Pde1a (phosphodiesterase 1A) - Rat Genome Database

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Gene: Pde1a (phosphodiesterase 1A) Heterocephalus glaber
Analyze
Symbol: Pde1a
Name: phosphodiesterase 1A
RGD ID: 18922758
Description: ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,898,913 - 4,206,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248443,898,993 - 4,207,596 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Pde1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,898,913 - 4,206,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248443,898,993 - 4,207,596 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PDE1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382182,140,041 - 182,716,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2182,139,968 - 182,523,359 (-)EnsemblGRCh38hg38GRCh38
GRCh372183,004,768 - 183,388,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,715,428 - 183,095,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 342182,832,688 - 183,212,759NCBI
Celera2176,602,916 - 176,983,707 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2174,860,781 - 175,243,522 (-)NCBIHuRef
CHM1_12183,010,710 - 183,393,630 (-)NCBICHM1_1
T2T-CHM13v2.02182,629,098 - 183,205,733 (-)NCBIT2T-CHM13v2.0
Pde1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,664,797 - 80,026,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,664,797 - 79,959,802 (-)EnsemblGRCm39 Ensembl
GRCm38279,834,453 - 80,196,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,834,453 - 80,129,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,674,610 - 79,969,569 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36279,635,295 - 79,929,810 (-)NCBIMGSCv36mm8
Celera281,494,586 - 81,789,784 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.64NCBI
Pde1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,152,053 - 85,432,289 (-)NCBIGRCr8
mRatBN7.2364,745,140 - 65,025,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,747,269 - 65,024,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,099,398 - 68,377,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,682,980 - 76,960,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0374,430,024 - 74,703,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,803,247 - 67,263,658 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,803,247 - 66,885,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0373,362,390 - 73,443,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,650,092 - 62,928,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1362,546,463 - 62,824,859 (-)NCBI
Celera364,201,583 - 64,477,508 (-)NCBICelera
Cytogenetic Map3q24NCBI
Pde1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540314,906,479 - 15,203,313 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540314,906,069 - 15,202,710 (+)NCBIChiLan1.0ChiLan1.0
PDE1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,789,542 - 85,184,965 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,804,515 - 85,199,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B69,407,511 - 69,798,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B187,215,372 - 187,605,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B187,215,046 - 187,604,948 (-)Ensemblpanpan1.1panPan2
PDE1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13625,250,398 - 25,591,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3625,256,314 - 25,578,768 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3625,212,919 - 25,448,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03625,410,014 - 25,745,454 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3625,410,016 - 25,732,666 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13625,542,676 - 25,772,033 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03625,472,278 - 25,701,927 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,608,455 - 25,838,496 (-)NCBIUU_Cfam_GSD_1.0
Pde1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303142,265,162 - 142,589,515 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,818,912 - 11,142,501 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,819,067 - 11,142,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,619,067 - 87,966,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11587,619,049 - 87,965,068 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21597,009,302 - 97,084,300 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,674,428 - 68,105,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,715,963 - 67,770,675 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040131,491,332 - 131,895,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026363   ⟹   ENSHGLP00000026131
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248443,898,913 - 4,114,428 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000026364   ⟹   ENSHGLP00000026132
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248443,898,913 - 4,114,428 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000026365   ⟹   ENSHGLP00000026133
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248443,903,524 - 4,206,706 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000026366   ⟹   ENSHGLP00000026134
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248443,913,270 - 3,966,845 (-)Ensembl
RefSeq Acc Id: XM_004868171   ⟹   XP_004868228
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248443,898,993 - 4,207,140 (-)NCBI
RefSeq Acc Id: XM_004868172   ⟹   XP_004868229
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248443,898,993 - 4,207,596 (-)NCBI
RefSeq Acc Id: XM_004868174   ⟹   XP_004868231
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248443,898,993 - 4,114,272 (-)NCBI
RefSeq Acc Id: XM_021247130   ⟹   XP_021102789
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248443,898,993 - 4,207,151 (-)NCBI
RefSeq Acc Id: XM_021247131   ⟹   XP_021102790
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248443,898,993 - 4,207,151 (-)NCBI
RefSeq Acc Id: XM_021247132   ⟹   XP_021102791
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248443,898,993 - 4,207,151 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004868229   ⟸   XM_004868172
- Peptide Label: isoform X2
- UniProtKB: G5BIQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102791   ⟸   XM_021247132
- Peptide Label: isoform X4
- UniProtKB: G5BIQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102790   ⟸   XM_021247131
- Peptide Label: isoform X1
- UniProtKB: G5BIQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102789   ⟸   XM_021247130
- Peptide Label: isoform X1
- UniProtKB: G5BIQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868228   ⟸   XM_004868171
- Peptide Label: isoform X2
- UniProtKB: G5BIQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868231   ⟸   XM_004868174
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J6Z5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000026132   ⟸   ENSHGLT00000026364
RefSeq Acc Id: ENSHGLP00000026131   ⟸   ENSHGLT00000026363
RefSeq Acc Id: ENSHGLP00000026134   ⟸   ENSHGLT00000026366
RefSeq Acc Id: ENSHGLP00000026133   ⟸   ENSHGLT00000026365


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018601 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026364 ENTREZGENE
  ENSHGLT00000026365 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
  PDEase_N UniProtKB/TrEMBL
NCBI Gene Pde1a ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam PDEase_I UniProtKB/TrEMBL
  PDEase_I_N UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0A0P6J6Z5 ENTREZGENE, UniProtKB/TrEMBL
  G5BIQ5 ENTREZGENE, UniProtKB/TrEMBL