Pde3a (phosphodiesterase 3A) - Rat Genome Database

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Gene: Pde3a (phosphodiesterase 3A) Rattus norvegicus
Analyze
Symbol: Pde3a
Name: phosphodiesterase 3A
RGD ID: 61942
Description: Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and estrogen binding activity. Involved in negative regulation of apoptotic process; negative regulation of cAMP-mediated signaling; and oocyte maturation. Located in cytosol. Biomarker of obesity and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A cGMP inhibited; phosphodiesterase 3A, cGMP inhibited; RNPDE3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Pde3aem1Bdr   Pde3aem2Bdr   Pde3aem3Bdr  
Genetic Models: SD-Pde3aem1Bdr SD-Pde3aem3Bdr SD-Pde3aem2Bdr
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24174,172,804 - 174,443,944 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,172,868 - 174,438,274 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4180,468,046 - 180,732,053 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04176,252,313 - 176,516,321 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04174,872,874 - 175,136,859 (+)NCBIRnor_WKY
Rnor_6.04175,431,904 - 175,703,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,431,904 - 175,700,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04239,659,270 - 239,921,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44178,658,896 - 178,930,417 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14178,904,019 - 179,175,541 (+)NCBI
Celera4162,714,211 - 162,977,642 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
8-Br-cAMP  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel sulfate  (ISO)
Olprinone hydrochloride  (ISO)
ozone  (ISO)
panobinostat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
roflumilast  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Ding B, etal., Circulation. 2005 May 17;111(19):2469-76. Epub 2005 May 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP. Liu H and Maurice DH, Br J Pharmacol. 1998 Dec;125(7):1501-10.
7. Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H283-91.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. Murray F, etal., Br J Pharmacol. 2002 Dec;137(8):1187-94.
10. Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats. Nagaoka T, etal., Diabetes. 1998 Jul;47(7):1135-44.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease. Netherton SJ, etal., Diabetes. 2002 Apr;51(4):1194-200.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Role of phosphodiesterase type 3A in rat oocyte maturation. Richard FJ, etal., Biol Reprod 2001 Nov;65(5):1444-51.
19. Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo. Tilley DG and Maurice DH, Mol Pharmacol. 2002 Sep;62(3):497-506.
20. cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles. Yanaka N, etal., Biosci Biotechnol Biochem. 2003 May;67(5):973-9.
Additional References at PubMed
PMID:9631240   PMID:11420239   PMID:17704206   PMID:18571642   PMID:19252089   PMID:19474061   PMID:21224496   PMID:23008439   PMID:27975297   PMID:28755400   PMID:31401933   PMID:32524868  
PMID:36259389  


Genomics

Comparative Map Data
Pde3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24174,172,804 - 174,443,944 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,172,868 - 174,438,274 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4180,468,046 - 180,732,053 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04176,252,313 - 176,516,321 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04174,872,874 - 175,136,859 (+)NCBIRnor_WKY
Rnor_6.04175,431,904 - 175,703,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4175,431,904 - 175,700,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04239,659,270 - 239,921,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44178,658,896 - 178,930,417 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14178,904,019 - 179,175,541 (+)NCBI
Celera4162,714,211 - 162,977,642 (+)NCBICelera
Cytogenetic Map4q44NCBI
PDE3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,368,537 - 20,688,583 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1220,368,537 - 20,688,583 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,521,471 - 20,841,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,413,464 - 20,725,148 (+)NCBINCBI36Build 36hg18NCBI36
Build 341220,413,485 - 20,725,646NCBI
Celera1225,677,589 - 25,989,565 (+)NCBICelera
Cytogenetic Map12p12.2NCBI
HuRef1220,294,054 - 20,609,054 (+)NCBIHuRef
CHM1_11220,487,485 - 20,802,952 (+)NCBICHM1_1
T2T-CHM13v2.01220,246,943 - 20,567,173 (+)NCBIT2T-CHM13v2.0
Pde3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396141,194,995 - 141,452,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6141,194,995 - 141,453,174 (+)EnsemblGRCm39 Ensembl
GRCm386141,249,269 - 141,506,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6141,249,269 - 141,507,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv376141,197,790 - 141,447,872 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366141,211,675 - 141,461,757 (+)NCBIMGSCv36mm8
Celera6144,313,875 - 144,561,276 (+)NCBICelera
Cytogenetic Map6G2NCBI
Pde3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,340,918 - 16,643,214 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,340,827 - 16,642,731 (+)NCBIChiLan1.0ChiLan1.0
PDE3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11220,763,999 - 21,068,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1220,763,999 - 21,064,391 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01220,380,213 - 20,690,540 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDE3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,555,558 - 26,878,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,560,547 - 26,878,913 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2719,575,517 - 19,894,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02726,888,527 - 27,207,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2726,892,255 - 27,208,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12726,750,810 - 27,069,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02726,736,440 - 27,052,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02719,282,366 - 19,598,748 (+)NCBIUU_Cfam_GSD_1.0
Pde3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,831,481 - 88,147,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,762,507 - 6,070,576 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365485,758,634 - 6,072,195 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,409,882 - 52,738,406 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,413,503 - 52,737,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,777,634 - 55,969,591 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,235,814 - 20,545,740 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,236,430 - 20,540,900 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606914,610,757 - 14,913,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,781,647 - 17,829,771 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,773,803 - 18,088,611 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde3a
1309 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000032843
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
BE120043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24174,389,595 - 174,389,797 (+)MAPPERmRatBN7.2
Rnor_6.04175,652,674 - 175,652,875NCBIRnor6.0
Rnor_5.04239,874,014 - 239,874,215UniSTSRnor5.0
RGSC_v3.44178,882,296 - 178,882,497UniSTSRGSC3.4
Celera4162,930,163 - 162,930,364UniSTS
RH 3.4 Map41042.6UniSTS
Cytogenetic Map4q44UniSTS
RH141641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24174,290,216 - 174,290,396 (+)MAPPERmRatBN7.2
Rnor_6.04175,553,287 - 175,553,466NCBIRnor6.0
Rnor_5.04239,774,923 - 239,775,102UniSTSRnor5.0
RGSC_v3.44178,780,737 - 178,780,916UniSTSRGSC3.4
Celera4162,830,756 - 162,830,935UniSTS
RH 3.4 Map41035.5UniSTS
Cytogenetic Map4q44UniSTS


Genetic Models
This gene Pde3a is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 40 6 6 3 6 14 22 25 11
Low 2 3 50 34 16 34 8 11 60 13 11 8
Below cutoff 1 1 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032843   ⟹   ENSRNOP00000032282
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,172,868 - 174,438,274 (+)Ensembl
Rnor_6.0 Ensembl4175,431,904 - 175,700,238 (+)Ensembl
RefSeq Acc Id: NM_017337   ⟹   NP_059033
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24174,173,193 - 174,437,158 (+)NCBI
Rnor_6.04175,431,904 - 175,700,238 (+)NCBI
Rnor_5.04239,659,270 - 239,921,900 (+)NCBI
RGSC_v3.44178,658,896 - 178,930,417 (+)RGD
Celera4162,714,211 - 162,977,642 (+)RGD
Sequence:
RefSeq Acc Id: XM_008763422   ⟹   XP_008761644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24174,316,786 - 174,443,944 (+)NCBI
Rnor_6.04175,578,872 - 175,703,844 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108280   ⟹   XP_038964208
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24174,172,804 - 174,443,944 (+)NCBI
Protein Sequences
Protein RefSeqs NP_059033 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761644 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964208 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA84964 (Get FASTA)   NCBI Sequence Viewer  
  EDM01550 (Get FASTA)   NCBI Sequence Viewer  
  Q62865 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_059033   ⟸   NM_017337
- UniProtKB: Q62865 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761644   ⟸   XM_008763422
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000032282   ⟸   ENSRNOT00000032843
RefSeq Acc Id: XP_038964208   ⟸   XM_039108280
- Peptide Label: isoform X1
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62865-F1-model_v2 AlphaFold Q62865 1-1141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61942 AgrOrtholog
BioCyc Gene G2FUF-42515 BioCyc
Ensembl Genes ENSRNOG00000025042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000032282 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032843 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
KEGG Report rno:50678 UniProtKB/Swiss-Prot
NCBI Gene 50678 ENTREZGENE
Pfam PDEase_I UniProtKB/Swiss-Prot
PhenoGen Pde3a PhenoGen
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
SMART HDc UniProtKB/Swiss-Prot
UniProt PDE3A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde3a  phosphodiesterase 3A  Pde3a  phosphodiesterase 3A, cGMP inhibited  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pde3a  phosphodiesterase 3A, cGMP inhibited  Pde3a  phosphodiesterase 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pde3a  phosphodiesterase 3A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference