Chrm4 (cholinergic receptor muscarinic 4) - Rat Genome Database

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Gene: Chrm4 (cholinergic receptor muscarinic 4) Heterocephalus glaber
Analyze
Symbol: Chrm4
Name: cholinergic receptor muscarinic 4
RGD ID: 18925403
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH Catatonia (ortholog); congenital disorder of glycosylation type IIc (ortholog); congestive heart failure (ortholog); FOUND IN asymmetric synapse (ortholog); axon terminus (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Muscarinic acetylcholine receptor M4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,162,712 - 2,171,012 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247672,162,719 - 2,170,921 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Chrm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,162,712 - 2,171,012 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247672,162,719 - 2,170,921 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CHRM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,383,789 - 46,391,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,383,789 - 46,391,776 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,405,339 - 46,413,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,363,216 - 46,364,683 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,363,215 - 46,364,683NCBI
Celera1146,554,217 - 46,555,684 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,113,598 - 46,115,064 (-)NCBIHuRef
CHM1_11146,405,093 - 46,406,560 (-)NCBICHM1_1
T2T-CHM13v2.01146,539,864 - 46,547,851 (-)NCBIT2T-CHM13v2.0
Chrm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,752,531 - 91,760,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,757,594 - 91,759,033 (+)EnsemblGRCm39 Ensembl
GRCm38291,922,189 - 91,929,835 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,927,249 - 91,928,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,762,346 - 91,769,986 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,728,088 - 91,729,527 (+)NCBIMGSCv36mm8
Celera293,312,590 - 93,320,231 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Chrm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,349,080 - 98,356,821 (+)NCBIGRCr8
mRatBN7.2377,893,425 - 77,901,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,368,613 - 81,376,348 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,967,641 - 89,975,378 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,818,870 - 87,826,600 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,833,272 - 80,841,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,531,619 - 87,539,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,301,988 - 76,309,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,203,520 - 76,206,094 (+)NCBI
Celera377,096,073 - 77,103,815 (+)NCBICelera
Cytogenetic Map3q24NCBI
Chrm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,647,663 - 1,655,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,647,663 - 1,655,363 (+)NCBIChiLan1.0ChiLan1.0
CHRM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,596,916 - 48,606,737 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,603,743 - 48,611,729 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,342,384 - 46,350,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,893,292 - 46,901,074 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,894,615 - 46,896,054 (-)Ensemblpanpan1.1panPan2
CHRM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11843,077,115 - 43,084,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,082,404 - 43,083,840 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,805,766 - 41,813,475 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01843,733,324 - 43,740,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,733,289 - 43,741,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,218,330 - 43,226,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,770,212 - 42,777,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,503,419 - 43,510,935 (+)NCBIUU_Cfam_GSD_1.0
Chrm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,567,540 - 20,576,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,493,774 - 2,689,731 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,685,209 - 2,687,751 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,122,704 - 16,130,810 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1216,119,794 - 16,131,080 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,468,644 - 17,476,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,937,455 - 18,945,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,942,643 - 18,944,079 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038116,222,834 - 116,230,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000024827   ⟹   ENSHGLP00000024605
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247672,162,712 - 2,171,012 (+)Ensembl
RefSeq Acc Id: XM_004851921   ⟹   XP_004851978
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247672,162,719 - 2,170,921 (+)NCBI
RefSeq Acc Id: XM_021264241   ⟹   XP_021119900
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247672,163,341 - 2,170,921 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004851978 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119900 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00279 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024605
Reference Protein Sequences
RefSeq Acc Id: XP_004851978   ⟸   XM_004851921
- UniProtKB: G5ATB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119900   ⟸   XM_021264241
- UniProtKB: G5ATB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000024605   ⟸   ENSHGLT00000024827


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017542 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024827 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Musac_Ach_M4_rcpt UniProtKB/TrEMBL
  Musac_Ach_rcpt UniProtKB/TrEMBL
KEGG Report hgl:101726411 UniProtKB/TrEMBL
NCBI Gene Chrm4 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/TrEMBL
  MUSCARINIC ACETYLCHOLINE RECEPTOR M4 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MUSCARINICR UniProtKB/TrEMBL
  MUSCRINICM4R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt G5ATB8 ENTREZGENE, UniProtKB/TrEMBL