Accsl (1-aminocyclopropane-1-carboxylate synthase-like) - Rat Genome Database

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Gene: Accsl (1-aminocyclopropane-1-carboxylate synthase-like) Rattus norvegicus
Analyze
Symbol: Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase-like
RGD ID: 1596039
Description: Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Orthologous to human ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like; 1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like; 1-aminocyclopropane-1-carboxylate synthase-like protein 2; LOC690470; probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; similar to 1-aminocyclopropane-1-carboxylate synthase
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,281,817 - 100,296,514 (-)NCBIGRCr8
mRatBN7.2379,826,464 - 79,841,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,826,464 - 79,841,163 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,299,961 - 83,314,714 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0391,899,045 - 91,913,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,744,523 - 89,759,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,762,861 - 82,777,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,762,862 - 82,777,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,463,444 - 89,494,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,272,847 - 78,287,544 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera379,028,543 - 79,043,240 (-)NCBICelera
Cytogenetic Map3q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Accsl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,281,817 - 100,296,514 (-)NCBIGRCr8
mRatBN7.2379,826,464 - 79,841,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,826,464 - 79,841,163 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,299,961 - 83,314,714 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0391,899,045 - 91,913,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,744,523 - 89,759,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,762,861 - 82,777,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,762,862 - 82,777,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,463,444 - 89,494,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,272,847 - 78,287,544 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera379,028,543 - 79,043,240 (-)NCBICelera
Cytogenetic Map3q31NCBI
ACCSL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381143,921,068 - 44,059,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1144,047,981 - 44,059,977 (+)EnsemblGRCh38hg38GRCh38
GRCh371144,069,531 - 44,081,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,026,107 - 44,038,103 (+)NCBINCBI36Build 36hg18NCBI36
Celera1144,216,736 - 44,228,734 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1143,778,609 - 43,790,603 (+)NCBIHuRef
CHM1_11144,068,495 - 44,080,491 (+)NCBICHM1_1
T2T-CHM13v2.01144,076,427 - 44,215,307 (+)NCBIT2T-CHM13v2.0
Accsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,685,705 - 93,760,827 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,685,706 - 93,760,827 (-)EnsemblGRCm39 Ensembl
GRCm38293,855,360 - 93,930,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl293,855,361 - 93,869,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37293,695,520 - 93,709,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36293,656,202 - 93,665,655 (-)NCBIMGSCv36mm8
Celera295,251,783 - 95,265,510 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
ACCSL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2946,186,370 - 46,276,261 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11146,192,310 - 46,282,195 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01144,008,231 - 44,020,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11144,503,010 - 44,515,148 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1144,426,872 - 44,515,148 (+)Ensemblpanpan1.1panPan2
Accsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494722,504,490 - 22,615,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365624,616,507 - 4,627,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365624,616,143 - 4,708,264 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACCSL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,271,070 - 18,281,431 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,271,066 - 18,431,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2219,881,457 - 19,891,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACCSL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,317,621 - 21,439,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,317,980 - 21,330,477 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038118,543,256 - 118,638,775 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Accsl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247673,988,469 - 4,000,309 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Accsl
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:135
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000068585
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 6 5
Below cutoff 2 42 14 1 14 1 8 11 67 32 22 6 8

Sequence


RefSeq Acc Id: ENSRNOT00000068585   ⟹   ENSRNOP00000063492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl379,826,464 - 79,841,163 (-)Ensembl
Rnor_6.0 Ensembl382,762,862 - 82,777,814 (-)Ensembl
RefSeq Acc Id: NM_001109594   ⟹   NP_001103064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83100,281,817 - 100,296,514 (-)NCBI
mRatBN7.2379,826,464 - 79,841,163 (-)NCBI
Rnor_6.0382,762,862 - 82,777,814 (-)NCBI
Rnor_5.0389,463,444 - 89,494,958 (-)NCBI
RGSC_v3.4378,272,847 - 78,287,544 (-)RGD
Celera379,028,543 - 79,043,240 (-)RGD
Sequence:
RefSeq Acc Id: XM_063284585   ⟹   XP_063140655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83100,281,836 - 100,293,767 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103064 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140655 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063492
  ENSRNOP00000063492.1
RefSeq Acc Id: NP_001103064   ⟸   NM_001109594
- UniProtKB: D3ZUW2 (UniProtKB/TrEMBL),   A6HNJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063492   ⟸   ENSRNOT00000068585
RefSeq Acc Id: XP_063140655   ⟸   XM_063284585
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUW2-F1-model_v2 AlphaFold D3ZUW2 1-617 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596039 AgrOrtholog
BioCyc Gene G2FUF-48662 BioCyc
Ensembl Genes ENSRNOG00000042533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068585 ENTREZGENE
  ENSRNOT00000068585.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotransferase_I/II UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_dom UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub2 UniProtKB/TrEMBL
KEGG Report rno:690470 UniProtKB/TrEMBL
NCBI Gene 690470 ENTREZGENE
PANTHER BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED UniProtKB/TrEMBL
  INACTIVE 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE-LIKE PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/TrEMBL
PhenoGen Accsl PhenoGen
PRINTS ACCSYNTHASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042533 RatGTEx
Superfamily-SCOP PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
UniProt A6HNJ8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUW2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-11 Accsl  1-aminocyclopropane-1-carboxylate synthase-like  Accsl  1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-09 Accsl  1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like  LOC690470  similar to 1-aminocyclopropane-1-carboxylate synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690470  similar to 1-aminocyclopropane-1-carboxylate synthase  LOC687451  similar to 1-aminocyclopropane-1-carboxylate synthase  Data merged from RGD:1585354 1643240 APPROVED
2006-11-20 LOC690470  similar to 1-aminocyclopropane-1-carboxylate synthase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687451  similar to 1-aminocyclopropane-1-carboxylate synthase      Symbol and Name status set to provisional 70820 PROVISIONAL