Gad1 (glutamate decarboxylase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gad1 (glutamate decarboxylase 1) Rattus norvegicus
Analyze
Symbol: Gad1
Name: glutamate decarboxylase 1
RGD ID: 2652
Description: Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including cellular response to serotonin; gamma-aminobutyric acid biosynthetic process; and positive regulation of locomotion involved in locomotory behavior. Located in neuronal cell body and presynaptic active zone. Used to study diabetes mellitus. Biomarker of several diseases, including autism spectrum disorder; drug psychosis; morphine dependence; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-alanine metabolic pathway; Canavan disease pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 67 kDa glutamic acid decarboxylase; GAD-67; Gad67; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 67 kDa isoform; glutamic acid decarboxylase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Gad1em15Yyan
Genetic Models: LE-Gad1em15Yyan
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8375,777,260 - 75,818,099 (+)NCBIGRCr8
GRCr8 Ensembl375,777,534 - 75,818,759 (+)EnsemblGRCr8 Ensembl
mRatBN7.2355,369,704 - 55,410,335 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl355,369,704 - 55,410,333 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx358,774,583 - 58,815,086 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0367,358,166 - 67,398,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,120,847 - 65,161,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0356,861,440 - 56,902,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl356,861,396 - 56,902,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0363,479,963 - 63,519,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4352,789,370 - 52,830,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera354,926,942 - 54,967,478 (+)NCBICelera
RGSC_v3.1352,685,741 - 52,726,408 (+)NCBI
Cytogenetic Map3q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1-methyl-1H-imidazole  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-METHYLIMIDAZOLE  (ISO)
2-palmitoylglycerol  (ISO)
3-Acetylpyridine  (EXP)
3-mercaptopropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-methylimidazole  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetic acid  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allylglycine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
apocynin  (ISO)
Aroclor 1254  (EXP)
atrazine  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (EXP)
carbamazepine  (ISO)
chaetocin  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clenbuterol  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
corticosterone  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (EXP)
D-glucose  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazepam  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dihydro-beta-erythroidine  (EXP)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
eticlopride(1+)  (EXP)
fenamidone  (ISO)
fluoxetine  (EXP)
fluvoxamine  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gamma-aminobutyric acid  (EXP,ISO)
genistein  (EXP)
glucose  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lipoic acid  (EXP)
malathion  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylazoxymethanol  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
Mipafox  (ISO)
monosodium L-glutamate  (EXP)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
oxidopamine  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
poly(I:C)  (EXP)
propanal  (ISO)
propranolol  (EXP)
pyridoxal 5'-phosphate  (EXP,ISO)
quercetin  (ISO)
raloxifene  (ISO)
reserpine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulpiride  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vigabatrin  (EXP)
vorinostat  (ISO)
VX nerve agent  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO)
axon terminus  (IEA,ISO)
cell cortex  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
GABA-ergic synapse  (IEA,ISO)
inhibitory synapse  (IEA,ISO)
neuron projection terminus  (IEA,ISO)
neuronal cell body  (IDA)
perinuclear region of cytoplasm  (IEA,ISO)
presynapse  (IEA,ISO)
presynaptic active zone  (IBA,IDA,IEA,ISO)
synapse  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats. Alele PE and Devaud LL, Alcohol Clin Exp Res. 2005 Jun;29(6):1027-34.
2. Developmentally regulated expression of an exon containing a stop codon in the gene for glutamic acid decarboxylase. Bond RW, etal., Proc Natl Acad Sci U S A 1990 Nov;87(22):8771-5.
3. Tracking the expression of excitatory and inhibitory neurotransmission-related proteins and neuroplasticity markers after noise induced hearing loss. Browne CJ, etal., PLoS One. 2012;7(3):e33272. doi: 10.1371/journal.pone.0033272. Epub 2012 Mar 12.
4. Caloric restriction augments brain glutamic acid decarboxylase-65 and -67 expression. Cheng CM, etal., J Neurosci Res. 2004 Jul 15;77(2):270-6. doi: 10.1002/jnr.20144.
5. Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Condie BG, etal., Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11451-5.
6. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. Dirkx R Jr, etal., J Biol Chem. 1995 Feb 3;270(5):2241-6.
7. Recombinant tissue plasminogen activator induces long-term anxiety-like behaviors via the ERK1/2-GAD1-GABA cascade in the hippocampus of a rat model. Dong MX, etal., Neuropharmacology. 2018 Jan;128:119-131. doi: 10.1016/j.neuropharm.2017.09.039. Epub 2017 Oct 3.
8. Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. Donner J, etal., Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):316-27. doi: 10.1002/ajmg.b.32029. Epub 2012 Feb 10.
9. Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9.
10. CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia. Fujihara K, etal., Transl Psychiatry. 2020 Dec 8;10(1):426. doi: 10.1038/s41398-020-01108-6.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Post-weaning social isolation rearing influences the expression of molecules related to inhibitory neurotransmission and structural plasticity in the amygdala of adult rats. Gilabert-Juan J, etal., Brain Res. 2012 Apr 11;1448:129-36. doi: 10.1016/j.brainres.2012.01.073. Epub 2012 Feb 4.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. Huang HS, etal., J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
15. mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. Huang ZZ, etal., J Neurosci. 2016 Jun 8;36(23):6321-31. doi: 10.1523/JNEUROSCI.0646-16.2016.
16. No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. Ikeda M, etal., Schizophr Res. 2007 Mar;91(1-3):22-6. Epub 2007 Feb 14.
17. GABAergic Alterations in the Rat Testis after Methamphetamine Exposure. Kaewman P, etal., Int J Med Sci. 2018 Aug 10;15(12):1349-1354. doi: 10.7150/ijms.27609. eCollection 2018.
18. Repeated morphine treatment alters polysialylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and cell proliferation in the adult rat hippocampus. Kahn L, etal., Eur J Neurosci. 2005 Jan;21(2):493-500. doi: 10.1111/j.1460-9568.2005.03883.x.
19. HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a. Kanda H, etal., Gene Ther. 2016 Apr;23(4):340-8. doi: 10.1038/gt.2016.3. Epub 2016 Jan 11.
20. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
21. Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells. Kobayashi S and Millhorn DE, J Neurochem. 2001 Mar;76(6):1935-48. doi: 10.1046/j.1471-4159.2001.00214.x.
22. Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence. Kuo PH, etal., Drug Alcohol Depend. 2009 Apr 1;101(1-2):80-7. doi: 10.1016/j.drugalcdep.2008.11.009. Epub 2008 Dec 25.
23. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
24. Rapid decrease of GAD 67 content before the convulsion induced by hyperbaric oxygen exposure. Li Q, etal., Neurochem Res. 2008 Jan;33(1):185-93. Epub 2007 Aug 22.
25. Increased GAD expression in the striatum after transient cerebral ischemia. Li Y, etal., Mol Cell Neurosci. 2010 Dec;45(4):370-7. doi: 10.1016/j.mcn.2010.07.010. Epub 2010 Jul 24.
26. Gad1 knock-out rats exhibit abundant spike-wave discharges in EEG, exacerbated with valproate treatment. Liu D, etal., Front Neurol. 2023 Sep 26;14:1243301. doi: 10.3389/fneur.2023.1243301. eCollection 2023.
27. Glutamate decarboxylase genes and alcoholism in Han Taiwanese men. Loh el-W, etal., Alcohol Clin Exp Res. 2006 Nov;30(11):1817-23. doi: 10.1111/j.1530-0277.2006.00218.x.
28. Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex. Mackowiak M, etal., Eur Neuropsychopharmacol. 2014 Feb;24(2):271-89. doi: 10.1016/j.euroneuro.2013.05.013. Epub 2013 Aug 8.
29. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain. Martin DL, etal., J Neurosci. 1991 Sep;11(9):2725-31.
30. Structural features and regulatory properties of the brain glutamate decarboxylases. Martin DL, etal., Neurochem Int. 2000 Aug-Sep;37(2-3):111-9.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus. Michelsen BK, etal., Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8754-8.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. Olexová L, etal., Neurosci Lett. 2016 Aug 26;629:9-14. doi: 10.1016/j.neulet.2016.06.035. Epub 2016 Jun 25.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. High-frequency stimulation of the subthalamic nucleus selectively reverses dopamine denervation-induced cellular defects in the output structures of the basal ganglia in the rat. Salin P, etal., J Neurosci 2002 Jun 15;22(12):5137-48.
42. Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia. Schreiber S, etal., World J Biol Psychiatry. 2011 Feb;12(1):57-65. Epub 2011 Jan 20.
43. GAD1 but not GAD2 polymorphisms are associated with heroin addiction phenotypes. Shi Y, etal., Neurosci Lett. 2020 Jan 19;717:134704. doi: 10.1016/j.neulet.2019.134704. Epub 2019 Dec 19.
44. Influence of progesterone on GAD65 and GAD67 mRNA expression in the dorsolateral striatum and prefrontal cortex of female rats repeatedly treated with cocaine. Souza MF, etal., Braz J Med Biol Res. 2009 Nov;42(11):1068-75. doi: 10.1590/S0100-879X2009001100011.
45. Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Sperk G, etal., Hippocampus. 2003;13(7):806-15. doi: 10.1002/hipo.10133.
46. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, etal., Cell Rep. 2014 Mar 27;6(6):1096-109. doi: 10.1016/j.celrep.2014.02.010. Epub 2014 Mar 6.
47. Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence. Veerasakul S, etal., Pharmacogenomics. 2017 Jan;18(1):17-22. doi: 10.2217/pgs-2016-0101. Epub 2016 Dec 14.
48. Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Woo TU, etal., Brain Res. 2008 Jul 7;1218:267-77. Epub 2008 Apr 16.
49. Polymorphisms in the glutamate decarboxylase 1 gene associated with heroin dependence. Wu W, etal., Biochem Biophys Res Commun. 2012 May 25;422(1):91-6. doi: 10.1016/j.bbrc.2012.04.112. Epub 2012 Apr 30.
50. Characterization of a cDNA coding for rat glutamic acid decarboxylase. Wyborski RJ, etal., Brain Res Mol Brain Res 1990 Aug;8(3):193-8.
51. DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment. Yan H, etal., Oncogene. 2016 Jul 28;35(30):3995-4008. doi: 10.1038/onc.2015.423. Epub 2015 Nov 9.
52. Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats. Zamberletti E, etal., Neurobiol Dis. 2014 Mar;63:35-47. doi: 10.1016/j.nbd.2013.10.028. Epub 2013 Nov 4.
53. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. Zhang TY, etal., J Neurosci. 2010 Sep 29;30(39):13130-7. doi: 10.1523/JNEUROSCI.1039-10.2010.
54. Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex. Zink M and Spanagel R, Neuroreport. 2005 Mar 15;16(4):377-80. doi: 10.1097/00001756-200503150-00014.
Additional References at PubMed
PMID:2299361   PMID:10671565   PMID:11064363   PMID:12074840   PMID:12634427   PMID:14512139   PMID:14596865   PMID:14622157   PMID:14642440   PMID:14651853   PMID:14663191   PMID:15039456  
PMID:15044549   PMID:15140559   PMID:15271064   PMID:15347806   PMID:15368530   PMID:15479642   PMID:15686475   PMID:16094313   PMID:16255028   PMID:17056007   PMID:17680886   PMID:17934249  
PMID:18022144   PMID:18165320   PMID:18606818   PMID:18758993   PMID:18801833   PMID:18973578   PMID:19190758   PMID:19596402   PMID:19701789   PMID:19885653   PMID:19911306   PMID:20096683  
PMID:20405034   PMID:20969567   PMID:22194107   PMID:22332935   PMID:23055511   PMID:23258346   PMID:23376695   PMID:23904086   PMID:23973096   PMID:24952328   PMID:24983209   PMID:25647668  
PMID:26066725   PMID:27702572   PMID:27733539   PMID:28306133   PMID:29111460   PMID:30051606   PMID:33325157   PMID:34209226   PMID:34972242   PMID:35917217   PMID:36113682   PMID:36587827  
PMID:37586565   PMID:38194067  


Genomics

Comparative Map Data
Gad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8375,777,260 - 75,818,099 (+)NCBIGRCr8
GRCr8 Ensembl375,777,534 - 75,818,759 (+)EnsemblGRCr8 Ensembl
mRatBN7.2355,369,704 - 55,410,335 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl355,369,704 - 55,410,333 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx358,774,583 - 58,815,086 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0367,358,166 - 67,398,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,120,847 - 65,161,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0356,861,440 - 56,902,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl356,861,396 - 56,902,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0363,479,963 - 63,519,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4352,789,370 - 52,830,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera354,926,942 - 54,967,478 (+)NCBICelera
RGSC_v3.1352,685,741 - 52,726,408 (+)NCBI
Cytogenetic Map3q22NCBI
GAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382170,813,210 - 170,861,151 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2170,813,213 - 170,861,151 (+)EnsemblGRCh38hg38GRCh38
GRCh372171,673,397 - 171,717,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362171,381,446 - 171,425,907 (+)NCBINCBI36Build 36hg18NCBI36
Build 342171,498,706 - 171,524,775NCBI
Celera2165,289,914 - 165,334,327 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2163,562,349 - 163,606,375 (+)NCBIHuRef
CHM1_12171,679,435 - 171,723,884 (+)NCBICHM1_1
T2T-CHM13v2.02171,290,353 - 171,338,262 (+)NCBIT2T-CHM13v2.0
Gad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39270,392,109 - 70,432,358 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl270,383,416 - 70,432,358 (+)EnsemblGRCm39 Ensembl
GRCm38270,561,303 - 70,602,014 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl270,553,072 - 70,602,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv37270,400,221 - 70,440,069 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36270,363,052 - 70,402,853 (+)NCBIMGSCv36mm8
Celera272,228,088 - 72,268,083 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map241.63NCBI
Gad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554493,963,705 - 4,001,850 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554493,964,006 - 4,001,850 (-)NCBIChiLan1.0ChiLan1.0
GAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21373,489,127 - 73,533,319 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B73,504,103 - 73,548,292 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B58,100,623 - 58,145,045 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B175,558,538 - 175,602,951 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B175,558,538 - 175,602,944 (+)Ensemblpanpan1.1panPan2
GAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13615,351,289 - 15,391,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3615,349,683 - 15,391,824 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3615,364,114 - 15,403,437 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03615,474,678 - 15,516,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3615,474,925 - 15,516,838 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13615,565,032 - 15,604,314 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03615,552,796 - 15,592,193 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03615,664,544 - 15,703,870 (+)NCBIUU_Cfam_GSD_1.0
Gad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303132,606,889 - 132,647,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365091,161,094 - 1,201,576 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365091,160,559 - 1,201,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1576,991,928 - 77,034,812 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11576,991,863 - 77,034,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21586,375,113 - 86,419,237 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q21-q22NCBI
GAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11056,351,495 - 56,396,476 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1056,353,253 - 56,396,524 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040143,149,876 - 143,195,107 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247878,308,759 - 8,347,686 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247878,308,759 - 8,345,929 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gad1
472 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir23arno-miR-23a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:185
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000000008
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
Z49976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2355,409,542 - 55,409,741 (+)MAPPERmRatBN7.2
Rnor_6.0356,901,347 - 56,901,545NCBIRnor6.0
Rnor_5.0363,519,087 - 63,519,285UniSTSRnor5.0
RGSC_v3.4352,829,246 - 52,829,444UniSTSRGSC3.4
Celera354,966,686 - 54,966,884UniSTS
Cytogenetic Map3q21UniSTS
Gad1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2355,410,044 - 55,410,265 (+)MAPPERmRatBN7.2
Rnor_6.0356,901,849 - 56,902,069NCBIRnor6.0
Rnor_5.0363,519,589 - 63,519,809UniSTSRnor5.0
RGSC_v3.4352,829,748 - 52,829,968UniSTSRGSC3.4
Celera354,967,188 - 54,967,408UniSTS
Cytogenetic Map3q21UniSTS
PMC30678P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2355,371,214 - 55,371,389 (+)MAPPERmRatBN7.2
Rnor_6.0356,862,950 - 56,863,124NCBIRnor6.0
Rnor_5.0363,481,473 - 63,481,647UniSTSRnor5.0
RGSC_v3.4352,790,880 - 52,791,054UniSTSRGSC3.4
Celera354,928,452 - 54,928,626UniSTS
Cytogenetic Map3q21UniSTS


Genetic Models
This gene Gad1 is modified in the following models/strains:
LE-Gad1em15Yyan    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 49 110 85 87 57 24 57 6 197 88 93 36 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000000008   ⟹   ENSRNOP00000000008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,781,497 - 75,818,097 (+)Ensembl
mRatBN7.2 Ensembl355,369,704 - 55,410,333 (+)Ensembl
Rnor_6.0 Ensembl356,861,396 - 56,902,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084375   ⟹   ENSRNOP00000068833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,777,534 - 75,802,639 (+)Ensembl
mRatBN7.2 Ensembl355,369,786 - 55,394,877 (+)Ensembl
Rnor_6.0 Ensembl356,861,522 - 56,886,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087134   ⟹   ENSRNOP00000074220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,781,394 - 75,818,099 (+)Ensembl
mRatBN7.2 Ensembl355,373,647 - 55,410,333 (+)Ensembl
Rnor_6.0 Ensembl356,868,167 - 56,902,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087712   ⟹   ENSRNOP00000072778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl356,862,691 - 56,902,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164935   ⟹   ENSRNOP00000103968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,777,557 - 75,818,097 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000166434   ⟹   ENSRNOP00000112627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,786,667 - 75,818,759 (+)Ensembl
RefSeq Acc Id: NM_017007   ⟹   NP_058703
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,777,452 - 75,818,099 (+)NCBI
mRatBN7.2355,369,704 - 55,410,335 (+)NCBI
Rnor_6.0356,861,440 - 56,902,139 (+)NCBI
Rnor_5.0363,479,963 - 63,519,879 (+)NCBI
RGSC_v3.4352,789,370 - 52,830,038 (+)RGD
Celera354,926,942 - 54,967,478 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591454   ⟹   XP_017446943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,777,972 - 75,818,099 (+)NCBI
mRatBN7.2355,370,406 - 55,410,335 (+)NCBI
Rnor_6.0356,862,139 - 56,902,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104242   ⟹   XP_038960170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,784,221 - 75,818,099 (+)NCBI
mRatBN7.2355,376,437 - 55,410,335 (+)NCBI
RefSeq Acc Id: XM_063283075   ⟹   XP_063139145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,777,260 - 75,818,099 (+)NCBI
RefSeq Acc Id: NP_058703   ⟸   NM_017007
- UniProtKB: P18088 (UniProtKB/Swiss-Prot),   C9E895 (UniProtKB/TrEMBL),   A0A0G2K7I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446943   ⟸   XM_017591454
- Peptide Label: isoform X1
- UniProtKB: P18088 (UniProtKB/Swiss-Prot),   C9E895 (UniProtKB/TrEMBL),   A0A0G2K7I5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072778   ⟸   ENSRNOT00000087712
Ensembl Acc Id: ENSRNOP00000000008   ⟸   ENSRNOT00000000008
Ensembl Acc Id: ENSRNOP00000074220   ⟸   ENSRNOT00000087134
Ensembl Acc Id: ENSRNOP00000068833   ⟸   ENSRNOT00000084375
RefSeq Acc Id: XP_038960170   ⟸   XM_039104242
- Peptide Label: isoform X2
- UniProtKB: B3VQJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139145   ⟸   XM_063283075
- Peptide Label: isoform X1
- UniProtKB: P18088 (UniProtKB/Swiss-Prot),   C9E895 (UniProtKB/TrEMBL),   A0A0G2K7I5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103968   ⟸   ENSRNOT00000164935
Ensembl Acc Id: ENSRNOP00000112627   ⟸   ENSRNOT00000166434

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18088-F1-model_v2 AlphaFold P18088 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692127
Promoter ID:EPDNEW_R2652
Type:single initiation site
Name:Gad1_1
Description:glutamate decarboxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0356,861,407 - 56,861,467EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2652 AgrOrtholog
BioCyc Gene G2FUF-49486 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  PWY0-1305 [L-glutamate degradation IX (via 4-aminobutanoate)] BioCyc
BioCyc Pathway Image GLUDEG-I-PWY BioCyc
  PWY0-1305 BioCyc
Ensembl Genes ENSRNOG00000000007 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000008 ENTREZGENE
  ENSRNOT00000000008.5 UniProtKB/Swiss-Prot
  ENSRNOT00000164935 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.170 UniProtKB/Swiss-Prot
InterPro PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
  Pyridoxal-P_BS UniProtKB/Swiss-Prot
KEGG Report rno:24379 UniProtKB/Swiss-Prot
NCBI Gene 24379 ENTREZGENE
PANTHER GLUTAMATE DECARBOXYLASE 1 UniProtKB/Swiss-Prot
  GLUTAMATE DECARBOXYLASE-RELATED UniProtKB/Swiss-Prot
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot
PhenoGen Gad1 PhenoGen
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000007 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A0A0G2K7I5 ENTREZGENE, UniProtKB/TrEMBL
  B3VQJ0 ENTREZGENE, UniProtKB/TrEMBL
  C9E895 ENTREZGENE, UniProtKB/TrEMBL
  DCE1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63211_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-08 Gad1  glutamate decarboxylase 1   Gad1  glutamic acid decarboxylase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gad1  glutamic acid decarboxylase 1    glutamate decarboxylase 1  Name updated 1299863 APPROVED
2002-06-10 Gad1  Glutamate decarboxylase 1 (brain)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease recognized as an antigen by human autoantibodies from patients with Iddm 728511
gene_process marker of GABA neuron activity in the external globus pallidus (GP), entopeduncular nucleus (EP), and substantia nigra pars reticulata (SNr) 628317
gene_regulation high-frequency stimulation of the subthalamic nucleus (STN) in hemiparkinsonian rats inhibits the lesion-induced mRNA in the SNr and in EP, partially, but not in the GP and striatum 628317