Pde2a (phosphodiesterase 2A) - Rat Genome Database

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Gene: Pde2a (phosphodiesterase 2A) Rattus norvegicus
Analyze
Symbol: Pde2a
Name: phosphodiesterase 2A
RGD ID: 620965
Description: Enables identical protein binding activity. Involved in several processes, including establishment of endothelial barrier; negative regulation of cAMP/PKA signal transduction; and response to hydrogen sulfide. Located in hippocampal mossy fiber; mitochondrion; and synaptic membrane. Biomarker of cardiomyopathy. Orthologous to human PDE2A (phosphodiesterase 2A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; Pde2; Pde2a2; phosphodiesterase 2A, cGMP-stimulated
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,235,623 - 165,327,466 (+)NCBIGRCr8
mRatBN7.21155,823,590 - 155,915,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,813,180 - 155,915,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,808,496 - 163,900,427 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,988,582 - 171,080,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,872,593 - 163,964,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
erianin  (ISO)
esketamine  (ISO)
ethanol  (ISO)
etoposide  (ISO)
ferric oxide  (EXP)
fipronil  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
ketamine  (EXP)
leflunomide  (EXP)
maneb  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sotorasib  (ISO)
sulindac sulfone  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
aorta development  (ISO)
cAMP-mediated signaling  (IBA)
cardiac septum development  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (ISO)
cellular response to cAMP  (ISO)
cellular response to cGMP  (ISO,ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO,ISS)
cellular response to lipopolysaccharide  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (ISO,ISS)
cellular response to mechanical stimulus  (ISO,ISS)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cGMP catabolic process  (IBA,ISO)
cGMP-mediated signaling  (IBA,ISO,ISS)
coronary vasculature development  (ISO)
establishment of endothelial barrier  (IDA)
heart development  (ISO)
heart valve development  (ISO)
intracellular signal transduction  (IMP,ISO)
monocyte differentiation  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of cAMP/PKA signal transduction  (IDA)
negative regulation of cGMP-mediated signaling  (IBA,ISO)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of vascular permeability  (ISO,ISS)
positive regulation of gene expression  (IBA,ISO)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of vascular permeability  (ISO,ISS)
regulation of cGMP-mediated signaling  (ISO)
regulation of mitochondrion organization  (IBA,IMP,ISO)
regulation of nitric oxide mediated signal transduction  (ISO)
response to hydrogen sulfide  (IEP)
signal transduction  (IEA)
ventricular septum development  (ISO)

Cellular Component
axon  (ISO)
cytoplasm  (IDA,IEA,ISO)
cytosol  (IBA,ISO,ISS)
dendrite  (ISO)
endoplasmic reticulum  (ISO,ISS)
Golgi apparatus  (ISO,ISS)
hippocampal mossy fiber  (IDA)
membrane  (IEA)
mitochondrial inner membrane  (IBA,IDA,IEA,ISO)
mitochondrial matrix  (IBA,IDA,IEA,ISO)
mitochondrial outer membrane  (IBA,IDA,IEA,ISO)
mitochondrion  (IDA,IEA,ISO)
nucleus  (IBA,ISO,ISS)
perinuclear region of cytoplasm  (IBA,ISO,ISS)
plasma membrane  (IDA,IEA,ISO,ISS)
presynaptic membrane  (ISO,ISS)
synaptic membrane  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, etal., J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.
2. An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
4. Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. de Oliveira SK, etal., J Biol Chem. 2007 May 4;282(18):13656-63. Epub 2007 Feb 28.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. Gustafsson AB and Brunton LL, Am J Physiol Cell Physiol 2002 Aug;283(2):C463-71.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A. Modis K, etal., Biochem Pharmacol. 2013 Nov 1;86(9):1311-9. doi: 10.1016/j.bcp.2013.08.064. Epub 2013 Sep 4.
10. PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. Monterisi S, etal., Elife. 2017 May 2;6. pii: e21374. doi: 10.7554/eLife.21374.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft). Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. Repaske DR, etal., J Biol Chem 1992 Sep 15;267(26):18683-8.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Sierksma AS, etal., Neuropharmacology. 2013 Jan;64:124-36. doi: 10.1016/j.neuropharm.2012.06.048. Epub 2012 Jul 4.
19. Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. Stephenson DT, etal., J Histochem Cytochem. 2009 Oct;57(10):933-49. doi: 10.1369/jhc.2009.953471. Epub 2009 Jun 8.
20. Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases. Wang J, etal., Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1146-54. doi: 10.1152/ajpheart.00252.2009. Epub 2010 Feb 5.
21. cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles. Yanaka N, etal., Biosci Biotechnol Biochem. 2003 May;67(5):973-9.
22. A novel cyclic GMP stimulated phosphodiesterase from rat brain. Yang Q, etal., Biochem Biophys Res Commun 1994 Dec 30;205(3):1850-8.
Additional References at PubMed
PMID:8586960   PMID:10375378   PMID:12271124   PMID:14687666   PMID:15210692   PMID:15938621   PMID:16150726   PMID:16651469   PMID:17561940   PMID:17704206   PMID:18499090   PMID:18684888  
PMID:19252089   PMID:19632989   PMID:19689430   PMID:19828435   PMID:20175220   PMID:21571906   PMID:23000621   PMID:24837549   PMID:25432985   PMID:25807483   PMID:25916722   PMID:26243800  
PMID:30053369   PMID:31100470   PMID:31505169   PMID:33087821   PMID:37296663  


Genomics

Comparative Map Data
Pde2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,235,623 - 165,327,466 (+)NCBIGRCr8
mRatBN7.21155,823,590 - 155,915,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,813,180 - 155,915,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,808,496 - 163,900,427 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,988,582 - 171,080,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,872,593 - 163,964,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
PDE2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,576,141 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,576,141 - 72,674,591 (-)EnsemblGRCh38hg38GRCh38
GRCh371172,287,185 - 72,385,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36Build 36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
T2T-CHM13v2.01172,502,658 - 72,602,659 (-)NCBIT2T-CHM13v2.0
Pde2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,070,905 - 101,162,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,070,898 - 101,162,034 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl7101,060,093 - 101,162,026 (+)EnsemblGRCm39 Ensembl
GRCm387101,421,691 - 101,512,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,410,886 - 101,512,819 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,421,691 - 101,512,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv377108,570,212 - 108,661,341 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,295,530 - 101,386,636 (+)NCBIMGSCv36mm8
Celera7101,780,588 - 101,872,064 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.57NCBI
Pde2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,735,822 - 18,827,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,765,591 - 18,826,717 (+)NCBIChiLan1.0ChiLan1.0
PDE2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2973,521,727 - 73,621,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,565,189 - 74,665,355 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,653,335 - 67,753,450 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,875,552 - 70,975,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,875,552 - 70,975,322 (-)Ensemblpanpan1.1panPan2
PDE2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,542,030 - 25,635,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,542,268 - 25,635,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,314,283 - 25,406,213 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,751,755 - 25,844,665 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,751,765 - 25,844,666 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12125,544,034 - 25,636,601 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,747,386 - 25,839,981 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,660,737 - 25,753,526 (+)NCBIUU_Cfam_GSD_1.0
Pde2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,256,724 - 60,344,873 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,856,144 - 1,944,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,856,256 - 1,944,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,136,637 - 7,227,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,896,906 - 7,988,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,812,877 - 63,912,602 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,812,840 - 63,880,492 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,969,532 - 62,070,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,269,347 - 4,369,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde2a
476 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:112
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000026586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1150452391168228760Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Rat171  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81165,278,545 - 165,278,781 (+)Marker Load Pipeline
mRatBN7.21155,866,514 - 155,866,750 (+)MAPPERmRatBN7.2
Rnor_6.01166,577,232 - 166,577,467NCBIRnor6.0
Rnor_5.01172,767,534 - 172,767,769UniSTSRnor5.0
RGSC_v3.41158,964,262 - 158,964,498RGDRGSC3.4
RGSC_v3.41158,964,263 - 158,964,498UniSTSRGSC3.4
RGSC_v3.11159,043,280 - 159,043,515RGD
Celera1153,947,476 - 153,947,711UniSTS
RH 3.4 Map11267.5UniSTS
RH 3.4 Map11267.5RGD
SHRSP x BN Map179.01UniSTS
SHRSP x BN Map179.01RGD
FHH x ACI Map172.14RGD
Cytogenetic Map1q32UniSTS
MARC_12039-12040:1004039373:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81165,324,745 - 165,325,172 (+)Marker Load Pipeline
mRatBN7.21155,912,713 - 155,913,140 (+)MAPPERmRatBN7.2
Rnor_6.01166,623,428 - 166,623,854NCBIRnor6.0
Rnor_5.01172,813,993 - 172,814,419UniSTSRnor5.0
RGSC_v3.41159,011,110 - 159,011,536UniSTSRGSC3.4
Celera1153,992,919 - 153,993,345UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026586   ⟹   ENSRNOP00000026586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,823,590 - 155,915,434 (+)Ensembl
Rnor_6.0 Ensembl1166,534,643 - 166,626,147 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090959   ⟹   ENSRNOP00000074500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,864,043 - 155,915,434 (+)Ensembl
Rnor_6.0 Ensembl1166,564,664 - 166,626,158 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114688   ⟹   ENSRNOP00000087319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,823,590 - 155,915,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120138   ⟹   ENSRNOP00000078823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,813,180 - 155,915,432 (+)Ensembl
RefSeq Acc Id: NM_001143847   ⟹   NP_001137319
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,235,623 - 165,327,466 (+)NCBI
mRatBN7.21155,823,590 - 155,915,434 (+)NCBI
Rnor_6.01166,534,643 - 166,626,147 (+)NCBI
Rnor_5.01172,724,783 - 172,816,723 (+)NCBI
RGSC_v3.41158,921,607 - 159,013,829 (+)RGD
Celera1153,905,701 - 153,995,638 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270604   ⟹   NP_001257533
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,266,009 - 165,327,466 (+)NCBI
mRatBN7.21155,853,978 - 155,915,434 (+)NCBI
Rnor_6.01166,564,664 - 166,626,158 (+)NCBI
Rnor_5.01172,724,783 - 172,816,723 (+)NCBI
Celera1153,934,920 - 153,995,649 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031079   ⟹   NP_112341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,266,009 - 165,327,466 (+)NCBI
mRatBN7.21155,853,978 - 155,915,434 (+)NCBI
Rnor_6.01166,564,727 - 166,626,147 (+)NCBI
Rnor_5.01172,724,783 - 172,816,723 (+)NCBI
RGSC_v3.41158,921,607 - 159,013,829 (+)RGD
Celera1153,934,983 - 153,995,638 (+)NCBI
Sequence:
RefSeq Acc Id: NP_112341   ⟸   NM_031079
- Peptide Label: isoform PDE2A2 precursor
- UniProtKB: Q01062 (UniProtKB/Swiss-Prot),   A6I6U9 (UniProtKB/TrEMBL),   F8WFW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137319   ⟸   NM_001143847
- Peptide Label: isoform PDE2A3
- UniProtKB: F8WFW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257533   ⟸   NM_001270604
- Peptide Label: isoform PDE2A1
- UniProtKB: A0A0G2K876 (UniProtKB/TrEMBL),   A0A8I5ZM10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026586   ⟸   ENSRNOT00000026586
Ensembl Acc Id: ENSRNOP00000074500   ⟸   ENSRNOT00000090959
Ensembl Acc Id: ENSRNOP00000087319   ⟸   ENSRNOT00000114688
Ensembl Acc Id: ENSRNOP00000078823   ⟸   ENSRNOT00000120138
Protein Domains
GAF   PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01062-F1-model_v2 AlphaFold Q01062 1-928 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690256
Promoter ID:EPDNEW_R781
Type:single initiation site
Name:Pde2a_1
Description:phosphodiesterase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01166,534,604 - 166,534,664EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620965 AgrOrtholog
BioCyc Gene G2FUF-58290 BioCyc
Ensembl Genes ENSRNOG00000019560 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026586 ENTREZGENE
  ENSRNOT00000130973 ENTREZGENE
  ENSRNOT00000147035 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
  3.30.450.40 UniProtKB/Swiss-Prot
InterPro GAF UniProtKB/Swiss-Prot
  GAF-like_dom_sf UniProtKB/Swiss-Prot
  HD/PDEase_dom UniProtKB/Swiss-Prot
  PDEase UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
KEGG Report rno:81743 UniProtKB/Swiss-Prot
NCBI Gene 81743 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam GAF UniProtKB/Swiss-Prot
  GAF_2 UniProtKB/Swiss-Prot
  PDEase_I UniProtKB/Swiss-Prot
PhenoGen Pde2a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019560 RatGTEx
SMART GAF UniProtKB/Swiss-Prot
  HDc UniProtKB/Swiss-Prot
Superfamily-SCOP GAF domain-like UniProtKB/Swiss-Prot
  HD-domain/PDEase-like UniProtKB/Swiss-Prot
UniProt A0A0G2K876 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM10 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5L2_RAT UniProtKB/TrEMBL
  A6I6U8_RAT UniProtKB/TrEMBL
  A6I6U9 ENTREZGENE, UniProtKB/TrEMBL
  A6I6V0_RAT UniProtKB/TrEMBL
  F8WFW5 ENTREZGENE, UniProtKB/TrEMBL
  PDE2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde2a  phosphodiesterase 2A  Pde2a  phosphodiesterase 2A, cGMP-stimulated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pde2a  phosphodiesterase 2A, cGMP-stimulated    cyclic GMP stimulated phosphodiesterase  Name updated 625702 APPROVED
2002-08-07 Pde2a  cyclic GMP stimulated phosphodiesterase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process activation decreases cAMP level during beta-adrenergic response (cAMP elevation and cAMP-dependent protein kinase activation) in cardiac fibroblasts 625635
gene_regulation activated by cGMP due to the increase of nitric oxide (NO) in cardiac fibroblasts 625635