   PMID:12477932   PMID:14687666   PMID:14702039   PMID:15650061   PMID:15938621   PMID:16344560  
PMID:17329248   PMID:17704206   PMID:19252089   PMID:19390057   PMID:19506089   PMID:19689430   PMID:19828435   PMID:19913121   PMID:20351714   PMID:20395239   PMID:20628086   PMID:21697861  
PMID:21724846   PMID:21766240   PMID:21873635   PMID:22446963   PMID:22658674   PMID:23381931   PMID:23810893   PMID:23899287   PMID:24705027   PMID:25230992   PMID:25941078   PMID:26095046  
PMID:26186194   PMID:28427099   PMID:28463107   PMID:28514442   PMID:31495888   PMID:32196122   PMID:32343157   PMID:32467598   PMID:33087821  


Genomics

Comparative Map Data
PDE2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,576,141 - 72,674,591 (-)EnsemblGRCh38hg38GRCh38
GRCh381172,576,141 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,287,185 - 72,385,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
Pde2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,070,898 - 101,162,036 (+)NCBIGRCm39mm39
GRCm39 Ensembl7101,060,093 - 101,162,026 (+)Ensembl
GRCm39 Ensembl7101,070,898 - 101,162,034 (+)Ensembl
GRCm387101,421,691 - 101,512,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,410,886 - 101,512,819 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,421,691 - 101,512,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv377108,570,212 - 108,661,341 (+)NCBIGRCm37mm9NCBIm37
MGSCv367101,295,530 - 101,386,636 (+)NCBImm8
Celera7101,780,588 - 101,872,064 (+)NCBICelera
Cytogenetic Map7E2NCBI
Pde2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,823,590 - 155,915,434 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
Pde2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,735,822 - 18,827,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,765,591 - 18,826,717 (+)NCBIChiLan1.0ChiLan1.0
PDE2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11170,875,552 - 70,975,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,875,552 - 70,975,322 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01167,653,335 - 67,753,450 (-)NCBIMhudiblu_PPA_v0panPan3
PDE2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,542,030 - 25,635,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,542,268 - 25,635,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,314,283 - 25,406,213 (+)NCBI
ROS_Cfam_1.02125,751,755 - 25,844,665 (+)NCBI
UMICH_Zoey_3.12125,544,034 - 25,636,601 (+)NCBI
UNSW_CanFamBas_1.02125,747,386 - 25,839,981 (+)NCBI
UU_Cfam_GSD_1.02125,660,737 - 25,753,526 (+)NCBI
Pde2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,256,724 - 60,344,873 (-)NCBI
SpeTri2.0NW_0049364981,856,256 - 1,944,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,136,637 - 7,227,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,896,906 - 7,988,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,812,877 - 63,912,602 (-)NCBI
ChlSab1.1 Ensembl163,812,840 - 63,880,492 (-)Ensembl
Vero_WHO_p1.0NW_02366604361,969,532 - 62,070,196 (+)NCBI
Pde2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBI

Position Markers
D11S1314  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,323,192 - 72,323,414UniSTSGRCh37
GRCh371172,323,249 - 72,323,404UniSTSGRCh37
Build 361172,000,840 - 72,001,062RGDNCBI36
Celera1169,627,796 - 69,627,945UniSTS
Celera1169,627,739 - 69,627,955RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,618,071 - 68,618,285UniSTS
HuRef1168,618,128 - 68,618,275UniSTS
Marshfield Genetic Map1173.64RGD
Genethon Genetic Map1177.5UniSTS
deCODE Assembly Map1178.75UniSTS
GeneMap99-GB4 RH Map11263.48UniSTS
NCBI RH Map11604.5UniSTS
SHGC-3230  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,287,206 - 72,287,373UniSTSGRCh37
Build 361171,964,854 - 71,965,021RGDNCBI36
Celera1169,589,467 - 69,589,634RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,580,069 - 68,580,236UniSTS
Stanford-G3 RH Map113165.0UniSTS
GeneMap99-GB4 RH Map11262.86UniSTS
Whitehead-RH Map11364.1UniSTS
NCBI RH Map11605.7UniSTS
GeneMap99-G3 RH Map113165.0UniSTS
D2S1960E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,287,243 - 72,287,352UniSTSGRCh37
Build 361171,964,891 - 71,965,000RGDNCBI36
Celera1169,589,504 - 69,589,613RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,580,106 - 68,580,215UniSTS
SHGC-111281  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,315,126 - 72,315,412UniSTSGRCh37
Build 361171,992,774 - 71,993,060RGDNCBI36
Celera1169,619,673 - 69,619,959RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,609,692 - 68,609,978UniSTS
TNG Radiation Hybrid Map1132497.0UniSTS
SHGC-150621  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,323,192 - 72,323,416UniSTSGRCh37
Build 361172,000,840 - 72,001,064RGDNCBI36
Celera1169,627,739 - 69,627,957RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,618,071 - 68,618,287UniSTS
TNG Radiation Hybrid Map1132493.0UniSTS
TNG Radiation Hybrid Map1529654.0UniSTS
WI-13191  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,287,199 - 72,287,305UniSTSGRCh37
Build 361171,964,847 - 71,964,953RGDNCBI36
Celera1169,589,460 - 69,589,566RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,580,062 - 68,580,168UniSTS
GeneMap99-GB4 RH Map11263.07UniSTS
Whitehead-RH Map11369.4UniSTS
NCBI RH Map11614.8UniSTS
PDE2A_222  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,287,151 - 72,287,983UniSTSGRCh37
Build 361171,964,799 - 71,965,631RGDNCBI36
Celera1169,589,412 - 69,590,244RGD
HuRef1168,580,014 - 68,580,846UniSTS
D11S1379E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,287,208 - 72,287,314UniSTSGRCh37
Build 361171,964,856 - 71,964,962RGDNCBI36
Celera1169,589,469 - 69,589,575RGD
Cytogenetic Map11q13.4UniSTS
HuRef1168,580,071 - 68,580,177UniSTS
MARC_12039-12040:1004039373:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,289,966 - 72,290,405UniSTSGRCh37
Build 361171,967,614 - 71,968,053RGDNCBI36
Celera1169,592,226 - 69,592,665RGD
HuRef1168,582,828 - 68,583,267UniSTS
D11S1314  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13.4UniSTS
Marshfield Genetic Map1173.64UniSTS
Genethon Genetic Map1177.5UniSTS
deCODE Assembly Map1178.75UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11126
Count of miRNA genes:1269
Interacting mature miRNAs:1710
Transcripts:ENST00000334456, ENST00000376450, ENST00000418754, ENST00000420501, ENST00000441209, ENST00000444035, ENST00000475807, ENST00000485058, ENST00000490749, ENST00000535701, ENST00000536308, ENST00000536458, ENST00000536918, ENST00000537631, ENST00000538299, ENST00000538749, ENST00000539367, ENST00000540345, ENST00000540380, ENST00000541998, ENST00000542223, ENST00000542969, ENST00000543575, ENST00000543750, ENST00000544239, ENST00000544570, ENST00000546038
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1752 1183 1082 72 370 38 2592 1100 2523 161 711 1044 35 1204 1586 1
Low 586 1571 619 533 762 407 1707 1064 1164 234 666 484 133 1201
Below cutoff 65 232 19 13 590 16 49 23 43 18 70 72 3 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001143839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI498038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP005019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY495089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI760519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA219662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA227593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA243617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA325165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA329075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA332549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA504595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA801834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB068707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000334456   ⟹   ENSP00000334910
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,576,141 - 72,674,422 (-)Ensembl
RefSeq Acc Id: ENST00000376450   ⟹   ENSP00000365633
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,576,142 - 72,642,431 (-)Ensembl
RefSeq Acc Id: ENST00000418754   ⟹   ENSP00000410310
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,577,211 - 72,674,408 (-)Ensembl
RefSeq Acc Id: ENST00000420501   ⟹   ENSP00000388997
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,578,910 - 72,582,369 (-)Ensembl
RefSeq Acc Id: ENST00000441209   ⟹   ENSP00000392457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,579,281 - 72,584,473 (-)Ensembl
RefSeq Acc Id: ENST00000444035   ⟹   ENSP00000411657
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,576,142 - 72,642,460 (-)Ensembl
RefSeq Acc Id: ENST00000475807   ⟹   ENSP00000439077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,584,551 - 72,590,419 (-)Ensembl
RefSeq Acc Id: ENST00000485058
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,597,510 - 72,643,131 (-)Ensembl
RefSeq Acc Id: ENST00000490749
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,590,933 - 72,596,626 (-)Ensembl
RefSeq Acc Id: ENST00000535701   ⟹   ENSP00000439302
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,597,604 - 72,674,422 (-)Ensembl
RefSeq Acc Id: ENST00000536308   ⟹   ENSP00000438559
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,590,199 - 72,642,411 (-)Ensembl
RefSeq Acc Id: ENST00000536458   ⟹   ENSP00000445750
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,642,254 - 72,658,121 (-)Ensembl
RefSeq Acc Id: ENST00000536918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,577,545 - 72,579,505 (-)Ensembl
RefSeq Acc Id: ENST00000537631   ⟹   ENSP00000443737
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,596,624 - 72,636,130 (-)Ensembl
RefSeq Acc Id: ENST00000538299   ⟹   ENSP00000441322
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,585,426 - 72,590,021 (-)Ensembl
RefSeq Acc Id: ENST00000538749   ⟹   ENSP00000439683
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,591,349 - 72,643,618 (-)Ensembl
RefSeq Acc Id: ENST00000539367   ⟹   ENSP00000445443
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,576,142 - 72,642,443 (-)Ensembl
RefSeq Acc Id: ENST00000540345   ⟹   ENSP00000446399
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,577,296 - 72,669,064 (-)Ensembl
RefSeq Acc Id: ENST00000540380
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,596,629 - 72,674,591 (-)Ensembl
RefSeq Acc Id: ENST00000541998   ⟹   ENSP00000438868
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,591,178 - 72,642,426 (-)Ensembl
RefSeq Acc Id: ENST00000542223   ⟹   ENSP00000440834
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,579,549 - 72,583,563 (-)Ensembl
RefSeq Acc Id: ENST00000542969   ⟹   ENSP00000443232
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,605,138 - 72,674,433 (-)Ensembl
RefSeq Acc Id: ENST00000543575   ⟹   ENSP00000442797
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,590,507 - 72,642,422 (-)Ensembl
RefSeq Acc Id: ENST00000543750   ⟹   ENSP00000438008
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,590,479 - 72,642,460 (-)Ensembl
RefSeq Acc Id: ENST00000544239
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,578,961 - 72,579,896 (-)Ensembl
RefSeq Acc Id: ENST00000544570   ⟹   ENSP00000442256
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,577,154 - 72,642,460 (-)Ensembl
RefSeq Acc Id: ENST00000546038   ⟹   ENSP00000438295
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1172,631,082 - 72,674,450 (-)Ensembl
RefSeq Acc Id: NM_001143839   ⟹   NP_001137311
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,576,141 - 72,642,443 (-)NCBI
GRCh371172,287,184 - 72,385,497 (-)NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBI
CHM1_11172,170,508 - 72,236,828 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001146209   ⟹   NP_001139681
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,576,141 - 72,669,064 (-)NCBI
GRCh371172,287,184 - 72,385,497 (-)NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBI
CHM1_11172,170,508 - 72,263,414 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243784   ⟹   NP_001230713
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,576,141 - 72,642,443 (-)NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBI
CHM1_11172,170,508 - 72,236,828 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002599   ⟹   NP_002590
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,576,141 - 72,674,422 (-)NCBI
GRCh371172,287,184 - 72,385,497 (-)NCBI
Build 361171,964,833 - 72,063,060 (-)NCBI Archive
HuRef1168,580,047 - 68,680,751 (-)NCBI
CHM1_11172,170,508 - 72,268,807 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005274040   ⟹   XP_005274097
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,576,141 - 72,636,125 (-)NCBI
GRCh371172,287,184 - 72,385,497 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002590   ⟸   NM_002599
- Peptide Label: isoform PDE2A3
- UniProtKB: O00408 (UniProtKB/Swiss-Prot),   Q8IW54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137311   ⟸   NM_001143839
- Peptide Label: isoform PDE2A2 precursor
- UniProtKB: O00408 (UniProtKB/Swiss-Prot),   Q8IW54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139681   ⟸   NM_001146209
- Peptide Label: isoform PDE2A4
- UniProtKB: O00408 (UniProtKB/Swiss-Prot),   Q8IW54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230713   ⟸   NM_001243784
- Peptide Label: isoform PDE2A1
- UniProtKB: O00408 (UniProtKB/Swiss-Prot),   Q8IW54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005274097   ⟸   XM_005274040
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000438868   ⟸   ENST00000541998
RefSeq Acc Id: ENSP00000443232   ⟸   ENST00000542969
RefSeq Acc Id: ENSP00000440834   ⟸   ENST00000542223
RefSeq Acc Id: ENSP00000438008   ⟸   ENST00000543750
RefSeq Acc Id: ENSP00000442797   ⟸   ENST00000543575
RefSeq Acc Id: ENSP00000442256   ⟸   ENST00000544570
RefSeq Acc Id: ENSP00000334910   ⟸   ENST00000334456
RefSeq Acc Id: ENSP00000438295   ⟸   ENST00000546038
RefSeq Acc Id: ENSP00000365633   ⟸   ENST00000376450
RefSeq Acc Id: ENSP00000392457   ⟸   ENST00000441209
RefSeq Acc Id: ENSP00000439302   ⟸   ENST00000535701
RefSeq Acc Id: ENSP00000410310   ⟸   ENST00000418754
RefSeq Acc Id: ENSP00000445750   ⟸   ENST00000536458
RefSeq Acc Id: ENSP00000438559   ⟸   ENST00000536308
RefSeq Acc Id: ENSP00000411657   ⟸   ENST00000444035
RefSeq Acc Id: ENSP00000443737   ⟸   ENST00000537631
RefSeq Acc Id: ENSP00000441322   ⟸   ENST00000538299
RefSeq Acc Id: ENSP00000439683   ⟸   ENST00000538749
RefSeq Acc Id: ENSP00000445443   ⟸   ENST00000539367
RefSeq Acc Id: ENSP00000388997   ⟸   ENST00000420501
RefSeq Acc Id: ENSP00000439077   ⟸   ENST00000475807
RefSeq Acc Id: ENSP00000446399   ⟸   ENST00000540345
Protein Domains
GAF   PDEase

Promoters
RGD ID:6789219
Promoter ID:HG_KWN:13639
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000219846
Position:
Human AssemblyChrPosition (strand)Source
Build 361171,978,721 - 71,979,221 (-)MPROMDB
RGD ID:6789216
Promoter ID:HG_KWN:13641
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:NM_001143839,   NR_026572,   OTTHUMT00000219840,   UC001OSN.1,   UC001OSO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,031,041 - 72,031,541 (-)MPROMDB
RGD ID:6789217
Promoter ID:HG_KWN:13642
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   NB4
Transcripts:OTTHUMT00000219845
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,031,504 - 72,032,004 (-)MPROMDB
RGD ID:6789214
Promoter ID:HG_KWN:13643
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_001146209
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,057,506 - 72,058,562 (-)MPROMDB
RGD ID:6789218
Promoter ID:HG_KWN:13644
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000219839,   UC001OSM.1,   UC001OSQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,063,531 - 72,064,031 (-)MPROMDB
RGD ID:6810092
Promoter ID:HG_ACW:13191
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:PDE2A.KAPR07,   PDE2A.PAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,068,851 - 72,069,552 (-)MPROMDB
RGD ID:7221447
Promoter ID:EPDNEW_H16470
Type:initiation region
Name:PDE2A_1
Description:phosphodiesterase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381172,674,422 - 72,674,482EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5
pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
NM_001143839.3(PDE2A):c.1933G>A (p.Asp645Asn) single nucleotide variant Malignant melanoma [RCV000069675] Chr11:72581448 [GRCh38]
Chr11:72292492 [GRCh37]
Chr11:71970140 [NCBI36]
Chr11:11q13.4
not provided
NM_001143839.3(PDE2A):c.1470C>T (p.Phe490=) single nucleotide variant Malignant melanoma [RCV000069676] Chr11:72584597 [GRCh38]
Chr11:72295641 [GRCh37]
Chr11:71973289 [NCBI36]
Chr11:11q13.4
not provided
NM_001143839.3(PDE2A):c.187G>A (p.Ala63Thr) single nucleotide variant Malignant melanoma [RCV000069677] Chr11:72608688 [GRCh38]
Chr11:72319732 [GRCh37]
Chr11:71997380 [NCBI36]
Chr11:11q13.4
not provided
NM_001143839.3(PDE2A):c.235C>A (p.Leu79Met) single nucleotide variant Malignant melanoma [RCV000062345] Chr11:72605205 [GRCh38]
Chr11:72316249 [GRCh37]
Chr11:71993897 [NCBI36]
Chr11:11q13.4
not provided
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_002599.5(PDE2A):c.658G>T (p.Gly220Trp) single nucleotide variant not provided [RCV000892253] Chr11:72590472 [GRCh38]
Chr11:72301516 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2456C>T (p.Thr819Met) single nucleotide variant Esophageal atresia [RCV000984666] Chr11:72578910 [GRCh38]
Chr11:72289954 [GRCh37]
Chr11:11q13.4
uncertain significance
NM_002599.5(PDE2A):c.1180C>T (p.Gln394Ter) single nucleotide variant EEG abnormality [RCV000850192]|Intellectual developmental disorder with paroxysmal dyskinesia or seizures [RCV001290006] Chr11:72586072 [GRCh38]
Chr11:72297116 [GRCh37]
Chr11:11q13.4
pathogenic
GRCh37/hg19 11q13.4(chr11:72330198-72392107)x3 copy number gain not provided [RCV000846548] Chr11:72330198..72392107 [GRCh37]
Chr11:11q13.4
uncertain significance
GRCh37/hg19 11q13.4(chr11:72291927-72349390)x3 copy number gain not provided [RCV000849366] Chr11:72291927..72349390 [GRCh37]
Chr11:11q13.4
uncertain significance
NM_002599.5(PDE2A):c.433+10A>T single nucleotide variant not provided [RCV000912625] Chr11:72597500 [GRCh38]
Chr11:72308544 [GRCh37]
Chr11:11q13.4
likely benign
NM_002599.5(PDE2A):c.323+1G>A single nucleotide variant Intellectual developmental disorder with paroxysmal dyskinesia or seizures [RCV001290009] Chr11:72605137 [GRCh38]
Chr11:72316181 [GRCh37]
Chr11:11q13.4
pathogenic
NM_002599.5(PDE2A):c.1922+5G>A single nucleotide variant Intellectual developmental disorder with paroxysmal dyskinesia or seizures [RCV001290007] Chr11:72581872 [GRCh38]
Chr11:72292916 [GRCh37]
Chr11:11q13.4
pathogenic
NM_002599.5(PDE2A):c.1439A>G (p.Asp480Gly) single nucleotide variant Intellectual developmental disorder with paroxysmal dyskinesia or seizures [RCV001290005] Chr11:72584649 [GRCh38]
Chr11:72295693 [GRCh37]
Chr11:11q13.4
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NM_002599.5(PDE2A):c.446C>T (p.Pro149Leu) single nucleotide variant Intellectual developmental disorder with paroxysmal dyskinesia or seizures [RCV001290008] Chr11:72596636 [GRCh38]
Chr11:72307680 [GRCh37]
Chr11:11q13.4
pathogenic
NM_002599.5(PDE2A):c.1359+10T>C single nucleotide variant not provided [RCV001512271] Chr11:72584862 [GRCh38]
Chr11:72295906 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.1737T>C (p.Asp579=) single nucleotide variant not provided [RCV001522784] Chr11:72582558 [GRCh38]
Chr11:72293602 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.336C>T (p.Ile112=) single nucleotide variant not provided [RCV001515408] Chr11:72597607 [GRCh38]
Chr11:72308651 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2205C>T (p.Ile735=) single nucleotide variant not provided [RCV001517193] Chr11:72579585 [GRCh38]
Chr11:72290629 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.671C>T (p.Thr224Ile) single nucleotide variant not provided [RCV001517194] Chr11:72590459 [GRCh38]
Chr11:72301503 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2133+3A>G single nucleotide variant not provided [RCV001522783] Chr11:72580883 [GRCh38]
Chr11:72291927 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2616-13del deletion not provided [RCV001518311] Chr11:72577607 [GRCh38]
Chr11:72288651 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2601A>G (p.Ala867=) single nucleotide variant not provided [RCV001522782] Chr11:72578247 [GRCh38]
Chr11:72289291 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.1677G>A (p.Glu559=) single nucleotide variant not provided [RCV001467189] Chr11:72583489 [GRCh38]
Chr11:72294533 [GRCh37]
Chr11:11q13.4
likely benign
NM_002599.5(PDE2A):c.1183-11C>A single nucleotide variant not provided [RCV001523253] Chr11:72585604 [GRCh38]
Chr11:72296648 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2655C>T (p.Tyr885=) single nucleotide variant not provided [RCV001517786] Chr11:72577555 [GRCh38]
Chr11:72288599 [GRCh37]
Chr11:11q13.4
benign
NM_002599.5(PDE2A):c.2817T>A (p.Asp939Glu) single nucleotide variant not provided [RCV001517867] Chr11:72577393 [GRCh38]
Chr11:72288437 [GRCh37]
Chr11:11q13.4
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8777 AgrOrtholog
COSMIC PDE2A COSMIC
Ensembl Genes ENSG00000186642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000334910 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000365633 UniProtKB/Swiss-Prot
  ENSP00000388997 UniProtKB/TrEMBL
  ENSP00000392457 UniProtKB/TrEMBL
  ENSP00000410310 UniProtKB/TrEMBL
  ENSP00000411657 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000438008 UniProtKB/TrEMBL
  ENSP00000438295 UniProtKB/TrEMBL
  ENSP00000438559 UniProtKB/TrEMBL
  ENSP00000438868 UniProtKB/TrEMBL
  ENSP00000439077 UniProtKB/TrEMBL
  ENSP00000439302 UniProtKB/TrEMBL
  ENSP00000439683 UniProtKB/TrEMBL
  ENSP00000440834 UniProtKB/TrEMBL
  ENSP00000441322 UniProtKB/TrEMBL
  ENSP00000442256 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000442797 UniProtKB/TrEMBL
  ENSP00000443232 UniProtKB/TrEMBL
  ENSP00000443737 UniProtKB/TrEMBL
  ENSP00000445443 UniProtKB/TrEMBL
  ENSP00000445750 UniProtKB/TrEMBL
  ENSP00000446399 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000334456 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000376450 UniProtKB/Swiss-Prot
  ENST00000418754 UniProtKB/TrEMBL
  ENST00000420501 UniProtKB/TrEMBL
  ENST00000441209 UniProtKB/TrEMBL
  ENST00000444035 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000475807 UniProtKB/TrEMBL
  ENST00000535701 UniProtKB/TrEMBL
  ENST00000536308 UniProtKB/TrEMBL
  ENST00000536458 UniProtKB/TrEMBL
  ENST00000537631 UniProtKB/TrEMBL
  ENST00000538299 UniProtKB/TrEMBL
  ENST00000538749 UniProtKB/TrEMBL
  ENST00000539367 UniProtKB/TrEMBL
  ENST00000540345 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000541998 UniProtKB/TrEMBL
  ENST00000542223 UniProtKB/TrEMBL
  ENST00000542969 UniProtKB/TrEMBL
  ENST00000543575 UniProtKB/TrEMBL
  ENST00000543750 UniProtKB/TrEMBL
  ENST00000544570 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000546038 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000186642 GTEx
HGNC ID HGNC:8777 ENTREZGENE
Human Proteome Map PDE2A Human Proteome Map
InterPro GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5138 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5138 ENTREZGENE
OMIM 602658 OMIM
  619150 OMIM
Pfam GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33125 PharmGKB
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C9JPD5_HUMAN UniProtKB/TrEMBL
  E9PEF1_HUMAN UniProtKB/TrEMBL
  F5GXX2_HUMAN UniProtKB/TrEMBL
  F5H130_HUMAN UniProtKB/TrEMBL
  F5H143_HUMAN UniProtKB/TrEMBL
  F5H1D7_HUMAN UniProtKB/TrEMBL
  F5H2R8_HUMAN UniProtKB/TrEMBL
  F5H2V7_HUMAN UniProtKB/TrEMBL
  F5H2Z0_HUMAN UniProtKB/TrEMBL
  F5H3Z7_HUMAN UniProtKB/TrEMBL
  F5H5P8_HUMAN UniProtKB/TrEMBL
  H0YFL1_HUMAN UniProtKB/TrEMBL
  H0YG13_HUMAN UniProtKB/TrEMBL
  H0YGL2_HUMAN UniProtKB/TrEMBL
  H7C009_HUMAN UniProtKB/TrEMBL
  L8E8Y0_HUMAN UniProtKB/TrEMBL
  O00408 ENTREZGENE, UniProtKB/Swiss-Prot
  Q8IW54 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R646 UniProtKB/Swiss-Prot
  B3KRV5 UniProtKB/Swiss-Prot
  E9PGI1 UniProtKB/Swiss-Prot
  F6W5Z0 UniProtKB/Swiss-Prot
  Q5J791 UniProtKB/Swiss-Prot
  Q5J792 UniProtKB/Swiss-Prot
  Q5J793 UniProtKB/Swiss-Prot
  Q6ZMR1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PDE2A  phosphodiesterase 2A    phosphodiesterase 2A, cGMP-stimulated  Symbol and/or name change 5135510 APPROVED