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Gene: Pde11a (phosphodiesterase 11A) Rattus norvegicus
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Symbol: Pde11a
Name: phosphodiesterase 11A
Description: Exhibits cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Localizes to the perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP and cGMP phosphodiesterase 11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; Pde11A2; Pde11A3; Pde11A4
Orthologs:
Homo sapiens (human) : PDE11A (phosphodiesterase 11A)  HGNC  Alliance
Mus musculus (house mouse) : Pde11a (phosphodiesterase 11A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde11a (phosphodiesterase 11A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE11A (phosphodiesterase 11A)
Canis lupus familiaris (dog) : PDE11A (phosphodiesterase 11A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde11a (phosphodiesterase 11A)
Sus scrofa (pig) : PDE11A (phosphodiesterase 11A)
more info ...
Allele / Splice: Pde11a_v3   Pde11a_v2   Pde11a_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0362,818,502 - 63,211,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0369,363,100 - 69,784,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,659,595 - 59,049,869 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1358,555,966 - 58,922,151 (-)NCBI
Celera360,413,273 - 60,785,139 (-)NCBICelera
Cytogenetic Map3q23-q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pde11a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621793
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.