Chrm4 (cholinergic receptor, muscarinic 4) - Rat Genome Database

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Gene: Chrm4 (cholinergic receptor, muscarinic 4) Rattus norvegicus
Symbol: Chrm4
Name: cholinergic receptor, muscarinic 4
RGD ID: 2344
Description: Enables guanyl-nucleotide exchange factor activity. Involved in response to organic substance. Located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Colocalizes with sarcolemma. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholinergic receptor, muscarin 4; M4; muscarinic acetylcholine receptor M4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2377,893,425 - 77,901,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,368,613 - 81,376,348 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0389,967,641 - 89,975,378 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0387,818,870 - 87,826,600 (+)NCBIRnor_WKY
Rnor_6.0380,833,272 - 80,841,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,531,619 - 87,539,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,301,988 - 76,309,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,203,520 - 76,206,094 (+)NCBI
Celera377,096,073 - 77,103,815 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(+)-trans-(S)-allethrin  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
alcuronium  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (ISO)
bisphenol A  (EXP)
brucine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbachol  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
Eburnamonine  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furtrethonium  (ISO)
haloperidol  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methoctramine tetrahydrochloride  (ISO)
methscopolamine  (ISO)
mevinphos  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (EXP,ISO)
oxotremorine M  (ISO)
pancuronium  (ISO)
paracetamol  (EXP)
parathion-methyl  (EXP)
Pipecuronium  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
risperidone  (ISO)
rocuronium  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
scopolamine  (ISO)
silicon dioxide  (EXP)
sotorasib  (ISO)
strychnine  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
tiotropium bromide  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichlorfon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tropicamide  (ISO)
valproic acid  (ISO)
vecuronium bromide  (ISO)
xanomeline  (EXP,ISO)


References - curated
# Reference Title Reference Citation
1. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2. Identification of a family of muscarinic acetylcholine receptor genes. Bonner TI, etal., Science 1987 Jul 31;237(4814):527-32.
3. Neuronal damage and changes in the expression of muscarinic acetylcholine receptor subtypes in the neonatal rat cerebral cortical upon exposure to sparteine, a quinolizidine alkaloid. Flores-Soto ME, etal., Int J Dev Neurosci. 2006 Oct;24(6):401-10. Epub 2006 Jul 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
7. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
8. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. Hersch SM, etal., J Neurosci. 1994 May;14(5 Pt 2):3351-63.
9. Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2. McClatchy DB, etal., J Biol Chem 2002 Aug 9;277(32):29268-74.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Loss of muscarinic M4 receptors in spinal cord of arthritic rats: implications for a role of M4 receptors in pain response. Mulugeta E, etal., Brain Res 2003 Aug 29;982(2):284-7.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
17. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
Additional References at PubMed
PMID:7916637   PMID:8617799   PMID:12433399   PMID:15200951   PMID:15326124   PMID:15927789   PMID:15951192   PMID:15979279   PMID:16758365   PMID:17709264   PMID:17845913   PMID:18816796  
PMID:19070673   PMID:20551968   PMID:21883220   PMID:21913336   PMID:22803069   PMID:29577888   PMID:31325565   PMID:32798726  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2377,893,425 - 77,901,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,368,613 - 81,376,348 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0389,967,641 - 89,975,378 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0387,818,870 - 87,826,600 (+)NCBIRnor_WKY
Rnor_6.0380,833,272 - 80,841,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,531,619 - 87,539,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,301,988 - 76,309,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,203,520 - 76,206,094 (+)NCBI
Celera377,096,073 - 77,103,815 (+)NCBICelera
Cytogenetic Map3q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381146,383,789 - 46,391,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1146,383,789 - 46,391,776 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,405,339 - 46,413,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,363,216 - 46,364,683 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,363,215 - 46,364,683NCBI
Celera1146,554,217 - 46,555,684 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,113,598 - 46,115,064 (-)NCBIHuRef
CHM1_11146,405,093 - 46,406,560 (-)NCBICHM1_1
T2T-CHM13v2.01146,539,864 - 46,547,851 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39291,752,534 - 91,760,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,757,594 - 91,759,033 (+)EnsemblGRCm39 Ensembl
GRCm38291,922,189 - 91,929,835 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,927,249 - 91,928,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,762,346 - 91,769,986 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,728,088 - 91,729,527 (+)NCBIMGSCv36mm8
Celera293,312,590 - 93,320,231 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554221,647,663 - 1,655,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,647,663 - 1,655,363 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11146,893,292 - 46,901,074 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,894,615 - 46,896,054 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,342,384 - 46,350,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11843,077,115 - 43,084,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,082,404 - 43,083,840 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,805,766 - 41,813,475 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01843,733,324 - 43,740,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,733,289 - 43,741,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,218,330 - 43,226,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,770,212 - 42,777,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,503,419 - 43,510,935 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494720,567,540 - 20,576,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,493,774 - 2,689,731 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365622,685,209 - 2,687,751 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl216,122,704 - 16,130,810 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1216,119,794 - 16,131,080 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,468,644 - 17,476,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1118,937,455 - 18,945,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,942,643 - 18,944,079 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038116,222,834 - 116,230,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247672,162,712 - 2,171,012 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247672,162,719 - 2,170,921 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Chrm4
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:111
Interacting mature miRNAs:142
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,900,850 - 77,901,058 (+)MAPPERmRatBN7.2
Rnor_6.0380,840,698 - 80,840,905NCBIRnor6.0
Rnor_5.0387,539,366 - 87,539,573UniSTSRnor5.0
RGSC_v3.4376,309,414 - 76,309,621UniSTSRGSC3.4
Celera377,103,500 - 77,103,707UniSTS
Cytogenetic Map3q32-q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,898,580 - 77,900,017 (+)MAPPERmRatBN7.2
Rnor_6.0380,838,428 - 80,839,864NCBIRnor6.0
Rnor_5.0387,537,096 - 87,538,532UniSTSRnor5.0
RGSC_v3.4376,307,144 - 76,308,580UniSTSRGSC3.4
Celera377,101,230 - 77,102,666UniSTS
Cytogenetic Map3q32-q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,898,549 - 77,900,106 (+)MAPPERmRatBN7.2
Rnor_6.0380,838,397 - 80,839,953NCBIRnor6.0
Rnor_5.0387,537,065 - 87,538,621UniSTSRnor5.0
RGSC_v3.4376,307,113 - 76,308,669UniSTSRGSC3.4
Celera377,101,199 - 77,102,755UniSTS
Cytogenetic Map3q32-q35UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 13
Low 2 53 14
Below cutoff 1 16 18 4 16 4 2 3 8 2 26 11 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023583   ⟹   ENSRNOP00000023586
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)Ensembl
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)Ensembl
RefSeq Acc Id: NM_031547   ⟹   NP_113735
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,893,425 - 77,901,166 (+)NCBI
Rnor_6.0380,833,272 - 80,841,013 (+)NCBI
Rnor_5.0387,531,619 - 87,539,681 (+)NCBI
RGSC_v3.4376,301,988 - 76,309,729 (+)RGD
Celera377,096,073 - 77,103,815 (+)RGD
RefSeq Acc Id: XM_008762022   ⟹   XP_008760244
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,893,591 - 77,901,166 (+)NCBI
Rnor_6.0380,833,423 - 80,841,165 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113735 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40663 (Get FASTA)   NCBI Sequence Viewer  
  EDL79547 (Get FASTA)   NCBI Sequence Viewer  
  P08485 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113735   ⟸   NM_031547
- UniProtKB: P08485 (UniProtKB/Swiss-Prot),   G3V894 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760244   ⟸   XM_008762022
- Peptide Label: isoform X1
- UniProtKB: G3V894 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023586   ⟸   ENSRNOT00000023583
Protein Domains


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2344 AgrOrtholog
BioCyc Gene G2FUF-48718 BioCyc
Ensembl Genes ENSRNOG00000017556 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023586 ENTREZGENE
  ENSRNOP00000023586.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023583 ENTREZGENE
  ENSRNOT00000023583.6 UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Musac_Ach_M4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Musac_Ach_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25111 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR24248:SF142 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chrm4 PhenoGen
  MUSCARINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUSCRINICM4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACM4_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Chrm4  cholinergic receptor, muscarinic 4    cholinergic receptor, muscarin 4  Name updated 1299863 APPROVED
2002-06-10 Chrm4  cholinergic receptor, muscarin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalized in the soma and neuropil 625569
gene_domains the m4i3 loop acts as a guanine exchange factor for eEF1A2 (essential GTP-binding protein) 625569
gene_expression predominant in the central nervous system, also found in exocrine glands and smooth muscle 61489
gene_expression expressed in the rat striatum 625569
gene_function G-protein coupled receptor 625569
gene_process mediates effects of acetylcholine in the central and peripheral nervous system 625569
gene_process inhibits adenylate cyclase 61489
gene_process breaks down phosphoinositides & modulates potassium channels 61489
gene_process may be involved in cholinergic mechanisms of pain relieg 1298759
gene_product member of the GPCR (G-protein-coupled-receptor) family 625569