Eef1a2 (eukaryotic translation elongation factor 1 alpha 2) - Rat Genome Database

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Gene: Eef1a2 (eukaryotic translation elongation factor 1 alpha 2) Rattus norvegicus
Analyze
Symbol: Eef1a2
Name: eukaryotic translation elongation factor 1 alpha 2
RGD ID: 3781
Description: Predicted to have GTPase activity; protein kinase binding activity; and translation elongation factor activity. Involved in response to electrical stimulus and response to inorganic substance. Localizes to neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A2 (eukaryotic translation elongation factor 1 alpha 2); PARTICIPATES IN RNA transport pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eEF1A-2; EEF1AL; EF-1-alpha-2; elongation factor 1 A-2; elongation factor 1-alpha 2; eukaryotic elongation factor 1 A-2; Ps10; RATPS10; statin S1; statin-like; statin-S1; STN; Stnl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,265,893 - 168,275,071 (-)NCBI
Rnor_6.0 Ensembl3176,657,107 - 176,666,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03176,657,104 - 176,666,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03180,367,136 - 180,376,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,295,327 - 170,304,505 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13170,201,363 - 170,210,541 (-)NCBI
Celera3164,310,775 - 164,319,957 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(Z)-3-butylidenephthalide  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fructose  (EXP)
genistein  (ISO)
graphite  (EXP,ISO)
LY294002  (ISO)
methapyrilene  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl isothiocyanate  (EXP)
pioglitazone  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrahydropalmatine  (ISO)
thimerosal  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9588196   PMID:11724805   PMID:12426392   PMID:15013623   PMID:15489334   PMID:16452087   PMID:17088255   PMID:17634366   PMID:18474610   PMID:21700703   PMID:22871113   PMID:24625528  
PMID:26316108  


Genomics

Candidate Gene Status
Eef1a2 is a candidate Gene for QTL Bp285
Comparative Map Data
Eef1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,265,893 - 168,275,071 (-)NCBI
Rnor_6.0 Ensembl3176,657,107 - 176,666,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03176,657,104 - 176,666,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03180,367,136 - 180,376,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,295,327 - 170,304,505 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13170,201,363 - 170,210,541 (-)NCBI
Celera3164,310,775 - 164,319,957 (+)NCBICelera
Cytogenetic Map3q43NCBI
EEF1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2063,488,014 - 63,499,185 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2063,488,013 - 63,499,239 (-)EnsemblGRCh38hg38GRCh38
GRCh382063,488,014 - 63,499,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372062,119,367 - 62,130,436 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,589,810 - 61,600,949 (-)NCBINCBI36hg18NCBI36
Build 342061,589,809 - 61,600,949NCBI
Celera2058,799,722 - 58,810,854 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2058,848,703 - 58,860,885 (-)NCBIHuRef
CHM1_12062,020,420 - 62,031,789 (-)NCBICHM1_1
Eef1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,783,551 - 180,798,808 (-)NCBIGRCm39mm39
GRCm39 Ensembl2180,789,446 - 180,798,807 (-)Ensembl
GRCm382181,141,758 - 181,157,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,147,653 - 181,157,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,882,397 - 180,891,720 (-)NCBIGRCm37mm9NCBIm37
MGSCv362181,077,100 - 181,086,422 (-)NCBImm8
Celera2185,234,189 - 185,243,512 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.6NCBI
Eef1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528717,338 - 729,692 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528717,338 - 726,383 (+)NCBIChiLan1.0ChiLan1.0
EEF1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12061,412,059 - 61,421,820 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,412,122 - 61,421,735 (-)Ensemblpanpan1.1panPan2
LOC487375
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,787,450 - 75,797,662 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,357,766 - 72,367,782 (-)NCBI
ROS_Cfam_1.0276,347,000 - 76,357,024 (-)NCBI
UMICH_Zoey_3.1273,169,322 - 73,179,344 (-)NCBI
UNSW_CanFamBas_1.0274,176,170 - 74,186,373 (-)NCBI
UU_Cfam_GSD_1.0275,181,724 - 75,191,917 (-)NCBI
Eef1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,345,359 - 195,353,489 (-)NCBI
SpeTri2.0NW_00493651410,799,002 - 10,807,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,517,503 - 62,526,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,517,811 - 62,526,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EEF1A2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12712,020 - 724,843 (+)NCBI
ChlSab1.1 Ensembl2713,522 - 724,859 (+)Ensembl
Eef1a2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474129,154,762 - 29,163,794 (-)NCBI

Position Markers
D3Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,266,540 - 168,266,819 (+)MAPPER
Rnor_6.03176,657,752 - 176,658,030NCBIRnor6.0
Rnor_5.03180,367,784 - 180,368,062UniSTSRnor5.0
RGSC_v3.43170,295,974 - 170,296,253RGDRGSC3.4
RGSC_v3.43170,295,975 - 170,296,253UniSTSRGSC3.4
RGSC_v3.13170,202,010 - 170,202,289RGD
Celera3164,319,027 - 164,319,309UniSTS
Cytogenetic Map3q43UniSTS
D3Arb15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,266,545 - 168,266,891 (+)MAPPER
Rnor_6.03176,657,757 - 176,658,102NCBIRnor6.0
Rnor_5.03180,367,789 - 180,368,134UniSTSRnor5.0
RGSC_v3.43170,295,979 - 170,296,325RGDRGSC3.4
RGSC_v3.43170,295,980 - 170,296,325UniSTSRGSC3.4
RGSC_v3.13170,202,016 - 170,202,361RGD
Celera3164,318,955 - 164,319,304UniSTS
RH 3.4 Map31539.0UniSTS
RH 3.4 Map31539.0RGD
RH 2.0 Map31055.9RGD
SHRSP x BN Map391.4899RGD
Cytogenetic Map3q43UniSTS
D3Mgh27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,266,545 - 168,266,691 (+)MAPPER
Rnor_6.03176,657,757 - 176,657,902NCBIRnor6.0
Rnor_5.03180,367,789 - 180,367,934UniSTSRnor5.0
RGSC_v3.43170,295,979 - 170,296,125RGDRGSC3.4
RGSC_v3.43170,295,980 - 170,296,125UniSTSRGSC3.4
RGSC_v3.13170,202,015 - 170,202,161RGD
Celera3164,319,155 - 164,319,304UniSTS
RH 3.4 Map31541.3RGD
RH 3.4 Map31541.3UniSTS
RH 2.0 Map31057.5RGD
SHRSP x BN Map391.5299RGD
Cytogenetic Map3q43UniSTS
D3Mco31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,266,538 - 168,266,827 (+)MAPPER
Rnor_6.03176,657,750 - 176,658,038NCBIRnor6.0
Rnor_5.03180,367,782 - 180,368,070UniSTSRnor5.0
RGSC_v3.43170,295,972 - 170,296,261RGDRGSC3.4
RGSC_v3.43170,295,973 - 170,296,261UniSTSRGSC3.4
Celera3164,319,019 - 164,319,311UniSTS
Cytogenetic Map3q43UniSTS
Eef1a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.43170,295,728 - 170,296,358UniSTSRGSC3.4
RGSC_v3.43170,295,332 - 170,295,464UniSTSRGSC3.4
Celera3164,318,922 - 164,319,556UniSTS
Celera3164,319,820 - 164,319,952UniSTS
L26479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,265,894 - 168,266,055 (+)MAPPER
Rnor_6.03176,657,106 - 176,657,266NCBIRnor6.0
Rnor_5.03180,367,138 - 180,367,298UniSTSRnor5.0
RGSC_v3.43170,295,329 - 170,295,489UniSTSRGSC3.4
Celera3164,319,795 - 164,319,955UniSTS
Cytogenetic Map3q43UniSTS
Eef1a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03180,367,141 - 180,367,273UniSTSRnor5.0
RGSC_v3.43170,295,332 - 170,295,464UniSTSRGSC3.4
Celera3164,319,820 - 164,319,952UniSTS
Cytogenetic Map3q43UniSTS
Eef1a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03180,367,537 - 180,368,167UniSTSRnor5.0
RGSC_v3.43170,295,728 - 170,296,358UniSTSRGSC3.4
Celera3164,318,922 - 164,319,556UniSTS
Cytogenetic Map3q43UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3170428815177699992Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:61
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000016947
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 4
Medium 37 8 8 64 4 8
Low 3 6 31 16 10 16 6 13 40 7
Below cutoff 24 23 9 23 22 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016947   ⟹   ENSRNOP00000016947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3176,657,107 - 176,666,282 (-)Ensembl
RefSeq Acc Id: NM_012660   ⟹   NP_036792
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,265,893 - 168,275,071 (-)NCBI
Rnor_6.03176,657,104 - 176,666,282 (-)NCBI
Rnor_5.03180,367,136 - 180,376,314 (-)NCBI
RGSC_v3.43170,295,327 - 170,304,505 (-)RGD
Celera3164,310,775 - 164,319,957 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591475   ⟹   XP_017446964
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03176,657,104 - 176,665,652 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036792   ⟸   NM_012660
- UniProtKB: P62632 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446964   ⟸   XM_017591475
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016947   ⟸   ENSRNOT00000016947
Protein Domains
tr-type G

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692746
Promoter ID:EPDNEW_R3271
Type:multiple initiation site
Name:Eef1a2_1
Description:eukaryotic translation elongation factor 1 alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03176,666,056 - 176,666,116EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3781 AgrOrtholog
Ensembl Genes ENSRNOG00000012477 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016947 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016947 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105980 IMAGE-MGC_LOAD
InterPro EFTu-like_2 UniProtKB/Swiss-Prot
  G_TR_CS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  TF_GTP-bd_dom UniProtKB/Swiss-Prot
  Transl_B-barrel_sf UniProtKB/Swiss-Prot
  Transl_elong_EF1A/Init_IF2_C UniProtKB/Swiss-Prot
  Transl_elong_EF1A_euk/arc UniProtKB/Swiss-Prot
  Transl_elong_EFTu/EF1A_C UniProtKB/Swiss-Prot
KEGG Report rno:24799 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91772 IMAGE-MGC_LOAD
NCBI Gene 24799 ENTREZGENE
Pfam GTP_EFTU UniProtKB/Swiss-Prot
  GTP_EFTU_D2 UniProtKB/Swiss-Prot
  GTP_EFTU_D3 UniProtKB/Swiss-Prot
PhenoGen Eef1a2 PhenoGen
PRINTS ELONGATNFCT UniProtKB/Swiss-Prot
PROSITE G_TR_1 UniProtKB/Swiss-Prot
  G_TR_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50447 UniProtKB/Swiss-Prot
  SSF50465 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGR TC204611
TIGRFAMs EF-1_alpha UniProtKB/Swiss-Prot
UniProt EF1A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P27706 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-01-12 Eef1a2  eukaryotic translation elongation factor 1 alpha 2  Stnl  statin-like  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-04-09 Stnl  statin-like    Statin-like protein  Name updated 629478 APPROVED
2002-06-10 Stnl  Statin-like protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology highly homologous to human EF-1 alpha gene 634174
gene_transcript 47 kb in size 634174