Gene: Gad1 (glutamate decarboxylase 1) Rattus norvegicus
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Symbol: Gad1
Name: glutamate decarboxylase 1
Description: Exhibits several functions, including anion binding activity; glutamate decarboxylase activity; and protein heterodimerization activity. Involved in gamma-aminobutyric acid biosynthetic process and response to drug. Localizes to the presynaptic active zone. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; schizophrenia; and spastic quadriplegia. Orthologous to human GAD1 (glutamate decarboxylase 1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-alanine metabolic pathway; Canavan disease pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (RS)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 67 kDa glutamic acid decarboxylase; GAD-67; Gad67; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 67 kDa isoform; glutamic acid decarboxylase 1
Orthologs:
Homo sapiens (human) : GAD1 (glutamate decarboxylase 1)  HGNC  Alliance
Mus musculus (house mouse) : Gad1 (glutamate decarboxylase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gad1 (glutamate decarboxylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GAD1 (glutamate decarboxylase 1)
Canis lupus familiaris (dog) : GAD1 (glutamate decarboxylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gad1 (glutamate decarboxylase 1)
Sus scrofa (pig) : GAD1 (glutamate decarboxylase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0356,861,440 - 56,902,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0363,479,963 - 63,519,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4352,789,370 - 52,830,038 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1352,685,741 - 52,726,408 (+)NCBI
Celera354,926,942 - 54,967,478 (+)NCBICelera
Cytogenetic Map3q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gad1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2652
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.