Pde2a (phosphodiesterase 2A) - Rat Genome Database

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Gene: Pde2a (phosphodiesterase 2A) Rattus norvegicus
Analyze
Symbol: Pde2a
Name: phosphodiesterase 2A
RGD ID: 620965
Description: Exhibits identical protein binding activity. Involved in several processes, including establishment of endothelial barrier; negative regulation of cAMP-mediated signaling; and response to hydrogen sulfide. Localizes to several cellular components, including hippocampal mossy fiber; membrane raft; and mitochondrion. Biomarker of cardiomyopathy. Orthologous to human PDE2A (phosphodiesterase 2A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; Pde2; Pde2a2; phosphodiesterase 2A, cGMP-stimulated
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,823,590 - 155,915,434 (+)NCBI
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
leflunomide  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sulindac sulfone  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
aorta development  (ISO)
cAMP-mediated signaling  (IBA,IEA,ISO)
cardiac septum development  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to cGMP  (IEA,ISO,ISS)
cellular response to drug  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO,ISS)
cellular response to lipopolysaccharide  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISO,ISS)
cellular response to mechanical stimulus  (ISO,ISS)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cGMP catabolic process  (IBA,IEA,ISO)
cGMP-mediated signaling  (IBA,IEA,ISO,ISS)
coronary vasculature development  (ISO)
establishment of endothelial barrier  (IDA)
heart development  (ISO)
heart valve development  (ISO)
monocyte differentiation  (ISO)
negative regulation of cAMP-mediated signaling  (IBA,IDA,IEA,ISO)
negative regulation of cell death  (IMP,ISO)
negative regulation of cGMP-mediated signaling  (IBA,ISO)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of vascular permeability  (IEA,ISO,ISS)
positive regulation of gene expression  (IBA,ISO)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of vascular permeability  (IEA,ISO,ISS)
regulation of cAMP-mediated signaling  (ISO,ISS)
regulation of cGMP-mediated signaling  (IEA,ISO)
regulation of mitochondrion organization  (IBA,IMP,ISO)
regulation of nitric oxide mediated signal transduction  (ISO)
response to hydrogen sulfide  (IEP)
signal transduction  (IBA,IEA)
ventricular septum development  (ISO)

Cellular Component
axon  (ISO)
cytoplasm  (IDA,ISO)
cytosol  (IBA,IEA,ISO,ISS)
dendrite  (ISO)
endoplasmic reticulum  (ISO,ISS)
Golgi apparatus  (ISO,ISS)
hippocampal mossy fiber  (IDA)
membrane raft  (IDA)
mitochondrial inner membrane  (IBA,IDA,IEA,ISO)
mitochondrial matrix  (IBA,IDA,ISO)
mitochondrial outer membrane  (IBA,IDA,IEA,ISO)
mitochondrion  (IDA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
perinuclear region of cytoplasm  (IBA,IEA,ISO,ISS)
plasma membrane  (IDA,IEA,ISO,ISS)
presynaptic membrane  (ISO,ISS)
synaptic membrane  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Acin-Perez R, etal., J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.
2. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
4. de Oliveira SK, etal., J Biol Chem. 2007 May 4;282(18):13656-63. Epub 2007 Feb 28.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Gustafsson AB and Brunton LL, Am J Physiol Cell Physiol 2002 Aug;283(2):C463-71.
8. KEGG
9. Modis K, etal., Biochem Pharmacol. 2013 Nov 1;86(9):1311-9. doi: 10.1016/j.bcp.2013.08.064. Epub 2013 Sep 4.
10. Monterisi S, etal., Elife. 2017 May 2;6. pii: e21374. doi: 10.7554/eLife.21374.
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
13. Pipeline to import KEGG annotations from KEGG into RGD
14. Repaske DR, etal., J Biol Chem 1992 Sep 15;267(26):18683-8.
15. RGD automated data pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Sierksma AS, etal., Neuropharmacology. 2013 Jan;64:124-36. doi: 10.1016/j.neuropharm.2012.06.048. Epub 2012 Jul 4.
19. Stephenson DT, etal., J Histochem Cytochem. 2009 Oct;57(10):933-49. doi: 10.1369/jhc.2009.953471. Epub 2009 Jun 8.
20. Wang J, etal., Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1146-54. doi: 10.1152/ajpheart.00252.2009. Epub 2010 Feb 5.
21. Yanaka N, etal., Biosci Biotechnol Biochem. 2003 May;67(5):973-9.
22. Yang Q, etal., Biochem Biophys Res Commun 1994 Dec 30;205(3):1850-8.
Additional References at PubMed
PMID:8586960   PMID:10375378   PMID:12271124   PMID:14687666   PMID:15210692   PMID:15938621   PMID:16150726   PMID:16651469   PMID:17561940   PMID:17704206   PMID:18499090   PMID:18684888  
PMID:19252089   PMID:19632989   PMID:19689430   PMID:19828435   PMID:20175220   PMID:21571906   PMID:23000621   PMID:24837549   PMID:25432985   PMID:25807483   PMID:25916722   PMID:26243800  
PMID:30053369   PMID:31100470   PMID:31505169  


Genomics

Comparative Map Data
Pde2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,823,590 - 155,915,434 (+)NCBI
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
PDE2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,576,141 - 72,674,591 (-)EnsemblGRCh38hg38GRCh38
GRCh381172,576,141 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,287,185 - 72,385,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
Pde2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,070,898 - 101,162,036 (+)NCBIGRCm39mm39
GRCm39 Ensembl7101,060,093 - 101,162,026 (+)Ensembl
GRCm39 Ensembl7101,070,898 - 101,162,034 (+)Ensembl
GRCm387101,421,691 - 101,512,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,410,886 - 101,512,819 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,421,691 - 101,512,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv377108,570,212 - 108,661,341 (+)NCBIGRCm37mm9NCBIm37
MGSCv367101,295,530 - 101,386,636 (+)NCBImm8
Celera7101,780,588 - 101,872,064 (+)NCBICelera
Cytogenetic Map7E2NCBI
Pde2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,735,822 - 18,827,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,765,591 - 18,826,717 (+)NCBIChiLan1.0ChiLan1.0
PDE2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11170,875,552 - 70,975,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,875,552 - 70,975,322 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01167,653,335 - 67,753,450 (-)NCBIMhudiblu_PPA_v0panPan3
PDE2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,542,030 - 25,635,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,542,268 - 25,635,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,314,283 - 25,406,213 (+)NCBI
ROS_Cfam_1.02125,751,755 - 25,844,665 (+)NCBI
UMICH_Zoey_3.12125,544,034 - 25,636,601 (+)NCBI
UNSW_CanFamBas_1.02125,747,386 - 25,839,981 (+)NCBI
UU_Cfam_GSD_1.02125,660,737 - 25,753,526 (+)NCBI
Pde2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,256,724 - 60,344,873 (-)NCBI
SpeTri2.0NW_0049364981,856,256 - 1,944,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,136,637 - 7,227,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,896,906 - 7,988,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,812,877 - 63,912,602 (-)NCBI
ChlSab1.1 Ensembl163,812,840 - 63,880,492 (-)Ensembl
Vero_WHO_p1.0NW_02366604361,969,532 - 62,070,196 (+)NCBI
Pde2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBI

Position Markers
D1Rat171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,866,514 - 155,866,750 (+)MAPPER
Rnor_6.01166,577,232 - 166,577,467NCBIRnor6.0
Rnor_5.01172,767,534 - 172,767,769UniSTSRnor5.0
RGSC_v3.41158,964,262 - 158,964,498RGDRGSC3.4
RGSC_v3.41158,964,263 - 158,964,498UniSTSRGSC3.4
RGSC_v3.11159,043,280 - 159,043,515RGD
Celera1153,947,476 - 153,947,711UniSTS
RH 3.4 Map11267.5RGD
RH 3.4 Map11267.5UniSTS
SHRSP x BN Map179.01UniSTS
SHRSP x BN Map179.01RGD
FHH x ACI Map172.14RGD
Cytogenetic Map1q32UniSTS
MARC_12039-12040:1004039373:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,912,713 - 155,913,140 (+)MAPPER
Rnor_6.01166,623,428 - 166,623,854NCBIRnor6.0
Rnor_5.01172,813,993 - 172,814,419UniSTSRnor5.0
RGSC_v3.41159,011,110 - 159,011,536UniSTSRGSC3.4
Celera1153,992,919 - 153,993,345UniSTS
Cytogenetic Map1q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779148198585664Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1130779148199254774Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1130779148199254774Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1130779148199254774Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978184188922Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1133946489178946489Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1134089429179089429Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1139523928170246858Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144723107174343537Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1153656062198656062Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1153834077232297227Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1154337847215828102Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1156446196214277437Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1156446783188289244Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1156446783189514504Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1161072673178935582Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1161784169219232156Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1161784169219232156Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1161784169219232156Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169219232156Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight as percentage of body weight (CMO:0000141)1166100317188289386Rat
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1166577232169318847Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1166577232211577232Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:112
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000026586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 31 17 14 17 1 1 64 33 30 11 1
Low 20 26 24 5 24 7 10 10 2 9 7
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026586   ⟹   ENSRNOP00000026586
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1166,534,643 - 166,626,147 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090959   ⟹   ENSRNOP00000074500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1166,564,664 - 166,626,158 (+)Ensembl
RefSeq Acc Id: NM_001143847   ⟹   NP_001137319
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,823,590 - 155,915,434 (+)NCBI
Rnor_6.01166,534,643 - 166,626,147 (+)NCBI
Rnor_5.01172,724,783 - 172,816,723 (+)NCBI
RGSC_v3.41158,921,607 - 159,013,829 (+)RGD
Celera1153,905,701 - 153,995,638 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270604   ⟹   NP_001257533
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,853,978 - 155,915,434 (+)NCBI
Rnor_6.01166,564,664 - 166,626,158 (+)NCBI
Rnor_5.01172,724,783 - 172,816,723 (+)NCBI
Celera1153,934,920 - 153,995,649 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031079   ⟹   NP_112341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,853,978 - 155,915,434 (+)NCBI
Rnor_6.01166,564,727 - 166,626,147 (+)NCBI
Rnor_5.01172,724,783 - 172,816,723 (+)NCBI
RGSC_v3.41158,921,607 - 159,013,829 (+)RGD
Celera1153,934,983 - 153,995,638 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112341   ⟸   NM_031079
- Peptide Label: isoform PDE2A2 precursor
- UniProtKB: Q01062 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001137319   ⟸   NM_001143847
- Peptide Label: isoform PDE2A3
- UniProtKB: Q01062 (UniProtKB/Swiss-Prot),   F8WFW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257533   ⟸   NM_001270604
- Peptide Label: isoform PDE2A1
- UniProtKB: A0A0G2K876 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026586   ⟸   ENSRNOT00000026586
RefSeq Acc Id: ENSRNOP00000074500   ⟸   ENSRNOT00000090959
Protein Domains
GAF   PDEase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690256
Promoter ID:EPDNEW_R781
Type:single initiation site
Name:Pde2a_1
Description:phosphodiesterase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01166,534,604 - 166,534,664EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 172815455 172815456 C T snv HWY/Slc (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620965 AgrOrtholog
Ensembl Genes ENSRNOG00000019560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026586 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074500 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026586 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000090959 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81743 ENTREZGENE
Pfam GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde2a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K876 ENTREZGENE, UniProtKB/TrEMBL
  F8WFW5 ENTREZGENE, UniProtKB/TrEMBL
  PDE2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde2a  phosphodiesterase 2A  Pde2a  phosphodiesterase 2A, cGMP-stimulated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pde2a  phosphodiesterase 2A, cGMP-stimulated    cyclic GMP stimulated phosphodiesterase  Name updated 625702 APPROVED
2002-08-07 Pde2a  cyclic GMP stimulated phosphodiesterase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process activation decreases cAMP level during beta-adrenergic response (cAMP elevation and cAMP-dependent protein kinase activation) in cardiac fibroblasts 625635
gene_regulation activated by cGMP due to the increase of nitric oxide (NO) in cardiac fibroblasts 625635