Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cd59 (CD59 molecule) Rattus norvegicus
Symbol: Cd59
Name: CD59 molecule
RGD ID: 2311
Description: Exhibits complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Localizes to compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of diabetic retinopathy and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 1,3-Propane sultone; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: Cb59b molecule; CD59 antigen; CD59 glycoprotein; CD59 molecule, complement regulatory protein; Cd59a; Cd59b; CD59b moleucle, complement regulatory protein; MAC-inhibitory protein; MAC-IP; MACIF; MACIP; membrane attack complex inhibition factor; protectin
Homo sapiens (human) : CD59 (CD59 molecule (CD59 blood group))  HGNC  Alliance
Mus musculus (house mouse) : Cd59b (CD59b antigen)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd59 (CD59 molecule (CD59 blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : CD59 (CD59 molecule (CD59 blood group))
Canis lupus familiaris (dog) : CD59 (CD59 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd59 (CD59 molecule (CD59 blood group))
Sus scrofa (pig) : CD59 (CD59 molecule)
Chlorocebus sabaeus (African green monkey) : CD59 (CD59 molecule (CD59 blood group))
more info ...
Allele / Splice: Cd59em1Ask  
Genetic Models: SD-Cd59em1Ask-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0394,010,481 - 94,028,660 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl394,010,475 - 94,028,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,650,411 - 100,668,036 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4389,243,600 - 89,245,129 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1389,318,629 - 89,333,534 (-)NCBI
Celera389,520,423 - 89,538,310 (+)NCBICelera
Cytogenetic Map3q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Cd59
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2311
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.